EP1512381A2 - Stent pour branche laterale possedant une partie proximale fendue - Google Patents
Stent pour branche laterale possedant une partie proximale fendue Download PDFInfo
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- EP1512381A2 EP1512381A2 EP04255234A EP04255234A EP1512381A2 EP 1512381 A2 EP1512381 A2 EP 1512381A2 EP 04255234 A EP04255234 A EP 04255234A EP 04255234 A EP04255234 A EP 04255234A EP 1512381 A2 EP1512381 A2 EP 1512381A2
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- Prior art keywords
- stent
- proximal
- strut members
- spokes
- section
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/856—Single tubular stent with a side portal passage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/848—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/954—Instruments specially adapted for placement or removal of stents or stent-grafts for placing stents or stent-grafts in a bifurcation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2002/821—Ostial stents
-
- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91525—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/006—Additional features; Implant or prostheses properties not otherwise provided for modular
Definitions
- intravascular stents are an excellent means to maintain the patency of blood vessels following balloon angioplasty.
- stent technology has advanced, more and more complex anatomy has been treatable with stents.
- a particularly difficult anatomy to treat is that of a bifurcation in a blood vessel at the ostium of a side branch.
- Fischell et al. U.S. Pat. No. 5,749,825, describe a stent system for bifurcations.
- the Fischell design has two guide wire lumens allowing the deployment of a stent in the first blood vessel while leaving a guide wire positioned through the stent struts into the second vessel which is a side branch.
- the profile (outside diameter) of the stenting system is significantly larger as compared to a stent delivery catheter that uses a single guide wire.
- Fischell does not address placement of a stent into the second branch (across the ostium,) which is often not at a 90-degree angle to the first vessel.
- a bifurcation stent delivery catheter with two distal balloons and one stent segment for each of the two vessels would address the issue of stenting the second branch vessel but such a device would be quite large in profile and extremely hard to deliver. If one places a first stent into a main artery with that stent being positioned across the ostium of the side branch and the side branch is not at a 90-degree angle to the main branch, then either the second stent will extend into the main branch of the artery, or some portion of the arterial wall at the ostium will not be properly supported by the second stent.
- a second stent is then implanted in the main branch, crushing flat the proximal end of the sidebranch stent.
- a guidewire is the advanced through the side of the main branch stent and the flattened area of the crushed sidebranch stent into the sidebranch.
- a balloon expansion of the "crushed" area "unjails” (opens) the stent for blood flow.
- this method leaves three layers of stent metal at the proximal end of the sidebranch stent, [i.e., both sides of the crushed sidebranch stent and the single layer of the main branch stent.] This is particularly troublesome with cytotoxic drug eluting stents (e.g. paclitaxel) where the proper dosing occurs over a narrow range.
- cytotoxic drug eluting stents e.g. paclitaxel
- Most current tubular stents use a multiplicity of circumferential sets of strut members connected by either straight longitudinal connecting links or undulating longitudinal flexible links.
- the circumferential sets of strut members are typically formed from a series of diagonal sections connected to curved sections forming a circumferential, closed-ring, zig-zag structure. This structure expands as the stent deploys, to form the elements of the stent that provide structural support for the arterial wall.
- the present invention uses a stent with a proximal end designed to be "split" apart, to provide metal coverage and drug delivery to the entire ostium of the sidebranch while avoiding the triple metal issue of using the crush technique.
- a stent could be self-expanding with its proximal end designed to flare apart when released from the stent delivery sheath, or it may be balloon expandable.
- the self-expanding embodiment would typically be made from a nickel titanium shape memory alloy, such as nitinol having a transition temperature above body temperature.
- the delivery catheter for this embodiment would typically have 3 radiopaque markers designed to indicate the distal end of the stent, the proximal end of the stent and the distal end of the proximal stent section designed to split apart upon deployment.
- just the proximal, split end section would have a transition temperature slightly above body temperature. After delivery of the stent into the sidebranch, there would be an added step of heating the most proximal section of the self-expanding above its transition temperature, to cause this section to flare. This could be accomplished by injecting saline solution at above the transition temperature of the proximal section of the stent.
- the balloon expandable embodiment can be delivered on a standard balloon stent delivery system.
