EP1551973A4 - New gdf-9 and gdf-9b (bmp-15) sequences for altering mammalian ovarian function and ovulation rate - Google Patents
New gdf-9 and gdf-9b (bmp-15) sequences for altering mammalian ovarian function and ovulation rateInfo
- Publication number
- EP1551973A4 EP1551973A4 EP03723538A EP03723538A EP1551973A4 EP 1551973 A4 EP1551973 A4 EP 1551973A4 EP 03723538 A EP03723538 A EP 03723538A EP 03723538 A EP03723538 A EP 03723538A EP 1551973 A4 EP1551973 A4 EP 1551973A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- gdf
- bmp
- sequences
- new
- ovarian function
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000003928 Bone morphogenetic protein 15 Human genes 0.000 title 2
- 108090000349 Bone morphogenetic protein 15 Proteins 0.000 title 2
- 101100448240 Mus musculus Gdf9 gene Proteins 0.000 title 1
- 230000002611 ovarian Effects 0.000 title 1
- 230000016087 ovulation Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Gynecology & Obstetrics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ51933002 | 2002-05-30 | ||
NZ51933002A NZ519330A (en) | 2002-05-30 | 2002-05-30 | New sequences for altering mammalian ovarian function and ovulation rate |
PCT/NZ2003/000109 WO2003102199A1 (en) | 2002-05-30 | 2003-05-30 | New gdf-9 and gdf-9b (bmp-15) sequences for altering mammalian ovarian function and ovulation rate |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1551973A1 EP1551973A1 (en) | 2005-07-13 |
EP1551973A4 true EP1551973A4 (en) | 2006-06-07 |
Family
ID=29707820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03723538A Withdrawn EP1551973A4 (en) | 2002-05-30 | 2003-05-30 | New gdf-9 and gdf-9b (bmp-15) sequences for altering mammalian ovarian function and ovulation rate |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1551973A4 (en) |
JP (1) | JP2006510345A (en) |
AU (1) | AU2003235525B2 (en) |
BR (1) | BR0311465A (en) |
CA (1) | CA2490051A1 (en) |
NZ (1) | NZ519330A (en) |
WO (1) | WO2003102199A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006059914A1 (en) * | 2004-12-02 | 2006-06-08 | Agresearch Limited | Modulation of ovulation |
BRPI0518809A2 (en) * | 2004-12-02 | 2008-12-09 | Agres Ltd | ovulation modulation |
WO2006130022A1 (en) * | 2005-05-30 | 2006-12-07 | Agresearch Limited | Modulation of ovulation by agonists and antagonists of bmprii |
DE602006018183D1 (en) * | 2005-09-13 | 2010-12-23 | Neocodex S L | PROCESS FOR IN VITRO DETECTION OF AN INVESTIGATION FOR DEVELOPING CHANGES IN OVARIANCE FUNCTION |
BRPI0706173C1 (en) * | 2007-11-23 | 2011-02-22 | Brasil Pesquisa Agropec | method for mass identification of animals with increased prolificacy |
ES2338960B1 (en) * | 2007-11-23 | 2011-04-19 | Carnes Oviaragon S.C.L. | PROCEDURE FOR IMPROVING PRODUCTIVITY IN SHEEP. |
WO2014018404A1 (en) * | 2012-07-21 | 2014-01-30 | Baylor College Of Medicine | Gdf9:bmp15 heterodimers for enhancing fertility |
CN104774836A (en) * | 2015-04-15 | 2015-07-15 | 兰州大学 | Polygene pyramiding early-breeding method for raising litter size of sheep |
EP3577457A4 (en) * | 2017-02-01 | 2021-01-20 | Robert Bruce Gilchrist | Gamete-secreted growth factors |
US11702457B2 (en) | 2018-05-09 | 2023-07-18 | Monash University | Agent and method for enhancing fertility |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6030617A (en) * | 1993-01-12 | 2000-02-29 | The Johns Hopkins University School Of Medicine | Use of growth differentiation factor-9 (GDF-9) to inhibit oocyte maturation |
