EP1509505A2 - Modulateurs a petites molecules du recepteur de serotonine 5-ht2a utiles pour la prophylaxie et le traitement de troubles associes - Google Patents

Modulateurs a petites molecules du recepteur de serotonine 5-ht2a utiles pour la prophylaxie et le traitement de troubles associes

Info

Publication number
EP1509505A2
EP1509505A2 EP03705889A EP03705889A EP1509505A2 EP 1509505 A2 EP1509505 A2 EP 1509505A2 EP 03705889 A EP03705889 A EP 03705889A EP 03705889 A EP03705889 A EP 03705889A EP 1509505 A2 EP1509505 A2 EP 1509505A2
Authority
EP
European Patent Office
Prior art keywords
phenyl
methyl
bromo
pyrazol
urea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP03705889A
Other languages
German (de)
English (en)
Inventor
Bradley Teegarden
Keith Drouet
Honnappa Jayakumar
William Thomsen
Paul Maffuid
Katie Elwell
Richard Foster
Michael Lawless
Qian Liu
Julian Smith
Konrad Feichtinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arena Pharmaceuticals Inc
Original Assignee
Arena Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharmaceuticals Inc filed Critical Arena Pharmaceuticals Inc
Publication of EP1509505A2 publication Critical patent/EP1509505A2/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne certains dérivés de pyrazole de formule (I) et leurs compositions pharmaceutiques qui modulent l'activité du récepteur de sérotonine 5-HT2A. L'invention concerne des composés et leurs compositions pharmaceutiques, utiles dans la prophylaxie ou le traitement visant à faire diminuer l'agrégation plaquettaire, la coronaropathie, l'infarctus du myocarde, l'accident ischémique transitoire, l'angine de poitrine, l'accident vasculaire cérébral, la fibrillation auriculaire, diminuant le risque de formation de caillots sanguins, l'asthme ou les symptômes associés, l'agitation ou un symptôme, les troubles du comportement, la psychose d'origine médicamenteuse, la psychose à forme d'état d'excitation, le syndrome de Gilles de la Tourette, le trouble maniaque, la psychose organique ou NSA, le trouble psychotique, la psychose, la schizophrénie aiguë, la schizophrénie chronique et la schizophrénie NSA et les troubles associés. La présente invention concerne également le procédé de prophylaxie ou de traitement de troubles induits par le récepteur de sérotonine 5-HT2A combiné à un antagoniste du récepteur D2 de dopamine tel que l'halopéridol, administré séparément ou ensemble.
EP03705889A 2002-01-23 2003-01-23 Modulateurs a petites molecules du recepteur de serotonine 5-ht2a utiles pour la prophylaxie et le traitement de troubles associes Pending EP1509505A2 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US38619802P 2002-01-23 2002-01-23
US386198P 2002-01-23
US38638402P 2002-06-05 2002-06-05
US386384P 2002-06-05
US40146702P 2002-08-05 2002-08-05
US401467P 2002-08-05
PCT/US2003/002059 WO2003062206A2 (fr) 2002-01-23 2003-01-23 Modulateurs a petites molecules du recepteur de serotonine 5-ht2a utiles pour la prophylaxie et le traitement de troubles associes

Publications (1)

Publication Number Publication Date
EP1509505A2 true EP1509505A2 (fr) 2005-03-02

Family

ID=27617596

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03705889A Pending EP1509505A2 (fr) 2002-01-23 2003-01-23 Modulateurs a petites molecules du recepteur de serotonine 5-ht2a utiles pour la prophylaxie et le traitement de troubles associes

Country Status (2)

Country Link
EP (1) EP1509505A2 (fr)
WO (1) WO2003062206A2 (fr)

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CA2490397A1 (fr) 2002-06-24 2003-12-31 Acadia Pharmaceuticals Inc. Derives de piperidine substitues en n en tant qu'agents recepteurs de la serotonine
US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
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EP1695966A1 (fr) * 2003-07-22 2006-08-30 Arena Pharmaceuticals, Inc. Dérivés diaryl et arylhétéroaryl de l'urée comme modulateurs du recepteur serotonin 5-HT2a, utiles pour la prophylaxe et le traitment des désordres associées
DE602004000260T2 (de) * 2003-07-22 2006-08-24 Arena Pharmaceuticals, Inc., San Diego Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen
CA2559038C (fr) * 2004-03-23 2013-09-10 Arena Pharmaceuticals, Inc. Methodes de preparation de n-aryl-n'-[3-(1h-pyrazol-5-yl) phenylurees] substituees et leurs intermediaires
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
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EP2019093A4 (fr) * 2006-05-19 2011-02-23 Eisai R&D Man Co Ltd Dérivé de cinnamide de type urée
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Also Published As

Publication number Publication date
WO2003062206A2 (fr) 2003-07-31
WO2003062206A3 (fr) 2004-01-08

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