EP1331881A1 - Images fluorescentes de transmission video d'une capsule ingestible - Google Patents

Images fluorescentes de transmission video d'une capsule ingestible

Info

Publication number
EP1331881A1
EP1331881A1 EP01981710A EP01981710A EP1331881A1 EP 1331881 A1 EP1331881 A1 EP 1331881A1 EP 01981710 A EP01981710 A EP 01981710A EP 01981710 A EP01981710 A EP 01981710A EP 1331881 A1 EP1331881 A1 EP 1331881A1
Authority
EP
European Patent Office
Prior art keywords
medical information
human
animal
transmitter
capsule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01981710A
Other languages
German (de)
English (en)
Inventor
Piotr Grodzinski
Yingjie Liu
Herbert Goronkin
Haixu Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Motorola Solutions Inc
Original Assignee
Motorola Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Motorola Inc filed Critical Motorola Inc
Publication of EP1331881A1 publication Critical patent/EP1331881A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041—Capsule endoscopes for imaging

Definitions

  • the present invention relates to a novel ingestible capsule for use in the field of medicine and method of using the capsule for the accumulation of medical data from within the body of animals, and in particular humans .
  • a colonoscopy generally includes direct visual examination of the colon, ileocecal value, and portions of the terminal ileum by means' of a fiberoptic endoscope.
  • a colonoscopy is typically performed by a qualified gastroenterologist. During a colonoscopy the patient is generally awake but sedated. During the procedure a flexible endoscope is inserted in rectum and advanced through the various portions of the lower GI tract. Important anatomic landmarks are identified and surfaces are examined for ulcerations, polyps, hemorrhagic sites, neoplasms, strictures, etc. Dependent upon identified conditions, colorectal cancer, or precancerous conditions of the colon are diagnosed. In many instances, of this invasive procedure, complications arise.
  • Perforation The most common complication being perforation of the colon in which diagnosis may be delayed for days until an infection is present .
  • Perforation may be caused by mechanical trauma from the instrument tip, especially if the wall is weakened. Less commonly, perforation may be non- instrumental, secondary to aggressive insufflation with air. However, serious complications from perforation have been reported in routine cases.
  • hemorrhaging can arise as a complication and many times requires repeat colonoscopy to coagulate the bleeding. In a few instances angiography and surgery have been required.
  • a third less common complication is respiratory depression, which is usually due to oversedation in the patient with chronic lung disease.
  • cancer detection means are known in the medical field, one of such is the use of cancer markers.
  • identification of appropriate and reliable diagnostic markers is essential.
  • One such procedure currently being utilized in the medical field to detect early stages of pre-colon cancer polyp development is the physical characterization of inner surfaces of the intestine using the endoscopy imaging techniques, such as those previously described with respect to colonoscopy, and flexible sigmoidoscopy and in-vivo imaging capsules.
  • Endoscopy and in-vivo imaging capsule techniques rely on the examination of physical appearance of the gastrointestinal tract for diagnosis, and thus lack the specificity and sensitivity provided by the inclusion of a biochemical sensor.
  • endoscopy, colonoscopy and in-vivo imaging capsules as we know them today rely on the illumination of the alimentary canal solely for imaging purposes.
  • cancer specific markers One method of utilizing these specific markers is based on the highly specific antigen/antibody interaction. It has been found that the specificity of the diagnosis resulting from antibody/antigen interaction can not be matched by any type of physical appearance evaluation. Therefore, chemical detection means are the most logical to pursue for in-vivo mode of detection. Thus, the combination of chemical detection with illuminated imaging would provide for an enhanced method of detection.
  • an ingestible capsule for determining medical information from within the alimentary canal of a human or an animal including a non-digestible outer shell that is configured to pass through the alimentary canal.
  • a lens housed within the outer shell are a lens, an illuminating LED, a filter, a CMOS imager, a transmitter, an antenna, and a miniature battery for powering the imager, the LED, and transmitter.
  • a method for obtaining diagnostic medical information including the steps of ingesting a fluorescent dye, such as an antibody-labeled fluorescent dye, thereby tagging predetermined target tissue, ingesting a rinsing liquid to wash away nonspecific fluorescent dye, and ingesting a capsule, characterized as illuminating and imaging the predetermined target tissue.
  • a fluorescent dye such as an antibody-labeled fluorescent dye
  • a rinsing liquid to wash away nonspecific fluorescent dye
  • ingesting a capsule characterized as illuminating and imaging the predetermined target tissue.
  • FIG. 1 illustrates a cross-sectional view of an ingestible capsule according to the present invention
  • FIG. 2 illustrates a simplified schematic circuit diagram of the ingestible capsule according to the present invention.
  • FIG. 1 illustrates in simplified cross- sectional view an ingestible capsule according to the present invention. More specifically, illustrated in FIG.l, is an ingestible capsule, designated 10 and the manner in which the components housed with ingestible capsule 10 are interrelated in general.
  • Ingestible capsule 10 typically comprises an optical dome 12, a lens 14, at least one illuminating LED 16, a filter 18, a CMOS imager 20, a transmitter 22, an antenna 24, and a power source 26, such as a miniature battery power source.
  • Components 12, 14, 16, 18, 20 and 22 are interrelated to provide for the detection of a predetermined factor or condition, such as the presence of an enzyme, antigen, antibody, specific pH level, or the like. Illustrated in a schematic flow diagram, referenced FIG. 2, are steps 30 included in the method of obtaining diagnostic medical information from within the alimentary canal of a human or animal according to the present invention.
  • a chemical dye material more specifically an ingestible fluorescent dye, such as an antibody- labeled dye, is ingested 32 by the patient.
  • a fluorescent rinsing liquid is ingested 34 by the patient to wash away any non-specific fluorescent dye.
