EP1284763A1 - Dispositif de transfert de liquide pour reconstitution de medicament ou transfert de medicament liquide - Google Patents

Dispositif de transfert de liquide pour reconstitution de medicament ou transfert de medicament liquide

Info

Publication number
EP1284763A1
EP1284763A1 EP01929836A EP01929836A EP1284763A1 EP 1284763 A1 EP1284763 A1 EP 1284763A1 EP 01929836 A EP01929836 A EP 01929836A EP 01929836 A EP01929836 A EP 01929836A EP 1284763 A1 EP1284763 A1 EP 1284763A1
Authority
EP
European Patent Office
Prior art keywords
chamber
liquid
drug
water
volume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01929836A
Other languages
German (de)
English (en)
Inventor
Terence Edward Weston
Matthew Simon Nussey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aradigm Corp
Original Assignee
Weston Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0011615A external-priority patent/GB0011615D0/en
Priority claimed from GB0027402A external-priority patent/GB0027402D0/en
Application filed by Weston Medical Ltd filed Critical Weston Medical Ltd
Publication of EP1284763A1 publication Critical patent/EP1284763A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2027—Separating means having frangible parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2041—Separating means having removable plugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ

Definitions

  • Liquid transfer device for drug reconstitution or liquid drug transfer
  • a number of drugs are not stable in aqueous solution, and must be stored in a dried form.
  • such drugs When first manufactured, such drugs are aqueous, and the dried form is attained by a process known as freeze drying or lyophilisation, whereby the drug is subjected to a vacuum to extract the water.
  • Some drugs may not be aqueous, and a solvent other than water might be used. Where reference is made below to water as a solvent it is to be understood that another solvent might be used instead.
  • lyophilised drugs are for parenteral administration by hypodermic syringe or needleless injector, and it is necessary to reconstitute the drug before use by adding a quantity of water equivalent to that which was removed from the original solution, or some other amount to render the drug suitable for absorption.
  • a common method is to present the dried drug in a sealed vial having a pierceable membrane closure, and to introduce the required quantity of water with a hypodermic needle through the closure.
  • Good practice requires that a second hypodermic syringe is used to withdraw the required quantity of reconstituted drug, and used to administer the dose to the patient. This method, although widely used, is time consuming and also wasteful, because it is always necessary to make up rather more drug than required for the injection, and since the aqueous drug is unstable, the excess must be discarded.
  • Other methods utilise devices based on a hypodermic syringe having two compartments, wherein the drug is stored in one, water in the other, and by moving the syringe plunger, the water is pressurised and caused to flow from a second compartment into the drug compartment.
  • the connection between the two compartments is made by either rupturing a separating membrane, or by valve means to cause a channel to connect the compartments.
  • Such devices are more or less automatic, in that the correct quantity of water is transferred with one relatively simple operation.
  • the user is required to complete the stroke of the syringe plunger to transfer the correct amount of water, and therefore it is possible to have insufficient water to completely dissolve the drug.
  • Needleless injectors are being used increasingly as an alternative to conventional hypodermic syringes, and use a powerful jet of liquid drug to first penetrate the epidermis and then deposit in the underlying tissues.
  • the construction of these devices usually requires that the drug compartment is filled immediately before use, and there are various injectors that use a drug transfer device between a vial and the drug compartment.
  • injectors that use a drug transfer device between a vial and the drug compartment.
  • These methods are suitable for drugs which have been reconstituted in a vial, but are just as time consuming and wasteful as the basic method used for hypodermic syringe filling. All of the prior art methods require a high degree of expertise and training, which limits the use of lyophilised drugs to healthcare professionals and those patients who need to self-administer such drugs on a regular basis and are familiar with the procedures.
  • One aspect of the invention aims to provide a convenient prefilled needleless injectors which has means for reconstituting a lyophilised drug within the device.
  • Another aspect of the invention relates to drugs in liquid form which require to be stored in a container constructed from a drug-compatible material That material may not be strong enough to withstand the stresses produced during needleless injector (often as high as 600 bars), and this other aspect of the invention aims to address this problem.
  • the present invention provides a method and apparatus for reconstituting lyophilised drugs in a needleless injector drug capsule (or variously called cartridge, chamber, ampoule, carpule, etc.) which is both more accurate and easier to use than those found in the prior art.
  • the drug may be in liquid form and be transferred by vacuum from a storage compartment to a dispensing compartment. In both applications, the constructions are very similar.
  • Lyophilised drugs are extremely hygroscopic, and need to be stored in a sealed dry atmosphere or in a vacuum.
