EP1408924A1 - Acide ascorbique stabilise, composition et procede d'utilisation - Google Patents

Acide ascorbique stabilise, composition et procede d'utilisation

Info

Publication number
EP1408924A1
EP1408924A1 EP00945153A EP00945153A EP1408924A1 EP 1408924 A1 EP1408924 A1 EP 1408924A1 EP 00945153 A EP00945153 A EP 00945153A EP 00945153 A EP00945153 A EP 00945153A EP 1408924 A1 EP1408924 A1 EP 1408924A1
Authority
EP
European Patent Office
Prior art keywords
composition
vitamin
particles
coo
wax
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00945153A
Other languages
German (de)
English (en)
Inventor
Robert Kleiman
James S. Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Flora Technologies Ltd
Original Assignee
International Flora Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Flora Technologies Ltd filed Critical International Flora Technologies Ltd
Publication of EP1408924A1 publication Critical patent/EP1408924A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers

Definitions

  • Fatty acids that are used in cosmetics formulations generally include at least stearic acid, oleic acid, myristic acid and palmitic acid.
  • Other typical fatty acids include linoleic acid, behenic acid, and other common fatty acids of the general formula C n H 2n+] COOH.
  • Confetti TM is advertised as having a good balance of structural integrity and rub-in characteristics, rubbing into the skin completely without any extra pressure.
  • the Material Safety Data Sheets (MSDS) on Confetti TM products identifies them as containing a natural oil (e.g., coconut oil, tocopheryl acetate, retinyl palmitate), propylene glycol, synthetic beeswax, petrolatum, allantoin, PVM/MA Decadiene crosspolymer and benzophenone, as well as pigments and/or dyes.
  • vitamin C and its derivatives in a composition that is both stable against environmental or ambient factors and that can be readily applied to the skin or hair of a subject.
  • the vitamin C need not be and preferably is not soluble in the wax at the softening point or melting point of the wax).
  • the vitamin C may be dispersed mechanically or dissolved or partially dissolved in a solvent and then recrystallized in the wax.
  • the paniculate vitamin C must be present in the final product.
  • Particles of the wax and stabilized vitamin C system are preferably provided with diameters between 200 and 2000 microns.
  • the particles of the vitamin C itself is preferably particles of less than 10 microns, less than 8 microns, less than 5 microns and/or less than 3 or less than 1 microns (with dimensions down to about 0.1 microns or 0.5 microns).
  • a preferred embodiment is the provision of the vitamin C in a wax comprising a unique product derived from jojoba oil.
  • the jojoba ester and the vitamin C were added to a high speed propeller mixing apparatus and heated to about to at least 40 °C, using high speed propeller agitation. The mixing was continued for a short period of time until the vitamin C was dispersed in the melted ester. The melted ester was formed into particles (between about 200 and 2000 microns) with particles of vitamin C dispersed therein. This process provided the particles desired in the practice of the present invention. The particles would quickly soften when applied to the skin and spread over the surface of the skin with light finger or hand pressure.
  • Example 2 The same example as Example 1 was repeated with a hydrocarbon wax with a melting point above 20 °C but below 60 °C. Similar mixing conditions were used and the final particulate product displayed similar results of spreading and softening upon application to the skin.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une composition stable destinée à l'administration de vitamine C. Cette composition comprend des particules de vitamine C (y compris les dérivés pharmaceutiques ou cosmétiques) dispersées dans une phase solide de cire chimiquement inerte à la vitamine C. Les proportions d'esters de jojoba doivent être sélectionnées de manière à procurer à la composition le toucher sec fortement souhaité. Ceci nécessite que la composition contiennent au moins 10 %, et de préférence au moins 60 % en poids d'une matière support (solvants et matières actives non compris). L'ingrédient doit être contenu au moins en quantité nécessaire pour être efficace ; ce qui, dans le cas de la vitamine C, représente au moins 5 % (par exemple, au moins 5,5 % ou au moins 6,0 % en poids), de préférence au moins 10 % en poids de la dispersion/suspension ayant la fonction de matière hydrosoluble ou hydrodispersable.
EP00945153A 1999-07-08 2000-07-01 Acide ascorbique stabilise, composition et procede d'utilisation Withdrawn EP1408924A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US349324 1989-05-08
US34932499A 1999-07-08 1999-07-08
PCT/US2000/018392 WO2001003664A1 (fr) 1999-07-08 2000-07-01 Acide ascorbique stabilise, composition et procede d'utilisation

Publications (1)