  • This process provide for the dye labeling of specific tissue, that is pre-identified by the ingestion 32 of the chemical dye material, more particularly the fluorescent dye.
  • ingestible capsule 10 is swallowed 36 by the patient similar to a conventional pill/capsule and propelled through the alimentary canal by natural contractions, called peristalsis.
  • This propelling of capsule 10 through the alimentary canal provides for the collection 38 of image data.
  • Illuminating LEDs 16 are fabricated to illuminate the alimentary canal, through the optical dome 12.
  • Illuminating LEDs 16 provide the light to illuminate the inner walls of the alimentary canal as the capsule 10 passes therethrough.
  • Lens 14 provides for the focusing of the light emitted from illuminating LEDs 16, back onto the imager 20.
  • Filter 18 provides for the blocking out of excitation light and allow for the transmission of emitted fluorescent light from dye labeled tissue. Filter 18 serves to detect a fluorescence signal from the dye labeled tissue notifying imager 20 to respond.
  • Low frequency transmitter 22 is then switched on upon the receipt of image data and is characterized as sending 40 a signal of the images to a receiver positioned outside the body. This presence of fluorescent labeled tissue which is imaged, means the presence of a predetermined factor or condition.
  • capsule 10 is passed through the alimentary canal and exits the body, while image data is received and interpreted by medical professionals 42.
  • capsule 10 is fabricated small enough to be easily swallowed by a human or animal.
  • capsule 10 is fabricated to be approximately 30 mm as illustrated by reference X, by less than approximately 11mm as illustrated by reference Y. More specifically, capsule 10 is approximately less than ⁇ 1" long, by less than " wide and is fabricated of a sealed,
  • non-digestible outer shell 11 that is shaped so as to easily pass through the alimentary canal.
  • Capsule 10 does not include any external wires, fibers, optical bundles or cables, although it is anticipated that capsule 10 can additionally include further optical components, etc., to further aid in diagnosing. As previously stated, capsule 10 is propelled by peristalsis, or natural contractions, through the alimentary canal, or gastrointestinal tract, and does not require any pushing force to propel it through the bowel.
  • biosensing in conjunction with fluorescence imaging.
  • biosensing involves the use of biological materials, such as enzymes, cells, antibodies, antigens, or the like, that interact in ⁇ some manner when the biological material (receptor) comes into contact with the substance of interest in the tested sample.
  • a fluorescent dye 32 and more particularly an antibody- labeled fluorescent dye, is utilized to detect and mark the existence of certain pre-identified condition or material.
  • the step of ingesting an antibody-labeled fluorescent dye 32 provides for diagnosis of a specific condition, such as that indicative of a cancer precursor.
  • an antibody-labeled fluorescent dye material is utilized, such as a semiconductor nanocrystal dye, for the purpose of in vivo labeling and serving as a staining agent for in-vivo fluorescence detection.
  • Nanocrystal dyes can be made from different kinds of semiconductor material. Compared to organic dyes, nanocrystal dyes have several unique characters and advantages. First, the size and in some cases the shape of the nanocrystal particles can be controlled during manufacture. It is anticipated that in some instances, the size of the nanoparticles can be tailored to suit specific applications, more particularly, the size of the particles can be fabricated to either penetrate or not penetrate a particular cell.
  • emission wavelength of the nanocrystal is size dependent, therefore by monitoring the emission wavelength of the nanocrystal, one can tell the size of the nanoparticles.
  • any light with a wavelength shorter than the nanoparticle' s emission wavelength will contribute to its excitation. Therefore nanocrystal dyes, have a better excitation efficiency compared to that of organic dyes.
  • nanocrystal dyes are more photostable than organic dyes .
  • these fluorescent nanoparticles or dyes 32 can be used to label other cell types.
  • the fluorescent nanoparticles can be used to selectively label muscle cells from a mixture of fibroblast cells, epithelial cells, etc. This has great implications for disease diagnostics in that any organ/structure of a human or animal consists of a mixture of cell types. In many cases, the abnormality of particular cell types has to be known before correct diagnostics.
  • the advantage of cell labeling by nanoparticles can improve many traditional biological assays, such as apoptosis assay, immunological assays and in situ hybridization.
  • the fluorescent nanocrystals are used in-vivo and are imaged by ingestible capsule 10.
  • specific antibody or chemical tagged semiconductor nanocrystal dyes are ingested 32 and thus delivered to the alimentary canal.
  • the fluorescent nanocrystal dyes are deposited either on a surface of the cancer tissue or actually penetrate into the cancer cell to stain the cell components.
  • the unbonded nanocrystal dyes are then washed away by the ingesting of a rinsing agent 34.
  • Capsule 10 travels through the alimentary canal and collects imaged data 38.
  • the fluorescent tagged cancer tissue is detected by capsule 10, by imaging the fluorescent matter. This image data is transmitted 40 via transmitter 22 to a remotely positioned receiver.
  • Sensing capsule 10 is ultimately passed 42 through the alimentary canal and exits the body.
  • Image data provided by imager 22 is received by a remote receiver and interpreted by a medical professional 42 for diagnosis.
  • numerous fluorescent dye materials 32 including antibody-labeled fluorescent dye materials, are utilized with differing marker properties, thereby serving as a diagnostic tool for a plurality of conditions, simultaneously.
  • a positioning indicator (not shown) can optionally be included for the purpose of determining the exact position of the capsule 10 at any given time in the alimentary canal.
  • an ingestible capsule including a small power source, such as a battery, a filtering means and an imager for the purpose of obtaining images of fluorescent tagged tissue is disclosed.
  • the transmitter emits a signal to an externally located receiver as it travels through the alimentary canal, thereby providing for images of an identified predetermined substance of interest .

