EP1419244A4 - Electrodes coated with treating agent and uses thereof - Google Patents

Electrodes coated with treating agent and uses thereof

Info

Publication number
EP1419244A4
EP1419244A4 EP02752177A EP02752177A EP1419244A4 EP 1419244 A4 EP1419244 A4 EP 1419244A4 EP 02752177 A EP02752177 A EP 02752177A EP 02752177 A EP02752177 A EP 02752177A EP 1419244 A4 EP1419244 A4 EP 1419244A4
Authority
EP
European Patent Office
Prior art keywords
electrodes
electrode
molecules
electrode assembly
wich
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02752177A
Other languages
German (de)
French (fr)
Other versions
EP1419244A2 (en
Inventor
Alan D King
Richard E Walters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cyto Pulse Sciences Inc
Original Assignee
Cyto Pulse Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyto Pulse Sciences Inc filed Critical Cyto Pulse Sciences Inc
Publication of EP1419244A2 publication Critical patent/EP1419244A2/en
Publication of EP1419244A4 publication Critical patent/EP1419244A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A61H39/002—Using electric currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

An object of the invention is to provide a method for delivery of macromolecules into biologicale cel ls in the tissues of a patient and includes the steps of: (a) providing electrodes (16) in an electrode assembly (12), whrein the electrodes have fixed electrode surfaces (42) wich are coated with at least one static layer of electrode releasable molecules (44) to be delivred; (b) providing a waveform generator (15) for generating electric fields; (c) establishing electrically conductive pathways between the electrodes (16) and the waveform generator (15); (d) locating the electrodes (16), such that the biological cells are situated therebetween, and (g) providing electric fields in the form of pulse waveforms from the waveform generator (15) to the electrodes (16), such that molecules in the at least one static layer of the electrode releasable molecules (44) on the electrodes (16) are delivered into the biological cells. The electrode releasable molecules (44) can be either electric field separable molecules and/or solvent separable material. Another object of the invention is to provide an apparatus for carrying out the method of the invention. The static-coated electrode assembly (12) can be provided in a sterile package (24), from wich the electrode assembly (12) is removed prior to use. The statically-coated electrode assembly (12) can be in a form of a disposable assembly (12) wich is removable and replaceable from an electrode assembly holder (13).
EP02752177A 2001-08-03 2002-08-02 Electrodes coated with treating agent and uses thereof Withdrawn EP1419244A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US920861 1997-08-29
US09/920,861 US6713291B2 (en) 1999-01-28 2001-08-03 Electrodes coated with treating agent and uses thereof
PCT/US2002/021314 WO2003013647A2 (en) 2001-08-03 2002-08-02 Electrodes coated with treating agent and uses thereof

Publications (2)

Publication Number Publication Date
EP1419244A2 EP1419244A2 (en) 2004-05-19
EP1419244A4 true EP1419244A4 (en) 2005-03-23

Family

ID=25444527

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02752177A Withdrawn EP1419244A4 (en) 2001-08-03 2002-08-02 Electrodes coated with treating agent and uses thereof

Country Status (7)

Country Link
US (2) US6713291B2 (en)
EP (1) EP1419244A4 (en)
JP (1) JP2005502399A (en)
CN (1) CN1539012A (en)
AU (1) AU2002355385A1 (en)
CA (1) CA2452488A1 (en)
WO (1) WO2003013647A2 (en)

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US20050026283A1 (en) * 2001-11-27 2005-02-03 Owe Ormar Method for combined parallel agent delivery and electroporation for cell structures and thereof
US7456012B2 (en) * 1997-11-06 2008-11-25 Cellectricon Ab Method and apparatus for spatially confined electroporation
US6514762B1 (en) * 1999-04-23 2003-02-04 New Mexico State University Technology Transfer Corporation Delivery of nucleotides by electrochemical release
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US7742811B2 (en) * 2000-03-13 2010-06-22 Onco Stim Implantable device and method for the electrical treatment of cancer
US6613025B1 (en) * 2000-05-25 2003-09-02 Scimed Life Systems, Inc. Method and apparatus for diagnostic and therapeutic agent delivery
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US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
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US7850645B2 (en) * 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
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US20080195035A1 (en) 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
ATE477833T1 (en) * 2005-06-27 2010-09-15 3M Innovative Properties Co MICRONEEDLE CARTRIDGE ASSEMBLY
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US8900180B2 (en) * 2005-11-18 2014-12-02 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
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US10736689B2 (en) 2008-08-20 2020-08-11 Prostacare Pty Ltd Low-corrosion electrode for treating tissue
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JP6607593B2 (en) * 2015-02-10 2019-11-20 国立大学法人 筑波大学 Demyelinating agent and electrode
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CN108601883A (en) * 2015-09-29 2018-09-28 埃吉诺维亚公司 Delivering method and composition
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US5964794A (en) * 1996-03-21 1999-10-12 Biotronik Mess- Und Therapiegeraete Gmbh & Co. Ingenieurbuero Berlin Implantable stimulation electrode
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Also Published As

Publication number Publication date
WO2003013647A2 (en) 2003-02-20
US20040203124A1 (en) 2004-10-14
EP1419244A2 (en) 2004-05-19
US20020061589A1 (en) 2002-05-23
WO2003013647A3 (en) 2003-09-04
US6713291B2 (en) 2004-03-30
JP2005502399A (en) 2005-01-27
CA2452488A1 (en) 2003-02-20
AU2002355385A1 (en) 2003-02-24
CN1539012A (en) 2004-10-20

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