EP1256329A1 - Straw for the preservation of small amounts of substances, notably of biological liquids - Google Patents

Straw for the preservation of small amounts of substances, notably of biological liquids Download PDF

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Publication number
EP1256329A1
EP1256329A1 EP02291120A EP02291120A EP1256329A1 EP 1256329 A1 EP1256329 A1 EP 1256329A1 EP 02291120 A EP02291120 A EP 02291120A EP 02291120 A EP02291120 A EP 02291120A EP 1256329 A1 EP1256329 A1 EP 1256329A1
Authority
EP
European Patent Office
Prior art keywords
sheath
core
straw
glitter
thermoplastic material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP02291120A
Other languages
German (de)
French (fr)
Other versions
EP1256329B1 (en
Inventor
Jean-Gérard Saint-Ramon
Francis Lesieur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IMV Technologies SA
Original Assignee
IMV Technologies SA
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Filing date
Publication date
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Publication of EP1256329A1 publication Critical patent/EP1256329A1/en
Application granted granted Critical
Publication of EP1256329B1 publication Critical patent/EP1256329B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A61D19/022—Containers for animal semen, e.g. pouches or vials ; Methods or apparatus for treating or handling animal semen containers, e.g. filling or closing
    • A61D19/024—Tube-like containers, e.g. straws
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Definitions

