EP1341413A1 - Composition for treating objects to be disinfected - Google Patents

Composition for treating objects to be disinfected

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Publication number
EP1341413A1
EP1341413A1 EP01270251A EP01270251A EP1341413A1 EP 1341413 A1 EP1341413 A1 EP 1341413A1 EP 01270251 A EP01270251 A EP 01270251A EP 01270251 A EP01270251 A EP 01270251A EP 1341413 A1 EP1341413 A1 EP 1341413A1
Authority
EP
European Patent Office
Prior art keywords
agents
composition according
composition
enzymatic
disinfected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01270251A
Other languages
German (de)
French (fr)
Inventor
Bertrand Letartre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratories Anios SA
Original Assignee
Laboratories Anios SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratories Anios SA filed Critical Laboratories Anios SA
Publication of EP1341413A1 publication Critical patent/EP1341413A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins

Definitions

  • TITLE Composition for the treatment of objects intended to be disinfected
  • the invention relates to a composition for the treatment of objects intended to be disinfected such as, for example, medical, surgical and / or endoscopic instruments, and / or installations in the food industry.
  • the invention may also be used in all fields, in particular household and / or professional, for which the disinfection of utensils, surfaces and / or others, is desired.
  • the use of objects in hospitals and / or food industries requires prior treatment to eliminate all microbial contamination and contamination such as blood, proteins or others.
  • the quality of the first step i.e. the detergency step, is paramount.
  • the resistance of bacteria to antimicrobial agents when included in a biofilm is much higher than that presented by bacteria in suspension. This is why the cleaning phase must necessarily allow the disorganization of microorganisms structured in biofilm so that the effectiveness of disinfectant molecules on micro- thus suspended organisms be increased.
  • a first object of the invention is to propose a composition for the treatment of objects such as, for example, medical, surgical and / or endoscopic instruments, and / or installations in the food industry, which overcomes the aforementioned drawbacks and makes it possible to destructure the biofilm capable of developing from microorganisms contaminating their surface.
  • the invention thus relates, according to a first aspect, to a composition for the treatment of objects intended to be disinfected such as, for example, medical, surgical and / or endoscopic instruments, and / or installations in the food industry, comprising enzymatic agents, characterized in that all or part of said agents are capable of targeting at least part of the binders of the biofilm capable of developing from microorganisms contaminating an inert surface.
  • enzymatic agents characterized in that all or part of said agents are capable of targeting at least part of the binders of the biofilm capable of developing from microorganisms contaminating an inert surface.
  • this entails the risk, in particular, of sucking a certain, non-solubilized quantity of this powder in micro-circuits, for example endoscopic channels, and of obstructing them at least partially.
  • the same risk can arise from the encapsulation residues of the enzymes themselves.
  • a second object of the invention is to propose a composition for the treatment of objects such as, for example, medical, surgical, and / or endoscopic instruments and / or installations in the food industry, which overcomes these drawbacks and is stabilized in liquid form, this even in the presence of said antimicrobial agents in said composition.