  • the present device comprises an evacuated chamber containing the freeze dried drug, separated from a second chamber containing the water. Means is provided for connecting the chambers so that atmospheric pressure causes the water or other solvent to flow into the drug chamber.
  • the evacuated chamber is of a predetermined volume, so that the correct amount of water is automatically transferred.
  • the two chambers are separated by a membrane, and a piercing member is provided which causes the atmospheric pressure to force the water into the drug chamber.
  • the initial part of movement by the piercing member opens a vent to atmosphere in the water chamber, so that the full atmospheric pressure is available to effect the transfer, and the remainder of the movement pierces the membrane to connect the chambers.
  • the chamber which contained the water is then detached, exposing the delivery orifice of the drug chamber.
  • two chambers are provided, one containing the dried drug, the other the water.
  • a connecting conduit is sealed with a removable resilient plug, and the drug chamber is evacuate.
  • the resilient plug is connected to a sealing closure in the water chamber, and when the closure is removed, the first part of the movement opens a port in the water chamber to the atmosphere, and completion of the movement removes the resilient plug from the connecting conduit.
  • the water is thus transferred to the drug chamber under the action of atmospheric pressure.
  • the chamber which contained the water is then detached, exposing the delivery orifice of the drug chamber.
  • the solvent is contained within a collapsible tube.
  • Means are provided to connect the outlet of the collapsible tube to the evacuated drug dispensing chamber, so that the air pressure acting on the tube causes the solvent to flow from the tube and into the drug dispensing chamber.
  • a fourth preferred embodiment is similar to the third, except that the drug is stored in the collapsible tube in liquid form, and then transferred to the empty evacuated dispensing chamber.
  • a common feature of the first two preferred embodiments is that the water- chamber is first opened to the atmosphere before the connecting means is enabled. This maximises the pressure difference between the chambers and ensures efficient transfer. In the collapsible tube embodiment, it is not necessary to open the solvent to atmosphere.
  • Another common feature of all embodiments is that there is preferably provided a slight excess of water in the water chamber, to guarantee complete filling of the evacuated drug chamber. Any excess water is contained within a reservoir in the detachable water chamber and discarded.
  • the detachable water chamber is "tamper evident", that is, it provides unambiguous evidence that the device has been operated, and furthermore, that it cannot be re-assembled.
  • the preferred embodiments use a frangible connection between the chambers.
  • the invention provides, in various embodiments, a device in which a solvent, or drug, or other substance, in liquid form, is initially held in a first chamber, and is transferred prior to use by atmospheric pressure into a second chamber in which a vacuum has previously been maintained, the second chamber either containing a drug for reconstitution by the solvent, or providing a space to receive the drug, or other substance, in liquid form.
  • FIG. 1 A detailed description of the preferred embodiments, with reference to the drawings, is set out below. It should be noted that the drawings generally refer to a device having a circular cross section, but that other cross sections may be adapted to fulfil the objective of the invention. Whilst only the drug capsule is shown and described, it may be pre-assembled to an actuator (i.e., the power unit and firing mechanism), or form an integral part of an injector, or be assembled by the operator to an actuator after reconstituting the drug.
  • an actuator i.e., the power unit and firing mechanism
  • FIG. 1 A detailed description of the preferred embodiments, with reference to the drawings, is set out below. It should be noted that the drawings generally refer to a device having a circular cross section, but that other cross sections may be adapted to fulfil the objective of the invention. Whilst only the drug capsule is shown and described, it may be pre-assembled to an actuator (i.e., the power unit and firing mechanism), or form an integral part of an injector, or be assembled by the operator to an actuator after
  • Figure 1A is a longitudinal cross-section through a cylindrical needleless injector drug capsule according to the first embodiment, comprised of an inner drug contact part with an outer layer of protective plastic, and a membrane separating the drug container and the water chamber.
  • a piercing tube is shown in Figures IB and 1C, and Figure ID shows the principle of operation of the piercing tube.
  • Figures 2A to 2D show the sequence for preparing the drug capsule.
  • Figures 3A to 3D show the sequence for preparing the drug capsule according to the second embodiment, which employs a resilient plug to separate the compartments.
  • Figure 4A shows an embodiment containing a liquid drug prior to freeze drying, and having a collapsible tube containing a solvent for reconstituting the drug after freeze drying.
  • Figures 4B to 4E show the stages required for reconstituting the drug and preparing the drug capsule for use.
  • Figures 5 A to 5E are similar to Figures 4D to 4E, except that there is no freeze dried drug, the liquid drug being stored in the collapsible tube prior to vacuum transfer to the dispensing chamber.
  • drug chamber 1 is connected to the water chamber 2 by the frangible connection 3.