  • the present invention relates to a straw for the conservation of small quantities of substances, including biological substances, in especially biological fluids.
  • the flakes produced according to this patent and used until now include a tripartite stopper consisting of two pads of a substance fibrous enclosing a powder capable of transforming on contact with a liquid in a waterproof paste or gel adhering to the wall of the tube creating a waterproof cap.
  • Patent FR-A-2 753 367 proposes a straw with a stopper tripartite comprising a hydrogel powder between two buffers, a tampon external and an internal buffer, said flake being characterized in that the length of the external buffer is at least twice the length of the internal buffer. According to this patent the absorption of the liquid contained in the straw is only very slightly reduced compared to that observed with a glitter fitted with a classic tripartite plug.
  • An object of the present invention is to have a straw provided a stopper that absorbs only a small amount of a liquid contained in the sparkling. More specifically, an object of the invention is to provide a glitter fitted with a cap which only absorbs a quantity of a liquid which is there content at most equal to about 4%.
  • the present invention fulfills the above object and provides a glitter for the storage of small quantities of substances, including substances biological, consisting of a segment of tube fitted inside one of its ends of a stopper comprising gelling powder, characterized in that said plug comprises a core of thermoplastic material sheathed by wires constituting a sheath.
  • the threads are synthetic, for example polyester.
  • Gelling powder is a material capable of being transformed contact of a liquid in an impermeable paste or gel adhering to the wall of the tube by creating a tight plug.
  • the gelling powder may for example be an alginate or else alcohol Polyvinyl.
  • the sheath can be produced in the form of a braid.
  • the braid according to the present invention can be produced by braiding, knitting, weaving or covering of threads, for example synthetic, on a core extruded in thermoplastic material.
  • Sheath wires can be treated to be hydrophilic or repellent. They are white or colored; in the latter case the sons of the sheath constitute a color indicator of the content of the glitter.
  • the core can also be colored, here also constituting an indicator color of the glitter content.
  • the gelling powder can also be colored, constituting here also a color indicator of the content of the glitter.
  • the fixing of the wires on the core can be carried out by tension or mass adhesive.
  • a thin thermoplastic sheath may cover the whole.
  • the straw can be provided with a tripartite plug or piece.
  • the plug of the glitter according to the invention is tripartite.
  • the external part which is not in direct contact with the contained liquid in the flake, consists of a core of sheathed thermoplastic material by threads, for example synthetic.
  • the internal part, in contact with the liquid contained in the straw, is consisting of a core of thermoplastic material sheathed by wires, by synthetic examples.
  • the intermediate part consists of gelling powder.
  • the plug of the glitter according to the invention is tripartite.
  • the external part which is not in direct contact with the contained liquid in the glitter, is a tampon, for example a braid, of fibrous substance standard, for example in polyester viscose.
  • the internal part, in contact with the liquid contained in the straw, is consisting of a core of thermoplastic material sheathed by wires, by synthetic examples.
  • the intermediate part consists of gelling powder.
  • the plug of the straw according to the invention is tripartite.
  • the external part which is not in direct contact with the contained liquid in the glitter is a tampon, for example a braid, of fibrous substance standard, for example in polyester viscose.
  • the internal part, in contact with the liquid contained in the straw, is consisting of a core of thermoplastic material sheathed by wires, by synthetic examples, said core comprising a bore.
  • the intermediate part consists of gelling powder.
  • the plug of the straw according to the invention is tripartite.
  • the external part which is not in direct contact with the contained liquid in the glitter, is a tampon, for example a braid, of fibrous substance standard, for example in polyester viscose.
  • the internal part, in contact with the liquid contained in the straw, is consisting of a core of thermoplastic material sheathed by wires, by synthetic examples, said core comprising a central braid of threads hydrophilic or water repellent.
  • the intermediate part consists of gelling powder.
  • the total length of the plug is between approximately 7 mm and approximately 14 mm.
  • the external part has a length between approximately 3 mm and approximately 6 mm.
  • the internal part has a length between approximately 2 mm and approximately 5 mm.
  • the intermediate part has a length of between approximately 1.5 mm and about 3 mm.
  • the plug of the straw according to the invention is in one piece and consists of a material core thermoplastic sheathed by threads, for example synthetic.
  • the sons of the sheath are impregnated with gelling powder.
  • the plug of the straw according to the invention is in one piece and consists of a material core thermoplastic sheathed by threads, for example synthetic and it includes a central braid in hydrophilic or water-repellent son impregnated with powder gelling.
  • the length of the one-piece stopper according to the invention is between about 5 mm and about 14 mm.
  • the straw of the invention leads to a very low absorption of the liquid contained therein, of the order of 4% and even less.
  • the glitter 1 consists of a segment of tube 2 provided at one of its ends with a tripartite plug 3.
  • the external part 31, which is not in contact with the contained liquid in the straw, consists of a core 43 of sheathed thermoplastic material by wires in a sheath 53.
  • the internal part 33 in contact with the liquid contained in the straw, consists of a core 43 of thermoplastic material sheathed by wires a sheath 53.
  • the intermediate part 32 consists of gelling powder 7.
  • the glitter 1 consists of a segment of tube 2 provided at one of its ends with a tripartite plug 3.
  • the external part 31, which is not in contact with the contained liquid in the glitter, is a braid with a fibrous substance.
  • the internal part 33 in contact with the liquid contained in the straw, consists of a core 43 of thermoplastic material sheathed by wires a sheath 53.
  • the intermediate part 32 consists of gelling powder 7.
  • the glitter 1 consists of a segment of tube 2 provided at one of its ends with a tripartite plug 3.
  • the external part 31, which is not in contact with the contained liquid in the glitter, is a braid with a fibrous substance.
  • the internal part 33 in contact with the liquid contained in the straw, consists of a core 43 of thermoplastic material sheathed by wires a sheath 53.
  • the core 43 has a bore 8.
  • the intermediate part 32 consists of gelling powder 7.
  • the glitter 1 consists of a segment of tube 2 provided at one of its ends with a tripartite plug 3.
  • the external part 31, which is not in contact with the contained liquid in the glitter, is a braid with a fibrous substance.
  • the internal part 33 in contact with the liquid contained in the straw, consists of a core 43 of thermoplastic material sheathed by wires a sheath 53.
  • the core 43 includes a central braid 63.
  • the intermediate part 32 consists of gelling powder 7.
  • the glitter 1 consists of a segment of tube 2 provided at one end with a one-piece plug 3.
  • the plug 3 consists of a core 4 of thermoplastic material sheathed by wires constituting a sheath 5.
  • the wires of sheath 5 are impregnated a gelling powder 7.
  • the glitter 1 consists of a segment of tube 2 provided at one end with a one-piece plug 3.
  • the plug 3 consists of a core 4 of thermoplastic material sheathed by wires constituting a sheath 5 and comprising a central braid 6 of synthetic threads impregnated with gelling powder 7.
  • the wires constituting the sheath 5 are impregnated with gelling powder.