  • the invention thus relates, according to another aspect, to a composition for the treatment of objects intended to be disinfected such as, for example, medical, surgical and / or endoscopic instruments and / or installations in the food industry, comprising enzymatic agents and the formulation of which is adapted in order to ensure their stability, in particular thanks to the choice of solvents used and / or in the use of chelating agents of the sodium iminodisuccinate and / or ethylene diamine sodium disuccinate type.
  • the invention relates to a composition for the treatment of objects intended to be disinfected such as, for example, medical, surgical and / or endoscopic instruments and / or installations in the food industry. It includes enzymatic agents.
  • all or part of said enzymatic agents are chosen for their specific activity with respect to vis of substrates, in particular of the exopolysaccharide type, identified as being binders of the biofilm capable of developing from microorganisms contaminating an inert surface, that is to say substrates allowing the adhesion of microorganisms to surfaces.
  • composition according to the invention thus allows the destructuring of the biofilm. Thanks to this action of disorganization of the microbial colonies which have adhered to the surfaces, all of the microorganisms are suspended in the medium and are thus more easily destroyed. The objects to be treated can then be more effectively disinfected.
  • Said enzymatic agents consist, for example, of a mixture of dextranase, alginate lyase, glucosidase, carbohydrase, and / or cellulase.
  • composition according to the invention may also contain possibly other enzymes capable of intervening in a process for removing organic stains such as, in particular, proteases, lipases and / or amylases.
  • the quantities of enzymes used form, for example, by weight, 0.1% to 25% of the composition.
  • said composition in liquid form.
  • said composition consists, for example, of a mainly non-aqueous medium. Its water content is, for example, less than
  • the composition according to the invention will comprise antimicrobial agents such as, for example, quaternary ammonium salts and / or derivatives of biguanide and / or alkylaminoalkylamines and / or derivatives of phosphonium and / or d 'Oxidizing agents liberating oxygen.
  • antimicrobial agents such as, for example, quaternary ammonium salts and / or derivatives of biguanide and / or alkylaminoalkylamines and / or derivatives of phosphonium and / or d 'Oxidizing agents liberating oxygen.
  • antimicrobial agents such as, for example, quaternary ammonium salts and / or derivatives of biguanide and / or alkylaminoalkylamines and / or derivatives of phosphonium and / or d 'Oxidizing agents liberating oxygen.
  • They form, for example, by weight, between 0.1 and 25% of the composition.
  • Such an association could also be favored by the use of chelating agents, of the sodium iminodisuccianate and / or ethylene diamine sodium disuccinate type, having the triple characteristic of being non-denaturing and / or inactivating with respect to enzymes. , to synergize the activity of antimicrobial principles and to be biodegradable.
  • said composition may also include agents capable of strengthening its detergent action. They are, for example, ethoxylated fatty alcohols and / or ethoxylated alkylphenols and / or copolymers of ethylene oxide and / or propylene and / or alkylpolyglycosides.
  • composition in accordance with the invention may also comprise anti-corrosion agents, active or passive, and / or mild alkaline reserves, such as monoethanolamine or triethanolamine.
  • Said composition is, for example, miscible in any proportion with water.
  • the dose for use varies, in particular, by weight, from 0.1 to 5% by volume of water.
  • its pH is fixed, substantially, between 4 and 11 at the use dilution.
  • Said composition can be used in the form of a bath in which the objects intended to be disinfected are immersed to be treated manually or using a machine. It may also be a spray or other.

