EP1259633A1 - Dispositif et systeme d'electrodes destines a des examens electrophysiologiques - Google Patents

Dispositif et systeme d'electrodes destines a des examens electrophysiologiques

Info

Publication number
EP1259633A1
EP1259633A1 EP01901195A EP01901195A EP1259633A1 EP 1259633 A1 EP1259633 A1 EP 1259633A1 EP 01901195 A EP01901195 A EP 01901195A EP 01901195 A EP01901195 A EP 01901195A EP 1259633 A1 EP1259633 A1 EP 1259633A1
Authority
EP
European Patent Office
Prior art keywords
counter electrode
electrode
measuring
measuring electrodes
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01901195A
Other languages
German (de)
English (en)
Inventor
Hugo Hämmerle
Wilfried Nisch
Cornelia Leibrock
Dieter Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NMI Naturwissenschaftliches und Medizinisches Institut
Original Assignee
NMI Naturwissenschaftliches und Medizinisches Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NMI Naturwissenschaftliches und Medizinisches Institut filed Critical NMI Naturwissenschaftliches und Medizinisches Institut
Publication of EP1259633A1 publication Critical patent/EP1259633A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/4833Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G01N33/4836Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures using multielectrode arrays

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne un dispositif (10) destiné à des examens électrophysiologiques sur des éléments biologiques (11), composé d'un support (12) sur lequel est disposé un réseau d'électrodes de mesure (14, 15), et d'un récipient (21) comportant une chambre de réception (24) pour la matière biologique (21) et le milieu de culture correspondant (25). Le récipient (21) est disposé autour des électrodes de mesure (14, 15) sur le support (12) de manière que ces électrodes soient en liaison électrique avec la chambre de réception (24). Une contre-électrode (38) disposée de manière permanente dans la chambre de réception (24) permet de mesurer des signaux électriques (S) entre les électrodes de mesure (14, 15) et la contre-électrode (38).
EP01901195A 2000-03-02 2001-01-24 Dispositif et systeme d'electrodes destines a des examens electrophysiologiques Withdrawn EP1259633A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10010081A DE10010081A1 (de) 2000-03-02 2000-03-02 Vorrichtung und Elektrodenanordnung für elektrophysiologische Untersuchungen
DE10010081 2000-03-02
PCT/EP2001/000728 WO2001064940A1 (fr) 2000-03-02 2001-01-24 Dispositif et systeme d'electrodes destines a des examens electrophysiologiques

Publications (1)

Publication Number Publication Date
EP1259633A1 true EP1259633A1 (fr) 2002-11-27

Family

ID=7633179

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01901195A Withdrawn EP1259633A1 (fr) 2000-03-02 2001-01-24 Dispositif et systeme d'electrodes destines a des examens electrophysiologiques

Country Status (4)

Country Link
US (1) US20030009112A1 (fr)
EP (1) EP1259633A1 (fr)
DE (1) DE10010081A1 (fr)
WO (1) WO2001064940A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649402B2 (en) * 2001-06-22 2003-11-18 Wisconsin Alumni Research Foundation Microfabricated microbial growth assay method and apparatus
JP4842512B2 (ja) * 2001-11-27 2011-12-21 セレクトリコン アーベー 並列薬剤送達と細胞構造の電気穿孔法を併合した方法及びその使用
WO2003068906A1 (fr) * 2002-02-12 2003-08-21 Cellectricon Ab Systemes et procedes de changement rapide de l'environnement liquide autour de capteurs
US7136696B2 (en) 2002-04-05 2006-11-14 The Cleveland Clinic Foundation Neuron signal analysis system and method
WO2004018690A1 (fr) * 2002-08-21 2004-03-04 Cellectricon Ab Systeme et procede destines a obtenir et a maintenir des joints haute resistance dans des enregistrements de patch-clamp
AU2003278461A1 (en) 2002-10-16 2004-05-04 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
DE10251767A1 (de) * 2002-11-07 2004-05-27 Forschungszentrum Jülich GmbH Vorrichtung und Verfahren zur Messung elektrischer Vorgänge an biologischen Membranen
US7547381B2 (en) * 2003-09-26 2009-06-16 Agency For Science, Technology And Research And National University Of Singapore Sensor array integrated electrochemical chip, method of forming same, and electrode coating
US20050256541A1 (en) * 2004-04-30 2005-11-17 Medtronic, Inc. Catheter with temporary stimulation electrode
US9121806B1 (en) * 2007-07-26 2015-09-01 University Of South Florida Impedance spectroscopy-based cellular analysis device
US9041154B2 (en) * 2013-03-06 2015-05-26 Nanya Technology Corp. Contact structure and semiconductor memory device using the same
WO2015049147A1 (fr) * 2013-10-01 2015-04-09 Koninklijke Philips N.V. Capteur voltampérométrique
JP6793918B2 (ja) * 2016-09-02 2020-12-02 日本光電工業株式会社 測定装置

