EP1318806A4 - Hemmstoffe der fettsäuresynthase - Google Patents

Hemmstoffe der fettsäuresynthase

Info

Publication number
EP1318806A4
EP1318806A4 EP01971255A EP01971255A EP1318806A4 EP 1318806 A4 EP1318806 A4 EP 1318806A4 EP 01971255 A EP01971255 A EP 01971255A EP 01971255 A EP01971255 A EP 01971255A EP 1318806 A4 EP1318806 A4 EP 1318806A4
Authority
EP
European Patent Office
Prior art keywords
fatty acid
acid synthase
synthase inhibitors
inhibitors
fatty
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01971255A
Other languages
English (en)
French (fr)
Other versions
EP1318806A1 (de
Inventor
Robert A Daines
Israil Pendrak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1318806A1 publication Critical patent/EP1318806A1/de
Publication of EP1318806A4 publication Critical patent/EP1318806A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP01971255A 2000-09-22 2001-09-20 Hemmstoffe der fettsäuresynthase Withdrawn EP1318806A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23460000P 2000-09-22 2000-09-22
US234600P 2000-09-22
PCT/US2001/029490 WO2002024197A1 (en) 2000-09-22 2001-09-20 Fatty acid synthase inhibitors

Publications (2)

Publication Number Publication Date
EP1318806A1 EP1318806A1 (de) 2003-06-18
EP1318806A4 true EP1318806A4 (de) 2004-01-21

Family

ID=22882034

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01971255A Withdrawn EP1318806A4 (de) 2000-09-22 2001-09-20 Hemmstoffe der fettsäuresynthase

Country Status (4)

Country Link
EP (1) EP1318806A4 (de)
JP (1) JP2004513887A (de)
AU (1) AU2001291160A1 (de)
WO (1) WO2002024197A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2968316T (pt) 2013-03-13 2019-10-29 Forma Therapeutics Inc Derivados de 2-hidroxi-1-{4-[(4-fenilfenil)carbonil]piperazin-1-il}etano-1-ona e compostos relacionados como inibidores da sintase de ácidos gordos (fasn) para o tratamento do cancro
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
CN113382633A (zh) 2018-10-29 2021-09-10 福马治疗股份有限公司 (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175283A (en) * 1990-06-04 1992-12-29 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5594134A (en) * 1995-03-31 1997-01-14 Merck & Co., Inc. Process of synthesizing N-acyl auxiliaries

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRICKNER, STEVEN J. ET AL: "N-Acyl 3-alkylidenyl- and 3-alkyl azetidin-2-ones: a new class of monocyclic.beta.-lactam antibacterial agents. 2. Synthesis and structure-activity relationships of heteroatom substituted 3-isopropylidene and 3-isopropyl analogs", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (1993), 3(11), 2241-6, vol. 3, no. 11, 1993, pages 2241 - 2246, XP009021759 *
MAZAAHIR KIDWAI ET AL.: "Synthesis of new 4-thiazolidinones and 2-azitidiones with their in vitro biological activities", INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 57, no. 6, 1995, pages 252 - 259, XP009021776 *
See also references of WO0224197A1 *

Also Published As

Publication number Publication date
AU2001291160A1 (en) 2002-04-02
EP1318806A1 (de) 2003-06-18
JP2004513887A (ja) 2004-05-13
WO2002024197A1 (en) 2002-03-28

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030307

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20031204

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61P 31/04 B

Ipc: 7A 61K 31/397 B

Ipc: 7A 61K 31/395 A

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040327