EP1316324A1 - Dispositif d'administration d'une substance - Google Patents

Dispositif d'administration d'une substance Download PDF

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Publication number
EP1316324A1
EP1316324A1 EP01128614A EP01128614A EP1316324A1 EP 1316324 A1 EP1316324 A1 EP 1316324A1 EP 01128614 A EP01128614 A EP 01128614A EP 01128614 A EP01128614 A EP 01128614A EP 1316324 A1 EP1316324 A1 EP 1316324A1
Authority
EP
European Patent Office
Prior art keywords
infusion
parameters
data
patient
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP01128614A
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German (de)
English (en)
Other versions
EP1316324B1 (fr
Inventor
Philipp Dr. Tanner
Andreas Dr. Hartlep
Christoph Pedain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brainlab AG
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Brainlab AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brainlab AG filed Critical Brainlab AG
Priority to EP01128614A priority Critical patent/EP1316324B1/fr
Priority to DE50107066T priority patent/DE50107066D1/de
Priority to AT01128614T priority patent/ATE301483T1/de
Priority to US10/075,108 priority patent/US7266227B2/en
Publication of EP1316324A1 publication Critical patent/EP1316324A1/fr
Application granted granted Critical
Publication of EP1316324B1 publication Critical patent/EP1316324B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/20—ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2046—Tracking techniques
    • A61B2034/2055—Optical tracking systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2072—Reference field transducer attached to an instrument or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/25—User interfaces for surgical systems
    • A61B2034/252—User interfaces for surgical systems indicating steps of a surgical procedure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/25—User interfaces for surgical systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14288—Infusion or injection simulation
    • A61M2005/14292—Computer-based infusion planning or simulation of spatio-temporal infusate distribution
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Definitions