Abstract

Paillette (1) pour la conservation de petites quantités de substances, notamment des substances biologiques, se composant d'un segment de tube (2) muni à l'intérieur de l'une de ses extrémités d'un bouchon (3) comportant de la poudre gélifiante, caractérisée en ce que ledit bouchon de paillette comprend un noyau (4) en matière thermoplastique gainé par des fils constituant une gaine (5). La paillette de l'invention n'absorbe que de très faibles quantités du liquide qui y est contenu. <IMAGE>Straw (1) for the conservation of small quantities of substances, in particular biological substances, consisting of a tube segment (2) provided inside one of its ends with a stopper (3) comprising gelling powder, characterized in that said glitter plug comprises a core (4) of thermoplastic material sheathed by wires constituting a sheath (5). The straw of the invention only absorbs very small quantities of the liquid contained therein. <IMAGE>

Description

La présente invention concerne une paillette pour la conservation de petites quantités de substances, notamment des substances biologiques, en particulier des liquides biologiques.The present invention relates to a straw for the conservation of small quantities of substances, including biological substances, in especially biological fluids.

Ce type de paillette, connue sous la dénomination de "paillette française", a été divulgué pour la première fois dans le Brevet Français N° 995 878.This type of glitter, known as "glitter French ", was first disclosed in the French Patent No. 995 878.

Les paillettes fabriquées selon ce brevet et utilisées jusqu'à présent comprennent un bouchon tripartite constitué par deux tampons d'une substance fibreuse enserrant une poudre susceptible de se transformer au contact d'un liquide en une pâte ou gel imperméable adhérant à la paroi du tube en créant un bouchon étanche.The flakes produced according to this patent and used until now include a tripartite stopper consisting of two pads of a substance fibrous enclosing a powder capable of transforming on contact with a liquid in a waterproof paste or gel adhering to the wall of the tube creating a waterproof cap.

Les paillettes à bouchon tripartite mises au point et commercialisées par la Demanderesse donnent toute satisfaction. Néanmoins, une certaine absorption de liquide contenu dans la paillette a pu être constatée, quoique très faible, de l'ordre de 7 %.The tripartite cap flakes developed and marketed by the Applicant give full satisfaction. Nevertheless, some absorption of liquid contained in the straw could be observed, although very low, around 7%.

Une solution qui a été proposée pour pallier le problème ci-dessus a été de remplacer le bouchon tripartite par une bille en matière plastique rigide ou métallique. Cette solution ne s'est pas avérée satisfaisante car, si l'absorption de liquide contenu dans la paillette a été réduite à zéro, de nouvelles difficultés rédhibitoires sont apparues, le bouchon n'étant plus du tout étanche aux liquides.A solution that has been proposed to overcome the above problem has been replace the tripartite plug with a rigid plastic ball, or metallic. This solution has not proved satisfactory because, if the absorption of liquid in the straw has been reduced to zero, new difficulties prohibitive have appeared, the cap is no longer waterproof at all liquids.

Le brevet FR-A-2 753 367 propose une paillette comportant un bouchon tripartite comprenant une poudre hydrogel entre deux tampons, un tampon externe et un tampon interne, ladite paillette étant caractérisée en ce que la longueur du tampon externe est au moins deux fois supérieure à la longueur du tampon interne. Selon ce brevet l'absorption du liquide contenu dans la paillette n'est que très faiblement réduite par rapport à celle constatée avec une paillette munie d'un bouchon tripartite classique.Patent FR-A-2 753 367 proposes a straw with a stopper tripartite comprising a hydrogel powder between two buffers, a tampon external and an internal buffer, said flake being characterized in that the length of the external buffer is at least twice the length of the internal buffer. According to this patent the absorption of the liquid contained in the straw is only very slightly reduced compared to that observed with a glitter fitted with a classic tripartite plug.

Un objet de la présente invention est de disposer d'une paillette munie d'un bouchon qui n'absorbe qu'une faible quantité d'un liquide contenu dans la paillette. Plus précisément, un objet de l'invention est de fournir une paillette munie d'un bouchon qui n'absorbe qu'une quantité d'un liquide qui y est contenu au plus égale à environ 4 %.An object of the present invention is to have a straw provided a stopper that absorbs only a small amount of a liquid contained in the sparkling. More specifically, an object of the invention is to provide a glitter fitted with a cap which only absorbs a quantity of a liquid which is there content at most equal to about 4%.

