EP1436406A4 - Procede de modulation ou d'examen des taux de ku70 dans des cellules - Google Patents

Procede de modulation ou d'examen des taux de ku70 dans des cellules

Info

Publication number
EP1436406A4
EP1436406A4 EP02761739A EP02761739A EP1436406A4 EP 1436406 A4 EP1436406 A4 EP 1436406A4 EP 02761739 A EP02761739 A EP 02761739A EP 02761739 A EP02761739 A EP 02761739A EP 1436406 A4 EP1436406 A4 EP 1436406A4
Authority
EP
European Patent Office
Prior art keywords
bax
cells
examining
levels
level
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02761739A
Other languages
German (de)
English (en)
Other versions
EP1436406A2 (fr
Inventor
Shigemi Matsuyama
Wseiyong Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Blood Center Research Foundation Inc
Original Assignee
Blood Center Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blood Center Research Foundation Inc filed Critical Blood Center Research Foundation Inc
Publication of EP1436406A2 publication Critical patent/EP1436406A2/fr
Publication of EP1436406A4 publication Critical patent/EP1436406A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne un procédé permettant de prédire si des cellules répondront à des thérapies à médiation par apoptose régulée à l'aide de la protéine Bax. Dans un mode de réalisation de cette invention, le procédé comprend les étapes consistant: (a) à examiner l'intensité de l'expression de la protéine Bax ou de l'ARNm Bax dans une cellule par rapport à un contrôle, et (b) en fonction de ce niveau d'intensité, à prédire si ces cellules répondront à des thérapies à médiation par apoptose régulée à l'aide de la protéine Bax, un taux élevé de Bax indiquant que les taux de Ku70 peuvent être abaissés et la sensibilité à l'apoptose augmentée. Dans un autre mode de réalisation, l'invention concerne un procédé de sensibilisation des cellules à une thérapie du cancer, lequel comprend l'étape consistant à réduire le taux de protéine Ku70 natif de la cellule. Dans un autre mode de réalisation encore, l'invention concerne une méthode de traitement de maladies liées à la mort cellulaire, qui comprend l'étape consistant à augmenter le taux de protéine Ku70 cellulaire.
EP02761739A 2001-09-24 2002-09-19 Procede de modulation ou d'examen des taux de ku70 dans des cellules Withdrawn EP1436406A4 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US32429201P 2001-09-24 2001-09-24
US324292P 2001-09-24
US36428702P 2002-03-14 2002-03-14
US364287P 2002-03-14
US37858502P 2002-05-08 2002-05-08
US378585P 2002-05-08
PCT/US2002/029737 WO2003027237A2 (fr) 2001-09-24 2002-09-19 Procede de modulation ou d'examen des taux de ku70 dans des cellules

Publications (2)

Publication Number Publication Date
EP1436406A2 EP1436406A2 (fr) 2004-07-14
EP1436406A4 true EP1436406A4 (fr) 2004-10-13

Family

ID=27406324

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02761739A Withdrawn EP1436406A4 (fr) 2001-09-24 2002-09-19 Procede de modulation ou d'examen des taux de ku70 dans des cellules

Country Status (4)

Country Link
US (3) US20030073661A1 (fr)
EP (1) EP1436406A4 (fr)
AU (1) AU2002326980A1 (fr)
WO (1) WO2003027237A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003074667A2 (fr) * 2002-03-01 2003-09-12 Blood Center Research Foundation Peptides reducteur de bax derives de ku-70 et leur utilisation dans la protection des cellules endommagees
US20080096824A1 (en) * 2003-02-28 2008-04-24 Shigemi Matsuyama Ku-70-derived bax-suppressing peptides and use thereof for the protection of damaged cells
CN104541170A (zh) * 2012-05-10 2015-04-22 尤特罗皮克斯制药股份有限公司 对癌症的代理功能性诊断测试
IN2014DN11205A (fr) 2012-06-20 2015-10-02 Eutropics Pharmaceuticals Inc
WO2014081953A1 (fr) 2012-11-21 2014-05-30 Richard David J Méthodes et compositions utiles dans le traitement de maladies faisant appel à des protéines de la famille bcl-2 et des dérivés d'isoquinoléine et de quinoléine
CN105555956B (zh) * 2013-07-09 2020-05-15 中央兰开夏大学 针对神经胶质瘤细胞的适体
US10732182B2 (en) 2013-08-01 2020-08-04 Eutropics Pharmaceuticals, Inc. Method for predicting cancer sensitivity
US10640803B2 (en) 2013-10-30 2020-05-05 Eutropics Pharmaceuticals, Inc. Methods for determining chemosensitivity and chemotoxicity
EP3245301B1 (fr) 2015-01-12 2020-11-11 Eutropics Pharmaceuticals, Inc. Essai de diagnostic dépendant du contexte pour guider le traitement du cancer
CA2982928A1 (fr) 2015-04-20 2016-10-27 Tolero Pharmaceuticals, Inc. Prediction de la reaction a l'alvocidib par identification de profil mitochondrial
CN111349118B (zh) 2015-05-18 2023-08-22 住友制药肿瘤公司 具有增加的生物利用度的阿伏西地前药
CA2993659A1 (fr) 2015-08-03 2017-02-09 Tolero Pharmaceuticals, Inc. Therapies combinatoires pour le traitement du cancer
WO2018094275A1 (fr) 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Promédicaments de l'alvocidib et leur utilisation en tant qu'inhibiteurs de protéines kinases
EP3362471B1 (fr) 2016-12-19 2021-11-17 Sumitomo Dainippon Pharma Oncology, Inc. Peptides profilants et procédés de profilage de sensibilité
WO2019055579A1 (fr) 2017-09-12 2019-03-21 Tolero Pharmaceuticals, Inc. Régime de traitement pour des cancers qui sont insensibles aux inhibiteurs de bcl-2 à l'aide de l'inhibiteur de mcl-1 alvocidib
KR20210099066A (ko) 2018-12-04 2021-08-11 스미토모 다이니폰 파마 온콜로지, 인크. 암의 치료를 위한 작용제로서 사용하기 위한 cdk9 억제제 및 그의 다형체
JP2022525149A (ja) 2019-03-20 2022-05-11 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置
CN114392345B (zh) * 2021-03-11 2023-08-25 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） E199l蛋白在促进细胞凋亡中的用途及方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9700574D0 (en) * 1997-01-13 1997-03-05 Cancer Res Campaign Tech Methods and means relating to retrotransposon and retroviral integration
US6399298B1 (en) * 1998-06-30 2002-06-04 Sloan-Kettering Institute For Cancer Research Ku70—related methods
CA2332179C (fr) * 1998-06-30 2011-06-28 Sloan-Kettering Institute For Cancer Research Utilisations d'adn-pk