  • the present invention relates to methods, devices and computer programs, which are used to prepare, plan and carry out an infusion.
  • the term “infusion” should be used to administer each Example liquid or solid substance or an infusion agent, such as medication, Cells, genes, enzymes, proteins, antibodies, hormones, viruses or the like are understood are, this substance introduced directly into a body or into body tissue to cross the blood-brain barrier, for example. Feeding the substance can be done in a relatively short time, for example, by injection or via a longer period, for example with a continuous and possibly variable supply rate the substance.
  • an infusion agent such as medication, Cells, genes, enzymes, proteins, antibodies, hormones, viruses or the like are understood are, this substance introduced directly into a body or into body tissue to cross the blood-brain barrier, for example. Feeding the substance can be done in a relatively short time, for example, by injection or via a longer period, for example with a continuous and possibly variable supply rate the substance.
  • the tissue arrangement for example in the case of tissue diseases it is relative to a dose required for treatment for a given target tissue high to ensure that the substance supplied is sufficiently high Dose can get into the target tissue even if the location of the substance is due of inaccuracies is not directly in the target tissue.
  • such substances are For example, often toxic to tumor treatment and thus unnecessarily pollute the surrounding area Tissue. For example, if a tumor is to be treated with chemotherapy, so toxic substances are used, which also cause damage in healthy tissue can.
  • US 6,026,316 describes a method for the delivery of medicaments, whereby Nuclear magnetic resonance (MR) data obtained are used to determine the position of the delivery device to determine and monitor the spatial distribution of the drug supplied.
  • MR Nuclear magnetic resonance
  • the invention relates to a method for planning a Infusion, d. H. for the administration of a substance or an active ingredient, in particular for Insertion into tissue, preferably into a predetermined tissue structure or volume, whereby patient data or patient parameters obtained therefrom are recorded.
  • MRI magnetic resonance imaging
  • CT computed tomography
  • X-ray X-ray
  • ultrasound ultrasound
  • the execution of the infusion is planned, d. H.
  • the infusion agent is selected and modified if necessary, for example diluted, and the time course of the pressure with which the infusion agent is supplied through the catheter should be specified.
  • the aim of such a selection and setting is to make a defined one Amount of the substance to be administered into a target tissue volume in order to to get a certain concentration there, with so little of the substance to be administered as possible in non-target tissue.
  • the recorded patient data can be used, with patient data being determined from these where exactly there is a volume of tissue to be treated in the patient’s body, such as a brain tumor.
  • a suitable catheter for example from an existing database by a user or be selected fully automatically and, if necessary, by post-processing to Example of cutting the catheter length to suit the application or patient for example with regard to the desired depth of penetration into tissue. It can also be determined where a suitable location for attaching the catheter is, in order to burden the infusion with as little healthy tissue as possible.
  • Known methods of positioning can advantageously be used reflective markers attached to the catheter and IR cameras can be detected, used to position the catheter at a desired position To attach patients. Markers can also be attached to the patient himself, which serve as a reference and by which a patient coordinate system is defined in which the catheter is placed at a certain determined location.
  • Preference is given to using the recorded patient data to plan the infusion patient-specific parameters are determined, such as the tissue or body structure in the area of the tissue to be treated by an infusion.
  • tissue density, the distribution of certain tissue structures, or the blood flow to one to determine specific tissue area can both directly from the recorded patient data, as well as from databases or one Combination of values stored in databases together with the recorded patient data be won.
  • values regarding the normal blood flow to certain tissue areas, the diffusion and perfusion behavior selected substances in the tissue under consideration, values relating to the tissue behavior after adding a known substance, for example by swelling of the Tissue or metabolic reactions are saved, which are used as patient parameters Planning an infusion can be used.
  • infusion agent parameters which are characteristic of are the substance to be administered or an active ingredient and for example the physical, Define chemical and / or biological properties. For example information relating to the molecular or particle size of the to be administered from a database Substance, the rate of diffusion of this substance in a given Type of tissue, the metabolism or the interaction of the substance with tissue due to of metabolic processes, one known for the substance for the type of tissue to be treated Diffusion coefficients or advantageous injection pressure or pressure gradients, an advantageous concentration, amount, or rate of administration, the order of magnitude of which is usually is in the ml / h range.
  • the infusion agent parameters listed as examples can be used individually or in combination with other planning parameters infusion.
  • Catheter parameters i. H. specific sizes for planning for a catheter the infusion used, with different types of catheters for example in a database can be made available for selection.
  • Catheter parameters relevant for infusion For example, the inside diameter of the catheter, surface quality, the material, in particular the rigidity of the catheter, the number and arrangement the exit openings on the catheter or a known suitability of a certain catheter type for a specific substance to be administered or a specific one to be treated Tissue type or tissue disease. In general, according to the invention, too multiple catheters are used.
  • a medicament a solution with, for example, can be used as the infusion agent Cells, viruses, genes, enzymes, proteins, hormones, antibodies or a combination be used from it.
