EP1478311B1 - Ostomievorrichtung - Google Patents

Ostomievorrichtung Download PDF

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Publication number
EP1478311B1
EP1478311B1 EP03706338A EP03706338A EP1478311B1 EP 1478311 B1 EP1478311 B1 EP 1478311B1 EP 03706338 A EP03706338 A EP 03706338A EP 03706338 A EP03706338 A EP 03706338A EP 1478311 B1 EP1478311 B1 EP 1478311B1
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EP
European Patent Office
Prior art keywords
bag
filter
inlet
ostomy appliance
opening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP03706338A
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English (en)
French (fr)
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EP1478311A1 (de
Inventor
Lars Bo Poulsen
Per Ole Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coloplast AS
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Coloplast AS
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Filing date
Publication date
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Publication of EP1478311A1 publication Critical patent/EP1478311A1/de
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/44—Devices worn by the patient for reception of urine, faeces, catamenial or other discharge; Portable urination aids; Colostomy devices
    • A61F5/441—Devices worn by the patient for reception of urine, faeces, catamenial or other discharge; Portable urination aids; Colostomy devices having venting or deodorant means, e.g. filters ; having antiseptic means, e.g. bacterial barriers

Definitions

  • the present invention relates to an ostomy appliance comprising a deodorising filter, in particular ostomy bags.
  • a consequence is, in many cases, that after a colostomy, an ileostomy or an urostomy, the patient is left with a stoma in the abdominal wall for the discharge of the effluents or waste products of the body, which are conveyed through the colon, the ileum or the ureter.
  • the discharge of visceral contents including intestinal gases cannot be regulated at will, and for that purpose the opening may be closed with a closure means, e.g. a tampon or a magnetic closure, or the patient will have to rely on an appliance to collect the material emerging from such opening in the form of a receiving bag which is later emptied and/or discarded at suitable times.
  • Ostomy appliances are well known. Such appliances may be two-piece or one-piece appliances. In both types of appliances, an adhesive wafer is attached to the wearer's skin. In case of a one-piece appliance, a receiving member or bag is attached to the adhesive wafer. In case of a two-piece appliance, the adhesive wafer forms part of a body side member and a receiving bag is attached releasably to the body side ostomy member for receiving exudates from the stoma.
  • the whole appliance including the adhesive skin barrier securing the appliance to the skin is normally removed and replaced by a fresh appliance.
  • the body side member is left in place up to several days, and only the receiving bag attached to the body side member is replaced.
  • the discharge of flatus may exceed the discharge of solid and liquid faecal matter by many hundred percent and therefore there is usually the need for the continuous or frequent venting of the intestine or the collecting bag.
  • the outflowing flatus is deodorised with a suitable filter.
  • the active filter is powdered active carbon, which absorbs H 2 S being the principal component of the smell of flatus.
  • filters for ostomy appliances are known.
  • the filters are designed so as to obtain a high security of deodorisation of the flatus by securing that there is no by-pass by which the flatus may circumvent the filter, and some measures have been discussed with respect to obtaining a better security against blocking of the inlet of the filter by solid discharged visceral content.
  • European Patent No. 0 235 928 discloses that a filter may be rendered suitable for use with ileostomy equipment when the filter wall adapted to face the source of intestinal gas is covered by a layer of sheet material, preferably plastic sheet material connected to the filter walls and, inside the periphery of this connection, provided with openings such as slits for the passage of intestinal gas.
  • a layer of sheet material preferably plastic sheet material connected to the filter walls and, inside the periphery of this connection, provided with openings such as slits for the passage of intestinal gas.
  • slits may open if the pressure is high giving free flow of gas and liquid through the layer of sheet material.
  • EP patent No. 0 443 728 B1 discloses a bag for receiving discharge from the human body comprising a filter and an intervening membrane covering the inlet opening of the filter, said intervening membrane being gas permeable but not liquid permeable. It is mentioned that the membrane may comprise a polyester film bonded to a PTFE film and that such membrane showed no leakage of water. There is no indication of security against leaking when exposed for discharge from an ileostomy or liquids from a colostomy.
