EP1505633B1 - Spectromètre de masse. - Google Patents

Spectromètre de masse. Download PDF

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Publication number
EP1505633B1
EP1505633B1 EP04026518A EP04026518A EP1505633B1 EP 1505633 B1 EP1505633 B1 EP 1505633B1 EP 04026518 A EP04026518 A EP 04026518A EP 04026518 A EP04026518 A EP 04026518A EP 1505633 B1 EP1505633 B1 EP 1505633B1
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EP
European Patent Office
Prior art keywords
ion
ion trap
ions
tunnel
trap
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP04026518A
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German (de)
English (en)
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EP1505633A2 (fr
EP1505633A3 (fr
Inventor
Robert Harold Bateman
Kevin Giles
Steven Pringle
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Micromass UK Ltd
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Micromass UK Ltd
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Priority claimed from GB0120121A external-priority patent/GB0120121D0/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Priority claimed from EP02254393.8A external-priority patent/EP1271608B1/fr
Publication of EP1505633A2 publication Critical patent/EP1505633A2/fr
Publication of EP1505633A3 publication Critical patent/EP1505633A3/fr
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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack

Definitions

  • the present invention relates to mass spectrometers.
  • Time of flight mass analysers are discontinuous devices in that they receive a packet of ions which is then injected into the drift region of the time of flight mass analyser by energising a pusher/puller electrode. Once injected into the drift regions, the ions become temporally separated according to their mass to charge ratio and the time taken for an ion to reach a detector can be used to give an accurate determination of the mass to charge ratio of the ion in question.
  • ion sources are continuous ion sources such as Electrospray or Atmospheric Pressure Chemical Ionisation ("APCI").
  • APCI Electrospray or Atmospheric Pressure Chemical Ionisation
  • the ion trap may continuously accumulate ions from the ion source and periodically release ions in a pulsed manner so as to ensure a high duty cycle when coupled to a time of flight mass analyser.
  • a commonly used ion trap is a 3D quadrupole ion trap.
  • 3D quadrupole ion traps comprise a central doughnut shaped electrode together with two generally concave endcap electrodes with hyperbolic surfaces.
  • 3D quadrupole ion traps are relatively small devices and the internal diameter of the central doughnut shaped electrode may be less than 1 cm with the two generally concave endcap electrodes being spaced by a similar amount.
  • US 5206506 discloses an ion processing unit according to the preamble of claim 1.
  • US 6107628 discloses an ion funnel for focussing dispersed charged particles .
  • US 5818055 discloses an ion guide to which an electrical travelling wave is applied so as to sweep ions into an ion trap.
  • ions are not substantially fragmented within the ion tunnel ion trap i.e. the ion tunnel ion trap is not used as a fragmentation cell.
  • an ion tunnel ion trap should not be construed as covering either a linear 2D rod set ion trap or a 3D quadrupole ion trap.
  • An ion tunnel ion trap is different from other forms of ion optical devices such as multipole rod set ion guides because the electrodes forming the main body of the ion trap comprise ring, annular, plate or substantially closed loop electrodes. Ions therefore travel within an aperture within the electrode which is not the case with multipole rod set ion guides.
  • the ion tunnel ion trap is advantageous compared with a 3D quadrupole ion trap since it may have a much larger ion confinement volume.
  • the ion confinement volume of the ion tunnel ion trap may be selected from the group consisting: (i) ⁇ 20 mm 3 ; (ii) ⁇ 50 mm 3 ; (iii) ⁇ 100 mm 3 ; (iv) ⁇ 200 mm 3 ; (v) ⁇ 500 mm 3 ; (vi) ⁇ 1000 mm 3 ; (vii) ⁇ 1500 mm 3 ; (viii) ⁇ 2000 mm 3 ; (ix) ⁇ 2500 mm 3 ; (x) ⁇ 3000 mm 3 ; and (xi) ⁇ 3500 mm 3 .
  • the increase in the volume available for ion storage may be at least a factor x2, x3, x4, x5, x6, x7, x8, x9, x10, or more than x10 compared with a conventional 3D quadrupole ion trap.
  • the electrodes forming the ion tunnel ion trap are connected to an AC or RF voltage supply which acts to confine ions with the ion tunnel ion trap.
  • the voltage supply may not necessarily output a sinusoidal waveform, and according to some embodiments a non-sinusoidal waveform such as a square wave may be provided.
  • the ion tunnel ion trap is arranged to accumulate and periodically release ions without substantially fragmenting ions.
  • an axial DC voltage gradient may be maintained in use along at least a portion of the length of the ion tunnel ion trap.
