EP1539931A4 - Agents de modulation de la differenciation et utilisations associees - Google Patents

Agents de modulation de la differenciation et utilisations associees

Info

Publication number
EP1539931A4
EP1539931A4 EP03735152A EP03735152A EP1539931A4 EP 1539931 A4 EP1539931 A4 EP 1539931A4 EP 03735152 A EP03735152 A EP 03735152A EP 03735152 A EP03735152 A EP 03735152A EP 1539931 A4 EP1539931 A4 EP 1539931A4
Authority
EP
European Patent Office
Prior art keywords
modulating agents
uses therefor
differentiation modulating
differentiation
therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03735152A
Other languages
German (de)
English (en)
Other versions
EP1539931A1 (fr
Inventor
Johannes Bernhard Prins
Louise Joyce Hutley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Verva Pharmaceuticals Pty Ltd
Original Assignee
University of Queensland UQ
Queensland Institute of Medical Research QIMR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Queensland UQ, Queensland Institute of Medical Research QIMR filed Critical University of Queensland UQ
Priority to EP10184571A priority Critical patent/EP2267117A3/fr
Publication of EP1539931A1 publication Critical patent/EP1539931A1/fr
Publication of EP1539931A4 publication Critical patent/EP1539931A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
EP03735152A 2002-06-27 2003-06-27 Agents de modulation de la differenciation et utilisations associees Withdrawn EP1539931A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10184571A EP2267117A3 (fr) 2002-06-27 2003-06-27 Agents de modulation de la différentiation et leurs utilisations

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39213002P 2002-06-27 2002-06-27
US392130P 2002-06-27
PCT/AU2003/000826 WO2004003179A1 (fr) 2002-06-27 2003-06-27 Agents de modulation de la differenciation et utilisations associees

Publications (2)

Publication Number Publication Date
EP1539931A1 EP1539931A1 (fr) 2005-06-15
EP1539931A4 true EP1539931A4 (fr) 2006-08-23

Family

ID=30000816

Family Applications (2)

Application Number Title Priority Date Filing Date
EP10184571A Withdrawn EP2267117A3 (fr) 2002-06-27 2003-06-27 Agents de modulation de la différentiation et leurs utilisations
EP03735152A Withdrawn EP1539931A4 (fr) 2002-06-27 2003-06-27 Agents de modulation de la differenciation et utilisations associees

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP10184571A Withdrawn EP2267117A3 (fr) 2002-06-27 2003-06-27 Agents de modulation de la différentiation et leurs utilisations

Country Status (7)

Country Link
EP (2) EP2267117A3 (fr)
JP (2) JP2005535629A (fr)
CN (1) CN1678734B (fr)
AU (2) AU2003236557B2 (fr)
CA (1) CA2490261A1 (fr)
NZ (1) NZ537208A (fr)
WO (1) WO2004003179A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2267117A3 (fr) * 2002-06-27 2011-07-13 Verva Pharmaceuticals Pty Ltd Agents de modulation de la différentiation et leurs utilisations
ATE506077T1 (de) * 2003-10-16 2011-05-15 Imclone Llc Fibroblasten-wachstumsfaktor-1-hemmer und behandlungsverfahren dafür
JPWO2005093083A1 (ja) * 2004-03-29 2008-02-14 和久 前田 疾病予測方法、及びその利用方法
US20090176306A1 (en) * 2005-06-10 2009-07-09 Toshio Taira Method of inducing differentiation from visceral preadipocyte to visceral adipocyte
GB0520063D0 (en) * 2005-10-03 2005-11-09 Novartis Forschungsstiftung Methods for regulating metabolism and diagnosing disease
US7946916B2 (en) 2006-01-12 2011-05-24 Waterleaf Ltd. Variable payout wager games
CN101058801B (zh) * 2007-04-13 2010-05-19 中国人民解放军第二军医大学 促进人皮下脂肪干细胞分化成熟的方法及其应用
NZ584827A (en) 2007-10-01 2012-10-26 Isis Pharmaceuticals Inc Antisense modulation of fibroblast growth factor receptor 4 expression
CN101259266B (zh) * 2008-04-14 2010-04-14 山东大学 一种前脂肪细胞异种疫苗及其制备方法和用途
US20130116171A1 (en) 2010-04-16 2013-05-09 Salk Institute For Biological Studies Methods for treating metabolic disorders using fgf
EP2721156B1 (fr) 2011-06-16 2016-12-21 Ionis Pharmaceuticals, Inc. Modulation antisens de l'expression du récepteur 4 du facteur de croissance fibroblastique
WO2013102209A1 (fr) 2011-12-30 2013-07-04 Joslin Diabetes Center, Inc. Compositions à base de glypican-4 et procédés destinés au traitement et au diagnostic d'une résistance à l'insuline
GB201202319D0 (en) 2012-02-10 2012-03-28 Orbsen Therapeutics Ltd Stromal stem cells
AU2014255755B2 (en) 2013-04-16 2018-10-25 Orbsen Therapeutics Limited Medical use of syndecan-2
WO2015061331A1 (fr) 2013-10-21 2015-04-30 Salk Institute For Biological Studies Peptides de facteur de croissance des fibroblastes (fgf) 2/fgf1 chimériques et procédés d'utilisation
EP3060238A4 (fr) 2013-10-21 2017-06-07 Salk Institute for Biological Studies Facteur de croissance de fibroblaste 1 (fgf) muté et méthodes d'utilisation
US20170065678A1 (en) * 2014-03-11 2017-03-09 Novartis Ag Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling
JP6920207B2 (ja) 2015-03-20 2021-08-18 オルブセン セラピューティクス リミテッド シンデカン−２のモジュレーターとその使用
WO2016172290A1 (fr) * 2015-04-21 2016-10-27 Salk Institute For Biological Studies Procédés de traitement de la lipodystrophie à l'aide de composés fgf-1
AU2016344134A1 (en) 2015-10-30 2018-05-31 Salk Institute For Biological Studies Treatment of steroid-induced hyperglycemia with fibroblast growth factor (FGF) 1 analogs
WO2017122095A1 (fr) 2016-01-15 2017-07-20 Orbsen Therapeutics Limited Compositions d'exosomes à base de sdc2 et leurs procédés d'isolement et d'utilisation
WO2019012334A2 (fr) 2017-07-14 2019-01-17 Orbsen Therapeutics Limited Procédés d'isolement et d'utilisation de cellules souches stromales cd39
US20210401728A1 (en) * 2018-10-26 2021-12-30 Ivan GALANIN Topical Compositions and Methods to Promote Optimal Dermal White Adipose Tissue Composition in Vivo
US11542309B2 (en) 2019-07-31 2023-01-03 Salk Institute For Biological Studies Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose
EP4200019A1 (fr) 2020-08-21 2023-06-28 Genzyme Corporation Anticorps anti-fgfr3 et méthodes d'utilisation

