EP1313756A4 - Anticorps specifiques aux lysines methylees dans des histones - Google Patents

Anticorps specifiques aux lysines methylees dans des histones

Info

Publication number
EP1313756A4
EP1313756A4 EP01964349A EP01964349A EP1313756A4 EP 1313756 A4 EP1313756 A4 EP 1313756A4 EP 01964349 A EP01964349 A EP 01964349A EP 01964349 A EP01964349 A EP 01964349A EP 1313756 A4 EP1313756 A4 EP 1313756A4
Authority
EP
European Patent Office
Prior art keywords
histones
antibodies specific
methylated lysines
lysines
methylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01964349A
Other languages
German (de)
English (en)
Other versions
EP1313756A1 (fr
Inventor
C David Allis
Brian D Strahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Virginia UVA
University of Virginia Patent Foundation
Original Assignee
University of Virginia UVA
University of Virginia Patent Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Virginia UVA, University of Virginia Patent Foundation filed Critical University of Virginia UVA
Publication of EP1313756A1 publication Critical patent/EP1313756A1/fr
Publication of EP1313756A4 publication Critical patent/EP1313756A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP01964349A 2000-08-25 2001-08-23 Anticorps specifiques aux lysines methylees dans des histones Withdrawn EP1313756A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22776700P 2000-08-25 2000-08-25
US227767P 2000-08-25
US30274701P 2001-07-03 2001-07-03
US302747P 2001-07-03
PCT/US2001/026283 WO2002018418A1 (fr) 2000-08-25 2001-08-23 Anticorps specifiques aux lysines methylees dans des histones

Publications (2)

Publication Number Publication Date
EP1313756A1 EP1313756A1 (fr) 2003-05-28
EP1313756A4 true EP1313756A4 (fr) 2004-12-22

Family

ID=26921747

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01964349A Withdrawn EP1313756A4 (fr) 2000-08-25 2001-08-23 Anticorps specifiques aux lysines methylees dans des histones

Country Status (5)

Country Link
EP (1) EP1313756A4 (fr)
JP (1) JP2004520270A (fr)
AU (1) AU2001285214A1 (fr)
CA (1) CA2420277A1 (fr)
WO (1) WO2002018418A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0111218D0 (en) 2001-05-08 2001-06-27 Cancer Res Ventures Ltd Assays methods and means
EP1483415A4 (fr) * 2002-02-20 2006-02-01 Univ Virginia Test diagnostique non invasif mettant en oeuvre des marqueurs de modification de l'histone
US7153691B2 (en) * 2002-11-13 2006-12-26 G6 Science Corp. Method of identifying and assessing DNA euchromatin in biological cells for detecting disease, monitoring wellness, assessing bio-activity, and screening pharmacological agents
US20060073517A1 (en) * 2003-03-10 2006-04-06 Allis C D Post-translational modifications of proteins as regulatory switches
JPWO2005054296A1 (ja) * 2003-12-02 2008-02-28 株式会社先端生命科学研究所 メチルリジンを認識する抗体及びその製造方法並びにその利用
EP1827454A4 (fr) * 2004-12-09 2008-07-16 Brigham & Womens Hospital Compositions et procedes a base de la kinase haspine
US20160069903A1 (en) 2014-09-10 2016-03-10 Fundació Institute De Ciències Foròniques Method for detecting cells
US10441644B2 (en) 2015-05-05 2019-10-15 The Regents Of The University Of California H3.3 CTL peptides and uses thereof
KR101590450B1 (ko) 2015-05-22 2016-02-02 중앙대학교 산학협력단 Filaggrin 유전자 프로모터의 히스톤 변형 검출 방법 및 이를 이용한 염증성 피부질환 진단용 조성물
WO2017184895A2 (fr) * 2016-04-20 2017-10-26 Aelan Cell Technologies, Inc. Compositions et méthodes liées à la protéine h1.0 diméthylée k180