D'autres objets et avantages de l'invention apparaítront à la lecture de la description ci-après.Other objects and advantages of the invention will appear on reading the description below.

La présente invention répond à l'objet ci-dessus et fournit une paillette pour la conservation de petites quantités de substances, notamment des substances biologiques, se composant d'un segment de tube muni à l'intérieur de l'une de ses extrémités d'un bouchon comportant de la poudre gélifiante, caractérisée en ce que ledit bouchon comprend un noyau en matière thermoplastique gainé par des fils constituant une gaine.The present invention fulfills the above object and provides a glitter for the storage of small quantities of substances, including substances biological, consisting of a segment of tube fitted inside one of its ends of a stopper comprising gelling powder, characterized in that said plug comprises a core of thermoplastic material sheathed by wires constituting a sheath.

De préférence, les fils sont synthétiques, par exemple en polyester.Preferably, the threads are synthetic, for example polyester.

La poudre gélifiante est une matière susceptible de se transformer au contact d'un liquide en une pâte ou gel imperméable adhérant à la paroi du tube en créant un bouchon étanche.Gelling powder is a material capable of being transformed contact of a liquid in an impermeable paste or gel adhering to the wall of the tube by creating a tight plug.

La poudre gélifiante peut par exemple être un alginate ou bien de l'alcool polyvinylique.The gelling powder may for example be an alginate or else alcohol Polyvinyl.

La gaine peut être réalisée sous forme d'une tresse.The sheath can be produced in the form of a braid.

La tresse selon la présente invention peut être fabriquée par tressage, tricotage, tissage ou guipage de fils, par exemple synthétiques, sur un noyau extrudé en matière thermoplastique.The braid according to the present invention can be produced by braiding, knitting, weaving or covering of threads, for example synthetic, on a core extruded in thermoplastic material.

Les fils de la gaine peuvent être traités pour être hydrophiles ou hydrofuges. Ils sont blancs ou de couleur ; dans ce dernier cas, les fils de la gaine constituent un indicateur couleur du contenu de la paillette.Sheath wires can be treated to be hydrophilic or repellent. They are white or colored; in the latter case the sons of the sheath constitute a color indicator of the content of the glitter.

Le noyau peut être également coloré, constituant ici aussi un indicateur couleur du contenu de la paillette.The core can also be colored, here also constituting an indicator color of the glitter content.

De même, la poudre gélifiante peut être aussi colorée, constituant ici aussi un indicateur couleur du contenu de la paillette. Similarly, the gelling powder can also be colored, constituting here also a color indicator of the content of the glitter.

La fixation des fils sur le noyau peut être effectuée par tension ou masse adhésive. Une gaine en matière thermoplastique de faible épaisseur pourra recouvrir l'ensemble.The fixing of the wires on the core can be carried out by tension or mass adhesive. A thin thermoplastic sheath may cover the whole.

Selon l'invention la paillette peut être munie d'un bouchon tripartite ou monobloc.According to the invention, the straw can be provided with a tripartite plug or piece.

Dans un premier mode de réalisation de l'invention, le bouchon de la paillette selon l'invention est tripartite.In a first embodiment of the invention, the plug of the glitter according to the invention is tripartite.

Il est constitué de trois parties sensiblement de même longueur ou de longueurs différentes.It consists of three parts of substantially the same length or different lengths.

La partie externe, qui n'est pas en contact direct avec le liquide contenu dans la paillette, est constituée d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques.The external part, which is not in direct contact with the contained liquid in the flake, consists of a core of sheathed thermoplastic material by threads, for example synthetic.

La partie interne, en contact avec le liquide contenu dans la paillette, est constituée d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques.The internal part, in contact with the liquid contained in the straw, is consisting of a core of thermoplastic material sheathed by wires, by synthetic examples.

La partie intermédiaire est constituée de poudre gélifiante.The intermediate part consists of gelling powder.

Dans un deuxième mode de réalisation de l'invention, le bouchon de la paillette selon l'invention est tripartite.In a second embodiment of the invention, the plug of the glitter according to the invention is tripartite.

Il est constitué de trois parties sensiblement de même longueur ou de longueurs différentes.It consists of three parts of substantially the same length or different lengths.