  • a filter for covering a vent of an ostomy appliance comprising an elongated, substantially flat filter body of a porous filter material interposed between gas and liquid impervious walls which are sealed to the body along its longitudinal side edges; gas inlet and outlet openings being provided in communication with the filter material adjacent to its respective longitudinal end regions, wherein both of the gas and liquid impervious walls are sealed to the upper and lower surfaces of the filter body, wherein the inlet opening is covered by a hydrophobic sheet, wherein the inlet opening is covered with a microporous oleophobic membrane and wherein a foam material is covering the inlet opening of the vent.
  • Such arrangement shows improved resistance against wetting and blocking of the filter caused by humidity or other liquid constituents of the visceral contents of an ostomy collection bag and, at the same time, shows improved resistance against clogging of the filter.
  • US Patent No. 4,938,750 discloses a medical device comprising a collection receptacle in the form of a thin walled pouch, a member affixed to the pouch wall comprising a plurality of isolated gas passages, each constituting a vent, separate deodorising filter means in each one of said passages and means for obstructing the flow through all but a selected one of said passages.
  • the passages and the filter means are located on a member which is preferably aligned with the stoma receiving opening. With this location, however, due to the close localisation of the filters, the risk of blocking of all filters is roughly of the same magnitude as in case of one filter.
  • the risk of blocking the filter disclosed in US Patent No. 4,938,750 is relatively high due to the localisation of the filters aligned with the stoma receiving opening.
  • EP patent application No. 1 051 955 A2 discloses a bag for receiving discharge from the human body, said bag having a distal and a proximal wall one of which has a gas venting aperture and a filter for deodorising gas vented through the venting aperture wherein a filter package may be located at one or both sides of the bag wall.
  • EP patent application No. 1051 955 A2 does not disclose more filters having separate inlet openings communicating with the inner space of the bag.
  • US Patent No. 4,938,749 discloses a filter housing for mounting on an ostomy pouch, said housing having a base member having a central gas inlet passageway and three exit passageways radially offset from the inlet passageway and said housing further having a cover member having a recess with three connecting passageways which extend in a radial direction a distance from the central axis of the cover member greater than the distance between exit passageways and the axis of the base member, said base member being able to move between a first position in which said connecting channel aligns with said exit passageway and a second position at which said connecting channel is remote from said exit passageway.
  • US Patent No. 4,938,749 does not disclose more filters having separate inlet openings communicating with the inner space of the bag.
  • US Patent No 4 449 970 discloses an ostomy appliance according to the preamble of claim 1.
  • Fig. 1 shows one embodiment of an ostomy appliance of the invention
  • Fig.2 shows another embodiment of an ostomy appliance of the invention
  • Fig.3 shows a third embodiment of an ostomy appliance of the invention
  • Fig. 4 shows a fourth embodiment of an ostomy appliance of the invention.
  • the invention in its broadest aspect relates to an ostomy appliance comprising a front wall and a rear wall of flexible material forming a bag, the rear wall having an opening into the bag by which waste material can enter the bag, said bag having two or more vents through which gas may escape from the bag and having a filter device covering each vent.
  • the present invention relates to an ostomy appliance comprising a front wall and a rear wall of flexible material forming a bag, the rear wall having an opening into the bag by which waste material can enter the bag, said bag having two or more vents through which gas may escape from the bag and having a filter device covering each vent, said filter device being provided with gas inlet and outlet openings in communication with at least one filter body, the arrangement being so that in use gas flows through the filter device from the inlet opening to the outlet opening, such gas flow being confined to said filter body, wherein one of the walls of the ostomy appliance is provided with at least two separate filter devices having separate inlet openings communicating with the inner space of the bag and wherein the inlet openings of the filter devices are located near the border of the bag.
  • the risk of blocking of the inlet opening of the filter is significantly reduced by the presence of two separate filter devices having separated inlet openings located near the border of the bag and communicating with the interior of the bag.