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention concerns a composition for treating objects to be disinfected, such as, for example medical, surgical and/or endoscopic instruments, and/or installations in agri-food industries, comprising enzymatic agents. The invention is characterised in that all or part of said agents are capable of targeting at least part of the biofilm binders likely to develop from micro-organisms contaminating an inert surface.

Description

TITRE : Composition pour le traitement d'objets destinés à être désinfectésTITLE: Composition for the treatment of objects intended to be disinfected
L'invention concerne une composition pour le traitement d'objets destinés à être désinfectés tels que, par exemple, des instruments médicaux, chirurgicaux et/ou endoscopiques, et/ou des installations en industries agro-alimentaires.The invention relates to a composition for the treatment of objects intended to be disinfected such as, for example, medical, surgical and / or endoscopic instruments, and / or installations in the food industry.
Toutefois, bien que plus particulièrement développée pour de telles applications, l'invention pourra également être utilisée dans tous les domaines, notamment ménagers et/ou professionnels, pour lesquels la désinfection d'ustensiles, de surfaces et/ou autres, est souhaitée. L'utilisation d'objets dans les milieux hospitaliers et/ou agroalimentaires nécessite un traitement préalable permettant d'éliminer au mieux toutes contaminations microbiennes et souillures telles que sang, protéines ou autres. Pour cela, il est actuellement connu d'utiliser consécutivement un produit nettoyant et un produit désinfectant. Cependant, la qualité de la première étape, c'est-à-dire l'étape de détergence, est primordiale.However, although more particularly developed for such applications, the invention may also be used in all fields, in particular household and / or professional, for which the disinfection of utensils, surfaces and / or others, is desired. The use of objects in hospitals and / or food industries requires prior treatment to eliminate all microbial contamination and contamination such as blood, proteins or others. For this, it is currently known to consecutively use a cleaning product and a disinfecting product. However, the quality of the first step, i.e. the detergency step, is paramount.
A cet effet, il a déjà été proposé des mélanges d'enzymes constitués de protéases, de lipases et/ou d'amylases. Toutefois, il est apparu, selon l'invention, que les résultats obtenus en terme de désinfection après utilisation de tels mélanges sont perfectibles. Plus précisément, il a été constaté que la survie des microorganismes dans un milieu est majoritairement liée à leur aptitude à coloniser les surfaces en formant une structure, appelée biofilm, qui présente une très forte résistance au stress, notamment artificiel tel que celui dû aux désinfectants. Cette structure est constituée des bactéries adhérentes à la surface des objets souillés et de composants permettant d'englober lesdites bactéries dans une matrice constituée, notamment, d'exopolysaccharides.To this end, mixtures of enzymes consisting of proteases, lipases and / or amylases have already been proposed. However, it has appeared, according to the invention, that the results obtained in terms of disinfection after the use of such mixtures can be improved. More specifically, it has been found that the survival of microorganisms in an environment is mainly linked to their ability to colonize surfaces by forming a structure, called biofilm, which has a very high resistance to stress, in particular artificial stress such as that due to disinfectants. . This structure consists of bacteria adhering to the surface of soiled objects and of components making it possible to include said bacteria in a matrix consisting, in particular, of exopolysaccharides.
La résistance des bactéries aux agents antimicrobiens lorsqu'elles sont incluses dans un biofilm est très supérieure à celle présentée par les bactéries en suspension. C'est pourquoi la phase de nettoyage doit nécessairement permettre la désorganisation des micro-organismes structurés en biofilm pour que l'efficacité des molécules désinfectantes sur les micro- organismes ainsi mis en suspension soit accrue.The resistance of bacteria to antimicrobial agents when included in a biofilm is much higher than that presented by bacteria in suspension. This is why the cleaning phase must necessarily allow the disorganization of microorganisms structured in biofilm so that the effectiveness of disinfectant molecules on micro- thus suspended organisms be increased.
