EP1299048A4 - Biodegradable vehicles and delivery systems of biologically active substances - Google Patents
Biodegradable vehicles and delivery systems of biologically active substancesInfo
- Publication number
- EP1299048A4 EP1299048A4 EP01918249A EP01918249A EP1299048A4 EP 1299048 A4 EP1299048 A4 EP 1299048A4 EP 01918249 A EP01918249 A EP 01918249A EP 01918249 A EP01918249 A EP 01918249A EP 1299048 A4 EP1299048 A4 EP 1299048A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- biologically active
- active substances
- delivery systems
- biodegradable vehicles
- biodegradable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/041—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/141—Plasticizers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/10—Esters; Ether-esters
- C08K5/11—Esters; Ether-esters of acyclic polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/605,661 US6432438B1 (en) | 1997-10-29 | 2000-06-28 | Biodegradable vehicle and filler |
US605661 | 2000-06-28 | ||
INMU069400 | 2000-07-25 | ||
IN694MU2000 IN189074B (en) | 2000-07-25 | 2000-07-25 | |
CN 00120871 CN1206001C (en) | 2000-06-28 | 2000-08-03 | Biodegradable carrier and biodegradable transfer system |
CN00120871 | 2000-08-03 | ||
PCT/US2001/006138 WO2002000137A1 (en) | 2000-06-28 | 2001-02-26 | Biodegradable vehicles and delivery systems of biologically active substances |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1299048A1 EP1299048A1 (en) | 2003-04-09 |
EP1299048A4 true EP1299048A4 (en) | 2005-09-28 |
Family
ID=27178759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01918249A Withdrawn EP1299048A4 (en) | 2000-06-28 | 2001-02-26 | Biodegradable vehicles and delivery systems of biologically active substances |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1299048A4 (en) |
JP (1) | JP2004511431A (en) |
CN (1) | CN1283215C (en) |
AU (1) | AU2001245346A1 (en) |
CA (1) | CA2413157A1 (en) |
NZ (1) | NZ523385A (en) |
WO (1) | WO2002000137A1 (en) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7666445B2 (en) | 2000-10-20 | 2010-02-23 | The Trustees Of The University Of Pennsylvania | Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use |
DE60231862D1 (en) * | 2001-02-23 | 2009-05-20 | Genentech Inc | ERODABLE POLYMERS FOR INJECTION |
GB0116341D0 (en) * | 2001-07-04 | 2001-08-29 | Smith & Nephew | Biodegradable polymer systems |
US6926903B2 (en) * | 2001-12-04 | 2005-08-09 | Inion Ltd. | Resorbable polymer composition, implant and method of making implant |
AR039729A1 (en) | 2002-06-25 | 2005-03-09 | Alza Corp | SHORT-TERM DEPOSIT FORMULATIONS |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
MXPA05001244A (en) * | 2002-07-31 | 2005-06-08 | Alza Corp | Injectable multimodal polymer depot compositions and uses thereof. |
CZ294328B6 (en) * | 2002-08-22 | 2004-11-10 | Pliva-Lachema A. S. | Biologically degradable composition with protracted release of a biologically active substance and process for preparing thereof |
RU2355385C2 (en) | 2002-11-06 | 2009-05-20 | Алза Корпорейшн | Compositions of prolongedaction with controlled release |
DK2526996T3 (en) | 2002-12-20 | 2019-12-02 | Xeris Pharmaceuticals Inc | Formulation for intracutaneous injection |
EP1628693A1 (en) * | 2003-06-04 | 2006-03-01 | Inion Ltd. | Biodegradable implant and method for manufacturing one |
US8815284B2 (en) | 2003-06-26 | 2014-08-26 | Psivida Us, Inc. | Bioerodible sustained release drug delivery systems |
CN1863557B (en) * | 2003-06-26 | 2010-06-16 | 普西维达公司 | In-situ gelling drug delivery system |
CA2539568C (en) * | 2003-09-23 | 2013-09-10 | Orthotherapeutics, Llc | Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects |
GB0329654D0 (en) | 2003-12-23 | 2004-01-28 | Smith & Nephew | Tunable segmented polyacetal |
US8329203B2 (en) | 2004-01-12 | 2012-12-11 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
US8221778B2 (en) | 2005-01-12 | 2012-07-17 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
EP2633853A1 (en) * | 2004-01-12 | 2013-09-04 | The Trustees of The University of Pennsylvania | Long-term delivery formulations and methods of use thereof |
GB0412866D0 (en) * | 2004-06-09 | 2004-07-14 | Novartis Ag | Organic compounds |
