EP1476225A2 - Dispositif et procede permettant de reduire le flux regule dans des ventilateurs oscillatoires - Google Patents

Dispositif et procede permettant de reduire le flux regule dans des ventilateurs oscillatoires

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Publication number
EP1476225A2
EP1476225A2 EP03715967A EP03715967A EP1476225A2 EP 1476225 A2 EP1476225 A2 EP 1476225A2 EP 03715967 A EP03715967 A EP 03715967A EP 03715967 A EP03715967 A EP 03715967A EP 1476225 A2 EP1476225 A2 EP 1476225A2
Authority
EP
European Patent Office
Prior art keywords
line
oscillating
gas
scrubber
gas flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03715967A
Other languages
German (de)
English (en)
Other versions
EP1476225A4 (fr
Inventor
Bradley P. Fuhrman
Mark S. Dowhy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1476225A2 publication Critical patent/EP1476225A2/fr
Publication of EP1476225A4 publication Critical patent/EP1476225A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0096—High frequency jet ventilation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
    • A61M16/0816—Joints or connectors
    • A61M16/0841—Joints or connectors for sampling
    • A61M16/0858—Pressure sampling ports

Definitions

  • the present invention relates generally to ventilators for supporting breathing in animals. More particularly, the present invention provides a device and method of ventilating.
  • Circuitry is provided which is operable to reverse the polarity of the flow of the current in the coil, thereby causing the diaphragm to move back and forth within the housing.
  • a tube connecting the space on the second side of the diaphragm to the gas source and the patient's airway is provided.
  • the U-shaped tube can be described as having a first limb with a distal end, a second limb with a distal end, and a tube between the limbs.
  • the patient line Connected to the tube between the limbs is another tube (the "patient line") that delivers gas from the U- shaped tube to the patient and also delivers gas from the patient to the U-shaped tube.
  • the patient line may be connected to the patient via an endotracheal tube.
  • the distal end of the first limb is placed in sealing relation to the diaphragm so that gas inside the U-shaped tube is caused to oscillate as the diaphragm moves back and forth.
  • Gas suitable for inspiration (“inspiratory gas”) is supplied at a location on the
  • Inspiratory gas passes through the first limb of the U-shaped tube, and exhaled gas exits to the atmosphere through the second limb of the U-shaped tube and out of the distal end of the second limb.
  • more inspiratory gas than needed by the patient is provided in order to move the expired gas into the second limb.
  • the inspiratory gas provided in excess of the needs of the patient is referred to herein as "bias flow”.
  • an inspiratory gas flow rate of approximately 20 liters per minute is used when ventilating infants, and as much as 60 to 80 liters per minute when ventilating older children and adults.
  • Such large volumes of inspiratory gas would quickly exhaust the available supply of most transport and ambulance vehicles.
  • prior art devices necessitate large and costly volumes of therapeutic gases that might be mingled with the inspiratory gas (e.g., volatile anesthetics, nitric oxide, vaporized perfluorocarbons, helium/oxygen mixtures etc.).
  • therapeutic gases e.g., volatile anesthetics, nitric oxide, vaporized perfluorocarbons, helium/oxygen mixtures etc.
  • such prior art devices are inefficient when one considers the amount of inspiratory gas required by the patient and the relatively large amount of inspiratory gas supplied to the ventilator.
  • An object of the present invention is to provide a device and a method of ventilating.
  • the object is achieved by a ventilating device having an oscillator, such as an oscillatory diaphragm, and gas flow circuit comprising an oscillating line having a first end in sealing or pneumatic relationship with the oscillator.
  • a gas supply line is connected to the oscillating line, and a patient line is connected to a second end of the oscillating line.
  • An outlet line is in pneumatic communication with the patient line, and an end of the outlet line distal from the patient line is connected to an outlet valve. The outlet valve releases gas from the outlet line during inhalation, and prevents the release of gas from the outlet line during exhalation.
  • the device has an oscillating line with a gas supply line connected thereto, a patient line connected to the second end of the oscillating line, an outlet line in pneumatic communication with the patient line, an outlet valve connected to the outlet line, one or more CO 2 scrubbers and one or more check valves to ensure unidirectional flow of gas through the one or more scrubbers.
  • This device of this embodiment can be attached to an oscillating ventilator.
