EP1476118A1 - Methode de distribution de substances pharmaceutiques - Google Patents
Methode de distribution de substances pharmaceutiquesInfo
- Publication number
- EP1476118A1 EP1476118A1 EP02801386A EP02801386A EP1476118A1 EP 1476118 A1 EP1476118 A1 EP 1476118A1 EP 02801386 A EP02801386 A EP 02801386A EP 02801386 A EP02801386 A EP 02801386A EP 1476118 A1 EP1476118 A1 EP 1476118A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- individual
- capsules
- capsule
- microspheres
- active substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/074—Filling capsules; Related operations
-
- G—PHYSICS
- G07—CHECKING-DEVICES
- G07F—COIN-FREED OR LIKE APPARATUS
- G07F17/00—Coin-freed apparatus for hiring articles; Coin-freed facilities or services
- G07F17/0092—Coin-freed apparatus for hiring articles; Coin-freed facilities or services for assembling and dispensing of pharmaceutical articles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2205/00—General identification or selection means
- A61J2205/10—Bar codes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2205/00—General identification or selection means
- A61J2205/20—Colour codes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2205/00—General identification or selection means
- A61J2205/30—Printed labels
Definitions
- the present invention relates to the field of dispensing pharmaceutical formulations.
- Medicinal dosage forms (such as tablets or capsules) contain an active substance present in micro— or milli— gram amounts combined with inactive substances which promote physical or chemical stability, ease of handling and identification of the product.
- blister packing be offered as a free service by dispensing pharmacists, putting a number of tablets together in a day-coded package.
- patients are still faced with the same large number of tablets to take, which discourages them from taking their treatment reliably.
- Blister packing is currently performed by only a few dispensing pharmacists as a special service, and is not widely available.
- the present invention therefore seeks to reduce the total number of dose forms ('pills') that patients are required to take daily.
- the present invention provides a device for filling a set of capsules with microspheres containing active substances to permit the dosage of each individual active substance in each capsule of the set to be varied to suit the requirements of an individual patient, which device comprises a plurality of loading stations each receiving a canister filled with micro-spheres containing a predetermined quantity of a respective one of the active substances, a programmable metering unit associated with the loading stations for metering programmed numbers of microspheres from the individual canisters, and means for introducing the counted micro-spheres into the individual capsules of the set.
- the invention thus provides a dispensing pharmacist with the facility to mix in one capsule a combination of different active substances in absolute and relative amounts that are specifically prescribed for the patient by a medical practitioner. Not only can the doses and relative amounts of the active substances be tailored to individual patient requirements in any one set, but the different capsules within a set may contain different doses from one another, enabling a particular drug to be phased in or out over the period during which the capsules of the set are to be taken by the patient. This is referred to as titration.
- such capsules should be prepared and packed in an easily available pack for patients locally in community or hospital pharmacies.
- the capsules, or their packaging if they are blister packed to be marked with a code that permits the contained active substances and their dosage to be determined.
- the canisters should be shaped externally to provide secure mounting onto the device in a predetermined orientation and that their internal shape be such as to ensure accurate delivery of micro-spheres under gravity.
- the canisters may be formed in two parts that seal hermetically against each other to prevent entry of water vapour or to contain a preservative gas introduced into the canisters. Such sealing of the canisters is also advantageous in that it prevents tampering.
- the filled capsules may additionally be sealed into an 'original pack' for dispensing to patients.
- micro-spheres In order to meter the correct number of micro-spheres from a supply canister into an individual capsule, it is possible to use as a programmable counter a reciprocating perforated plate, or an indented wheel, controlled by an indexing stepping mechanism. As an alternative, individual microspheres may be counted optically (by interruption of a light beam) and the flow of microspheres into a capsule may be stopped when the desired number has been reached.
- each capsule or more preferably the blister pack containing several capsules may be suitably encoded, for example by means of a bar code or colour coding.
- the encoded data may be used to identify the dispensing pharmacy, to identify the contained medications, using information stored in a database in the pharmacy.
- microspheres The range of active substances to be formulated in microspheres is potentially wide, but would be most appropriate where the typical dose ranged from micrograms to tens of milligrams.
- the external design of the manufacturers' supply canisters for the microspheres may preferably be of standardised dimensions and mechanisms for sealing/unsealing and encoding so as to ensure secure mounting into the capsule filling device and to allow positive identification of the contents of the canister through a mechanical/electrical/radio/magnetic signalling system adopting a standard code.
- the internal design characteristics of the manufacturers' supply canister for the microspheres may be variable to permit adjustment of storage conditions for an adequate shelf life for the individual active substances .