Publication Number Publication Date
EP1408924A1 true EP1408924A1 (fr) 2004-04-21

Family

ID=23371893

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00945153A Withdrawn EP1408924A1 (fr) 1999-07-08 2000-07-01 Acide ascorbique stabilise, composition et procede d'utilisation

Country Status (2)

Country Link
EP (1) EP1408924A1 (fr)
WO (1) WO2001003664A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436379B1 (en) * 1997-10-17 2002-08-20 International Flora Technologies Ltd. Emollient for cuticle treatment and delivery system therefore
AU2001247264B2 (en) * 2000-03-03 2005-08-18 Australian Importers, Ltd. Micronized vitamin C formulation
US7101563B1 (en) 2000-03-03 2006-09-05 Australian Importers, Ltd. Micronized vitamin C formulation
US6706768B2 (en) * 2002-03-21 2004-03-16 International Flora Technologies, Ltd. Production and use of novel alkoxylated monoesters
US7304177B2 (en) * 2003-10-10 2007-12-04 International Flora Technologies, Ltd. Method for improving spreading properties of cosmetic ingredients
WO2008103926A1 (fr) * 2007-02-22 2008-08-28 Innlabs, Llc Préparation de vitamine c
JP4341983B2 (ja) * 2007-12-07 2009-10-14 株式会社資生堂 皮膚外用剤
WO2012036743A1 (fr) * 2010-09-16 2012-03-22 Kalamazoo Holdings, Inc. Graisses fluides et huiles comestibles stables et compositions améliorées d'acide ascorbique pour les produire
KR20210000375A (ko) * 2019-06-25 2021-01-05 (주)아모레퍼시픽 무계면활성제형 화장료 조성물
KR102233930B1 (ko) 2020-09-23 2021-03-30 주식회사 코리아나화장품 안정화된 아스코빅애씨드를 포함하는 화장료 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3247065A (en) * 1963-10-14 1966-04-19 Hoffmann La Roche Free-flowing coated ascorbic acid
US5589194A (en) * 1993-09-20 1996-12-31 Minnesota Mining And Manufacturing Company Method of encapsulation and microcapsules produced thereby
US5843411A (en) * 1997-02-06 1998-12-01 Topix Pharmaceuticals Inc. Stabilization of ascorbic acid, ascorbic acid derivatives and/or extracts containing ascorbic acid for topical use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0103664A1 *

Also Published As

Publication number Publication date
WO2001003664B1 (fr) 2001-08-09
WO2001003664A1 (fr) 2001-01-18

Similar Documents

Publication Publication Date Title
EP1047657B1 (fr) Compositions emollientes sur base d'esters d'huile de jojoba
KR101817490B1 (ko) 4-헥실레소르시놀의 고투명성 수성 농축물
EP0979066B1 (fr) Excipients sous forme de gel particulaire cosmetique pour agents actifs appliques localement
FR2659554A1 (fr) Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant.
EP0452202B1 (fr) Composition cosmétique ou dermo-pharmaceutique aqueuse contenant en suspension des sphéroides hydratés d'une substance lipidique hydrophile
TW200413020A (en) Vesicle dispersion and cosmetic containing the same
JPWO2003015741A1 (ja) 保湿剤並びに保湿剤を含有する化粧品及び外用剤
CA2629979A1 (fr) Nouvelles compositions de resveratrol
US20040091435A1 (en) Deodorant and antiperspirant controlled release system
EP1408924A1 (fr) Acide ascorbique stabilise, composition et procede d'utilisation
US6432421B1 (en) Emollient compositions with polyethylene beads
WO2009084032A2 (fr) Formulation topique hydrophobe stable à base de plantes
USRE38141E1 (en) Dry emollient compositions
JP4722351B2 (ja) 酸化的に安定な長鎖エチルエステル皮膚軟化薬
JP6930847B2 (ja) 化粧料又は皮膚外用剤
JP2011207849A (ja) 口唇用化粧料
JP6930846B2 (ja) 化粧料又は皮膚外用剤
JP2002332207A (ja) 固形透明化粧料
RU2216305C1 (ru) Детский крем
JP4754671B2 (ja) 化粧料
JP6930848B2 (ja) 化粧料又は皮膚外用剤
JP6898137B2 (ja) 化粧料又は皮膚外用剤
RU2074706C1 (ru) Косметическая фитомаска для лица
CA1279016C (fr) Agent cosmetique banchissant
JP2019151558A (ja) 化粧料及び皮膚外用剤

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020610

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040203