- a stent delivery system may have at least two balloon sections, with the proximal section having a greater diameter than the distal section, so as to spread apart the split proximal end of the present invention stent.
- the balloon proximal section might also be much more compliant than the distal section, so that as higher pressures are used, the ratio of the diameter of the proximal balloon section to the distal balloon section increases.
- the stent delivery system would also have three marker bands, to allow the user to visualize the distal end of the stent, the proximal end of the stent and the distal end of the "split" proximal end.
- the method for use of the present invention stent and stent delivery system is to insert a first guidewire into the branch vessel and advance the stent delivery system until the marker at the distal end of the split proximal end is aligned with the downstream edge of the sidebranch ostium.
- the balloon is then inflated to deliver the stent into the sidebranch. If the two zone balloon is being used as a stent delivery system, the initial inflation will cause the split proximal end to flare apart. If the stent is delivered on a standard balloon angioplasty catheter, then a second balloon of larger diameter would be used to post-dilate the proximal end of the split end stent.
- a stent is then advanced into the main branch and deployed, further spreading the split proximal end of the split end sidebranch stent outward against the wall of the main branch.
- a guidewire is then placed through the main branch stent and the opening into the sidebranch is enlarged using balloon inflation. The final result is a double layer of metal at the ostium of the sidebranch where additional anti-restenosis drug elution is desirable.
- the present invention stent uses longitudinally connected circumferential sets of strut members formed from alternating curved sections (crowns) and straight sections. It is the circumferential sets of strut members that form the support structure of the stent.
- the proximal split end section of the stent has the same number of spokes as crowns (curved sections) in the most proximal circumferential set of strut members. In an alternate embodiment there is one spoke for every two crowns in the most proximal circumferential set of strut members. It is also envisioned that more than one spoke per crown is possible, although a ratio of one-half or one will best fit typical coronary stent geometry. For example in a typical closed cell 3mm diameter coronary stent such as that sold under the mark CORDIS BX Velocity stent (Miami Lakes, Florida), there are 6 cells (i.e. 12 crowns) in each circumferential set of strut members.
- the split ends are connected to an extra long circumferential set of strut members that will further connect the ends of the individual spokes of the split end stent and would enhance stent retention at the stent proximal end as compared with unconnected spokes.
- Another object of this invention is to have a stent delivery system with a larger diameter proximal section designed to spread the spokes of the split proximal end of a split end sidebranch stent.
- Still another object of the present invention is to have a self-expanding split end stent with the proximal split end section "pre-set" to flare outward when released.
- Yet another object of the present invention is to have a self-expanding split end stent formed from a nickel titanium based shape memory alloy, such as nitinol, with the proximal split end section having a transition temperature above body temperature.
- Another object of this invention is to have the proximal-most circumferential set of strut members connected to each of the spreadable spokes, the circumferential set of strut members being of much greater length than all other circumferential sets of strut members in the stent.
- a final object of this invention is to have a method for deploying a stents at a bifurcation or sidebranch where a first split end sidebranch stent is delivered into the sidebranch, the proximal spreadable spokes are flared out, and then a second stent is delivered into the main branch, the second stent pressing the flared spokes into the arterial wall.
- the sidebranch is then "unjailed" in the standard manner, and the procedure is complete.
- FIG. 1A shows an artery with a side branch, (i.e., a bifurcated artery) where a first "prior art” stent 1 has been deployed into the main branch and a second "prior art” stent 2A has been deployed into the side branch leaving the section 3 of the arterial wall at the ostium of the side branch un-stented and therefore unsupported.
- the side branch vessel attaches to the main branch at an acute angle f that is less than 90 degrees.
- FIG. 1B shows an artery with side branch where a first "prior art” stent 1 has been deployed into the main branch and a second "prior art” stent 2B has been deployed into the side branch.
- the second stent 2B extends part way into the main branch causing the stents to overlap.
- Such an extension of metal into an artery can cause turbulent blood flow that can readily result in subacute thrombosis.
- FIGS. 2A through 2C are an illustration of the "crush" method for stenting a sidebranch vessel.
- a stent 6 is expanded into the ostium of the side branch with a significant portion of the stent 6 protruding into the main branch.