  • a sleeve 8 surrounds the drug chamber 8, and has a screw thread 9 by which the drug capsule may be connected to the operating device.
  • the drug contact material may be glass or a plastic material which requires the protection and support of a sleeve, but of course it is possible to make the entire component from one material only if the application permits.
  • Chambers 1 and 2 are separated by the membrane 10, which is sealingly attached to a mounting surface 32, and the piston 4 seals the volume 6.
  • the piston 4 is positioned so that the volume 6 between the piston 4 and injection orifice 25 is that required for the volume of reconstituted drug.
  • the drug chamber 1 contains the lyophilised drug 5, and the volume 6 is held under a vacuum.
  • the friction between the piston 4 and the bore of chamber 1 is sufficient to prevent movement of the piston 4 as a result of the pressure exerted by the atmosphere, and the membrane 10 is sufficiently strong to resist damage by the pressure difference.
  • the membrane 10 should be able to withstand prolonged contact with water.
  • the piston 4 and membrane 10 should have good sealing properties to prevent undue loss of vacuum.
  • the total evacuated thus comprises the volume 6 within the chamber 1, and a small reservoir 7 in chamber 2, the two being in hydraulic communication via the injection orifice 25.
  • the open end of chamber 2 carries a piercing tube 11.
  • the piercing tube 11 has a bore 13 in one end, through which an air inlet hole 14 and outlet hole 15 are located. Hole 15 is located also on the centreline of a curved section groove 16.
  • the other end of the piercing tube 11 is the cutter 17.
  • Figure 1C is an enlarged view of the cutter 17, showing the section shaped in the form of a crescent, 18, and tapered to a sharp tip 19.
  • the piercing tube 11 is frangibly attached at 21 to a carrier 20.
  • the piercing tube 11 is assembled to a resilient seal 12 having a central aperture therein.
  • the seal 12 is in the form of a washer, and preferably made from a pharmaceutical grade rubber.
  • the edges of the aperture in the seal must be sharp and free from surface defects, so that when the edges are in contact with the curved surface of groove 16 it forms a seal against the ingress of bacteria. (This type of seal is commonly used to seal the stem of aerosol valves used for dispensing cosmetics, paint, and many other products, and in that context, will efficiently seal against loss of pressurised propellant gas for many years).
  • the water chamber is filled with water 22, and the sub-assembly of piercing tube 11 and its carrier 20, plus seal 12, is assembled into the water chamber 2 and retained by lugs 23. A slight compression is applied by the lugs 23 to the carrier 20, so that the seal 12 is sealingly pressed against the abutment 24.
  • FIG. 2A this shows the assembled and filled drug capsule, as previously described, and Figure 2B shows the initial effect of pushing in the stem of the piercing tube 11 in the direction of arrow X.
  • the frangible connection 21 is broken, and the seal 12 is deflected, so that the lower edge of the hole in the seal 12 breaks away from the curved face of groove 16 of the piercing tube 11.
  • This connects the inside of the water chamber 2 to atmosphere via hole 15, bore 13 and hole 14.
  • Hole 14 provides an air entry hole if the end of bore 13 is blocked by the user, but a groove in the end face of piercing tube 11 would suffice, and hole 14 then becomes unnecessary). This is shown in more detail in the enlarged view of the water chamber in figure ID
  • the filling takes a second or so, and afterwards, the water chamber 2, complete with piercing tube 11, seal 12, membrane 10 and the excess water, is snapped of at frangible connection 3 and discarded, as shown in Figure 2D.
  • the capsule may then be attached to an actuator, (or it may have been pre-assembled to an actuator), and the injection may then be administered.
  • FIG. 3 A shows the assembled drug capsule comprising a drug chamber 1, connected to the water chamber 2 by the frangible connection 3.
  • a sleeve 8 surrounds the drug chamber 8, and has a screw thread 9 by which the drug capsule may be connected to the operating device.
  • the drug contact material may be glass or a plastic material which requires the protection and support of a sleeve, but of course it is possible to make the entire component from one material only if the application permits.
  • the piston 4 seals the volume 6, and is positioned so that the volume 6 between the piston 4 and injection orifice 25 is that required for the volume of reconstituted drug.
  • a small reservoir 7 is located at one end of the water chamber 2 and connects to the drug chamber 1 via the injection orifice 25.
  • a resilient plug 26 is sealingly inserted into the reservoir 7.
  • the drug chamber 1 contains the lyophilised drug 5, and the volume 6 is held under a vacuum. The friction between the piston 4 and the bore of chamber 1 is sufficient to prevent movement of the piston 4 as a result of the pressure exerted by the atmosphere.
  • the resilient plug 26 is able to maintain a vacuum-tight seal and resist deterioration by the water for reconstitution.
  • the water chamber 2 is filled with the required volume of water 22, and a cap 28, which has a longitudinally extending barb 29 and a sealing ring 27, is inserted into the open end of the chamber 2.
  • the barb engages with a hole in the resilient plug 26 so that the resilient plug 26 becomes firmly attached to the cap 28.
  • Seal 27 prevents bacterial contamination of the water 22.
  • Figure 3B shows the first stage of preparation, whereby the cap 28 is pulled out a small distance in the direction of the arrow X. This drags the resilient plug 26 partly out of the reservoir 7; note that the plug 26 still seals in against the wall of reservoir 7 to prevent loss of the vacuum in the drug chamber 1.