  • material present in the bag is hampered from entering, at the same time, both pathways leading to the inlet openings of the filter devices which has been found nearly to eliminate the risk of blocking of both filters by directly pressing the contents of the bag against the inlet openings of the filters e.g. when a lying person turns. e.g. in bed.
  • the appliances of the invention may be made from elements already used in the manufacture of ostomy appliances by applying an extra filter device and it is also simple to establish a desired distance between the inlet openings of the filters to minimise the risk of blocking.
  • the effect of having two separate filters openings is improved when the separated inlet openings of the filters are spaced a certain distance from each other, a certain effect being found already at a distance of at least 15 mm, the effect increasing with increasing distance until a distance comparable to the width of the bag is reached. It is preferred, that the distance is at least 50 mm and it is especially preferred, that the distance corresponds to 90% or more of the width of the bag for which the filter device is intended.
  • inlet openings of the filter devices are spaced at an angle of at least 45 degrees essentially along radii of a circle of reference having a perimeter concentric with the inlet opening of the bag, and it is preferred that the inlet openings are spaced at an angle of at least 90 degrees.
  • the inlet openings are spaced at an angle of at least 135 degrees which will be very suitable taking into account the shape of a bag where the filter device is to be placed but angles of up to 180 degrees are considered suitable for the purpose of the present invention.
  • the inlet openings of the filter devices of an ostomy appliance are generally located near the border of the bag, preferably between the border of the bag and the perimeter of the opening into the bag by which waste material can enter the bag in order to reduce the risk of such material directly coming into contact with the inlet openings of the filter devices and maybe blocking the same.
  • the inlet openings are preferred located as close to the border as possible, suitably less than 3 centimetres from the border, e.g. between 0.5 and 2 centimetres and more suitably about 1-1.5 centimetres from the border.
  • Filter devices for use in accordance with the present invention may be any filter device known per se for ostomy purposes and are suitably devices of the kind disclosed in GB 1 571 382 or preferably in WO 98/44880 . Such filter devices are suitably of generally circular or elongated shape. It is considered an embodiment of the invention to use more than one kind of filter devices in one bag, e.g. a circular and an elongated filter device.
  • the filter devices have border lines being a part of a circle which renders it easier to locate the filters at the top border of the bag.
  • Elongated filter devices may be placed in a bag of the invention in any desired and suitable configuration as long as the inlet openings fulfil the above-mentioned criteria.
  • elongated filter devices may be located generally along the border of the bag or having the longest extent generally in an angle thereto.
  • an elongated filter device may be placed extending along a line forming an angle from about 0 to about 90 degrees (i.e. along a radius) with the tangent of the border of the bag nearest the inlet opening of the filter device.
  • At least the part of the top of the bag wherein the filters are secured has a border line being a part of a circle having the same diameter as the filter devices allowing a localisation of the filters inside the bag very near to the border of the bag.
  • the filter devices are located at opposite sides of the vertical centre line of the bag.
  • elongated filter devices are located end to end at the top of the bag, preferably having their inlet openings located opposite the adjacent ends.
  • Two elongated filter devices each having only one inlet opening which is not centrally located may be arranged in a "heads-to tail" relationship or in such a relationship that their inlet openings are located in the ends nearest the other filter device or preferably in the ends being most distant from the other filter device.
  • the present invention relates to an ostomy appliance comprising a front wall and a rear wall of flexible material forming a bag, the rear wall having an opening into the bag by which waste material can enter the bag said bag having two or more vents through which gas may escape from the bag and having a filter device covering each vent, said filter device being provided with gas inlet and outlet openings in communication with at least one filter body, the arrangement being so that in use gas flows through the filter device from the inlet opening to the outlet opening, such gas flow being confined to said filter body, wherein each of the walls of the ostomy appliance is provided with at least one vent and a filter device having an inlet opening communicating with the inner space of the bag and wherein the inlet openings of the filter devices are located near the border of the bag.