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3429583A1 (de) * 1984-08-10 1986-02-20 Siemens AG, 1000 Berlin und 8000 München Verfahren zur elektrochemischen bestimmung der sauerstoffkonzentration
US4886591A (en) * 1988-08-04 1989-12-12 Universite De Sherbrooke Phosphate bonded composite electrodes
DE69029911T2 (de) * 1989-12-14 1997-09-04 Univ California Verfahren zur erhöhung der funktionslebensdauer eines implantierbaren fühlers
US5593852A (en) * 1993-12-02 1997-01-14 Heller; Adam Subcutaneous glucose electrode
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
US5432086A (en) * 1992-11-18 1995-07-11 Sy-Lab Vertriebsgellschaft M.B.H. Apparatus for the automatic monitoring of microorganism culture
US5810725A (en) 1993-04-16 1998-09-22 Matsushita Electric Industrial Co., Ltd. Planar electrode
EP0627621B1 (fr) * 1993-06-04 1997-05-21 AVL Medical Instruments AG Méthode et appareil pour l'examen du métabolisme dans des cellules
GB2289339B (en) * 1994-05-12 1998-09-16 Cambridge Life Sciences Flow-through electrochemical biosensor
US5563067A (en) 1994-06-13 1996-10-08 Matsushita Electric Industrial Co., Ltd. Cell potential measurement apparatus having a plurality of microelectrodes
US5981268A (en) * 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
US6169394B1 (en) * 1998-09-18 2001-01-02 University Of The Utah Research Foundation Electrical detector for micro-analysis systems

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0164940A1 *

Also Published As

Publication number Publication date
US20030009112A1 (en) 2003-01-09
WO2001064940A1 (fr) 2001-09-07
DE10010081A1 (de) 2001-09-13

Similar Documents

Publication Publication Date Title
DE2502621C3 (de) Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen
EP1311655B1 (fr) Dispositif et procede pour mettre en contact electrique des cellules biologiques en suspension dans un liquide
DE19744649C2 (de) Verfahren zur Messung bioelektrischer Signale von Zellen nach der Patch-Clamp-Methode sowie Verwendung einer Vorrichtung hierzu
DE10392210T5 (de) Verfahren und Vorrichtung zum Überwachen einer analytischen Konzentration mittels einer Osmose-Differenz-Druckmessung
EP1259633A1 (fr) Dispositif et systeme d'electrodes destines a des examens electrophysiologiques
EP0418359A1 (fr) Ensemble de plusieurs microelectrodes
DE2433212A1 (de) Verfahren und vorrichtung zur substratkonzentrationsmessung
EP0938383A1 (fr) Dispositif pour effectuer des analyses d'echantillons cellulaires ou similaires
EP1178315A1 (fr) Dispositif et procédé pour examiner des cellules à l'aide de la méthode patch-clamp
EP0960933A1 (fr) Appareil et procédé de mesure
DE3643263C2 (fr)
EP3100039B1 (fr) Dispositif de mesure de propriétés biologiques et/ou électroniques d'un échantillon ainsi que des utilisations de ceux-ci
EP2044438B1 (fr) Installation pour des mesures en ligne sur des cellules
DE10142393C1 (de) Vorrichtung und Verfahren zur Erfassung bioelektrischer Signale aus elektrophysiologisch aktiven Bereichen in Sphäroiden
DE69533827T2 (de) Elektrochemische bewertung des verhaltens von zellen und deren stoffwechselaktivität
WO2019121162A1 (fr) Appareil de mesure, procédé de mesure, appareil de test à haut débit et trousse de mesure pour des mesures électrophysiologiques, en particulier sur des agrégats cellulaires
DE4417078C2 (de) Vorrichtung zum Mikroskopieren von biologischen Zellen
DE102020126759B3 (de) Piezoelektrisches Membran-Mikroelektroden Array
WO2011018107A1 (fr) Procédé et dispositif permettant de mesurer les propriétés physiques d’échantillons biologiques
DE3725597A1 (de) Sensor zur messung der aktivitaet von ionen, sowie verfahren zu dessen herstellung
EP2607475B1 (fr) Cellule de monitoring et procédé d'analyse de la croissance cellulaire et tissulaire
DE3434154C2 (fr)
DE102020210718B3 (de) Vorrichtung und Verfahren zur Detektion von einem Wassertransport durch mindestens eine Schicht biologischer Zellen
EP1717574A1 (fr) Détection du joint de matière biologique sur un support à l'aide d'une analyse de bruit
DE4244338A1 (de) Elektrochemische Meßkette zur ortsaufgelösten Konzentrationsbestimmung von chemisch und/oder biochemisch relevanten Analyten

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020920

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: HAEMMERLE, HUGO

Inventor name: NISCH, WILFRIED

Inventor name: LEIBROCK, CORNELIA

Inventor name: MARTIN, DIETER

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060801