  • an infusion to be carried out can be planned for patient data in such a way that that the largest possible proportion of a substance in a target tissue area by infusion is introduced, with as little of the substance as possible being released into non-target tissue.
  • a substance to be introduced into tissue by infusion can thus also be used a particularly suitable and correctly positioned catheter type and the correct injection pressure in a suitable concentration at a desired rate taking into account of metabolic and diffusion processes in a tissue area to be treated of a patient are brought in to a desired concentration in this tissue area to obtain the substance to be introduced, for example in the case of brain tumors the blood-brain barrier was overcome by the direct introduction of the substance by infusion can be.
  • the surrounding tissue is stressed as little as possible.
  • a simulation of the infusion to be carried out for example by calculating the infusion agent distribution in Tissue using the collected patient data and the various mentioned above Parameters are carried out.
  • Such a simulation can be used to distribute the infusion agent determined both statically and dynamically as a function of time and advantageous can be represented graphically.
  • it can be determined before an infusion is carried out be whether a desired concentration distribution of the substance to be introduced in the Target tissue can be obtained, or whether, if necessary, infusion agent parameters, catheter parameters or position parameters need to be changed to make the success of the Ensure infusion.
  • backward or inverse planning can also be carried out according to the invention, wherein
  • certain treatment data are predefined by an operator, such as for example the target volume to be treated, advantageously together with risk structures such as nerve tracts, which should not be affected by the infusion and the type of tissue to be treated. It can either be fully automatic or in interaction with the user, for example by displaying a selection menu, the course of the infusion is determined, d. H. it can be one or more types of catheters selected together with suitable infusion means, the catheter arrangement (s) with regard Position and / or depth of penetration determined and the infusion agent parameters set to get the best possible infusion treatment for the given target volume to enable.
  • the planning procedures described above, in particular the selection of the individual parameters, can be fully automated, for example, using data stored in databases Values, semi-automatically, for example, by a user Selections from a displayed menu or manually, for example, by a user parameter values to be entered.
  • Suitable computers are advantageous here used together with input and output elements, for example display elements Elements to be selected, tissue structures, calculated concentration distributions of the infusion agent in tissue and show more information.
  • the present invention relates to a computer program, which, when loaded into a computer or running on a computer that executes the method described above or parts thereof.
  • the present also relates Invention on a storage medium for such a program or a computer program product with the program mentioned above.
  • An inventive device for planning an infusion has a planning system on, which from a computer system, preferably with input and output devices and associated software. It is advantageous to use a monitor to display through determined the computer from elements specified in databases or from calculations Values or spatial distributions.
  • a navigation system is also advantageously provided which, for example, is to be positioned on Reflective markers, light-emitting diodes or coils attached to the elements and IR cameras or magnetic field generators, with which using a suitable known software and hardware an exact positioning for example Catheter can be done on a body.
  • the device according to the invention comprises elements, devices and systems, with which the process steps described above can be carried out.
  • the invention relates to an infusion process, wherein the infusion is preferably prepared as described above and then the infusion agent is introduced into the body or tissue.
  • Verification or verification is carried out, using a suitable data acquisition or Imaging system the distribution of the infusion agent in the tissue during or is determined after the infusion process.
  • a suitable data acquisition or Imaging system the distribution of the infusion agent in the tissue during or is determined after the infusion process.
  • nuclear magnetic resonance or Ultrasound methods are used, and it may be advantageous to use the infusion agent add a contrast agent to the distribution of the infusion agent in the body tissues to be able to clearly determine or measure.
  • Deviations from the actual values determined during the verification process are preferred Infusion agent distribution in the tissue determined before or during the infusion Planning data determined and preferably displayed.
  • the infusion parameters are advantageously corrected, d. H. a change in chemical and / or physical composition or properties of the infusion agent and / or a change in the supply, for For example, a change in the injection pressure or the delivery quantity by which during verification to be able to correct the determined deviation from the planned distribution. If If necessary, a catheter can also be repositioned or replaced.
  • the verification and determination of the deviation and correction is advantageously carried out in Real time, so that the infusion can be carried out in a controlled manner via feedback, to get the desired infusion success, d. H. the infusion agent as desired to the specified target area.
  • the present invention relates to a computer program, which, when loaded into a computer or running on a computer that carries out the method described above.
  • the present invention also relates to Storage medium for such a program or a computer program product with the program mentioned above.
  • the present invention relates to a device for Carrying out an infusion process as described above with a verification device to determine the spatial distribution of an infusion agent in a body, especially in a tissue area.