- a second stent 8 is expanded by a stent delivery catheter 4 with balloon 5 into the main branch. This expansion produces the crushed stent 6' having a flattened proximal end.
- a guidewire 9 is placed through a cell in the side of the stent 8, through the "crushed" stent 6' and into the side branch vessel.
- FIG. 3 is a flat layout view of one embodiment of the present invention split end stent 10.
- the distal section of the stent is similar to that of the stent sold under the mark CORDIS BX Velocity, having a multiplicity of circumferential sets of strut members 12 connected by undulating flexible links 14.
- the proximal end of the stent 10 has six spokes 15. Each spoke 15 is composed of an end segment 16 and an undulating flexible link 14 that connects the end segments 16 to the most proximal circumferential set of strut members 18.
- the spokes 15 are designed to be spread outward by a balloon during the stenting procedure (see FIGS. 5A through 5D) so as to effectively cover the ostium of a side branch.
- the end segments 16 have a shape designed to provide sufficient surface area for an effective dose from a drug eluting coating
- the drug may be a cytostatic drug such as sirolimus, everolimus, the expanded drug ABT-578 or other sirolimus analogues, or it may be a cytotoxic drug such as paclitaxel.
- an outer heparin surface coating may be applied to reduce the potential for sub-acute thrombosis.
- FIG. 4 is a three dimensional sketch of the present invention split end stent 10 of FIG. 3 with spokes 15 at the proximal end of the stent.
- FIG. 4 shows the configuration of the stent 10 after it has been cut and electropolished, but before it is mounted on a stent delivery catheter.
- FIGs. 5A through 5D show steps in the stenting of a sidebranch/bifurcation using the stent 10 of FIGs. 3 and 4.
- the split end stent 10 of FIGs. 2 and 3 is deployed at the ostium of main branch and sidebranch vessels.
- FIG. 5A shows the use of a balloon catheter 20 to spread the spokes 15 of the proximal section of the balloon expandable split end stent 10 following an earlier deployment of the stent 10 into the ostium of the side branch vessel.
- the balloon catheter 20 has balloon 22 inner shaft 24 and outer shaft 26. The balloon catheter 20 is inserted into the ostium of the sidebranch over the guide wire 30.
- FIG. 5B shows the split end stent 10 with flared proximal spokes 15 after removal of the balloon catheter 20 and just before stenting of the main branch vessel.
- FIG. 5C shows the deployment of a balloon expandable stent 50 into the main branch vessel with the stent delivery system 40 having balloon 42, inner shaft 44 and outer shaft 46.
- the stent delivery system 40 is advanced to the deployment site over the guidewire 60.
- FIG. 5D shows the resulting two stent structure with a guidewire placed through a cell 50 of the main branch stent 50 through the side branch stent 10 and into the side branch just before final unjailing of the side branch by balloon expansion of the cell 52 in the main branch stent 50.
- FIG. 6 is a flat layout of another embodiment of the present invention split end stent 70 having one spoke 75 for each crown 76 in the most proximal circumferential set of strut members 78.
- the widened proximal end of each spoke 75 has a radiopaque insert 73, such as is used in the stent sold under the mark CORDIS SMARTER.
- the radiopaque insert 73 would facilitate visualization of the flared spokes to ensure proper deployment.
- Examples of typical materials used in the radiopaque insert would be a radiopaque metal such as gold, platinum or tantalum, or alloys such as the carat-gold and platinum-iridium alloys.
- elemental Palladium and Iridium are biocompatible materials that would exhibit desirable radiopacity, as does tungsten, which could be sputtered onto the stent surface.
- every spoke 75 of the stent 70 has a radiopaque marker 73, it is also envisioned that only a subset of the spokes, (e.g. half of the spokes) might have the radiopaque inserts. It is also envisioned that radiopaque inserts might be added to any of the embodiments of the stents described herein.
- each spoke 75 has an undulating shape to allow it the flexibility to adapt to the shape of the side branch ostium, it is envisioned that straight spokes could also work, especially if the stent has a relatively thin wall (e.g. less than 0.1 mm (0.004")).
- the stent 70 with two spokes 75 for each crown 76 would provide a better metal coverage and therefore more uniform drug delivery at the ostium of a side branch than the stent 10 as the stent 70 has twice the number of spokes as the stent 10.