EP1181041A2 (en) * | 1999-04-30 | 2002-02-27 | Curis, Inc. | Morphogen-induced enhancement of fertility |
NZ500844A (en) * | 2000-05-05 | 2003-06-30 | Agres Ltd | Nucleotide sequences (mutated GDF-9B polypeptides) involved in increasing and decreasing mammalian ovulation rate |
NZ502796A (en) * | 2000-06-15 | 2003-02-28 | Agres Ltd | Nucleotide and amino acid sequences of oocyte factors related to GDF-9B or GDF-9 |
-
2002
- 2002-05-30 NZ NZ51933002A patent/NZ519330A/en not_active IP Right Cessation
-
2003
- 2003-05-30 CA CA002490051A patent/CA2490051A1/en not_active Abandoned
- 2003-05-30 AU AU2003235525A patent/AU2003235525B2/en not_active Ceased
- 2003-05-30 JP JP2004510436A patent/JP2006510345A/en active Pending
- 2003-05-30 WO PCT/NZ2003/000109 patent/WO2003102199A1/en active Application Filing
- 2003-05-30 EP EP03723538A patent/EP1551973A4/en not_active Withdrawn
- 2003-05-30 BR BR0311465-1A patent/BR0311465A/en not_active Application Discontinuation
Non-Patent Citations (6)
Title |
---|
BODENSTEINER K J ET AL: "Molecular cloning of the ovine growth/differentiation factor-9 gene and expression of growth/differentiation factor-9 in ovine and bovine ovaries", BIOLOGY OF REPRODUCTION, SOCIETY FOR THE STUDY OF REPRODUCTION, CHAMPAIGN, IL, US, vol. 60, no. 2, February 1999 (1999-02-01), pages 381 - 386, XP002192638, ISSN: 0006-3363 * |
DATABASE EMBL [online] 4 August 1998 (1998-08-04), "Ovis aries growth differentiation factor-9 gene, complete cds.", XP002358265, retrieved from EBI accession no. EM_PRO:AF078545 Database accession no. AF078545 * |
GALLOWAY SUSAN M ET AL: "Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 25, no. 3, July 2000 (2000-07-01), pages 279 - 283, XP002188991, ISSN: 1061-4036 * |
HANRAHAN J P: "Evidence for single gene effects on ovulation rate in the Cambridge and Beclare breeds", [INRA COLLOQUIA; MAJOR GENES FOR REPRODUCTION IN SHEEP] INRA (INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE) {A}, 147 RUE DE L'UNIVERSITE, 75007 PARIS, FRANCE SERIES : COLLOQUES DE L'INRA (ISSN 0293-1915), 1991, & 2ND INTERNATIONAL WORKSHOP; TOULOUSE, FRANCE; JULY 16-18, 1990, pages 93 - 102, XP008056997, ISSN: 2-7380-0337-0 * |
HANRAHAN JAMES P ET AL: "Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries).", BIOLOGY OF REPRODUCTION, vol. 70, no. 4, April 2004 (2004-04-01), pages 900 - 909, XP008056979, ISSN: 0006-3363 * |
See also references of WO03102199A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU2003235525B2 (en) | 2008-09-11 |
WO2003102199A1 (en) | 2003-12-11 |
AU2003235525A1 (en) | 2003-12-19 |
BR0311465A (en) | 2005-04-05 |
EP1551973A1 (en) | 2005-07-13 |
JP2006510345A (en) | 2006-03-30 |
CA2490051A1 (en) | 2003-12-11 |
NZ519330A (en) | 2004-12-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20041222 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
|
DAX | Request for extension of the european patent (deleted) | ||
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: NATIONAL UNIVERSITY OF IRELAND, GALWAY Owner name: MULSANT, PHILIPPE Owner name: HANRAHAN, JAMES PATRICK Owner name: OVITA LIMITED |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20060504 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: NATIONAL UNIVERSITY OF IRELAND, GALWAY Owner name: MULSANT, PHILIPPE Owner name: HANRAHAN, JAMES PATRICK Owner name: AGRESEARCH LIMITED |
|
17Q | First examination report despatched |
Effective date: 20070719 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20071130 |