  • An axial DC voltage gradient may be particularly beneficial in that it can be arranged so as to urge ions within the ion trap towards the downstream exit region of the ion trap. When the trapping potential at the exit of the ion trap is then removed, ions are urged out of the ion tunnel ion trap by the axial DC voltage gradient. This represents a significant improvement over other forms of ion traps which do not have axial DC voltage gradients.
  • the axial DC voltage difference maintained along a portion of the ion tunnel ion trap is selected from the group consisting of: (i) 0.1-0.5 V; (ii) 0.5-1.0 V; (iii) 1.0-1.5 V; (iv) 1.5-2.0 V; (v) 2.0-2.5 V; (vi) 2.5-3.0 V; (vii) 3.0-3.5 V; (viii) 3.5-4.0 V; (ix) 4.0-4.5 V; (x) 4.5-5.0 V; (xi) 5.0-5.5 V; (xii) 5.5-6.0 V; (xiii) 6.0-6.5 V; (xiv) 6.5-7.0 V; (xv) 7.0-7.5 V; (xvi) 7.5-8.0 V; (xvii) 8.0-8.5 V; (xviii) 8.5-9.0 V; (xix) 9.0-9.5 V; (xx) 9.5-10.0 V; and (xxi) > 10V.
  • an axial DC voltage gradient is maintained along at least a portion of ion tunnel ion trap selected from the group consisting of: (i) 0.01-0.05 V/cm; (ii) 0.05-0.10 V/cm; (iii) 0.10-0.15 V/cm; (iv) 0.15-0.20 V/cm; (v) 0.20-0.25 V/cm; (vi) 0.25-0.30 V/cm; (vii) 0.30-0.35 V/cm; (viii) 0.35-0.40 V/cm; (ix) 0.40-0.45 V/cm; (x) 0.45-0.50 V/cm; (xi) 0.50-0.60 V/cm; (xii) 0.60-0.70 V/cm; (xiii) 0.70-0.80 V/cm; (xiv) 0.80-0.90 V/cm; (xv) 0.90-1.0 V/cm; (xvi) 1.0-1.5 V/cm;
  • the ion tunnel ion trap comprises a plurality of segments, each segment comprising a plurality of electrodes having apertures through which ions are transmitted and wherein all the electrodes in a segment are maintained at substantially the same DC potential and wherein adjacent electrodes in a segment are supplied with different phases of an AC or RF voltage.
  • a segmented design simplifies the electronics associated with the ion tunnel ion trap.
  • the ion tunnel ion trap preferably consists of: (i) 10-20 electrodes; (ii) 20-30 electrodes; (iii) 30-40 electrodes; (iv) 40-50 electrodes; (v) 50-60 electrodes; (vi) 60-70 electrodes; (vii) 70-80 electrodes; (viii) 80-90 electrodes; (ix) 90-100 electrodes; (x) 100-110 electrodes; (xi) 110-120 electrodes; (xii) 120-130 electrodes; (xiii) 130-140 electrodes; (xiv) 140-150 electrodes; (xv) > 150 electrodes; (xvi) ⁇ 5 electrodes; and (xvii) ⁇ 10 electrodes.
  • the diameter of the apertures of at least 50% of the electrodes forming the ion tunnel ion trap is preferably selected from the group consisting of: (i) ⁇ 10 mm; (ii) ⁇ 9 mm; (iii) ⁇ 8 mm; (iv) ⁇ 7 mm; (v) ⁇ 6 mm; (vi) ⁇ 5 mm; (vii) ⁇ 4 mm; (viii) ⁇ 3 mm; (ix) ⁇ 2 mm; and (x) ⁇ 1 mm.
  • At least 50%, 60%, 70%, 80%, 90% or 95% of the electrodes forming the ion tunnel ion trap may have apertures which are substantially the same size or area in contrast to an ion funnel arrangement.
  • the thickness of at least 50% of the electrodes farming the ion tunnel ion trap may be selected from the group consisting of: (i) ⁇ 3 mm; (ii) ⁇ 2.5 mm; (iii) ⁇ 2.0 mm; (iv) ⁇ 1.5 mm; (v) ⁇ 1.0 mm; and (vi) ⁇ 0.5 mm.
  • at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 95% of the electrodes are connected to both a DC and an AC or RF voltage supply.
  • the ion tunnel ion trap has a length selected from the group consisting of: (i) ⁇ 5 cm; (ii) 5-10 cm; (iii) 10-15 cm; (iv) 15-20 cm; (v) 20-25 cm; (vi) 25-30 cm; and (vii) > 30 cm.
  • means is provided for introducing a gas into the ion tunnel ion trap for collisional cooling without fragmentation of ions.
  • Ions emerging from the ion tunnel ion trap will therefore have a narrower spread of energies which is beneficial when coupling the ion trap to a time of flight mass analyser.
  • the ions may be arranged to enter the ion tunnel ion trap with a majority of the ions having an energy ⁇ 5 eV for a singly charged ion so as to cause collisional cooling of the ions.
  • the ion tunnel ion trap may be maintained, in use, at a pressure selected from the group consisting of: (i) > 1.0 x 10 -3 mbar; (ii) > 5.0 x 10 -3 mbar; (iii) > 1.0 x 10 -2 mbar; (iv) 10 -3 -10 -2 mbar; and (v) 10 -4 -10 -1 mbar.
  • the ion source may comprise an Electrospray ("ESI”), Atmospheric Pressure Chemical Ionisation (“APCI”), Atmospheric Pressure Photo Ionisation (“APPI”), Matrix Assisted Laser Desorption Ionisation (“MALDI”), Laser Desorption Ionisation ion source, Inductively Coupled Plasma (“ICP”), Electron Impact (“EI”) or Chemical Ionisation (“CI”) ion source.
  • EI Electrospray
  • APCI Atmospheric Pressure Chemical Ionisation
  • APPI Atmospheric Pressure Photo Ionisation
  • MALDI Matrix Assisted Laser Desorption Ionisation
  • ICP Inductively Coupled Plasma
  • EI Electron Impact
  • CI Chemical Ionisation
  • Preferred ion sources such as Electrospray or APCI ion sources are continuous ion sources whereas a time of flight analyser is a discontinuous device in that it requires a packet of ions.
  • the ions are then injected with substantially the same energy into a drift region. Ions become temporally separated in the drift region accordingly to their differing masses, and the transit time of the ion through the drift region is measured giving an indication of the mass of the ion.