La partie externe, qui n'est pas en contact direct avec le liquide contenu dans la paillette, est un tampon, par exemple une tresse, en substance fibreuse standard, par exemple en polyester viscose.The external part, which is not in direct contact with the contained liquid in the glitter, is a tampon, for example a braid, of fibrous substance standard, for example in polyester viscose.

La partie interne, en contact avec le liquide contenu dans la paillette, est constituée d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques.The internal part, in contact with the liquid contained in the straw, is consisting of a core of thermoplastic material sheathed by wires, by synthetic examples.

La partie intermédiaire est constituée de poudre gélifiante.The intermediate part consists of gelling powder.

Dans un troisième mode de réalisation, le bouchon de la paillette selon l'invention est tripartite.In a third embodiment, the plug of the straw according to the invention is tripartite.

Il est constitué de trois parties sensiblement de même longueur ou de longueurs différentes. It consists of three parts of substantially the same length or different lengths.

La partie externe, qui n'est pas en contact direct avec le liquide contenu dans la paillette est un tampon, par exemple une tresse, en substance fibreuse standard, par exemple en polyester viscose.The external part, which is not in direct contact with the contained liquid in the glitter is a tampon, for example a braid, of fibrous substance standard, for example in polyester viscose.

La partie interne, en contact avec le liquide contenu dans la paillette, est constituée d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques, ledit noyau comportant un alésage.The internal part, in contact with the liquid contained in the straw, is consisting of a core of thermoplastic material sheathed by wires, by synthetic examples, said core comprising a bore.

La partie intermédiaire est constituée de poudre gélifiante.The intermediate part consists of gelling powder.

Dans un quatrième mode de réalisation, le bouchon de la paillette selon l'invention est tripartite.In a fourth embodiment, the plug of the straw according to the invention is tripartite.

Il est constitué de trois parties sensiblement de même longueur ou de longueurs différentes.It consists of three parts of substantially the same length or different lengths.

La partie externe, qui n'est pas en contact direct avec le liquide contenu dans la paillette, est un tampon, par exemple une tresse, en substance fibreuse standard, par exemple en polyester viscose.The external part, which is not in direct contact with the contained liquid in the glitter, is a tampon, for example a braid, of fibrous substance standard, for example in polyester viscose.

La partie interne, en contact avec le liquide contenu dans la paillette, est constituée d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques, ledit noyau comportant une tresse centrale en fils hydrophiles ou hydrofuges.The internal part, in contact with the liquid contained in the straw, is consisting of a core of thermoplastic material sheathed by wires, by synthetic examples, said core comprising a central braid of threads hydrophilic or water repellent.

La partie intermédiaire est constituée de poudre gélifiante.The intermediate part consists of gelling powder.

Dans le cas d'un bouchon tripartite, la longueur totale du bouchon est comprise entre environ 7 mm et environ 14 mm.In the case of a tripartite plug, the total length of the plug is between approximately 7 mm and approximately 14 mm.

La partie externe a une longueur comprise entre environ 3 mm et environ 6 mm.The external part has a length between approximately 3 mm and approximately 6 mm.

La partie interne a une longueur comprise entre environ 2 mm et environ 5 mm.The internal part has a length between approximately 2 mm and approximately 5 mm.

La partie intermédiaire a une longueur comprise entre environ 1,5 mm et environ 3 mm.The intermediate part has a length of between approximately 1.5 mm and about 3 mm.

Dans un cinquième mode de réalisation, le bouchon de la paillette selon l'invention est monobloc et il est constitué d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques. Les fils de la gaine sont imprégnés de poudre gélifiante. In a fifth embodiment, the plug of the straw according to the invention is in one piece and consists of a material core thermoplastic sheathed by threads, for example synthetic. The sons of the sheath are impregnated with gelling powder.

Dans un sixième mode de réalisation, le bouchon de la paillette selon l'invention est monobloc et il est constitué d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques et il comprend une tresse centrale en fils hydrophiles ou hydrofuges imprégnée de poudre gélifiante.In a sixth embodiment, the plug of the straw according to the invention is in one piece and consists of a material core thermoplastic sheathed by threads, for example synthetic and it includes a central braid in hydrophilic or water-repellent son impregnated with powder gelling.

La longueur du bouchon monobloc selon l'invention est comprise entre environ 5 mm et environ 14 mm.The length of the one-piece stopper according to the invention is between about 5 mm and about 14 mm.

