EP1436269A1 - Oxadiazolyl-biphenylcarboxamides et leur utilisation comme inhibiteurs de la kinase p38 - Google Patents

Oxadiazolyl-biphenylcarboxamides et leur utilisation comme inhibiteurs de la kinase p38

Info

Publication number
EP1436269A1
EP1436269A1 EP02787487A EP02787487A EP1436269A1 EP 1436269 A1 EP1436269 A1 EP 1436269A1 EP 02787487 A EP02787487 A EP 02787487A EP 02787487 A EP02787487 A EP 02787487A EP 1436269 A1 EP1436269 A1 EP 1436269A1
Authority
EP
European Patent Office
Prior art keywords
methyl
alkyl
oxadiazol
biphenyl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02787487A
Other languages
German (de)
English (en)
Inventor
Richard Martyn c/o GlaxoSmithKline ANGELL
Paul GlaxoSmithKline BAMBOROUGH
George Stuart c/o GlaxoSmithKline COCKERILL
Kathryn Jane GlaxoSmithKline SMITH
Ann Louise GlaxoSmithKline WALKER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of EP1436269A1 publication Critical patent/EP1436269A1/fr
Withdrawn legal-status Critical Current

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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
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  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
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Abstract

L'invention concerne des composés représentés par la formule (I) dans laquelle R3 représente le groupe (A), ou leurs sels ou solvates acceptables sur le plan pharmaceutique, ainsi que leur utilisation comme produits pharmaceutiques, en particulier comme inhibiteurs de la kinase p38.
EP02787487A 2001-10-17 2002-10-16 Oxadiazolyl-biphenylcarboxamides et leur utilisation comme inhibiteurs de la kinase p38 Withdrawn EP1436269A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0124932 2001-10-17
GBGB0124932.5A GB0124932D0 (en) 2001-10-17 2001-10-17 Chemical compounds
PCT/EP2002/011574 WO2003033482A1 (fr) 2001-10-17 2002-10-16 Oxadiazolyl-biphenylcarboxamides et leur utilisation comme inhibiteurs de la kinase p38

Publications (1)

Publication Number Publication Date
EP1436269A1 true EP1436269A1 (fr) 2004-07-14

Family

ID=9924028

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02787487A Withdrawn EP1436269A1 (fr) 2001-10-17 2002-10-16 Oxadiazolyl-biphenylcarboxamides et leur utilisation comme inhibiteurs de la kinase p38

Country Status (5)

Country Link
US (1) US20050065195A1 (fr)
EP (1) EP1436269A1 (fr)
JP (1) JP2005508357A (fr)
GB (1) GB0124932D0 (fr)
WO (1) WO2003033482A1 (fr)

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