Un premier but de l'invention est de proposer une composition pour le traitement d'objets tels que, par exemple, des instruments médicaux, chirurgicaux et/ou endoscopiques, et/ou des installations en industries agro- alimentaires, qui pallie les inconvénients précités et permet de déstructurer le biofilm susceptible de se développer à partir des micro-organismes contaminant leur surface.A first object of the invention is to propose a composition for the treatment of objects such as, for example, medical, surgical and / or endoscopic instruments, and / or installations in the food industry, which overcomes the aforementioned drawbacks and makes it possible to destructure the biofilm capable of developing from microorganisms contaminating their surface.
L'invention concerne ainsi, selon un premier aspect, une composition pour le traitement d'objets destinés à être désinfectés tels que, par exemple, des instruments médicaux, chirurgicaux et/ou endoscopiques, et/ou des installations en industries agro-alimentaires, comprenant des agents enzymatiques, caractérisé par le fait que tout ou partie desdits agents sont aptes à cibler au moins une partie des liants du biofilm susceptibles de se développer à partir des micro-organismes contaminant une surface inerte. Cela étant, en raison de l'instabilité notoire des enzymes en milieu liquide, en particulier lorsqu'elles sont associées à des principes actifs antimicrobiens, la grande majorité des compositions à base d'enzymes sont formulées sous forme de poudre, à solubiliser avant emploi.The invention thus relates, according to a first aspect, to a composition for the treatment of objects intended to be disinfected such as, for example, medical, surgical and / or endoscopic instruments, and / or installations in the food industry, comprising enzymatic agents, characterized in that all or part of said agents are capable of targeting at least part of the binders of the biofilm capable of developing from microorganisms contaminating an inert surface. However, due to the notorious instability of enzymes in a liquid medium, in particular when they are combined with antimicrobial active principles, the vast majority of enzyme-based compositions are formulated in powder form, to be dissolved before use. .
Pourtant, ceci entraîne le risque, notamment, d'aspirer une certaine quantité, non solubilisée de cette poudre dans des micro-circuits, par exemple des canaux endoscopiques, et de les obstruer au moins partiellement. Le même risque peut survenir à partir des résidus d'encapsulation des enzymes elles-mêmes.However, this entails the risk, in particular, of sucking a certain, non-solubilized quantity of this powder in micro-circuits, for example endoscopic channels, and of obstructing them at least partially. The same risk can arise from the encapsulation residues of the enzymes themselves.
Un second but de l'invention est de proposer une composition pour le traitement d'objets tels que, par exemple, des instruments médicaux, chirurgicaux, et/ou endoscopiques et/ou des installations en industries agroalimentaires, qui pallie ces inconvénients et soit stabilisée sous forme liquide, ceci même en cas de présence dans ladite composition d'agents antimicrobiens. L'invention concerne ainsi, selon un autre aspect, une composition pour le traitement d'objets destinés à être désinfectés tels que, par exemple, des instruments médicaux, chirurgicaux et/ou endoscopiques et/ou des installations en industries agro-alimentaires, comprenant des agents enzymatiques et dont la formulation est adaptée afin d'assurer la stabilité de ceux-ci, notamment grâce au choix des solvants utilisés et/ou à l'emploi d'agents chélatants de type iminodisuccinate de sodium et/ou ethylène diamine disuccinate de sodium.A second object of the invention is to propose a composition for the treatment of objects such as, for example, medical, surgical, and / or endoscopic instruments and / or installations in the food industry, which overcomes these drawbacks and is stabilized in liquid form, this even in the presence of said antimicrobial agents in said composition. The invention thus relates, according to another aspect, to a composition for the treatment of objects intended to be disinfected such as, for example, medical, surgical and / or endoscopic instruments and / or installations in the food industry, comprising enzymatic agents and the formulation of which is adapted in order to ensure their stability, in particular thanks to the choice of solvents used and / or in the use of chelating agents of the sodium iminodisuccinate and / or ethylene diamine sodium disuccinate type.