La paillette de l'invention conduit à une absorption très faible du liquide qui y est contenu, de l'ordre de 4 % et même moins.The straw of the invention leads to a very low absorption of the liquid contained therein, of the order of 4% and even less.

L'invention sera décrite plus en détail mais de façon non limitative en référence aux Figures annexées dans lesquelles

  • la Figure 1 représente une vue partielle d'une paillette de l'invention selon le premier mode de réalisation,
  • la Figure 2 représente une vue partielle d'une paillette de l'invention selon le deuxième mode de réalisation,
  • la Figure 3 représente une vue partielle d'une paillette de l'invention selon le troisième mode de réalisation,
  • la Figure 4 représente une vue partielle d'une paillette de l'invention selon le quatrième mode de réalisation,
  • la Figure 5 représente une vue partielle d'une paillette de l'invention selon le cinquième mode de réalisation,
  • la Figure 6 représente une vue partielle d'une paillette de l'invention selon le sixième mode de réalisation.
The invention will be described in more detail but without limitation with reference to the accompanying Figures in which
  • FIG. 1 represents a partial view of a straw of the invention according to the first embodiment,
  • FIG. 2 represents a partial view of a straw of the invention according to the second embodiment,
  • FIG. 3 represents a partial view of a straw of the invention according to the third embodiment,
  • FIG. 4 represents a partial view of a straw of the invention according to the fourth embodiment,
  • FIG. 5 represents a partial view of a straw of the invention according to the fifth embodiment,
  • Figure 6 shows a partial view of a straw of the invention according to the sixth embodiment.

En référence à la Figure 1, la paillette 1 se compose d'un segment de tube 2 muni à l'une de ses extrémités d'un bouchon 3 tripartite.Referring to Figure 1, the glitter 1 consists of a segment of tube 2 provided at one of its ends with a tripartite plug 3.

La partie externe 31, qui n'est pas en contact avec du liquide contenu dans la paillette, est constituée d'un noyau 43 en matière thermoplastique gainé par des fils en une gaine 53.The external part 31, which is not in contact with the contained liquid in the straw, consists of a core 43 of sheathed thermoplastic material by wires in a sheath 53.

La partie interne 33, en contact avec du liquide contenu dans la paillette, est constituée d'un noyau 43 en matière thermoplastique gainé par des fils en une gaine 53.The internal part 33, in contact with the liquid contained in the straw, consists of a core 43 of thermoplastic material sheathed by wires a sheath 53.

La partie intermédiaire 32 est constituée de poudre gélifiante 7. The intermediate part 32 consists of gelling powder 7.

En référence à la Figure 2, la paillette 1 se compose d'un segment de tube 2 muni à l'une de ses extrémités d'un bouchon 3 tripartite.Referring to Figure 2, the glitter 1 consists of a segment of tube 2 provided at one of its ends with a tripartite plug 3.

La partie externe 31, qui n'est pas en contact avec du liquide contenu dans la paillette, est une tresse en substance fibreuse.The external part 31, which is not in contact with the contained liquid in the glitter, is a braid with a fibrous substance.

La partie interne 33, en contact avec du liquide contenu dans la paillette, est constituée d'un noyau 43 en matière thermoplastique gainé par des fils en une gaine 53.The internal part 33, in contact with the liquid contained in the straw, consists of a core 43 of thermoplastic material sheathed by wires a sheath 53.

La partie intermédiaire 32 est constituée de poudre gélifiante 7.The intermediate part 32 consists of gelling powder 7.

En référence à la Figure 3, la paillette 1 se compose d'un segment de tube 2 muni à l'une de ses extrémités d'un bouchon 3 tripartite.With reference to Figure 3, the glitter 1 consists of a segment of tube 2 provided at one of its ends with a tripartite plug 3.

La partie externe 31, qui n'est pas en contact avec du liquide contenu dans la paillette, est une tresse en substance fibreuse.The external part 31, which is not in contact with the contained liquid in the glitter, is a braid with a fibrous substance.

La partie interne 33, en contact avec du liquide contenu dans la paillette, est constituée d'un noyau 43 en matière thermoplastique gainé par des fils en une gaine 53. Le noyau 43 comporte un alésage 8.The internal part 33, in contact with the liquid contained in the straw, consists of a core 43 of thermoplastic material sheathed by wires a sheath 53. The core 43 has a bore 8.