- the canisters may be filled with an inert gas, masked against entry of light, or coated to prevent water vapour entry.
- the external design of the microsphere supply canisters may suitably incorporate a standardised space for labelling giving visual identification and details of contents .
- the capsule filling device may be controlled by a computer installation that includes a printer and the computer may be programmed to print labels that give details of the dispensing pharmacy, patient name, active substance, manufacturer, expiry date and manufacturers' product codes.
- labels may be self adhesive and prepared for attachment to the original dispensing pack and to the outside of a cardboard box containing treatment supply for a 28 or 30 day period.
- the original dispensing pack containing the individually filled capsules should preferably identify capsules for individual days of the week for ease of treatment compliance.
- Such packs may also conform to standardised dimensions and carry protrusions and/or perforations for engagement with the mechanism of an optional additional device for the extraction of the capsules from the original dispensing pack at the patients home .
- the first may be fully automatic, containing original treatment pack for one month's supply of capsules, with ability to present the dose form to the patient at a preset time with audible tone/voice recording/ isual alert.
- the second may be a semi-automatic device for easy removal of the capsule from the original dispensing pack, aiding patients with low sight, reduced manual dexterity or poor memory (prompted by magnifying lens window to view day of the week on the contained original dispensing pack) .
- the individual components for implementation of the invention may comprise pre-manufactured pharmaceutical capsules which are separated into component halves .
- the lower-parts may be inserted vertically into strips or wheels which hold twenty eight or fifty six half capsules arranged around the margin of the strip or wheel.
- the wheel or strip is capable of precision mounting into the capsule-filling device to allow precise filling of capsules with microspheres .
- a matching strip or wheel is provided to contain pre-inserted matching top-halves of the capsules. Batch closure of filled capsules is effected by application of opposing strips or wheels containing capsule upper and lower halves .
- the capsule halves may be of different colours (e.g. red, orange, yellow, green, light blue, dark blue, brown, black, white, transparent, and they may have superimposed contrasting colour band(s). In this manner, colour coding may be achieved to allow the origin of the capsules to be identified.
- Alphanumeric codes may alternatively or additionally be pre-printed onto one half of capsule (e.g. 10 characters) and such codes may be standardised to enable national identification.
- the microsphere canister will typically contain sufficient spheres for various doses for multiples of twenty eight capsules. Asymmetric shape can be used to ensure standard orientation into the capsule filling device. Labels printed onto the canister can be encoded to allow automatic transfer of details of manufacturer, active substance, dose, batch, product licence number and expiry date. The canister is sealed until insertion into the capsule filling device for security against loss of microsphere or contamination of contents .
- the capsule filling device should be able to carry plastic strips or wheels containing 28 or 30 capsules and to allow mounting of up to ten manufacturers' canisters of microspheres .
- the filling device is microprocessor controlled for accurate dispensing of appropriate numbers of each type of microsphere into each capsule in turn.
- the microprocessor of the filling device should preferably be able to interface with a pharmacy computer to allow transfer of prescribing information without re-keying of prescription data to the device, and despatching of securely encoded data to distant secure database via internet connection from the device, via the pharmacy computer.
- the filling device may also be designed to allow future prescription data entry by barcode read directly off prescription form via the pharmacy computer or downloaded from medical practitioners' systems.
- the invention resides not in the construction of any one of the necessary components but in the provision of a device that affords the pharmacist the flexibility to tailor the composition of the active substances in a set of capsules to the needs of an individual patient, as prescribed by a medical practitioner. In this way, a patient need only swallow one capsule at any one time, thereby ensuring that the patient adheres to the regime specified by the practitioner.