  • the ion tunnel ion trap according to the preferred embodiment is effective in essentially coupling a continuous ion source with a discontinuous mass analyser such as a time of flight mass analyser.
  • the ion tunnel ion trap comprises an entrance and/or exit electrode for trapping ions within the ion tunnel ion trap.
  • the DC potential applied to individual electrodes or groups of electrodes can be individually controlled, numerous different desired axial DC potential profiles can be generated.
  • a mass spectrometer comprising:
  • the upstream portion of the ion tunnel ion trap has a length which is at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90% of the total length of the ion tunnel ion trap.
  • the downstream portion of the ion tunnel ion trap has a length which is less than or equal to 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90% of the total length of the ion tunnel ion trap.
  • the downstream portion of the ion tunnel ion trap is shorter than the upstream portion of the ion tunnel ion trap.
  • a mass spectrometer comprising:
  • an axial DC voltage gradient is maintained along at least 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90% or 95% of the length of the ion trap.
  • the continuous ion source comprises an Electrospray or Atmospheric Pressure Chemical Ionisation ion source.
  • the discontinuous mass analyser comprises a time of flight mass analyser.
  • the ion tunnel ion trap 1 comprises a housing having an entrance aperture 2 and an exit aperture 3.
  • the entrance and exit apertures 2,3 are preferably substantially circular apertures.
  • the plates forming the entrance and/or exit apertures 2,3 may be connected to independent programmable DC voltage supplies (not shown).
  • Each ion tunnel segment 4a;4b;4c comprises two interleaved and electrically isolated sections i.e. an upper and lower section.
  • the ion tunnel segment 4a closest to the entrance aperture 2 preferably comprises ten electrodes (with five electrodes in each section) and the remaining ion tunnel segments 4b,4c preferably each comprise eight electrodes (with four electrodes in each section). All the electrodes are preferably substantially similar in that they have a central substantially circular aperture (preferably 5 mm in diameter) through which ions are transmitted.
  • the entrance and exit apertures 2,3 may be smaller e.g. 2.2 mm in diameter than the apertures in the electrodes or the same size.
  • All the ion tunnel segments 4a,4b,4c are preferably connected to the same AC or RF voltage supply, but different segments 4a;4b;4c may be provided with different DC voltages.
  • the two sections forming an ion tunnel segment 4a;4b;4c are connected to different, preferably opposite, phases of the AC or RF voltage supply.
  • a single ion tunnel section is shown in greater detail in Figs. 3(a)-(c) .
  • the ion tunnel section has four (or five) electrodes 5, each electrode 5 having a 5 mm diameter central aperture 6.
  • the four (or five) electrodes 5 depend or extend from a common bar or spine 7 and are preferably truncated at the opposite end to the bar 7 as shown in Fig. 3(a) .
  • Each electrode 5 is typically 0.5 mm thick.
  • Two ion tunnel sections are interlocked or interleaved to provide a total of eight (or ten) electrodes 5 in an ion tunnel segment 4a;4b;4c with a 1 mm inter-electrode spacing once the two sections have been interleaved.
  • All the eight (or ten) electrodes 5 in an ion tunnel segment 4a;4b;4c comprised of two separate sections are preferably maintained at substantially the same DC voltage.
  • Adjacent electrodes in an ion tunnel segment 4a;4b;4c comprised of two interleaved sections are connected to different, preferably opposite, phases of an AC or RF voltage supply i.e. one section of an ion tunnel segment 4a;4b;4c is connected to one phase (RF+) and the other section of the ion tunnel segment 4a;4b;4c is connected to another phase (RF-).
  • Each ion tunnel segment 4a;4b;4c is mounted on a machined PEEK support that acts as the support for the entire assembly.
  • Individual ion tunnel sections are located and fixed to the PEEK support by means of a dowel and a screw. The screw is also used to provide the electrical connection to the ion tunnel section.
  • the PEEK supports are held in the correct orientation by two stainless steel plates attached to the PEEK supports using screws and located correctly using dowels. These plates are electrically isolated and have a voltage applied to them.
  • Gas for collisionally cooling ions without substantially fragmenting ions may be supplied to the ion tunnel ion trap 1 via a 4.5 mm ID tube.
  • a substantially regular stepped axial accelerating DC electric field is provided along the length of the ion tunnel ion trap 1 using two programmable DC power supplies DC1 and DC2 and a resistor potential divider network of 1 M ⁇ resistors.
  • An AC or RF voltage supply provides phase (RF+) and anti-phase (RF-) voltages at a frequency of preferably 1.75 MHz and is coupled to the ion tunnel sections 4a,4b,4c via capacitors which are preferably identical in value (100pF). According to other embodiments the frequency may be in the range of 0.1-3.0 MHz.