  • the device of the present invention is adapted for connecting to the U-type ventilator attachments of the prior art.
  • the device has a gas flow circuit comprising an oscillating line having a first end and a second end. The first end is adapted for connecting to an oscillating ventilator either directly or through another device such as a conventional U-type tube, a patient line connected to the second end of the oscillating line, a return line connected to the oscillating line, one or more CO 2 scrubbers and one or more check valves to ensure unidirectional flow of gas.
  • the device may have an outlet valve and a gas supply line or when used in conjunction with a conventional U-type tube, may use the outlet valve and the gas supply line of the conventional U-type tube.
  • a ventilation device such as the one described above, is provided.
  • a patient in pneumatic communication with the patient line is provided and gas is supplied to the oscillating line.
  • the oscillator is moved toward the oscillating line and the outlet valve is opened. Then, the oscillator is moved away from the oscillating line and the outlet valve is closed.
  • Figure 1 is a schematic sectional view of a device according to the present invention illustrating the major components of the device and utilizing a CO 2 scrubber;
  • Figures 2a and 2b are schematic sectional representations of the closed and open positions respectively of an outlet valve according to the present invention.
  • Figures 3a and 3c are each a schematic sectional representation of an embodiment of the present invention.
  • Figure 3b is a schematic sectional representation of another embodiment of the present invention.
  • Figures 4a and 4b are schematic sectional views of other embodiments of the present invention having a CO 2 scrubber
  • Figure 5 is a schematic sectional representation of another embodiment of the present invention.
  • Figure 6 is a schematic sectional view of another embodiment of the invention without a CO 2 scrubber
  • Figures 7a and 7b are schematic sectional representations of the closed and open positions respectively of another outlet valve according to the present invention.
  • Figure 8 is a flow chart showing steps of a method according to the present invention.
  • Figures 9a, 9b, 9c and 9c are schematic sectional views of an embodiment of the invention that can be connected to a U-type oscillator tube (9a, 9b and 9c) or to an oscillating ventilator (9d).
  • gas means a pure gas or a mixture of gases.
  • gas may refer to a mixture of O 2 and N 2 , and may include therapeutic gases.
  • a device 10 according to the present invention can be connected to an oscillating machine having an oscillator 11, such as a diaphragm, like those described in U.S. Patent No. 4,719,910 and No. 5,307,794. As illustrated in Figure
  • an inspiratory gas source 5 is connected to a device 10 according to the present invention through supply line 8.
  • the flow of inspiratory gas into the device 10 can be regulated by a flow regulator 9 connected to supply line 8.
  • a flow regulator 9 connected to supply line 8.
  • the flow of inspiratory gas from supply line 8 and into connecting line 18 is essentially at a constant rate.
  • Connecting line 18 is connected to the oscillating line 14.
  • an inbound check valve 20 is in the oscillating line 14.
  • the portion of the oscillating line 14 that is downstream of the inbound check valve 20 is referred to herein as the inbound line 15.
  • the check valve 20 permits the flow of gas in the direction of arrow 21 and prevents the flow of gas in the opposite direction.
  • the inbound check valve 20 opens allowing gas to flow in the direction of arrow 21.
  • the inbound check valve 20 shuts, effectively stopping the flow of gas through inbound line 15.
  • inbound line 15 may be placed an O 2 sensor 24 and a CO 2 sensor 22 to monitor the quality of the gas therein. Additional modifiers and monitors like humidifiers, nebulizers and the like can also be installed.
  • Inbound line 15 connects to patient line 25, which is in turn connected to an endotracheal tube (not shown in Figure 1) for delivery of gas to the patient's airways, and ultimately to the patient's lungs.
  • Inbound line 15 is also connected to exhalation line 30.
  • exhalation line 30 may be placed a pressure monitoring device, such as a manometer, through port 28.
  • Exhalation line 30 includes a scrubber line 36 and connects to recirculation line 34.
  • Recirculation line 34 connects to the oscillating line 14.
  • a two-position valve 32 which directs the flow of gas either toward the recirculation line 34 or toward the scrubber line 36.
  • the two position valve 32 is normally positioned to direct the flow of gas to the scrubber line 36.
  • the two-position valve 32 is normally adjusted so that no gas flows through recirculation line 34.
  • a scrubber canister 38 Included in the exhalation line 30 is a scrubber canister 38, an outbound line 40, and a discharge line 16.