- the stent 70 has a distal section constructed of circumferential sets of strut members 72, connected by a multiplicity of undulating flexible links 75.
- each of the embodiments shown herein has a distal section that is a closed cell design, a split proximal end type design is equally applied to open cell stents.
- FIG. 7 is a flat layout of still another embodiment of the split end stent 80 having a proximal end circumferential set of strut members 86 having sufficient length to accommodate the flaring of the proximal end.
- the proximal section of the stent 80 is similar to that of the stents 10 and 70 of FIGS. 3 and 6 respectively having circumferential sets of strut members 82 connected by a multiplicity of undulating flexible links 84.
- the flare-able proximal end circumferential set of strut members 86 attaches to the most proximal standard circumferential set of strut members 88 via flexible links 89.
- the mid portions of the proximal circumferential set of strut members 86 have been coated with a radiopaque material 85 such as gold or platinum. It should be noted that only the straight sections of the circumferential set of strut members 86 have been coated to avoid any potential cracking of the coating during expansion of the stent 80. It is also envisioned that such a radiopaque marking could be applied to the proximal spokes of any of the other embodiments described herein such as the stent 10 of FIG. 3 and/or the stent 70 of FIG. 6.
- connection 83 of the links 89 to the most proximal circumferential set of strut members 88 of the stent 80 has a tapered shape to provide strain relief. This tapered shape is seen more clearly in the close up of the section 8 shown in FIG. 8.
- the flexible links 89 of the stent 80 have an undulating shape, straight connecting links would also work with this design.
- the advantage of the design of the stent 80 over the embodiments illustrated by the stents 10 and 70 is that in having a closed circumferential structure at its proximal end, the stent 80 will be better retained when crimped on a balloon stent delivery catheter.
- the stents 10, 70 and 80 can be either balloon expandable or self-expanding. If balloon expandable, the stents should be made from a biocompatible metal such as stainless steel, tantalum or cobalt-chromium alloys. If self-expanding, the stents would typically be made from a nickel titanium based shape memory alloy, such as nitinol.
- FIG. 9 is a longitudinal cross section of the post deployment configuration of the present invention balloon expandable split end stent 10 with stent delivery system 90
- the stent delivery system 90 has a balloon 92 with a cylindrical shaped distal section 99 and larger diameter proximal section 98, designed to flare the proximal spokes 15 of the stent 10.
- the stent delivery system 90 is designed to be advanced over a guidewire 60, and has a distal end construction similar to that of standard balloon angioplasty catheters.
- a balloon inflation lumen 97 is placed between the inner shaft 94 and outer shaft 96.
- the balloon 92 attaches at its proximal end to the outer shaft 96 and at its distal end to the inner shaft 94.
- the stent delivery system 90 utilizes three radiopaque marker bands 91, 93 and 95.
- the marker band 91 marks the proximal end of the mounted stent 10 and the marker band 95 marks the distal end of the mounted stent 10.
- the marker band 93 marks the distal end of the spokes 15, and can be used to properly position the stent delivery system 90 before stent deployment at the ostium of a side branch vessel.
- the stent delivery system 90 has a proximal section (not shown) that can be in the form of a standard over-the-wire stent delivery system or a standard rapid exchange stent delivery system.