  • Preferred embodiments thereof as well as preferred location of the filter devices in this embodiment correspond to the ones stated above for ostomy appliances having two vents in the same wall.
  • an ostomy appliance of the invention comprises two vents each covered by a filter device.
  • the filter devices may in accordance with the invention be placed at the inner side or at the outer side of the ostomy appliance as found suitable for the application in question considering the intended use.
  • the ostomy receiving bag according to the invention may be adapted for use together with an ostomy body side member (2-piece appliance) wherein the receiving bag is provided with coupling means for releasable securing to matching coupling means placed on the ostomy body side member and wherein the inlet opening is adapted for alignment with a hole of the ostomy body side member for receiving a stoma.
  • the ostomy receiving bag according to the invention may, as an alternative, be adapted for use directly (1-piece appliance) in which case the bag is provided with an adhesive wafer for securing the receiving bag to the user's skin, said bag and wafer having an inlet opening for receiving a stoma.
  • the receiving bag itself comprising front and rear walls sealed together along the rim and provided with an inlet opening may be made in analogy with and from materials conventionally used for the preparation of ostomy appliances.
  • Such materials are suitably films composed of any suitable material which is heat sealable and sufficiently impervious for unpleasant odours such as polyolefin films or combinations of such films, e.g. polyethylene or a coextrudate of polyethylene and polyvinylidene.
  • the receiving bag is an open bag of the kind disclosed in WO 99/66859 having two filter devices.
  • An ostomy body side member for use together with an ostomy receiving bag according to the invention may be produced from standard materials normally used for preparation of disposable ostomy and wound and incontinence devices.
  • the adhesive wafer for a body side member or of a 1-piece ostomy appliance bag according to the invention may be made from a medical grade barrier adhesives known in the such as the formulation being disclosed, for example in US Patents Nos. 4,367,732 , 5,051,259 or 5,714,225 .
  • the body side member and the receiving bag are provided with matching coupling means.
  • the coupling means for use in connection with the present invention may be any suitable coupling means known per se for coupling of ostomy base plates to ostomy collecting bags, e.g. a mechanical coupling such as matching coupling rings such as the coupling rings disclosed in WO 91/01118 and WO 91/01119 or WO 94/18919 or matching flanges for adhesive connection of the type disclosed in U.S. Patent No. 5,800,415 .
  • a mechanical coupling such as matching coupling rings such as the coupling rings disclosed in WO 91/01118 and WO 91/01119 or WO 94/18919 or matching flanges for adhesive connection of the type disclosed in U.S. Patent No. 5,800,415 .
  • FIG. 1 of the drawings showing an embodiment of an ostomy appliance of the invention, seen from the side facing the user, which shows a preferred one-piece embodiment of an ostomy appliance of the invention comprising a front wall and a rear wall of a flexible material, said rear wall having an opening 1 into the bag by which waste material can enter the bag.
  • the appliance has an adhesive wafer 2 for adhering to the user's skin.
  • the appliance has vent openings 3,3', for clarity shown in full-drawn line even if hidden behind the wafer, on the front wall through which gas may escape from the bag, said vent opening being covered of two filter devices 4,4' wherein gas inlet and outlet openings are provided in communication with the filter body, the arrangement being so that in use, gas flows through the filter from the inlet opening to the outlet opening, such gas flow being confined to said filter body.
  • the filter devices are preferably secured to the wall by welding in a manner known per se.
  • Fig. 2 shows another embodiment of an ostomy appliance of the invention corresponding to the embodiment of Fig. 1 apart from that all the top 5 of the bag has a border line being a part of a circle and the filters having outer border lines being part of a circle having essentially the same radius allowing a localisation of the filter very near to the inner rim of the bag.
  • Fig. 3 shows further embodiment of an ostomy appliance of the invention corresponding the embodiment shown in Fig. 2 wherein the two filter devices are located end to end at the top of the bag.
  • Fig. 4 shows yet another embodiment of an ostomy appliance of the invention corresponding the embodiment shown in Fig. 1 wherein the appliance is in the form of an open bag having a closable open end 5 enabling an emptying of the bag without detaching the same.
  • the bag may be closed in a manner known per se using closing means known per se for closing open ostomy appliances.