La partie intermédiaire 32 est constituée de poudre gélifiante 7.The intermediate part 32 consists of gelling powder 7.

En référence à la Figure 4, la paillette 1 se compose d'un segment de tube 2 muni à l'une de ses extrémités d'un bouchon 3 tripartite.Referring to Figure 4, the glitter 1 consists of a segment of tube 2 provided at one of its ends with a tripartite plug 3.

La partie externe 31, qui n'est pas en contact avec du liquide contenu dans la paillette, est une tresse en substance fibreuse.The external part 31, which is not in contact with the contained liquid in the glitter, is a braid with a fibrous substance.

La partie interne 33, en contact avec du liquide contenu dans la paillette, est constituée d'un noyau 43 en matière thermoplastique gainé par des fils en une gaine 53. Le noyau 43 comporte une tresse centrale 63.The internal part 33, in contact with the liquid contained in the straw, consists of a core 43 of thermoplastic material sheathed by wires a sheath 53. The core 43 includes a central braid 63.

La partie intermédiaire 32 est constituée de poudre gélifiante 7.The intermediate part 32 consists of gelling powder 7.

En référence à la Figure 5, la paillette 1 se compose d'un segment de tube 2 muni à l'une de ses extrémités d'un bouchon 3 monobloc.Referring to Figure 5, the glitter 1 consists of a segment of tube 2 provided at one end with a one-piece plug 3.

Le bouchon 3 est constitué d'un noyau 4 en matière thermoplastique gainé par des fils constituant une gaine 5. Les fils de la gaine 5 sont imprégnés d'une poudre gélifiante 7.The plug 3 consists of a core 4 of thermoplastic material sheathed by wires constituting a sheath 5. The wires of sheath 5 are impregnated a gelling powder 7.

En référence à la Figure 6, la paillette 1 se compose d'un segment de tube 2 muni à l'une de ses extrémités d'un bouchon 3 monobloc. With reference to Figure 6, the glitter 1 consists of a segment of tube 2 provided at one end with a one-piece plug 3.

Le bouchon 3 est constitué d'un noyau 4 en matière thermoplastique gainé par des fils constituant une gaine 5 et comprenant une tresse centrale 6 en fils synthétiques imprégnée de poudre gélifiante 7.The plug 3 consists of a core 4 of thermoplastic material sheathed by wires constituting a sheath 5 and comprising a central braid 6 of synthetic threads impregnated with gelling powder 7.

Les fils constituant la gaine 5 sont imprégnés de poudre gélifiante.The wires constituting the sheath 5 are impregnated with gelling powder.

L'homme du métier comprendra que bien que l'invention ait été décrite et illustrée pour des modes de réalisation particuliers, de nombreuses variantes peuvent être envisagées tout en restant dans le cadre de l'invention tel que défini dans les revendications annexées.Those skilled in the art will understand that although the invention has been described and illustrated for particular embodiments, many variants can be envisaged while remaining within the scope of the invention such that defined in the appended claims.

Claims (17)