  • Four 10 ⁇ H inductors are provided in the DC supply rails to reduce any RF feedback onto the DC supplies.
  • FIG. 4 shows how, in one embodiment, the axial DC potential varies across a 10 cm central portion of the ion tunnel ion trap 1.
  • the inter-segment voltage step in this particular embodiment is -1V. However, according to more preferred embodiments lower voltage steps of e.g. approximately -0.2V may be used.
  • Fig. 5 shows a potential energy surface across several ion tunnel segments 4b at a central portion of the ion tunnel ion trap 1. As can be seen, the potential energy profile is such that ions will cascade from one ion tunnel segment to the next.
  • the ion tunnel ion trap 1 traps, accumulates or otherwise confines ions within the ion tunnel ion trap 1.
  • the DC voltage applied to the final ion tunnel segment 4c i.e. that closest and adjacent to the exit aperture 3 is independently controllable and can in one mode of operation be maintained at a relatively high DC blocking or trapping potential (DC3) which is more positive for positively charged ions (and vice versa for negatively charged ions) than the preceding ion tunnel segment(s) 4b.
  • DC3 DC blocking or trapping potential
  • Other embodiments are also contemplated wherein other ion tunnel segments 4a,4b may alternatively and/or additionally be maintained at a relatively high trapping potential.
  • an AC or RF voltage may or may not be applied to the final ion tunnel segment 4c.
  • the DC voltage supplied to the plates forming the entrance and exit apertures 2,3 is also preferably independently controllable and preferably no AC or RF voltage is supplied to these plates.
  • Embodiments are also contemplated wherein a relatively high DC trapping potential may be applied to the plates forming entrance and/or exit aperture 2,3 in addition to or instead of a trapping potential being supplied to one or more ion tunnel segments such as at least the final ion tunnel segment 4c.
  • the DC trapping potential applied to e.g. the final ion tunnel segment 4c or to the plate forming the exit aperture 3 is preferably momentarily dropped or varied, preferably in a pulsed manner.
  • the DC voltage may be dropped to approximately the same DC voltage as is being applied to neighbouring ion tunnel segment(s) 4b.
  • the voltage may be dropped below that of neighbouring ion tunnel segment(s) so as to help accelerate ions out of the ion tunnel ion trap 1.
  • a V-shaped trapping potential may be applied which is then changed to a linear profile having a negative gradient in order to cause ions to be accelerated out of the ion tunnel ion trap 1.
  • the voltage on the plate forming the exit aperture 3 can also be set to a DC potential such as to cause ions to be accelerated out of the ion tunnel ion trap 1.
  • Fig. 6 shows how the DC potential may vary along a portion of the length of the ion tunnel ion trap 1 when no axial DC field is applied and the ion tunnel ion trap 1 is acting in a trapping or accumulation mode.
  • 0 mm corresponds to the midpoint of the gap between the fourteenth 4b and fifteenth (and final) 4c ion tunnel segments.
  • the blocking potential was set to +5V (for positive ions) and was applied to the last (fifteenth) ion tunnel segment 4c only.
  • the preceding fourteen ion tunnel segments 4a,4b had a potential of - 1V applied thereto.
  • the plate forming the entrance aperture 2 was maintained at 0V DC and the plate forming the exit aperture 3 was maintained at -1V.
  • FIG. 7(a) shows a portion of the axial DC potential profile for an ion tunnel ion trap 1 according to one embodiment operated in a "fill" mode of operation
  • Fig. 7(b) shows a corresponding "closed” mode of operation
  • Fig. 7(c) shows a corresponding "empty” mode of operation.
  • 0 mm corresponds to the midpoint of the gap between the tenth and eleventh ion tunnel segments 4b.
  • the first nine segments 4a,4b are held at -1V, the tenth and fifteenth segments 4b act as potential barriers and ions are trapped within the eleventh, twelfth, thirteenth and fourteenth segments 4b.
  • the trap segments are held at a higher DC potential (+5V) than the other segments 4b.
  • the potential barriers When closed the potential barriers are held at +5V and when open they are held at -1V or -5V. This arrangement allows ions to be continuously accumulated and stored, even during the period when some ions are being released for subsequent mass analysis, since ions are free to continually enter the first nine segments 4a,4b.
  • a relatively long upstream length of the ion tunnel ion trap 1 may be used for trapping and storing ions and a relatively short downstream length may be used to hold and then release ions.
  • a relatively short downstream length By using a relatively short downstream length, the pulse width of the packet of ions released from the ion tunnel ion trap 1 may be constrained. In other embodiments multiple isolated storage regions may be provided.