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nursing (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Materials For Medical Uses (AREA)
  • Massaging Devices (AREA)

Claims (7)

  1. Stomavorrichtung, die eine vordere Wand und eine hintere Wand aus einem flexiblen Material aufweist, die einen Beutel bilden, wobei die hintere Wand eine in den Beutel führende Öffnung (1) besitzt, durch die Ausscheidungsmaterial in den Beutel eintreten kann, und der Beutel zwei oder mehr Entlüftungsöffnungen (3, 3'), durch die Gas aus dem Beutel austreten kann, und eine Filtervorrichtung (4, 4') aufweist, die jede Entlüftungsöffnung (3, 3') überdeckt und mit einer Gas-Einlassöffnung und einer Gas-Auslassöffnung, die mit mindestens einem Filterkörper in Verbindung stehen, ausgerüstet ist, wobei die Anordnung so ist, dass bei der Benutzung Gas von der Einlassöffnung durch die Filtervorrichtung hindurch zur Auslassöffnung strömt und der Gasstrom auf den Filterkörper eingegrenzt ist, wobei eine der Wände der Stomavorrichtung mit mindestens zwei separaten Filtervorrichtungen (4, 4') versehen ist, die separate Einlassöffnungen aufweisen, die mit dem Innenraum des Beutels in Verbindung stehen, und wobei die Einlassöffnungen der Filtervorrichtungen in der Nähe des Randes des Beutels angeordnet sind,
    dadurch gekennzeichnet, dass die Einlassöffnungen der Filtervorrichtungen unter einem Winkel von mindestens 45 Grad längs Radien eines Bezugskreises mit einem Umfang, der zur Einlassöffnung des Beutels konzentrisch ist, beabstandet sind und die Einlassöffnungen weniger als drei Zentimeter vom Rand angeordnet sind.
  2. Stomavorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Filtervorrichtungen (4, 4') Randkonturen aufweisen, die einen Teil eines Kreises bilden.
  3. Stomavorrichtung nach Anspruch 2, dadurch gekennzeichnet, dass mindestens der Teil des oberen Endes des Beutels, in dem die Filter befestigt sind, eine Randkontur aufweist, die einen Teil eines Kreises bildet, dessen Durchmesser gleich dem Durchmesser der Filtervorrichtungen (4, 4') ist.
  4. Stomavorrichtung nach Anspruch 2 oder 3, dadurch gekennzeichnet, dass das obere Ende (5) des Beutels eine Randkontur aufweist, die einen Teil eines Kreises bildet, dessen Durchmesser gleich dem Durchmesser der Filtervorrichtungen (4, 4') ist.
  5. Stomavorrichtung nach einem der Ansprüche 2 bis 4, dadurch gekennzeichnet, dass die Filtervorrichtungen (4, 4') auf einander gegenüberliegenden Seiten der senkrechten Mittellinie des Beutels angeordnet sind.
  6. Stomavorrichtung nach einem der Ansprüche 2 bis 4, dadurch gekennzeichnet, dass die Filtervorrichtungen (4, 4') mit aneinanderstoßenden Enden am oberen Ende (5) des Beutels angeordnet sind.
  7. Stomavorrichtung, die eine vordere Wand und eine hintere Wand aus einem flexiblen Material aufweist, die einen Beutel bilden, wobei die hintere Wand eine in den Beutel führende Öffnung (1) besitzt, durch die Ausscheidungsmaterial in den Beutel eintreten kann, und der Beutel zwei oder mehr Entlüftungsöffnungen (3, 3'), durch die Gas aus dem Beutel austreten kann, und eine Filtervorrichtung (4, 4') aufweist, die jede Entlüftungsöffnung (3, 3') überdeckt und mit einer Gas-Einlassöffnung und einer Gas-Auslassöffnung, die mit mindestens einem Filterkörper in Verbindung stehen, ausgerüstet ist, wobei die Anordnung so ist, dass bei der Benutzung Gas von der Einlassöffnung durch die Filtervorrichtung hindurch zur Auslassöffnung strömt und der Gasstrom auf den Filterkörper eingegrenzt ist, wobei jede der Wände der Stomavorrichtung mit mindestens einer Entlüftungsöffnung und einer Filtervorrichtung (4, 4') versehen ist, die eine Einlassöffnung aufweist, die mit dem Innenraum des Beutels in Verbindung steht, und wobei die Einlassöffnungen der Filtervorrichtungen (4, 4') in der Nähe des Randes des Beutels angeordnet sind,
    dadurch gekennzeichnet, dass die Einlassöffnungen der Filtervorrichtungen unter einem Winkel von mindestens 45 Grad längs Radien eines Bezugskreises mit einem Umfang, der zur Einlassöffnung des Beutels konzentrisch ist, beabstandet sind und die Einlassöffnungen weniger als drei Zentimeter vom Rand angeordnet sind.
EP03706338A 2002-02-28 2003-02-26 Ostomievorrichtung Expired - Lifetime EP1478311B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK200200317A DK175356B1 (da) 2002-02-28 2002-02-28 Stomiindretning
DK200200317 2002-02-28
PCT/DK2003/000122 WO2003071997A1 (en) 2002-02-28 2003-02-26 An ostomy appliance