  • a second scrubber 68 may also be included and used when the scrubber canister 38 is not being used, for example, while scrubber canister 38 is being replaced or recharged, for example, by purging CO 2 using a separate flow of gas (not shown) .
  • the scrubber valves 70 A and 70B preferably operate together so that either scrubber canister 38 or the second scrubber 68 is in operation.
  • the scrubber valves 70A and 70B are not two separate valves, but instead a slide type valve, commonly used in the medical community, having an outer cylindrical shell and a movable inner cylinder, each with holes therethrough that allow either the scrubber canister 38 or the second scrubber 68 to be in service.
  • the outbound line 40 is fitted with an outbound check valve 42, which permits the flow of gas in the direction of arrow 43 and prevents the flow of gas in the opposite direction.
  • Downstream of the outbound check valve 42 is discharge line 16 having within it a shut-off valve 44.
  • the shut-off valve 44 is normally set to the open position.
  • the shut-off valve 44 in its open position, permits the flow of gas, but in its closed position blocks the flow of gas.
  • Discharge line 16 connects to oscillating line 14.
  • Oscillating line 14 connects at one end to the patient line 25, and is placed in sealing relationship at the other end with the oscillator 11.
  • the oscillator 11 is a diaphragm of a high frequency oscillating machine.
  • outlet line 50 Connected to the oscillating line 14 is an outlet line 50, which is in turn connected to outlet valve 52.
  • the outlet valve 52 may open and shut in response to a control pressure provided via control line 54.
  • the closed and open positions of outlet valve 52 are shown in Figures 2a and 2b respectively.
  • the external control pressure may be provided to control line 54 by the oscillating machine that controls the oscillator 11.
  • the control pressure provided by line 54 is substantially stable and the oscillating pressure in line 14 caused by movement of the diaphragm 11 causes the outlet valve 52 to open and close.
  • operation of the outlet valve 52 may be by other means, such as a solenoid.
  • High frequency oscillation of the oscillator 11 facilitates movement of gas into and out of the patient's airways.
  • a pressurizing cycle occurs
  • the expiration phase when the oscillator 11 is moving away from the oscillating line 14, a depressurizing cycle occurs.
  • the pressure on the upstream side of the inbound check valve 20 increases, forcing it to open thereby allowing gas to flow in the direction of arrow 21, and consequently into the patient's lungs via patient line 25.
  • the oscillator 11 moves away from the oscillating line 14 and the pressure differential across the inbound check valve 20 causes the inbound check valve 20 to close.
  • the exhaled gas is pushed by the patient's lungs into exhalation line 30, and into the CO 2 scrubber camster 38.
  • the pressure differential across the outbound check valve 42 causes the outbound check valve 42 to open.
  • CO 2 scrubbed gas is returned to oscillating line 14 through the normally open shut-off valve 44.
  • the gas returning to the oscillating line 14 via the discharge line 16 mixes with the gas in the oscillating line 14.
  • FIGs 2a and 2b illustrate the open and closed positions of the pneumatic version of the outlet valve 52.
  • the control pressure supplied by control line 54 exceeds the pressure in the oscillating line 14 ( Figure 2a)
  • the outlet valve 52 is in the closed position and gas from oscillating line 14 is prevented from escaping from the device 10.
  • the control pressure supplied by control line 54 is less than the pressure in the oscillating line 14 ( Figure 2b)
  • the outlet valve 52 is in the open position and gas from oscillating line 14 is allowed to escape from the device 10.
  • the outlet valve 52 is closed for at least part of the expiration phase (i.e. when the pressure in oscillating line 14 is decreasing due to movement of the oscillator 11 away from the device 10), and the outlet valve 52 is open for at least part of the inspiration phase
  • the CO 2 scrubber canister 38 in the device 10 of the present invention may be used in other locations.
  • the scrubber canister 38 may be placed at the end of patient line 25 distal from the inbound line 15.
  • suitable check valves 20, 42 and return line 67 can be incorporated to assure unidirectional flow through the scrubber canister 38.
  • a bypass line 66 could be provided to accommodate replacement of the scrubber canister 38.
  • the second scrubber canister 68 is provided in the bypass line 66.
  • 68 may be incorporated into any embodiment described herein which has a scrubber canister 38.
  • the device depicted in Figures 3a, 3b and 3c could be used with prior art ventilator circuits.
  • the scrubber canister 38 contains a material that removes unwanted gas, such as CO 2 .