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Basic Packing Technique (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0125064 | 2001-10-18 | ||
GB0125064A GB2380937A (en) | 2001-10-18 | 2001-10-18 | Method of dispensing a plurality of medical substances into capsules |
PCT/GB2002/004631 WO2003032891A1 (fr) | 2001-10-18 | 2002-10-14 | Methode de distribution de substances pharmaceutiques |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1476118A1 true EP1476118A1 (fr) | 2004-11-17 |
EP1476118B1 EP1476118B1 (fr) | 2011-11-23 |
Family
ID=9924112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02801386A Expired - Lifetime EP1476118B1 (fr) | 2001-10-18 | 2002-10-14 | Methode de distribution de substances pharmaceutiques |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1476118B1 (fr) |
AT (1) | ATE534366T1 (fr) |
ES (1) | ES2377516T3 (fr) |
GB (2) | GB2380937A (fr) |
WO (1) | WO2003032891A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014184781A1 (fr) | 2013-05-17 | 2014-11-20 | David Slovick | Dispositif de comptage pour la distribution de substances pharmaceutiques |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7086532B2 (en) | 2003-07-16 | 2006-08-08 | Allergan, Inc. | Titration/compliance pack with increasing doses |
WO2012087492A2 (fr) | 2010-12-23 | 2012-06-28 | Tailorpill Technologies, Llc | Système et procédés de composition de pilules personnalisées |
US10327994B2 (en) * | 2016-05-02 | 2019-06-25 | Dose Pack Llc | System and methods for customized medicine dosages in a capsule |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3638688A (en) * | 1970-02-24 | 1972-02-01 | Brunswick Corp | Coded oral solids magazine and dispenser |
IT1203137B (it) * | 1978-11-09 | 1989-02-15 | Facchini Libero | Macchina opercolatrice a movimento continuo per il confezionamento di prodotti pulverulenti o granulari |
BR8300014A (pt) * | 1982-01-07 | 1983-08-30 | Uss Eng & Consult | Aparelho para fabricacao de cartuchos de elemento chumbador |
IT1171950B (it) * | 1983-09-30 | 1987-06-10 | Mg 2 Spa | Procedimento per l'alimentazione, l'orientamento, il riempimento, la chiusura e l'espulsione di capsule ed impianto che attua tale procedimento |
JPH0620919B2 (ja) * | 1987-06-18 | 1994-03-23 | 日本エランコ株式会社 | 硬質カプセルへの粒状物充填方法およびその装置 |
FR2689092B1 (fr) * | 1992-03-31 | 1994-12-30 | Boiron | Dispositif pour compter un nombre déterminé de billes ou analogues, puis pour les regrouper dans un récipient. |
EP0587085A3 (en) * | 1992-09-11 | 1994-09-14 | Ihde Stefan Klaus Alfred | Method and device for dosing and mixing multicomponent material |
SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
IE970731A1 (en) * | 1997-10-07 | 2000-10-04 | Fuisz Internat Ltd | Product and method for the treatment of hyperlipidemia |
US5960609A (en) * | 1998-06-12 | 1999-10-05 | Microdose Technologies, Inc. | Metering and packaging method and device for pharmaceuticals and drugs |
US6183779B1 (en) * | 1999-03-22 | 2001-02-06 | Pharmascience Inc. | Stabilized pharmaceutical composition of a nonsteroidal anti-inflammatory agent and a prostaglandin |
US6340476B1 (en) * | 1999-04-06 | 2002-01-22 | Armaquest, Inc. | Pharmaceutical dosage form for pulsatile delivery of methylphenidate |
US7163693B1 (en) * | 1999-07-30 | 2007-01-16 | Smithkline Beecham Plc | Multi-component pharmaceutical dosage form |
BR9905261A (pt) * | 1999-09-30 | 2001-07-24 | Libbs Farmaceutica Ltda | Uma nova associação medicamentosa de liberação programada |
DE19951504C2 (de) * | 1999-10-26 | 2002-02-21 | 3M Espe Ag | Mischvorrichtung und -verfahren |
AU2002306629A1 (en) * | 2001-03-02 | 2002-09-19 | Euro-Celtique, S.A. | Method and apparatus for compounding individualized dosage forms |
-
2001
- 2001-10-18 GB GB0125064A patent/GB2380937A/en not_active Withdrawn
-
2002
- 2002-10-14 EP EP02801386A patent/EP1476118B1/fr not_active Expired - Lifetime
- 2002-10-14 WO PCT/GB2002/004631 patent/WO2003032891A1/fr not_active Application Discontinuation
- 2002-10-14 AT AT02801386T patent/ATE534366T1/de active
- 2002-10-14 ES ES02801386T patent/ES2377516T3/es not_active Expired - Lifetime
- 2002-10-14 GB GB0408460A patent/GB2397763A/en not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO03032891A1 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014184781A1 (fr) | 2013-05-17 | 2014-11-20 | David Slovick | Dispositif de comptage pour la distribution de substances pharmaceutiques |
Also Published As
Publication number | Publication date |
---|---|
GB2397763A (en) | 2004-08-04 |
ATE534366T1 (de) | 2011-12-15 |
GB2380937A (en) | 2003-04-23 |
GB0408460D0 (en) | 2004-05-19 |
ES2377516T3 (es) | 2012-03-28 |
EP1476118B1 (fr) | 2011-11-23 |
GB0125064D0 (en) | 2001-12-12 |
WO2003032891A1 (fr) | 2003-04-24 |
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