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5989829A (en) * 1991-08-09 1999-11-23 Washington University Autoantibodies and their targets in the diagnosis of peripheral neuropathies
WO2003004050A1 (fr) * 2001-07-03 2003-01-16 University Of Virginia Patent Foundation Methylation de l'histone h4 au niveau de l'arginine 3

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5989829A (en) * 1991-08-09 1999-11-23 Washington University Autoantibodies and their targets in the diagnosis of peripheral neuropathies
WO2003004050A1 (fr) * 2001-07-03 2003-01-16 University Of Virginia Patent Foundation Methylation de l'histone h4 au niveau de l'arginine 3

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BRIGGS SCOTT D ET AL: "Histone H3 lysine 4 methylation is mediated by set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae", GENES AND DEVELOPMENT, vol. 15, no. 24, 15 December 2001 (2001-12-15), pages 3286 - 3295, XP002280395, ISSN: 0890-9369 *
MULLER S ET AL: "IMMUNOGENICITY OF FREE HISTONES AND OF HISTONES COMPLEXED WITH RNA", MOLECULAR IMMUNOLOGY, vol. 28, no. 7, 1991, pages 763 - 772, XP002280388, ISSN: 0161-5890 *
NAKAYAMA JUN-ICHI ET AL: "Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 292, no. 5514, 2001, pages 110 - 113, XP002177964, ISSN: 0036-8075 *
REA STEPHEN ET AL: "Regulation of chromatin structure by site-specific histone H3 methyltransferases", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 406, no. 6796, August 2000 (2000-08-01), pages 593 - 599, XP002154907, ISSN: 0028-0836 *
See also references of WO0218418A1 *
SIMS ROBERT J III ET AL: "Histone lysine methylation: A signature for chromatin function.", TRENDS IN GENETICS, vol. 19, no. 11, November 2003 (2003-11-01), pages 629 - 639, XP002280390, ISSN: 0168-9525 (ISSN print) *
STALLCUP MICHAEL R: "Role of protein methylation in chromatin remodeling and transcriptional regulation", ONCOGENE, vol. 20, no. 24 Review Issue 3, 28 May 2001 (2001-05-28), pages 3014 - 3020, XP002280396, ISSN: 0950-9232 *
STEMMER C ET AL: "Mapping of linear histone regions exposed at the surface of the nucleosome in solution", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 273, no. 1, 17 October 1997 (1997-10-17), pages 52 - 60, XP004461390, ISSN: 0022-2836 *
TAPLICK J ET AL: "Histone H4 acetylation during interleukin-2 stimulation of mouse T cells", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 436, no. 3, 9 October 1998 (1998-10-09), pages 349 - 352, XP004258451, ISSN: 0014-5793 *
TURNER B M ET AL: "HISTONE H4 ACETYLATION IN HUMAN CELLS FREQUENCY OF ACETYLATION AT DIFFERENT SITES DEFINED BY IMMUNOLABELING WITH SITE-SPECIFIC ANTIBODIES", FEBS LETTERS, vol. 253, no. 1-2, 1989, pages 141 - 145, XP002280389, ISSN: 0014-5793 *
WHITE D A ET AL: "Preparation of Site-Specific Antibodies to Acetylated Histones", METHODS: A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 19, no. 3, November 1999 (1999-11-01), pages 417 - 424, XP004466844, ISSN: 1046-2023 *

Also Published As

Publication number Publication date
JP2004520270A (ja) 2004-07-08
WO2002018418A1 (fr) 2002-03-07
CA2420277A1 (fr) 2002-03-07
EP1313756A1 (fr) 2003-05-28
AU2001285214A1 (en) 2002-03-13

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030324

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: STRAHL, BRIAN, D.

Inventor name: ALLIS, C., DAVID

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 39/395 B

Ipc: 7A 61K 38/04 B

Ipc: 7G 01N 33/53 B

Ipc: 7C 07K 16/18 B

Ipc: 7C 07K 7/00 A

A4 Supplementary search report drawn up and despatched

Effective date: 20041110

17Q First examination report despatched

Effective date: 20050622

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20061122