L'invention sera mieux comprise à la lecture de la description qui va suivre qui développe ses avantages et certains de ses modes de réalisation. L'invention concerne une composition pour le traitement d'objets destinés à être désinfectés tels que, par exemple, des instruments médicaux, chirurgicaux et/ou endoscopiques et/ou des installations en industries agro-alimentaires. Elle comprend des agents enzymatiques.The invention will be better understood on reading the description which follows which develops its advantages and some of its embodiments. The invention relates to a composition for the treatment of objects intended to be disinfected such as, for example, medical, surgical and / or endoscopic instruments and / or installations in the food industry. It includes enzymatic agents.
Selon un premier aspect de l'invention, afin de présenter une efficacité accrue vis-à-vis des objets présentant en surface une contamination microbienne et/ou des souillures, tout ou partie desdits agents enzymatiques sont choisis pour leur activité spécifique vis-à-vis de substrats, notamment de type exopolysaccharide, identifiés comme étant des liants du biofilm susceptible de se développer à partir des micro-organismes contaminant une surface inerte, c'est-à-dire des substrats permettant l'adhésion des microorganismes aux surfaces.According to a first aspect of the invention, in order to present an increased efficiency with respect to objects having microbial contamination and / or soil on the surface, all or part of said enzymatic agents are chosen for their specific activity with respect to vis of substrates, in particular of the exopolysaccharide type, identified as being binders of the biofilm capable of developing from microorganisms contaminating an inert surface, that is to say substrates allowing the adhesion of microorganisms to surfaces.
La composition conforme à l'invention permet de la sorte la déstructuration du biofilm. Grâce à cette action de désorganisation des colonies microbiennes ayant adhéré aux surfaces, l'ensemble des micro- organismes est mis en suspension dans le milieu et est ainsi plus facilement détruit. Les objets à traiter peuvent alors être désinfectés de manière plus efficace.The composition according to the invention thus allows the destructuring of the biofilm. Thanks to this action of disorganization of the microbial colonies which have adhered to the surfaces, all of the microorganisms are suspended in the medium and are thus more easily destroyed. The objects to be treated can then be more effectively disinfected.
Lesdits agents enzymatiques sont constitués, par exemple, par un mélange de dextranase, d'alginate lyase, de glucosidase, de carbohydrase, et/ou de cellulase.Said enzymatic agents consist, for example, of a mixture of dextranase, alginate lyase, glucosidase, carbohydrase, and / or cellulase.
La composition conforme à l'invention peut également contenir éventuellement d'autres enzymes aptes à intervenir dans un processus d'élimination des souillures organiques telles que, notamment, des protéases, des lipases et/ou des amylases.The composition according to the invention may also contain possibly other enzymes capable of intervening in a process for removing organic stains such as, in particular, proteases, lipases and / or amylases.
A ce sujet, les quantités d'enzymes utilisés forment, par exemple, en poids, 0,1 % à 25 % de la composition.In this regard, the quantities of enzymes used form, for example, by weight, 0.1% to 25% of the composition.
Selon un autre aspect de l'invention, afin d'éviter les inconvénients dus à la forme poudre, ladite composition se présente sous forme liquide. Pour assurer sa stabilité et limiter l'activation enzymatique, avant utilisation, ladite composition est constituée, par exemple, d'un milieu principalement non aqueux. Sa teneur en eau est, par exemple, inférieure àAccording to another aspect of the invention, in order to avoid the drawbacks due to the powder form, said composition is in liquid form. To ensure its stability and limit the enzymatic activation, before use, said composition consists, for example, of a mainly non-aqueous medium. Its water content is, for example, less than
20 %, en poids. Elle pourra varier, par exemple, de 0 à 15 % en poids.20% by weight. It may vary, for example, from 0 to 15% by weight.
Cela étant, selon l'un et/ou l'autre des aspects de l'invention évoqués plus haut, on pourra assurer un nettoyage et une désinfection simultanée desdits objets. Pour cela, la composition conforme à l'invention comprendra des agents antimicrobiens tels que, par exemple, des sels d'ammonium quaternaire et/ou des dérivés de biguanide et/ou d'alkylaminoalkylamines et/ou des dérivés de phosphonium et/ou d'agents oxydants libérateurs d'oxygène. Ils forment, par exemple, en poids, entre 0,1 et 25 % de la composition. L'association enzymes-agents antimicrobiens est obtenue, par exemple, dans un tiers solvant permettant la réduction de la mobilité moléculaire, notamment de type glycol.However, according to one and / or the other of the aspects of the invention mentioned above, it will be possible to ensure simultaneous cleaning and disinfection of said objects. For this, the composition according to the invention will comprise antimicrobial agents such as, for example, quaternary ammonium salts and / or derivatives of biguanide and / or alkylaminoalkylamines and / or derivatives of phosphonium and / or d 'Oxidizing agents liberating oxygen. They form, for example, by weight, between 0.1 and 25% of the composition. The combination of enzymes and antimicrobial agents is obtained, for example, in a third solvent allowing the reduction of molecular mobility, in particular of the glycol type.