  • the scrubber canister 38 may contain sodium hydroxide, calcium hydroxide, or barium hydroxide.
  • Sodium hydroxide and calcium hydroxide mixed with silica is available as Soda LimeTM.
  • Another commercially available CO 2 scrubber is BaralymeTM which comprises barium hydroxide and calcium hydroxide.
  • FIGs 4a and 4b show two additional embodiments of the present invention.
  • the scrubber canister 38 may be placed in the oscillating line 14 upstream of the CO 2 and O 2 sensors 22, 24, or as shown in Figure 4b, downstream of the sensors 22, 24.
  • check valves are not required to direct the flow of inspiratory gas toward the patient line 25 or to direct the flow of expired gas toward the scrubber canister 38.
  • Figure 5 shows another embodiment of the present invention in which the scrubber is located in the oscillating line 14, and gas flows through the scrubber canister 38 toward the patient line 25. Flow from the patient line 25 moves through the exhalation line 30 to oscillating line 14. A check valve 42 is in bypass line 66 to assure that flow moves through exhalation line 30 in one direction only. An additional check valve 20 may be included in oscillating line 14 to assure flow through the scrubber canister 38 in one direction only.
  • the exhaled gas is simply allowed to leave a device 100.
  • the device 100 is connected to an inspiratory gas source 5 through connecting line 18.
  • the inspiratory gas enters an oscillating line 14 and moves toward the patient line 25 in the direction of arrow 21 via the inbound check valve 20.
  • CO 2 and O 2 sensors 22, 24 and pressure monitoring port 28 can be placed near the patient line 25.
  • the exhaled gas is conducted by the exhalation line 30 to another type of outlet valve 52.
  • the outlet valve 52 shown in Figures 6, 7a and 7b operates based on the pressure differential between oscillating line 14 and the exhalation line 30.
  • outlet valve 52 is caused to close the end 132 of exhalation line 30 by the rising pressure in oscillating line 14.
  • the pressure in the outlet line 50 causes the outlet valve 52 to open the end 132 and allow gas to escape to the atmosphere.
  • outlet valve 52 is closed and there is no communication between the exhalation line 30 and the atmosphere, and for at least part of the depressurization cycle, outlet valve 52 is open and there is communication between line 30 and the atmosphere.
  • FIGs 7a and 7b show a preferred embodiment of the outlet valve 52 shown in Figure 6.
  • the outlet valve 52 in Figures 7a and 7b has a first flexible membrane 300 disposed in the oscillating line 14 and a second flexible membrane 303 situated to selectively close the end 132 of the outlet line 50.
  • the flexible membranes 300, 303 are connected by a pressure communication line 306.
  • the pressure communication line 306 may be filled with a gas or a fluid.
  • the pressure in the pressure communication line 306 is above the pressure in outlet line 50, the end 132 of the outlet line 50 is closed by the second flexible membrane 303.
  • gas is allowed to escape from the end 132 of the outlet line 50. It will be recognized that due to the first flexible membrane 300, the pressure in oscillating line 14 will change the pressure in the pressure communication line 306.
  • a control pressure line 309 is connected to the pressure communication line 306.
  • the pressure in the pressure communication line 306 may be changed, and thereby, the pressure in the outlet line 50 required to open the end 132 of the outlet line 50 may be changed.
  • device 10 may be connected to an U-type oscillator tube (termed herein as a connecting tube) of the prior art.
  • the U-type tubes typically have a gas supply line and an outlet valve or means.
  • the device has a gas flow circuit comprising an oscillating line, a patient line and a return line.
  • the first end of the oscillating line 14 is adapted for communication with a connector 402 of the U-type oscillator tube 400 as indicated by dotted lines 404.
  • the second end of the oscillating line 14 is connected to patient line 25.
  • a return line 67 is provided for return of exhaled air.
  • the return line at both ends is connected to the oscillating line.
  • check valve 20 On the oscillating line between the ends of the return line is located check valve 20 to move the gas toward patient line 25.
  • a CO 2 scrubber 38 is located in the return line ( Figure 9a) or in the oscillating line ( Figure 9b).
  • another, check valve 42 is provided in the return line.
  • the device may also have a gas supply line and an outlet valve. For use of this device directly with an oscillating ventilator 410 as indicated by dotted lines 404 ( Figure
  • a gas supply line 8 having a flow regulator 9 is connected to any location in the gas flow circuit through connecting line 18.
  • An outlet valve 52 may also be placed at any location in the gas flow circuit.