  • the verification device can be, for example Magnetic resonance, X-ray or an ultrasound system with which the infusion agent or its distribution and concentration in the tissue can be detected.
  • a computer system is preferably provided with a display device in order to evaluate the determined spatial distribution of the infusion agent in the tissue, a deviation determined from a previously set infusion schedule and automatically if necessary make a change in infusion parameters or an operator propose such a change to modify the infusion so that it is as planned can be carried out.
  • systems can be provided with which the concentration of the infusion agent can be changed and / or the injection pressure or the injection quantity can be changed using a pump, for example, in order to obtain an infusion agent distribution in the tissue as previously planned.
  • Figure 1 shows schematically a flow chart for the preparation according to the invention and Performing an infusion.
  • patient data for example entered by a magnetic resonance scanner, which are used to determine a specific Determine the target tissue area for the infusion and the infusion dose to be delivered to plan.
  • This data can be obtained, for example, by the nuclear magnetic resonance system 3, as in FIG 3 schematically shown, obtained after the examination of a patient to be treated become.
  • parameters stored in databases for the properties of the tissue structures and for different types of catheters the determination of the exact location of the tissue volume to be treated one or more for suitable infusion catheters are selected.
  • Patient parameters obtained can be taken together with the catheter parameters and, for example, the infusion agent parameters stored in databases used to plan the infusion.
  • as few catheters or needles as possible should be placed through as few accesses as possible.
  • This optimized planning of the infusion dose is output via a display so that, for example, a two-dimensional or three-dimensional representation by displaying different cutting planes can display the result of the infusion planning.
  • the infusion plan thus created is transmitted to a navigation system via an interface, such as the VectorVision® system shown schematically in FIG. 3, based on on the planning data the selected catheter (s) on the given Positions on the body.
  • the positioning can be done automatically, for example under Using a robot, or guided by the navigation system, done by hand, it can be shown on a display device whether a catheter is positioned correctly is or still needs to be moved in a certain direction.
  • the actual infusion with the carried out by planning given infusion agent parameters. In doing so, again patient data collection is performed to determine the actual distribution of the infusion agent in the tissue.
  • the parameters and the simulation results for the infusion based on them are compared between the actual distribution of the infusion agent and the predetermined desired one Infusion agent distribution carried out and, if necessary, the parameters such as For example the concentration of the injection medium, the delivery quantity or the injection pressure to carry out the infusion, preferably taking into account known mechanisms of action modified to get the desired, planned infusion result.
  • the measured actual distribution of the infusion agent concentration can preferably be combined with any deviations and correction procedures on a display in order to enable, for example, an operator to manually enter the injection process intervene.
  • Figure 2 shows schematically a simplified flow of a planning according to the invention and Perform an injection.
  • patient data is through an imaging diagnostic Techniques such as a magnetic resonance imaging technique are used to measure the current patient parameters such as tissue density, blood flow and location of a patient to receive tissue to be treated.
  • an imaging diagnostic Techniques such as a magnetic resonance imaging technique are used to measure the current patient parameters such as tissue density, blood flow and location of a patient to receive tissue to be treated.
  • the infusion is planned and / or simulated for catheter and infusion agent parameters.
  • the infusion plan is sent to a navigation platform passed with which the catheter or catheters as provided in the infusion plan to be positioned on the patient.
  • the infusion begins after positioning the infusion device and is with the planned and possibly simulated parameters carried out, optionally, as shown in Figures 1 and 2, a comparison of the actual performed infusion with the infusion plan and in case of deviations a modification of the corresponding parameters, preferably using known ones Mechanisms of action is made.
  • FIG. 3 schematically shows a device which is used to plan and implement an inventive device Infusion can be used.
  • Patient data are in one MRI scanner 3 received and to a planning system 1 and a navigation system 2 passed.
  • the navigation system 2 using, for example known reflectors or markers attached to one or more catheters or the catheter is positioned at a desired location on a body using position data the marker can be detected by IR cameras 2a.
  • Planning system 1 determines for a given infusion to be performed using that from the magnetic resonance system 3 determined patient parameters, the suitable catheter parameters and infusion parameters, to carry out the infusion.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
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  • Epidemiology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Hematology (AREA)
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  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Robotics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Paper (AREA)
  • Multi-Process Working Machines And Systems (AREA)
EP01128614A 2001-11-30 2001-11-30 Dispositif pour planifier une infusion Expired - Lifetime EP1316324B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01128614A EP1316324B1 (fr) 2001-11-30 2001-11-30 Dispositif pour planifier une infusion
DE50107066T DE50107066D1 (de) 2001-11-30 2001-11-30 Vorrichtung zur Planung einer Infusion
AT01128614T ATE301483T1 (de) 2001-11-30 2001-11-30 Vorrichtung zur planung einer infusion
US10/075,108 US7266227B2 (en) 2001-11-30 2002-02-13 Device and method for administering a substance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01128614A EP1316324B1 (fr) 2001-11-30 2001-11-30 Dispositif pour planifier une infusion