US20060257448A1 (en) * | 2005-05-10 | 2006-11-16 | The University Of Zurich | Resorbable polymer composition, implant and method of making implant |
CA2619552A1 (en) * | 2005-08-18 | 2007-02-22 | Smith & Nephew, Plc | Multimodal high strength devices and composites |
US8852638B2 (en) * | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
US20090048667A1 (en) * | 2005-11-16 | 2009-02-19 | Tokai University Educational System | Controlled Drug-Release Composition and Drug-Releasable Medical Device |
AU2008240418B2 (en) | 2007-04-18 | 2013-08-15 | Smith & Nephew Plc | Expansion moulding of shape memory polymers |
ATE547129T1 (en) | 2007-04-19 | 2012-03-15 | Smith & Nephew Inc | MULTIMODAL SHAPE MEMORY POLYMERS |
EP2150288B1 (en) | 2007-04-19 | 2011-04-13 | Smith & Nephew, Inc. | Graft fixation |
HUE030789T2 (en) | 2007-05-18 | 2017-06-28 | Durect Corp | Improved depot formulations |
BRPI0811319A2 (en) | 2007-05-25 | 2015-02-10 | Tolmar Therapeutics Inc | FLUID COMPOSITION, METHOD FOR FORMATION OF A FLUID COMPOSITION, BIODEGRADABLE IMPLANT FORMED IN SITU, METHOD FOR FORMATION OF A BIODEGRADABLE IMPLANT, KIT, IMPLANT AND TREATMENT METHOD |
US8619257B2 (en) * | 2007-12-13 | 2013-12-31 | Kimberley-Clark Worldwide, Inc. | Recombinant bacteriophage for detection of nosocomial infection |
WO2009080275A1 (en) * | 2007-12-21 | 2009-07-02 | Ludwig-Maximilians-Universität | Extruded rod-shaped devices for controlled release of biological substances to humans and animals |
US8557273B2 (en) * | 2008-04-18 | 2013-10-15 | Medtronic, Inc. | Medical devices and methods including polymers having biologically active agents therein |
JP2013522239A (en) * | 2010-03-12 | 2013-06-13 | サーモディクス,インコーポレイテッド | Injectable drug delivery system |
US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
US20120046225A1 (en) | 2010-07-19 | 2012-02-23 | The Regents Of The University Of Colorado, A Body Corporate | Stable glucagon formulations for the treatment of hypoglycemia |
CN105853348B (en) | 2011-03-10 | 2019-08-30 | Xeris药物公司 | Parenteral injection stablizing solution |
WO2013036309A2 (en) * | 2011-06-10 | 2013-03-14 | Wong Vernon G | Sustained release formulations for delivery of proteins to the eye and methods of preparing same |
WO2013067022A1 (en) | 2011-10-31 | 2013-05-10 | Xeris Pharmaceuticals, Inc. | Formulations for the treatment of diabetes |
US9125805B2 (en) | 2012-06-27 | 2015-09-08 | Xeris Pharmaceuticals, Inc. | Stable formulations for parenteral injection of small molecule drugs |
CN103830767A (en) * | 2012-11-26 | 2014-06-04 | 韩冰 | Sucrose acetate isobutyrate gel and application thereof |
US9018162B2 (en) | 2013-02-06 | 2015-04-28 | Xeris Pharmaceuticals, Inc. | Methods for rapidly treating severe hypoglycemia |
US20140308352A1 (en) | 2013-03-11 | 2014-10-16 | Zogenix Inc. | Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material |
BR112015022023B1 (en) | 2013-03-11 | 2022-12-06 | Durect Corporation | INJECTABLE CONTROLLED RELEASE COMPOSITION COMPRISING HIGH VISCOSITY LIQUID CARRIER |
AU2014268434B2 (en) | 2013-05-24 | 2018-11-22 | Icon Bioscience, Inc. | Use of sustained release dexamethasone in post-cataract surgery inflammation |
KR102428675B1 (en) | 2014-08-06 | 2022-08-02 | 엑스에리스 파머수티클스, 인크. | Syringes, kits, and methods for intracutaneous and/or subcutaneous injection of pastes |
US20170290846A1 (en) * | 2014-09-30 | 2017-10-12 | University Of Tennessee Research Foundation | In situ gelling form for long-acting drug delivery |
US9649364B2 (en) | 2015-09-25 | 2017-05-16 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic formulations in aprotic polar solvents |
AR105215A1 (en) * | 2015-07-01 | 2017-09-13 | Santen Pharmaceutical Co Ltd | DEPOSIT FORMULATION CONTAINING ESTERS OF CITRUS ACID |
US11590205B2 (en) | 2015-09-25 | 2023-02-28 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents |
US20170128632A1 (en) * | 2015-11-10 | 2017-05-11 | II William Charles McJames | Device and method for controlling the release of bioactive and therapeutic agents from an implantable medical device |
SG11201805138VA (en) * | 2015-12-17 | 2018-07-30 | Verita Res Pte Ltd | Injectable composition and a method of treatment of the physical addiction |