  • the scrubber canister 38 may be placed at any location in the oscillating line or return line, but is preferably placed in the return line.
  • a second CO 2 scrubber canister 68 may be provided in another return line 66.
  • Scrubber valves 70A and 70B operate as described above such that either scrubber canister 38 or scrubber canister 68 is in use.
  • Oxygen and CO 2 sensors, and pressure monitoring devices can also be placed in the gas flow circuit as shown in Figures 1, 4a, 4b or 6.
  • VO 2 is the volume rate of oxygen consumed by the patient
  • FmO 2 is the mole fraction of oxygen in the mixed gas crossing inbound check valve 20;
  • FiO 2 l-FiN 2 .
  • FiN 2 is the mole fraction of nitrogen in the inspiratory gas
  • FmO 2 l-FmN 2 , where FmN 2 is the mole fraction of nitrogen in the mixed gas exiting the outlet valve 52;
  • Tables 1-9 illustrate the FmO 2 achieved at various inspiratory gas flow rates (VI) assuming an oxygen consumption rate of 5 ml/kg/min.
  • VI/VO 2 indicates the minimum flow rate of inspiratory gas needed to achieve an FmO2 that is within 10% of the corresponding FiO 2 .
  • the inspiratory gas corresponding to Table 1 was air (21% oxygen).
  • an inspiratory gas flow rate of 50 ml/kg/min results in the fraction of O 2 in the mixed gas (mixture of inspiratory gas and scrubbed exhaled gas) to be about 0.12.
  • the ratio of FmO 2 to FiO 2 is about 0.58.
  • a flow rate of inspiratory gas of 200 ml/min is needed.
  • Tables 2-9 illustrate the flow rate of inspiratory gas required for FiO 2 values of 0.3 (30% oxygen) to 1.0 (pure oxygen). With a higher percentage of oxygen in the inspiratory gas, a lower flow of inspiratory gas is needed to achieve the same ratio of FmO 2 to FiO 2 .
  • Figure 8 shows steps of a method according to the present invention.
  • a ventilating device such as the device 10 described above, is provided (step 200).
  • a patient connected to the patient line is provided (step 203) and gas is supplied with the gas supply line to the oscillating line (step 206).
  • the oscillator is moved toward the oscillating line and the outlet valve is opened (step 209).
  • the oscillator is moved away from the oscillating line and the outlet valve is closed (step 212).
  • the gas is supplied to the oscillating line at approximately a constant flow rate.
  • Devices and methods according to the present invention are more efficient than currently available high frequency oscillating ventilators primarily because the present invention substantially reduces the need for bias flow. This reduction in bias flow enables smaller ventilation systems. It is now clear the device and method of the present invention reduces the volume of bias flow required for safe ventilation. By using the present device, it is believed the volume of inspiratory gas delivered to the ventilator can be reduced from 20,000 to 80,000 ml/min to as little as 20 to 800 ml/min.
  • Another advantage of the present invention may be to counter the loss of mean lung volume associated with prolonged oscillatory ventilation, which is believed to be a problem with this form of mechanical ventilation. It is currently believed by some that this problem might be intensified by reductions in inspiratory gas flow.
  • One approach to this problem that may counter a tendency to lose mean lung volume and thus preserve lung expansion involves redirection of some or all of the inspiratory gas flow to a small channel adapted to the endotracheal tube to allow delivery of some or all of the bias flow directly to the trachea. While potentially hazardous at high (conventional) inspiratory gas flow rates, it is believed that this would be safe at the lower inspiratory gas flow rates envisioned for this invention.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Structures Of Non-Positive Displacement Pumps (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Cette invention concerne un dispositif et un procédé de ventilation d'un patient permettant de réduire le flux régulé par rapport à des ventilateurs oscillatoires. Le dispositif comprend un circuit d'écoulement gazeux comportant un conduit oscillant, un conduit d'alimentation et un conduit d'expiration ou un conduit de retour. Une canalisation d'amenée du gaz et une soupape de sortie sont en communication pneumatique avec le circuit d'écoulement gazeux. Le circuit comporte un ou plusieurs épurateurs de CO2 et un ou plusieurs clapets anti-retour. Est également décrite une méthode de ventilation à l'aide d'un tel dispositif.
EP03715967A 2002-02-01 2003-02-03 Dispositif et procede permettant de reduire le flux regule dans des ventilateurs oscillatoires Withdrawn EP1476225A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35346102P 2002-02-01 2002-02-01
US353461P 2002-02-01
PCT/US2003/003069 WO2003063751A2 (fr) 2002-02-01 2003-02-03 Dispositif et procede permettant de reduire le flux regule dans des ventilateurs oscillatoires

