EP1529115A4 - Sir2-aktivität - Google Patents
Sir2-aktivitätInfo
- Publication number
- EP1529115A4 EP1529115A4 EP02749837A EP02749837A EP1529115A4 EP 1529115 A4 EP1529115 A4 EP 1529115A4 EP 02749837 A EP02749837 A EP 02749837A EP 02749837 A EP02749837 A EP 02749837A EP 1529115 A4 EP1529115 A4 EP 1529115A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- sir2 activity
- sir2
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30337001P | 2001-07-06 | 2001-07-06 | |
US30345601P | 2001-07-06 | 2001-07-06 | |
US303456P | 2001-07-06 | ||
US303370P | 2001-07-06 | ||
US19015902A | 2002-07-05 | 2002-07-05 | |
US190159 | 2002-07-05 | ||
PCT/US2002/021461 WO2003004621A2 (en) | 2001-07-06 | 2002-07-08 | Sir2 activity |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1529115A2 EP1529115A2 (de) | 2005-05-11 |
EP1529115A4 true EP1529115A4 (de) | 2005-08-24 |
Family
ID=32074257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02749837A Withdrawn EP1529115A4 (de) | 2001-07-06 | 2002-07-08 | Sir2-aktivität |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1529115A4 (de) |
AU (1) | AU2002320325B2 (de) |
CA (1) | CA2453195A1 (de) |
WO (1) | WO2003004621A2 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8642284B1 (en) | 1999-12-15 | 2014-02-04 | Massachusetts Institute Of Technology | Methods for identifying agents that alter NAD-dependent deacetylation activity of a SIR2 protein |
US7452664B2 (en) | 1999-12-15 | 2008-11-18 | Massachusetts Institute Of Technology | Methods for identifying agents which alter histone protein acetylation |
US7572575B2 (en) | 2000-12-13 | 2009-08-11 | Massachusetts Institute Of Technology | SIR2 activity |
WO2003046207A2 (en) | 2001-11-27 | 2003-06-05 | Fred Hutchinson Cancer Research Center | Methods for inhibiting deacetylase activity |
US7351542B2 (en) | 2002-05-20 | 2008-04-01 | The Regents Of The University Of California | Methods of modulating tubulin deacetylase activity |
ATE497015T1 (de) | 2002-05-23 | 2011-02-15 | Univ California | Verfahren zum auswählen von modulatoren der mitochondrialen nad-abhängigen deacetylase, sirt3 |
US20070099830A1 (en) | 2005-04-21 | 2007-05-03 | Massachusetts Institute Of Technology | Sirt4 activities |
US8518635B2 (en) | 2006-06-12 | 2013-08-27 | The J. David Gladstone Institutes | Regulation of protein activity by reversible acetylation |
-
2002
- 2002-07-08 EP EP02749837A patent/EP1529115A4/de not_active Withdrawn
- 2002-07-08 CA CA002453195A patent/CA2453195A1/en not_active Abandoned
- 2002-07-08 WO PCT/US2002/021461 patent/WO2003004621A2/en not_active Application Discontinuation
- 2002-07-08 AU AU2002320325A patent/AU2002320325B2/en not_active Ceased
Non-Patent Citations (2)
Title |
---|
GUARENTE, LEONARD: "SIR2 and aging - the exception that proves the rule", TRENDS IN GENETICS, vol. 17, no. 7, 1 July 2001 (2001-07-01), pages 301 - 392 * |
MUTH VIOLA ET AL: "Acetylation of TAFI68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 20, no. 6, 15 March 2001 (2001-03-15), pages 1353 - 1362, XP002334003, ISSN: 0261-4189 * |
Also Published As
Publication number | Publication date |
---|---|
AU2002320325B2 (en) | 2008-04-03 |
WO2003004621A3 (en) | 2005-03-17 |
CA2453195A1 (en) | 2003-01-16 |
WO2003004621A2 (en) | 2003-01-16 |
AU2002320325A2 (en) | 2003-01-21 |
EP1529115A2 (de) | 2005-05-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0402171A3 (en) | Pyrazolopyrimidinone derivatives having pde7-inhibitory activity | |
IL159439A0 (en) | Iodobenzopyran-4-one derivatives having fungicidal activity | |
IL161990A0 (en) | Cetylene derivatives having mglur 5antagonistic activity | |
AU2002357860A8 (en) | Enzymes | |
DE60223075D1 (en) | Aberrometer | |
AU2002312371A1 (en) | Aryl-benzimidazole compounds having antiinfective activity | |
GB2390952B (en) | Monitor | |
EP1353546A4 (de) | Beschreibung | |
EP1362800A4 (de) | Strohhalm | |
IL154364A0 (en) | Arylalkane-sulfonamides having endothelin-antagonist activity | |
EP1529115A4 (de) | Sir2-aktivität | |
EP1394120A4 (de) | Desinfektionsmittel | |
GB0112561D0 (en) | Active plate | |
GB0128650D0 (en) | Construction elements | |
IL142732A0 (en) | Sprinklers | |
EP1457259A4 (de) | Photokatalysator | |
GB0112563D0 (en) | Active plate | |
DE60231474D1 (en) | Monitor | |
GB0108110D0 (en) | Keeps | |
GB0102946D0 (en) | Enzyme | |
TW493677U (en) | Doorstopper structure | |
GB0108961D0 (en) | Antimicrobial activity assessment | |
GB0115750D0 (en) | Harrow | |
GB0123923D0 (en) | Harrow | |
CA94979S (en) | Disinfectant center |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20040206 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20050712 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH Owner name: MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: IMAI, SHIN-ICHIRO Inventor name: VAZIRI, HOMAYOUN Inventor name: GUARENTE, LEONARD |
|
17Q | First examination report despatched |
Effective date: 20080821 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20131015 |