Une telle association pourra également être favorisée par l'utilisation d'agents chélatants, de type iminodisuccianate de sodium et/ou ethylène diamine disuccinate de sodium, présentant la triple particularité d'être non dénaturant et/ou inactivant vis-à-vis des enzymes, de synergiser l'activité des principes antimicrobiens et d'être biodégradables.Such an association could also be favored by the use of chelating agents, of the sodium iminodisuccianate and / or ethylene diamine sodium disuccinate type, having the triple characteristic of being non-denaturing and / or inactivating with respect to enzymes. , to synergize the activity of antimicrobial principles and to be biodegradable.
Selon un mode particulier de mise en oeuvre de l'invention, ladite composition pourra également comprendre des agents aptes à renforcer son action détergente. Il s'agit, par exemple, d'alcools gras éthoxylés et/ou d'alkylphénols éthoxylés et/ou de copolymères d'oxyde ethylène et/ou de propylène et/ou d'alkylpolyglycosides.According to a particular embodiment of the invention, said composition may also include agents capable of strengthening its detergent action. They are, for example, ethoxylated fatty alcohols and / or ethoxylated alkylphenols and / or copolymers of ethylene oxide and / or propylene and / or alkylpolyglycosides.
De plus, de manière à permettre un renforcement de son action, la composition conforme à l'invention pourra encore comprendre des agents anti-corrosifs, actifs ou passifs, et/ou des réserves alcalines douces, telles que monoéthanolamine ou triéthanolamine.In addition, in order to allow a strengthening of its action, the composition in accordance with the invention may also comprise anti-corrosion agents, active or passive, and / or mild alkaline reserves, such as monoethanolamine or triethanolamine.
Ladite composition est, par exemple, miscible en toute proportion dans l'eau. La dose d'emploi varie, notamment, en poids, de 0,1 à 5 % par volume d'eau. A titre d'exemple, son pH est fixé, sensiblement, entre 4 et 11 à la dilution d'emploi. Ladite composition pourra être utilisée sous la forme d'un bain dans lequel les objets destinés à être désinfectés sont immergés pour être traités manuellement ou à l'aide d'une machine. Il pourra encore s'agir d'une aspersion ou autre.Said composition is, for example, miscible in any proportion with water. The dose for use varies, in particular, by weight, from 0.1 to 5% by volume of water. For example, its pH is fixed, substantially, between 4 and 11 at the use dilution. Said composition can be used in the form of a bath in which the objects intended to be disinfected are immersed to be treated manually or using a machine. It may also be a spray or other.
Un exemple non limitatif de formulation de la composition conforme à l'invention est présenté ci-dessous, les proportions étant données en poids et la somme de celles-ci étant égale à 100 % :A nonlimiting example of formulation of the composition in accordance with the invention is presented below, the proportions being given by weight and the sum of these being equal to 100%:
- agent antimicrobien 1 à 20 %- antimicrobial agent 1 to 20%
- dextranase- dextranase
- alginate lyase 0,1 à 3 % - glucosidase- alginate lyase 0.1 to 3% - glucosidase
- carbohydrase - carbohydrase
- autres enzymes 0,1 à 5 %- other enzymes 0.1 to 5%
- agents détergents non ioniques 2 à 8 %- non-ionic detergents 2 to 8%
- agents complexants de type iminodisucciante de sodium et/ou ethylène diamine disuccinate de sodium 3 à 10 %- complexing agents such as sodium iminodisuccurant and / or ethylene diamine sodium disuccinate 3 to 10%
- agents anti corrosifs 1 à 5 %- anti-corrosion agents 1 to 5%
- réserve alcaline 1 à 5 %- alkaline reserve 1 to 5%
- tiers solvant 29 à 92 % - eau 0 à 15 %.- third solvent 29 to 92% - water 0 to 15%.
Naturellement, d'autres exemples de mise en oeuvre, à la portée de l'homme de l'art, auraient pu être envisagés sans pour autant sortir du cadre de l'invention. Naturally, other examples of implementation, to the scope of the skilled person, could have been envisaged without departing from the scope of the invention.