Publications (2)

Publication Number Publication Date
EP1476225A2 true EP1476225A2 (fr) 2004-11-17
EP1476225A4 EP1476225A4 (fr) 2007-12-05

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP03715967A Withdrawn EP1476225A4 (fr) 2002-02-01 2003-02-03 Dispositif et procede permettant de reduire le flux regule dans des ventilateurs oscillatoires

Country Status (6)

Country Link
EP (1) EP1476225A4 (fr)
JP (1) JP2005515840A (fr)
BR (1) BR0307412A (fr)
CA (1) CA2474428A1 (fr)
MX (1) MXPA04007412A (fr)
WO (1) WO2003063751A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013122326A1 (fr) * 2012-02-16 2013-08-22 연세대학교 산학협력단 Dispositif manuel de respiration artificielle
KR101489430B1 (ko) * 2012-02-16 2015-02-03 연세대학교 원주산학협력단 수동식 인공호흡장치
GB2512401B (en) * 2013-03-27 2015-10-14 Carefusion Corp Arrangement and method for guiding expired respiratory gas flow through a housing assembly for removing undesirable respiratory gas component and breathing
US9199050B2 (en) 2012-04-30 2015-12-01 Carefusion Corporation Arrangement and method for guiding expired respiratory gas flow using gas routing device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001008736A1 (fr) * 1999-08-03 2001-02-08 The Research Foundation Of State University Of New York Dispositif et procede destines a reduire un debit de surplus dans des ventilateurs oscillatoires

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Publication number Priority date Publication date Assignee Title
JPS59101159A (ja) * 1982-11-30 1984-06-11 泉工医科工業株式会社 二連噴流管を有する人工呼吸器
US4719910A (en) 1985-04-29 1988-01-19 Jensen Robert L Oscillating ventilator and method
US5092326A (en) * 1987-11-19 1992-03-03 Winn Bryan D Apparatus and method for a ventilator system
US5307794A (en) 1992-04-01 1994-05-03 Sensormedics Corporation Oscillating ventilator apparatus and method and patient isolation apparatus
US5555880A (en) * 1994-01-31 1996-09-17 Southwest Research Institute High frequency oscillatory ventilator and respiratory measurement system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001008736A1 (fr) * 1999-08-03 2001-02-08 The Research Foundation Of State University Of New York Dispositif et procede destines a reduire un debit de surplus dans des ventilateurs oscillatoires

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO03063751A2 *

Also Published As

Publication number Publication date
WO2003063751A3 (fr) 2004-04-29
EP1476225A4 (fr) 2007-12-05
CA2474428A1 (fr) 2003-08-07
JP2005515840A (ja) 2005-06-02
MXPA04007412A (es) 2005-06-20
BR0307412A (pt) 2005-01-04
WO2003063751A2 (fr) 2003-08-07

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