  • a slot (or hole) 30 through the wall of water chamber 2 is uncovered by the seal 27, and connects the water chamber to atmospheric air.
  • further withdrawal of the cap 28 removes the resilient plug 26 completely from the reservoir 7, which brings the drug chamber 1 and water chamber 2 into hydraulic connection via the injection orifice 25, and the vacuum within the drug chamber 1 draws in the water 22 from water chamber 2. There is an excess of water 22 available, which remains in the reservoir 7.
  • the filling takes a second or so, and afterwards, the water chamber 2, complete with cap 28, seal 27, plug 26, and the excess water, is snapped of at frangible connection 3 and discarded (Fig.3D).
  • the capsule may then be attached to an actuator, (or it may have been pre-assembled to an actuator), and the injection may then be administered.
  • the cap 28 may be frangibly attached to the water chamber to provide tamper evidence.
  • Figure 4A illustrates the third preferred embodiment and shows a drug capsule 101 which may have one or more layers 101, and which has been filled with the required volume of drug 115 in liquid form. This volume is the space between a piston 104 and an injection orifice 112.
  • the drug capsule 101 has screw threads or other means 116 for attaching the capsule to a power source for dispensing the drug.
  • Piston 104 is able to sealingly slide within the bore of the drug capsule 101 but has sufficient friction to resist movement when the pressure difference across the piston is slightly more than one atmosphere.
  • the drug capsule 101 has a connector 102 attached, preferably frangibly so, at 103, and connector 102 carries at least one resilient sealing element 105.
  • a reservoir 106 for water or other solvent is assembled over the connector 102, but without sealing on the seals 105.
  • the reservoir 106 has a tube 107 sealing attached and closed by a pierceable membrane 110 and crimped seal 107.
  • the tube 107 contains the water, or other solvent, 108 for reconstitution, preferably de-gassed and without entrapped bubbles of gas.
  • Pierceable membrane 110 may be integral with the tube 107, or with the reservoir 106, the objective being to seal the contents from the atmosphere. Any two, or all three, of the tube 107, reservoir 106 and membrane 110 may, if desired form a single integrally formed unit.
  • the tube 107 may, if desired, be lined with a material to enhance its storage properties. Between the injection orifice 12 and the membrane 110 there is a conduit 113 which is in gaseous connection with a cavity 114.
  • a membrane cutter 111 is attached to, or integral with, the end face of the connector 102.
  • Part of the freeze drying process requires a vacuum to be applied to the drug to be dried. This is done in this embodiment by placing the whole device in a vacuum chamber, and drawing air through the gap between the connector 102 and slots 118 in the reservoir 106, as indicated by arrow E.
  • the reservoir 106 is pushed further onto the connector 102 in the direction of arrow X, so that the seals 105 seal on the bore of cavity 114.
  • the freeze dried drug diagrammatically indicated at 119 in Figure 4B, is contained within the evacuated capsule void 120, which is in communication with the conduit 113 and cavity 114.
  • the reservoir 106 When it is required to reconstitute the drug 119, the reservoir 106 is pushed in the direction of arrow X, so that the cutter 111 pierces the membrane 110 to make a flap therein through which the water 103 may flow, as shown in Figure 4C.
  • Atmospheric pressure acting on the collapsible tube 107 squeezes the tube 107 to force the water 108 through the ruptured membrane 110, the conduit 113, the injection orifice 112 and into the drug capsule void 120.
  • the water dissolves the freeze dried drug 119, and since the void 120 is the volume which was previously occupied by the liquid drug 115 (Fig.4 A) the amount and concentration of the reconstituted drug is the same as the original.
  • the reservoir 106 is pushed onto the drug capsule 101 in the manner described above, dogs 117 on the connector 102 engage with slots 118 on the reservoir 106.
  • the final steps in the preparation of the capsule are to twist the reservoir 106 relative to the capsule 101, and because the reservoir 106 is engaged with the connector 102 via the dogs 117 and slots 118, it shears from the capsule 101 at the frangible connection 103. It will be seen that this shearing operation cannot be carried out before the reservoir 106 is pushed on to the capsule 101, and this cannot be carried out before reconstitution has taken place.
  • the reservoir 106 and connector 102 are discarded and the capsule is ready to give an injection.
  • the components are the same as those described in the third embodiment ( Figures 4A to 4E ) except that the drug is stable in its liquid form and stored within the collapsible tube.
  • the void 120 is still evacuated to provide the necessary pressure difference to allow the atmospheric pressure to squeeze the collapsible tube.
  • the liquid in the liquid chamber may be separated for atmosphere by a piston whose upper end is exposed to atmosphere from the outset, or at least immediately prior to use.
  • the liquid is thus under atmospheric pressure as a result of the piston bearing on it. This pressure is effective to transfer the liquid to the drug capsule.
  • the transfer can take place immediately this exposure occurs.
  • the piston may be subjected to a spring force which supplements the atmospheric pressure.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)