Publications (2)

Publication Number Publication Date
EP1478311A1 EP1478311A1 (de) 2004-11-24
EP1478311B1 true EP1478311B1 (de) 2007-08-08

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EP03706338A Expired - Lifetime EP1478311B1 (de) 2002-02-28 2003-02-26 Ostomievorrichtung

Country Status (11)

Country Link
US (1) US7367965B2 (de)
EP (1) EP1478311B1 (de)
JP (1) JP4369242B2 (de)
CN (1) CN100500117C (de)
AT (1) ATE369104T1 (de)
AU (1) AU2003208311B2 (de)
CA (1) CA2477100C (de)
DE (1) DE60315423T2 (de)
DK (2) DK175356B1 (de)
ES (1) ES2291616T3 (de)
WO (1) WO2003071997A1 (de)

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WO2019120451A1 (en) * 2017-12-22 2019-06-27 Coloplast A/S Base plate and a sensor assembly part for an ostomy appliance and a method for manufacturing a base plate and sensor assembly part
CN111447897B (zh) * 2017-12-22 2022-07-29 科洛普拉斯特公司 具有角形泄漏检测的造口术器具
AU2018391323B2 (en) 2017-12-22 2024-03-21 Coloplast A/S Base plate and sensor assembly of an ostomy system having a leakage sensor
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LT3727219T (lt) 2017-12-22 2023-09-11 Coloplast A/S Drėgmės aptikimo pagrindo plokštė ostomijos prietaisui ir drėgmės sklidimo pagrindo plokštėje ir (arba) jutiklių montavimo dalyje nustatymo sistema
WO2019120443A1 (en) * 2017-12-22 2019-06-27 Coloplast A/S Sensor assembly part and a base plate for an ostomy appliance and a method for manufacturing a base plate or a sensor assembly part
EP3727222B1 (de) 2017-12-22 2024-05-08 Coloplast A/S Sensorbauteil für künstlichen darmausgang und verfahren zur herstellung eines sensorbauteils
EP3727229A1 (de) * 2017-12-22 2020-10-28 Coloplast A/S Kupplungsteil mit einem scharnier für eine stomagrundplatte und sensorbauteil
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AU2018391395B2 (en) 2017-12-22 2024-05-23 Coloplast A/S Base plate for an ostomy appliance, a monitor device and a system for an ostomy appliance
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Also Published As

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CN100500117C (zh) 2009-06-17
CA2477100A1 (en) 2003-09-04
ATE369104T1 (de) 2007-08-15
JP4369242B2 (ja) 2009-11-18
DK200200317A (da) 2003-08-29
DE60315423D1 (de) 2007-09-20
AU2003208311B2 (en) 2008-09-25
CA2477100C (en) 2010-11-02
DK1478311T3 (da) 2007-12-27
DE60315423T2 (de) 2008-04-30
ES2291616T3 (es) 2008-03-01
DK175356B1 (da) 2004-09-06
CN1694661A (zh) 2005-11-09
AU2003208311A1 (en) 2003-09-09
JP2005518835A (ja) 2005-06-30
WO2003071997A1 (en) 2003-09-04
US7367965B2 (en) 2008-05-06
US20050085779A1 (en) 2005-04-21
EP1478311A1 (de) 2004-11-24

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