Claims (5)

  1. Spectromètre de masse, comprenant :
    un piège à ions à tunnel d'ions (1) comprenant une pluralité d'électrodes (5) dotées d'ouvertures (6) au travers desquelles des ions sont transmis lors de l'utilisation, les ions n'étant essentiellement pas fragmentés à l'intérieur dudit piège à ions à tunnel d'ions (1), et les électrodes étant reliées à une alimentation en tension alternative ou RF servant à confiner les ions dans le piège à ions,
    le spectromètre de masse étant caractérisé par des moyens destinés à appliquer un potentiel continu axial au piège à ions à tunnel d'ions de manière à ce que, dans un mode de fonctionnement, une partie amont du piège à ions à tunnel d'ions continue de recevoir des ions dans le piège à ions à tunnel d'ions alors qu'une partie aval du piège à ions à tunnel d'ions séparée de la partie amont par une barrière de potentiel stocke et libère périodiquement des ions.
  2. Spectromètre de masse selon la revendication 1, ladite partie amont du piège à ions à tunnel d'ions (1) présentant une longueur égale à au moins 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80% ou 90% de la longueur totale du piège à ions à tunnel d'ions.
  3. Spectromètre de masse selon la revendication 1, ladite partie aval du piège à ions à tunnel d'ions (1) présentant une longueur inférieure ou égale à 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80% ou 90% de la longueur totale du piège à ions à tunnel d'ions.
  4. Spectromètre de masse selon la revendication 1, la partie aval du piège à ions à tunnel d'ions (1) étant plus courte que la partie amont du piège à ions à tunnel d'ions.
  5. Procédé de spectrométrie de masse, comprenant l'étape consistant à :
    utiliser un piège à ions à tunnel d'ions (1) comprenant une pluralité d'électrodes (5) dotées d'ouvertures (6) au travers desquelles des ions sont transmis, les ions n'étant essentiellement pas fragmentés à l'intérieur dudit piège à ions à tunnel d'ions (1), et les électrodes étant reliées à une alimentation en tension alternative ou RF qui confine les ions dans le piège à ions,
    le procédé étant caractérisé en ce qu'il comprend l'étape consistant à appliquer un potentiel continu axial au piège à ions à tunnel d'ions de manière à ce que, dans un mode de fonctionnement, une partie amont du piège à ions à tunnel d'ions continue de recevoir des ions dans le piège à ions à tunnel d'ions alors qu'une partie aval du piège à ions à tunnel d'ions séparée de la partie amont par une barrière de potentiel stocke et libère périodiquement des ions.
EP04026518A 2001-06-25 2002-06-24 Spectromètre de masse. Expired - Lifetime EP1505633B1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB0115409 2001-06-25
GB0115409A GB0115409D0 (en) 2001-06-25 2001-06-25 Mass spectrometers and methods of mass spectrometry
GB0119449A GB0119449D0 (en) 2001-06-25 2001-08-09 Gas collision cell
GB0119449 2001-08-09
GB0120121A GB0120121D0 (en) 2001-06-25 2001-08-17 Gas collision cell
GB0120121 2001-08-17
GB0120111A GB0120111D0 (en) 2001-06-25 2001-08-17 Mass spectrometers and methods of mass spectrometry
GB0120111 2001-08-17
EP02254393.8A EP1271608B1 (fr) 2001-06-25 2002-06-24 Spectromètre de masse