Abstract

La présente invention concerne un dispositif et un procédé permettant de reconstituer un médicament lyophilisé, le médicament étant stocké sous vide dans un compartiment du dispositif et le solvant dans un autre compartiment à une pression sensiblement sous-atmosphérique, un moyen permettant de relier les compartiments de façon que le vide entraîne l'écoulement du solvant dans le compartiment du médicament et, par conséquent, la dissolution de ce dernier. Dans un autre mode de réalisation, le médicament, ou une autre matière, peut être stocké sous forme liquide dans un compartiment du dispositif et entraîné à s'écouler dans l'autre compartiment sous l'effet du vide.
EP01929836A 2000-05-16 2001-05-16 Dispositif de transfert de liquide pour reconstitution de medicament ou transfert de medicament liquide Withdrawn EP1284763A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0011615A GB0011615D0 (en) 2000-05-16 2000-05-16 Reconstitution device for lyophilised drugs
GB0011615 2000-05-16
GB0027402 2000-11-09
GB0027402A GB0027402D0 (en) 2000-11-09 2000-11-09 Liquid transfer device for drug reconstruction or liquid drug transfer
PCT/GB2001/002156 WO2001087385A1 (fr) 2000-05-16 2001-05-16 Dispositif de transfert de liquide pour reconstitution de medicament ou transfert de medicament liquide

Publications (1)

Publication Number Publication Date
EP1284763A1 true EP1284763A1 (fr) 2003-02-26

Family

ID=26244266

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01929836A Withdrawn EP1284763A1 (fr) 2000-05-16 2001-05-16 Dispositif de transfert de liquide pour reconstitution de medicament ou transfert de medicament liquide

Country Status (4)

Country Link
EP (1) EP1284763A1 (fr)
JP (1) JP2003533289A (fr)
AU (1) AU5651601A (fr)
WO (1) WO2001087385A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7086431B2 (en) 2002-12-09 2006-08-08 D'antonio Consultants International, Inc. Injection cartridge filling apparatus
EP1962947A4 (fr) * 2005-12-20 2017-06-28 Antares Pharma, Inc. Dispositif d'injection sans aiguille
DE102008048981A1 (de) 2008-09-25 2010-04-15 Lts Lohmann Therapie-Systeme Ag Injektor und Zwei-Kammer-System mit sterilen Komponenten
DE102009004828B4 (de) 2009-01-13 2010-12-09 Lts Lohmann Therapie-Systeme Ag Injektor mit verdrängbarem Stopfenteil
US10143625B2 (en) 2015-03-17 2018-12-04 Recon Therapeutics, Inc. Pharmaceutical reconstitution

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4010747A (en) 1974-10-25 1977-03-08 Clark Wesley D Method of storing an ampoule for a needleless hypodermic injector
GB9504878D0 (en) 1995-03-10 1995-04-26 Weston Medical Ltd Viscously coupled actuator
GB9607549D0 (en) 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
FR2749169B1 (fr) * 1996-06-04 1998-08-21 Delab Procede pour constituer une preparation injectable et dispositif pour la mise en oeuvre de ce procede
GB9819962D0 (en) * 1998-09-15 1998-11-04 Weston Medical Ltd Needleless injection cartridge

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0187385A1 *

Also Published As

Publication number Publication date
AU5651601A (en) 2001-11-26
WO2001087385A1 (fr) 2001-11-22
JP2003533289A (ja) 2003-11-11

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