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SAWADA M ET AL: "Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70", NATURE CELL BIOLOGY, MACMILLAN PUBLISHERS, GB, vol. 5, no. 4, 24 March 2003 (2003-03-24), pages 352 - 357, XP002967925, ISSN: 1465-7392 *
SAWADA M.: "Ku70 suppresses cell death by inhibiting mitochondrial translocation of Bax", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 43, March 2002 (2002-03-01), pages 998, XP001182668 *

Also Published As

Publication number Publication date
WO2003027237A3 (fr) 2003-11-06
US20070036775A1 (en) 2007-02-15
AU2002326980A1 (en) 2003-04-07
US20050026201A1 (en) 2005-02-03
WO2003027237A2 (fr) 2003-04-03
EP1436406A2 (fr) 2004-07-14
US20030073661A1 (en) 2003-04-17

Similar Documents

Publication Publication Date Title
WO2003027237A3 (fr) Procede de modulation ou d'examen des taux de ku70 dans des cellules
WO2002069900A3 (fr) Procede de traitement de troubles proliferatifs d'origine genetique par des inhibiteurs de hsp90
WO2002089747A3 (fr) Compositions et procedes pour la therapie et le diagnostic du cancer de la prostate
WO1996035774A3 (fr) Fragments d'angiostatine, angiostatine agregee et procedes d'utilisation
CA2291892A1 (fr) Fragments d'angiostatine et leur procede d'utilisation
NO973838D0 (no) DNA-molekyler, deres fremstilling samt anvendelse ved genterapi
EP0961833A4 (fr) Hyaluronidase du plasma humain
WO2002074156A3 (fr) Compositions et procedes de therapie et de diagnostic du cancer du colon
ATE313625T1 (de) ßFUNCTIONAL GENOMICSß UNTER VERWENDUNG VON ZINK FINGER PROTEINEN
WO2003102016A3 (fr) Enzyme inactivant le peptide amyloide pour traiter la maladie d'alzheimer
WO2002012328A3 (fr) Compositions et methodes utilisees dans la therapie et le diagnostic du cancer du colon
WO2003031650A3 (fr) Genes et proteines utilises dans la prevention, la prediction, le pronostic et la therapie de la maladie cardiovasculaire
WO2002058534A3 (fr) Compositions et methodes pour le traitement et le diagnostic du cancer du colon
DE69928395D1 (de) Cyclin-e2 proteine und dafür kodierende gene
DE60044350D1 (de) Prostata-spezifisches gen pcgem1 und methoden zu dessen verwendung zur erkennung, behandlung und prävention von prostatakrebs
CA2278808A1 (fr) Procedes pour la culture de cellules et la multiplication de virus
WO2005042719A3 (fr) Methodes permettant de traiter et de prevenir lesion ischemique au retour de la perfusion a l'aide d'agents interferant avec l'adn
WO2002012280A3 (fr) Compositions et procedes pour le diagnostic et le traitement du cancer du colon
WO2005017100A3 (fr) Ribonucleases et procedes de production de ribonucleases par recombinaison
WO1999031128A3 (fr) Proteines du type facteur humain de necrose tumorale r2
WO2001044448A3 (fr) Proteines d'oxydoreductase humaines
WO2003026494A3 (fr) Galectines-1 et -4 dans le developpement des tumeurs
WO2001094409A3 (fr) Traitement et diagnostic du cancer du pancreas et compositions a cet effet
WO2002101076A3 (fr) Procedes d'expression ciblee d'un acide nucleique therapeutique
WO1998046747A3 (fr) Genes de la region de non-recombinaison du chromosome y

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20040419

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20040830

17Q First examination report despatched

Effective date: 20050512

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20051123