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP02254393.8A Division EP1271608B1 (fr) 2001-06-25 2002-06-24 Spectromètre de masse
EP02254393.8A Division-Into EP1271608B1 (fr) 2001-06-25 2002-06-24 Spectromètre de masse

Publications (3)

Publication Number Publication Date
EP1505633A2 EP1505633A2 (fr) 2005-02-09
EP1505633A3 EP1505633A3 (fr) 2006-05-24
EP1505633B1 true EP1505633B1 (fr) 2012-10-17

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EP04026518A Expired - Lifetime EP1505633B1 (fr) 2001-06-25 2002-06-24 Spectromètre de masse.
EP04029441A Expired - Lifetime EP1580790B1 (fr) 2001-06-25 2002-06-25 Spectromètre de masse

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GB (3) GB0115409D0 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0219872D0 (en) * 2002-08-27 2002-10-02 Univ Belfast Charged particle manipulation
DE102005021836A1 (de) * 2005-05-11 2006-11-16 Geoforschungszentrum Potsdam Verfahren und Vorrichtung zum massenselektiven Ionentransport

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2758214A (en) * 1952-12-16 1956-08-07 Jr William E Glenn Time-of-flight mass spectrometer
US5140158A (en) * 1990-10-05 1992-08-18 The United States Of America As Represented By The United States Department Of Energy Method for discriminative particle selection
US5206506A (en) * 1991-02-12 1993-04-27 Kirchner Nicholas J Ion processing: control and analysis
US5689111A (en) * 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
DE19628179C2 (de) * 1996-07-12 1998-04-23 Bruker Franzen Analytik Gmbh Vorrichtung und Verfahren zum Einschuß von Ionen in eine Ionenfalle
US6107628A (en) * 1998-06-03 2000-08-22 Battelle Memorial Institute Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum

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EP1505633A2 (fr) 2005-02-09
GB0120111D0 (en) 2001-10-10
EP1580790A2 (fr) 2005-09-28
EP1580790A3 (fr) 2006-05-24
EP1580790B1 (fr) 2012-12-26
GB0115409D0 (en) 2001-08-15
GB0119449D0 (en) 2001-10-03
EP1505633A3 (fr) 2006-05-24

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