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Endoscopes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne une nouvelle capsule ingestible améliorée (10) et un procédé permettant de déterminer des informations médicales de l'intérieur du canal alimentaire d'un être humain ou d'un animal à l'aide d'une capsule ingestible comprenant une enveloppe extérieure non digestible (11). L'enveloppe extérieure renferme une lentille (14), une diode électroluminescente (16) d'éclairage, un filtre (18), un imageur (20), un émetteur (22), une antenne (24), et une batterie miniature (26) d'alimentation de l'imageur, de la diode électroluminescente et de l'émetteur. L'invention concerne un procédé amélioré permettant d'obtenir des informations médicales de diagnostic, consistant à ingérer (32) un colorant fluorescent, par exemple une matière colorante fluorescente étiquetée anticorps, marquant ainsi une région d'intérêt, à ingérer (34) un liquide de rinçage destiné à éliminer tout colorant fluorescent non spécifique, et à ingérer une capsule (36), se caractérisant par l'éclairage et la mise en images de la région d'intérêt marquée. Lorsque les images sont reçues, un émetteur basse fréquence, alimenté par une batterie miniature, envoie (40) un signal vidéo à l'extérieur du corps à un récepteur. Le signal transmis permet de générer des images de la région d'intérêt marquée.
EP01981710A 2000-10-30 2001-10-17 Images fluorescentes de transmission video d'une capsule ingestible Withdrawn EP1331881A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70294100A 2000-10-30 2000-10-30
US702941 2000-10-30
PCT/US2001/032420 WO2002036007A1 (fr) 2000-10-30 2001-10-17 Images fluorescentes de transmission video d'une capsule ingestible