- the stent delivery system 90 is ideally suited to delivery a split end stent such as the stents 10, 70 or 80, it is envisioned that the stents might be delivered on a standard stent delivery system without the flaring section 98 of the stent delivery system 90. A second balloon would then be required to flare the split proximal end as shown in FIG. 5A.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/654,118 US20050049680A1 (en) | 2003-09-03 | 2003-09-03 | Side branch stent with split proximal end |
US654118 | 2003-09-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1512381A2 true EP1512381A2 (fr) | 2005-03-09 |
EP1512381A3 EP1512381A3 (fr) | 2005-03-16 |
Family
ID=34136665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04255234A Withdrawn EP1512381A3 (fr) | 2003-09-03 | 2004-08-28 | Stent pour branche laterale possedant une partie proximale fendue |
Country Status (3)
Country | Link |
---|---|
US (1) | US20050049680A1 (fr) |
EP (1) | EP1512381A3 (fr) |
CA (1) | CA2480369A1 (fr) |
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US8187314B2 (en) | 2003-04-14 | 2012-05-29 | Tryton Medical, Inc. | Prothesis and deployment catheter for treating vascular bifurcations |
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US8257432B2 (en) | 2003-04-14 | 2012-09-04 | Tryton Medical, Inc. | Vascular bifurcation prosthesis with at least one frond |
US8109987B2 (en) | 2003-04-14 | 2012-02-07 | Tryton Medical, Inc. | Method of treating a lumenal bifurcation |
US9775728B2 (en) | 2003-04-14 | 2017-10-03 | Tryton Medical, Inc. | Vascular bifurcation prosthesis |
US8529618B2 (en) | 2003-04-14 | 2013-09-10 | Tryton Medical, Inc. | Ostium support for treating vascular bifurcations |
US7758630B2 (en) | 2003-04-14 | 2010-07-20 | Tryton Medical, Inc. | Helical ostium support for treating vascular bifurcations |
US7731747B2 (en) | 2003-04-14 | 2010-06-08 | Tryton Medical, Inc. | Vascular bifurcation prosthesis with multiple thin fronds |
US7972372B2 (en) | 2003-04-14 | 2011-07-05 | Tryton Medical, Inc. | Kit for treating vascular bifurcations |
US8876884B2 (en) | 2003-04-14 | 2014-11-04 | Tryton Medical, Inc. | Prosthesis and deployment catheter for treating vascular bifurcations |
EP3424463A1 (fr) * | 2003-11-08 | 2019-01-09 | Cook Medical Technologies LLC | Système d'endoprothèses d'aortes et de branches vasculaires |
EP1799151A4 (fr) * | 2004-09-15 | 2014-09-17 | Conor Medsystems Inc | Endoprothese vasculaire pour bifurcation, dotee d'une extremite pouvant etre ecrasee, et procede de placement d'une endoprothese vasculaire au niveau d'une bifurcation |
EP1799151A2 (fr) * | 2004-09-15 | 2007-06-27 | Conor Medsystems, Inc. | Endoprothese vasculaire pour bifurcation, dotee d'une extremite pouvant etre ecrasee, et procede de placement d'une endoprothese vasculaire au niveau d'une bifurcation |
EP1811923A4 (fr) * | 2004-10-13 | 2009-12-16 | Tryton Medical Inc | Catheter a ballonnet echelonne destine au traitement de bifurcations vasculaires |
US7717953B2 (en) | 2004-10-13 | 2010-05-18 | Tryton Medical, Inc. | Delivery system for placement of prosthesis at luminal OS |
US8252038B2 (en) | 2004-10-13 | 2012-08-28 | Tryton Medical, Inc. | System for delivering a prosthesis to a luminal OS |
WO2006044637A2 (fr) | 2004-10-13 | 2006-04-27 | Tryton Medical, Inc. | Catheter a ballonnet echelonne destine au traitement de bifurcations vasculaires |
US7972369B2 (en) | 2004-10-13 | 2011-07-05 | Tryton Medical, Inc. | Method for delivering a luminal prosthesis |
US8926685B2 (en) | 2004-10-13 | 2015-01-06 | Tryton Medical, Inc. | Prosthesis for placement at a luminal OS |
EP1811923A2 (fr) * | 2004-10-13 | 2007-08-01 | Tryton Medical, Inc. | Catheter a ballonnet echelonne destine au traitement de bifurcations vasculaires |
EP2462903A1 (fr) * | 2004-10-13 | 2012-06-13 | Tryton Medical, Inc. | Cathéter à ballonnet échelonné et prothèse permettant de traiter les bifurcations vasculaires |