CN106823010A (en) * | 2016-12-28 | 2017-06-13 | 四川国纳科技有限公司 | The purposes of bioabsorbable polyphosphate amino acid copolymer material |
US11752099B2 (en) * | 2017-03-27 | 2023-09-12 | W. L. Gore & Associates, Inc. | Injectable and biodegradable polymer formulations for controlled release of bioactive agents |
EP4378463A2 (en) | 2017-06-02 | 2024-06-05 | Xeris Pharmaceuticals, Inc. | Precipitation resistant small molecule drug formulations |
KR20220140711A (en) | 2020-01-13 | 2022-10-18 | 듀렉트 코퍼레이션 | Reduced Impurity Sustained Release Drug Delivery Systems and Related Methods |
CN115779142B (en) * | 2022-11-18 | 2024-01-12 | 江南大学 | Degradable drug-carrying coating for zinc alloy implant surface, and preparation method and application thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0537559A1 (en) * | 1991-10-15 | 1993-04-21 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
US5447725A (en) * | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
WO1998027963A2 (en) * | 1996-12-20 | 1998-07-02 | Alza Corporation | Gel composition and methods |
WO1998048859A1 (en) * | 1997-04-30 | 1998-11-05 | Guilford Pharmaceuticals Inc. | Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same |
WO1999047073A1 (en) * | 1998-03-19 | 1999-09-23 | Merck & Co., Inc. | Liquid polymeric compositions for controlled release of bioactive substances |
WO2000024374A1 (en) * | 1998-10-28 | 2000-05-04 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
Family Cites Families (6)
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---|---|---|---|---|
NL188266C (en) * | 1975-07-29 | 1992-05-18 | Merck & Co Inc | PROCESS FOR THE PREPARATION OF AN ORGANIC IMPLANT. |
US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US5324520A (en) * | 1988-12-19 | 1994-06-28 | Vipont Pharmaceutical, Inc. | Intragingival delivery systems for treatment of periodontal disease |
US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US5487897A (en) * | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
SE9100610D0 (en) * | 1991-03-04 | 1991-03-04 | Procordia Ortech Ab | BIORESORBABLE MATERIAL FOR MEDICAL USE |
-
2001
- 2001-02-26 AU AU2001245346A patent/AU2001245346A1/en not_active Abandoned
- 2001-02-26 EP EP01918249A patent/EP1299048A4/en not_active Withdrawn
- 2001-02-26 WO PCT/US2001/006138 patent/WO2002000137A1/en not_active Application Discontinuation
- 2001-02-26 CN CNB018118518A patent/CN1283215C/en not_active Expired - Fee Related
- 2001-02-26 NZ NZ523385A patent/NZ523385A/en unknown
- 2001-02-26 CA CA002413157A patent/CA2413157A1/en not_active Abandoned
- 2001-02-26 JP JP2002504922A patent/JP2004511431A/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0537559A1 (en) * | 1991-10-15 | 1993-04-21 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
US5447725A (en) * | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
WO1998027963A2 (en) * | 1996-12-20 | 1998-07-02 | Alza Corporation | Gel composition and methods |
WO1998027962A2 (en) * | 1996-12-20 | 1998-07-02 | Alza Corporation | Injectable depot gel composition and method of preparing the composition |
WO1998048859A1 (en) * | 1997-04-30 | 1998-11-05 | Guilford Pharmaceuticals Inc. | Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same |
WO1999047073A1 (en) * | 1998-03-19 | 1999-09-23 | Merck & Co., Inc. | Liquid polymeric compositions for controlled release of bioactive substances |
WO2000024374A1 (en) * | 1998-10-28 | 2000-05-04 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
Non-Patent Citations (7)
Title |
---|
GRAHAM P D ET AL: "Phase inversion dynamics of PLGA solutions related to drug delivery", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 58, no. 2, 29 March 1999 (1999-03-29), pages 233 - 245, XP004164095, ISSN: 0168-3659 * |
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Also Published As
Publication number | Publication date |
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JP2004511431A (en) | 2004-04-15 |
WO2002000137A1 (en) | 2002-01-03 |
CN1283215C (en) | 2006-11-08 |
CN1438858A (en) | 2003-08-27 |
EP1299048A1 (en) | 2003-04-09 |
NZ523385A (en) | 2005-09-30 |
AU2001245346A1 (en) | 2002-01-08 |
CA2413157A1 (en) | 2002-01-03 |
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