Publications (1)

Publication Number Publication Date
EP1331881A1 true EP1331881A1 (fr) 2003-08-06

Family

ID=24823243

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01981710A Withdrawn EP1331881A1 (fr) 2000-10-30 2001-10-17 Images fluorescentes de transmission video d'une capsule ingestible

Country Status (4)

Country Link
EP (1) EP1331881A1 (fr)
JP (1) JP2004522467A (fr)
AU (1) AU2002213335A1 (fr)
WO (1) WO2002036007A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10146197B4 (de) * 2001-09-14 2016-04-21 Karl Storz Gmbh & Co. Kg Intrakorporale Sonde zur Analyse oder Diagnose beispielsweise von Hohlorganen und Körperhöhlen im menschlichen oder tierischen Körper
JP2006507885A (ja) * 2002-11-29 2006-03-09 ギブン イメージング リミテッド 生体内診断の方法、装置及びシステム
DE10327034A1 (de) * 2003-06-16 2005-01-20 Siemens Ag Vorrichtung zur Untersuchung im Körper mit Licht
JP4253550B2 (ja) * 2003-09-01 2009-04-15 オリンパス株式会社 カプセル型内視鏡
JP4009581B2 (ja) 2003-11-18 2007-11-14 オリンパス株式会社 カプセル型医療システム
US7623690B2 (en) * 2004-03-30 2009-11-24 Carestream Health, Inc. System and method for classifying in vivo images according to anatomical structure
WO2007066288A2 (fr) * 2005-12-07 2007-06-14 Koninklijke Philips Electronics, N.V. Depistage gastro-intestinal electronique
EP2046188B1 (fr) 2006-07-24 2019-03-27 Philips Intellectual Property & Standards GmbH Caméra en capsule avec éclairage variable du tissu environnant
JP5340557B2 (ja) * 2007-05-08 2013-11-13 オリンパスメディカルシステムズ株式会社 カプセル型医療装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5519124A (en) * 1978-07-27 1980-02-09 Olympus Optical Co Camera system for medical treatment
IL108352A (en) * 1994-01-17 2000-02-29 Given Imaging Ltd In vivo video camera system
US6240312B1 (en) * 1997-10-23 2001-05-29 Robert R. Alfano Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment
IL134017A (en) * 2000-01-13 2008-04-13 Capsule View Inc Camera for photography inside the intestines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0236007A1 *

Also Published As

Publication number Publication date
JP2004522467A (ja) 2004-07-29
AU2002213335A1 (en) 2002-05-15
WO2002036007A1 (fr) 2002-05-10

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