Claims

REVENDICATIONS
1. Composition pour le traitement d'objets destinés à être désinfectés, tels que, par exemple, des instruments médicaux, chirurgicaux et/ou endoscopiques, et/ou des installations en industries agro-alimentaires, comprenant des agents enzymatiques, caractérisée par le fait que tout ou partie desdits agents sont aptes à cibler au moins une partie des liants du biofilm susceptibles de se développer à partir des micro-organismes contaminant une surface inerte.1. Composition for the treatment of objects intended to be disinfected, such as, for example, medical, surgical and / or endoscopic instruments, and / or installations in the food industry, comprising enzymatic agents, characterized by the fact that all or part of said agents are capable of targeting at least part of the biofilm binders capable of developing from microorganisms contaminating an inert surface.
2. Composition selon la revendication 1 , dans laquelle lesdits agents enzymatiques sont constitués au moins d'agents ciblant les exopolysaccharides.2. Composition according to claim 1, in which said enzymatic agents consist at least of agents targeting exopolysaccharides.
3. Composition selon la revendication 1 , dans laquelle lesdits agents enzymatiques sont constitués par un mélange contenant au moins une dextranase, une alginate lyase, une carbohydrase et/ou une glucosidase. 3. Composition according to claim 1, in which said enzymatic agents consist of a mixture containing at least one dextranase, an alginate lyase, a carbohydrase and / or a glucosidase.
4. Composition selon la revendication 1 , comprenant en outre des agents aptes à renforcer l'action détergente.4. Composition according to claim 1, further comprising agents capable of enhancing the detergent action.
5. Composition selon la revendication 4, dans laquelle les agents aptes à renforcer l'action détergente sont constitués par des alcools gras éthoxylés et/ou des alkylphénols éthoxylés et/ou des copolymères d'oxyde ethylène et/ou de propylène et/ou des alkylpolyglycosides.5. Composition according to claim 4, in which the agents capable of enhancing the detergent action consist of ethoxylated fatty alcohols and / or ethoxylated alkylphenols and / or copolymers of ethylene oxide and / or propylene and / or alkylpolyglycosides.
6. Composition selon l'une quelconque des revendications précédentes, comprenant, en outre, des agents antimicrobiens en association avec lesdits agents enzymatiques.6. Composition according to any one of the preceding claims, further comprising antimicrobial agents in combination with said enzymatic agents.
7. Composition selon l'une quelconque des revendications précédentes prévue sous forme liquide.7. Composition according to any one of the preceding claims provided in liquid form.
8. Composition selon la revendication 7 constituée d'un milieu principalement non aqueux.8. Composition according to claim 7 consisting of a mainly non-aqueous medium.
9. Composition selon la revendication 8, dans laquelle ladite composition comprend un tiers solvant permettant la réduction de la mobilité moléculaire.9. Composition according to claim 8, in which said composition comprises a third solvent allowing the reduction of molecular mobility.
10. Composition selon l'une quelconque des revendications 7, 8 ou 9, comprenant en outre des chelatants de type iminodisuccinate de sodium ou l'ethylène diamine disuccinate de sodium. 10. Composition according to any one of claims 7, 8 or 9, further comprising chelating agents of the sodium iminodisuccinate or ethylene diamine sodium disuccinate type.
EP01270251A 2000-12-15 2001-12-14 Composition for treating objects to be disinfected Withdrawn EP1341413A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0016437 2000-12-15
FR0016437A FR2818150B1 (en) 2000-12-15 2000-12-15 COMPOSITION FOR THE TREATMENT OF OBJECTS FOR DISINFECT
PCT/FR2001/004012 WO2002047484A1 (en) 2000-12-15 2001-12-14 Composition for treating objects to be disinfected

Publications (1)

Publication Number Publication Date
EP1341413A1 true EP1341413A1 (en) 2003-09-10

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EP01270251A Withdrawn EP1341413A1 (en) 2000-12-15 2001-12-14 Composition for treating objects to be disinfected

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AU (1) AU2002219313A1 (en)
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WO (1) WO2002047484A1 (en)

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WO2007123271A2 (en) * 2006-04-21 2007-11-01 Kao Corporation Composition of biofilm control agent
EP2089065B1 (en) 2006-10-27 2015-01-21 E.I. Du Pont De Nemours And Company Method for prion decontamination
US8512731B2 (en) * 2007-11-13 2013-08-20 Medtronic Minimed, Inc. Antimicrobial coatings for medical devices and methods for making and using them
WO2012048757A1 (en) * 2010-10-15 2012-04-19 S.A. Realco Product and method for the removal of biofilms
DE102014202223A1 (en) * 2014-02-06 2015-08-06 Henkel Ag & Co. Kgaa Use of aminocarboxylic acids for the stabilization of low-water liquid washing or cleaning agent components

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See references of WO0247484A1 *

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WO2002047484A1 (en) 2002-06-20
AU2002219313A1 (en) 2002-06-24
FR2818150B1 (en) 2004-04-30
FR2818150A1 (en) 2002-06-21

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