Publications (2)

Publication Number Publication Date
EP1316324A1 true EP1316324A1 (fr) 2003-06-04
EP1316324B1 EP1316324B1 (fr) 2005-08-10

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EP01128614A Expired - Lifetime EP1316324B1 (fr) 2001-11-30 2001-11-30 Dispositif pour planifier une infusion

Country Status (4)

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US (1) US7266227B2 (fr)
EP (1) EP1316324B1 (fr)
AT (1) ATE301483T1 (fr)
DE (1) DE50107066D1 (fr)

Cited By (5)

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Publication number Priority date Publication date Assignee Title
US6828378B2 (en) * 2000-04-28 2004-12-07 Center For Advanced Science And Technology Incubation, Ltd. Compound comprising crosslinked polyrotaxane
EP1645308A1 (fr) 2004-10-06 2006-04-12 BrainLAB AG Méthode et appareil d'assistance au traitement de tissue
EP1905466A1 (fr) * 2006-09-28 2008-04-02 BrainLAB AG Indentification d'une région d'infusion dans un tissue hétérogène
US7740606B2 (en) 2005-11-21 2010-06-22 Brainlab Ag Method and apparatus for automated optimization of treatment plans
WO2012116747A1 (fr) * 2011-03-03 2012-09-07 Brainlab Ag Planification et simulation d'infusion assistées par ordinateur

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US7734326B2 (en) * 2002-06-20 2010-06-08 Brainlab Ag Method and device for preparing a drainage
US7338465B2 (en) 2002-07-02 2008-03-04 Patton Medical Devices, Lp Infusion device and method thereof
US7715902B2 (en) * 2002-09-12 2010-05-11 Brainlab Ag Determining distribution for planning an infusion
US8029454B2 (en) 2003-11-05 2011-10-04 Baxter International Inc. High convection home hemodialysis/hemofiltration and sorbent system
US7848543B2 (en) * 2004-02-05 2010-12-07 Brainlab Ag Method and system for prediction and management of material and information transport in an organism
US8702580B2 (en) * 2004-10-06 2014-04-22 Brainlab Ag Method and device for assisting in a tissue treatment
US9907485B2 (en) * 2004-10-15 2018-03-06 Brainlab Ag Targeted immunization and plaque destruction against Alzheimer's disease
US9901413B2 (en) * 2004-10-15 2018-02-27 Brainlab Ag Targeted infusion of agents for treatment of ALS
US9924888B2 (en) * 2004-10-15 2018-03-27 Brainlab Ag Targeted infusion of agents against parkinson's disease
CN102512187B (zh) * 2004-11-16 2015-08-12 拜耳医疗保健公司 对病人体内的药物传播建模的系统和方法
JP5232473B2 (ja) 2004-11-24 2013-07-10 メドラッド インコーポレーテッド 注入処理中に生成される圧力をモデル化するためのシステム及び装置
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EP1316324B1 (fr) 2005-08-10
ATE301483T1 (de) 2005-08-15
US7266227B2 (en) 2007-09-04
DE50107066D1 (de) 2005-09-15
US20030114751A1 (en) 2003-06-19

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