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WO2001070977A2 (fr) * 2000-03-22 2001-09-27 Amgen, Inc. Molecules analogues au recepteur du facteur de croissance du fibroblaste, et leurs utilisations
EP1202065A1 (fr) * 2000-10-25 2002-05-02 Aventis Pharma S.A. Le facteur de transcription NET de la famillie "TCF" comme régulateur de l'expression angiogénique
WO2003099796A1 (fr) * 2002-05-23 2003-12-04 Cytopia Pty Ltd Inhibiteurs de proteine kinase
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WO2000071129A1 (fr) * 1999-05-21 2000-11-30 Bristol-Myers Squibb Company Pyrrolotriazines inhibiteurs de kinases
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WO2001070977A2 (fr) * 2000-03-22 2001-09-27 Amgen, Inc. Molecules analogues au recepteur du facteur de croissance du fibroblaste, et leurs utilisations
EP1202065A1 (fr) * 2000-10-25 2002-05-02 Aventis Pharma S.A. Le facteur de transcription NET de la famillie "TCF" comme régulateur de l'expression angiogénique
WO2003099796A1 (fr) * 2002-05-23 2003-12-04 Cytopia Pty Ltd Inhibiteurs de proteine kinase
WO2004001059A2 (fr) * 2002-06-20 2003-12-31 Bristol-Myers Squibb Company Inhibiteurs heterocycliques de kinases

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RUSSELL T R ET AL: "CONVERSION OF 3T3 FIBROBLASTS INTO ADIPOSE CELLS: TRIGGERING OF DIFFERENTIATION BY PROSTAGLANDIN F2ALPHA AND I-METHYL-3-ISOBUTYL XANTHINE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 12, no. 73, 1 December 1976 (1976-12-01), pages 4516 - 4520, XP001079689, ISSN: 0027-8424, DOI: 10.1073/pnas.73.12.4516 *
SASAKI K ET AL: "Actions of acidic fibroblast growth factor fragments on food intake in rats", OBESITY RESEARCH, BATON ROUGE, LA, US, vol. 3, no. Suppl 5, 1 December 1995 (1995-12-01), pages 697S - 706S, ISSN: 1071-7323 *
SASAKI K ET AL: "EFFECTS OF FRIBROBLAST GROWTH FACTROS AND RELATED PEPTIDES ON FOOD INTAKE BY RATS", PHYSIOLOGY AND BEHAVIOR, ELSEVIER SCIENCE LTD., OXFORD, GB, vol. 56, no. 2, 1 January 1994 (1994-01-01), pages 211 - 218, XP000943197, ISSN: 0031-9384, DOI: 10.1016/0031-9384(94)90186-4 *
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See also references of WO2004003179A1 *
SERRERO G ET AL: "Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 212, no. 3, 26 July 1995 (1995-07-26), pages 1125 - 1132, XP008081146, ISSN: 0006-291X, DOI: 10.1006/bbrc.1995.2085 *

Also Published As

Publication number Publication date
CN1678734A (zh) 2005-10-05
NZ537208A (en) 2009-02-28
CA2490261A1 (fr) 2004-01-08
AU2003236557B2 (en) 2009-10-01
EP2267117A3 (fr) 2011-07-13
JP2005535629A (ja) 2005-11-24
CN1678734B (zh) 2012-12-12
EP2267117A2 (fr) 2010-12-29
EP1539931A1 (fr) 2005-06-15
AU2009251219B2 (en) 2013-01-10
JP2010215636A (ja) 2010-09-30
AU2003236557A1 (en) 2004-01-19
AU2009251219A1 (en) 2010-01-28
WO2004003179A1 (fr) 2004-01-08

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