EP1529115A4 - Activite de sir2 - Google Patents

Activite de sir2

Info

Publication number
EP1529115A4
EP1529115A4 EP02749837A EP02749837A EP1529115A4 EP 1529115 A4 EP1529115 A4 EP 1529115A4 EP 02749837 A EP02749837 A EP 02749837A EP 02749837 A EP02749837 A EP 02749837A EP 1529115 A4 EP1529115 A4 EP 1529115A4
Authority
EP
European Patent Office
Prior art keywords
sir2 activity
sir2
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02749837A
Other languages
German (de)
English (en)
Other versions
EP1529115A2 (fr
Inventor
Leonard Guarente
Homayoun Vaziri
Shin-Ichiro Imai
Wei Gu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Whitehead Institute for Biomedical Research
Massachusetts Institute of Technology
Original Assignee
Elixir Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elixir Pharmaceuticals Inc filed Critical Elixir Pharmaceuticals Inc
Publication of EP1529115A2 publication Critical patent/EP1529115A2/fr
Publication of EP1529115A4 publication Critical patent/EP1529115A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP02749837A 2001-07-06 2002-07-08 Activite de sir2 Withdrawn EP1529115A4 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US190159 1988-05-04
US30337001P 2001-07-06 2001-07-06
US30345601P 2001-07-06 2001-07-06
US303456P 2001-07-06
US303370P 2001-07-06
US19015902A 2002-07-05 2002-07-05
PCT/US2002/021461 WO2003004621A2 (fr) 2001-07-06 2002-07-08 Activite de sir2

Publications (2)

Publication Number Publication Date
EP1529115A2 EP1529115A2 (fr) 2005-05-11
EP1529115A4 true EP1529115A4 (fr) 2005-08-24

Family

ID=32074257

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02749837A Withdrawn EP1529115A4 (fr) 2001-07-06 2002-07-08 Activite de sir2

Country Status (4)

Country Link
EP (1) EP1529115A4 (fr)
AU (1) AU2002320325B2 (fr)
CA (1) CA2453195A1 (fr)
WO (1) WO2003004621A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642284B1 (en) 1999-12-15 2014-02-04 Massachusetts Institute Of Technology Methods for identifying agents that alter NAD-dependent deacetylation activity of a SIR2 protein
US7452664B2 (en) 1999-12-15 2008-11-18 Massachusetts Institute Of Technology Methods for identifying agents which alter histone protein acetylation
US7572575B2 (en) 2000-12-13 2009-08-11 Massachusetts Institute Of Technology SIR2 activity
WO2003046207A2 (fr) 2001-11-27 2003-06-05 Fred Hutchinson Cancer Research Center Procedes d'inhibition de l'activite deacetylase
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
DE60335875D1 (de) 2002-05-23 2011-03-10 Univ California Verfahren zum Auswählen von Modulatoren der mitochondrialen NAD-abhängigen Deacetylase, SIRT3
US20070099830A1 (en) 2005-04-21 2007-05-03 Massachusetts Institute Of Technology Sirt4 activities
US8518635B2 (en) 2006-06-12 2013-08-27 The J. David Gladstone Institutes Regulation of protein activity by reversible acetylation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GUARENTE, LEONARD: "SIR2 and aging - the exception that proves the rule", TRENDS IN GENETICS, vol. 17, no. 7, 1 July 2001 (2001-07-01), pages 301 - 392 *
MUTH VIOLA ET AL: "Acetylation of TAFI68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 20, no. 6, 15 March 2001 (2001-03-15), pages 1353 - 1362, XP002334003, ISSN: 0261-4189 *

Also Published As

Publication number Publication date
AU2002320325B2 (en) 2008-04-03
WO2003004621A3 (fr) 2005-03-17
WO2003004621A2 (fr) 2003-01-16
EP1529115A2 (fr) 2005-05-11
CA2453195A1 (fr) 2003-01-16
AU2002320325A2 (en) 2003-01-21

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20040206

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20050712

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH

Owner name: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

RIN1 Information on inventor provided before grant (corrected)

Inventor name: IMAI, SHIN-ICHIRO

Inventor name: VAZIRI, HOMAYOUN

Inventor name: GUARENTE, LEONARD

17Q First examination report despatched

Effective date: 20080821

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20131015