US7429268B2 (en) | 2004-12-08 | 2008-09-30 | Innovational Holdings, Llc | Expandable medical device with differential hinge performance |
US7862601B2 (en) * | 2005-05-23 | 2011-01-04 | Incept Llc | Apparatus and methods for delivering a stent into an ostium |
WO2006127784A2 (fr) * | 2005-05-23 | 2006-11-30 | Incept Llc | Endoprotheses actionnees mecaniquement et appareils et procedes de leur administration |
US9034025B2 (en) | 2005-05-23 | 2015-05-19 | Ostial Corporation | Balloon catheters and methods for use |
WO2006127784A3 (fr) * | 2005-05-23 | 2007-05-03 | Incept Llc | Endoprotheses actionnees mecaniquement et appareils et procedes de leur administration |
US7582111B2 (en) | 2005-08-22 | 2009-09-01 | Incept, Llc | Steep-taper flared stents and apparatus and methods for delivering them |
US10092429B2 (en) | 2005-08-22 | 2018-10-09 | Incept, Llc | Flared stents and apparatus and methods for delivering them |
JP2009505742A (ja) * | 2005-08-22 | 2009-02-12 | インセプト・リミテッド・ライアビリティ・カンパニー | フレア展開ステント、ならびにこれを製造・使用する装置および方法 |
WO2007024964A1 (fr) * | 2005-08-22 | 2007-03-01 | Incept, Llc | Stents evases, appareil et procedes de production et d'utilisation |
US8702777B2 (en) | 2005-08-22 | 2014-04-22 | Incept, Llc | Steep-taper flared stents and apparatus and methods for delivering them |
WO2007051183A1 (fr) * | 2005-10-28 | 2007-05-03 | Incept, Llc | Stents evases, appareils et procedes pour leur pose |
US7766893B2 (en) | 2005-12-07 | 2010-08-03 | Boston Scientific Scimed, Inc. | Tapered multi-chamber balloon |
US8142395B2 (en) | 2005-12-07 | 2012-03-27 | Boston Scientific Scimed, Inc. | Tapered multi-chamber balloon |
WO2008054576A1 (fr) * | 2006-11-03 | 2008-05-08 | Boston Scientific Limited | Ballonnet à accès par ramification latérale contraignant le vaisseau principal |
US8398695B2 (en) | 2006-11-03 | 2013-03-19 | Boston Scientific Scimed, Inc. | Side branch stenting system using a main vessel constraining side branch access balloon and side branching stent |
US8414611B2 (en) | 2006-11-03 | 2013-04-09 | Boston Scientific Scimed, Inc. | Main vessel constraining side-branch access balloon |
US8070794B2 (en) | 2007-01-09 | 2011-12-06 | Stentys S.A.S. | Frangible bridge structure for a stent, and stent including such bridge structures |
WO2008084376A3 (fr) * | 2007-01-09 | 2008-10-16 | Stentys S A S | Structure de pont cassable pour une endoprothèse vasculaire et endoprothèse vasculaire comprenant de telles structures de pont |
WO2008084376A2 (fr) * | 2007-01-09 | 2008-07-17 | Stentys S.A.S. | Structure de pont cassable pour une endoprothèse vasculaire et endoprothèse vasculaire comprenant de telles structures de pont |
FR2911063A1 (fr) * | 2007-01-09 | 2008-07-11 | Stentys S A S Soc Par Actions | Structure de pont ruptible pour un stent, et stent incluant de telles structures de pont. |
WO2009071243A3 (fr) * | 2007-12-06 | 2009-09-03 | Translumina Gmbh | Support de vaisseau implantable |
US9149373B2 (en) | 2009-07-02 | 2015-10-06 | Tryton Medical, Inc. | Method of treating vascular bifurcations |
US8382818B2 (en) | 2009-07-02 | 2013-02-26 | Tryton Medical, Inc. | Ostium support for treating vascular bifurcations |
US8366763B2 (en) | 2009-07-02 | 2013-02-05 | Tryton Medical, Inc. | Ostium support for treating vascular bifurcations |
US10500072B2 (en) | 2010-11-24 | 2019-12-10 | Poseidon Medical Inc. | Method of treating vascular bifurcations |
US9707108B2 (en) | 2010-11-24 | 2017-07-18 | Tryton Medical, Inc. | Support for treating vascular bifurcations |
US10500077B2 (en) | 2012-04-26 | 2019-12-10 | Poseidon Medical Inc. | Support for treating vascular bifurcations |
Also Published As
Publication number | Publication date |
---|---|
EP1512381A3 (fr) | 2005-03-16 |
US20050049680A1 (en) | 2005-03-03 |
CA2480369A1 (fr) | 2005-03-03 |
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