Paillette (1) pour la conservation de petites quantités de substances, notamment des substances biologiques, se composant d'un segment de tube (2) muni à l'intérieur de l'une de ses extrémités d'un bouchon (3) comportant de la poudre gélifiante (7), caractérisée en ce que ledit bouchon de paillette comprend un noyau (4, 43) en matière thermoplastique gainé par des fils constituant une gaine (5, 53).Straw (1) for the conservation of small quantities of substances, in particular biological substances, consisting of a tube segment (2) provided inside one of its ends with a stopper (3) comprising the gelling powder (7), characterized in that said glitter plug comprises a core (4, 43) made of thermoplastic material sheathed by wires constituting a sheath (5, 53). Paillette selon la revendication 1, caractérisée en ce que les fils de la gaine (5, 53) sont synthétiques.A straw according to claim 1, characterized in that the threads of the sheath (5, 53) are synthetic. Paillette selon la revendication 2, caractérisée en ce que les fils synthétiques sont en polyester.A straw according to claim 2, characterized in that the synthetic threads are made of polyester. Paillette selon l'une quelconque des revendications 1 à 3, caractérisée en ce que la gaine (5) est réalisée sous la forme d'une tresse.A straw according to any one of claims 1 to 3, characterized in that the sheath (5) is produced in the form of a braid. Paillette selon l'une quelconque des revendications 1 à 4, caractérisée en ce que le bouchon (3) est tripartite et constitué d'une partie externe, qui n'est pas en contact direct avec le liquide contenu dans ladite paillette, et d'une partie interne en contact avec le liquide contenu dans ladite paillette, lesdites partie externe et partie interne enserrant une partie intermédiaire constituée de poudre gélifiante.A straw according to any one of claims 1 to 4, characterized in that the stopper (3) is tripartite and consists of an external part, which is not in direct contact with the liquid contained in said straw, and an internal part in contact with the liquid contained in said flake, said external part and internal part enclosing an intermediate part made up of gelling powder. Paillette selon l'une quelconque des revendications 1 à 4, caractérisée en ce que le bouchon (3) est monobloc.A straw according to any one of claims 1 to 4, characterized in that the plug (3) is in one piece. Paillette selon la revendication 5, caractérisée en ce que le bouchon (3) tripartite est constitué d'une partie externe (31) composé d'un noyau (41) en matière thermoplastique gainé par des fils en constituant une gaine (51), d'une partie interne (33) composée d'un noyau (43) en matière thermoplastique gainé par des fils en constituant une gaine (53) et d'une partie intermédiaire (32) composée de poudre gélifiante (7).A straw according to claim 5, characterized in that the three-part stopper (3) consists of an external part (31) composed of a core (41) of thermoplastic material sheathed by wires constituting a sheath (51), d 'an internal part (33) composed of a core (43) of thermoplastic material sheathed by wires constituting a sheath (53) and an intermediate part (32) composed of gelling powder (7). Paillette selon la revendication 5, caractérisée en ce que le bouchon (3) tripartite est constitué d'une partie externe (31) composée d'un tampon en substance fibreuse, d'une partie interne (33) composée d'un noyau (43) en matière thermoplastique gainé par des fils en constituant une gaine (53) et d'une partie intermédiaire (32) composée de poudre gélifiante (7).A straw according to claim 5, characterized in that the three-part stopper (3) consists of an external part (31) composed of a pad of fibrous substance, of an internal part (33) composed of a core (43 ) in thermoplastic material sheathed by wires constituting a sheath (53) and an intermediate part (32) composed of gelling powder (7). Paillette selon la revendication 5, caractérisée en ce que le bouchon (3) tripartite est constitué d'une partie externe (31) composée d'un tampon en substance fibreuse, d'une partie interne (33) composée d'un noyau (43) en matière thermoplastique gainé par des fils en constituant une gaine (53), ledit noyau comportant un alésage (8) et d'une partie intermédiaire (32) composée de poudre gélifiante (7).A straw according to claim 5, characterized in that the three-part stopper (3) consists of an external part (31) composed of a pad of fibrous substance, of an internal part (33) composed of a core (43 ) made of thermoplastic material sheathed by wires constituting a sheath (53), said core comprising a bore (8) and an intermediate part (32) composed of gelling powder (7). Paillette selon la revendication 5, caractérisée en ce que le bouchon (3) tripartite est constitué d'une partie externe (31) composée d'un tampon en substance fibreuse, d'une partie interne (33) composée d'un noyau (43) en matière thermoplastique gainé par des fils en constituant une gaine (53), ledit noyau comportant une tresse centrale (63), et d'une partie intermédiaire composée de poudre gélifiante (7).A straw according to claim 5, characterized in that the three-part stopper (3) consists of an external part (31) composed of a pad of fibrous substance, of an internal part (33) composed of a core (43 ) made of thermoplastic material sheathed by wires constituting a sheath (53), said core comprising a central braid (63), and an intermediate part composed of gelling powder (7). Paillette selon la revendication 6, caractérisée en ce que le bouchon monobloc est constitué d'un noyau (4) en matière thermoplastique gainé par des fils constituant une gaine (5) imprégnés d'une poudre gélifiante (7).A straw according to claim 6, characterized in that the one-piece stopper consists of a core (4) of thermoplastic material sheathed by wires constituting a sheath (5) impregnated with a gelling powder (7). Paillette selon la revendication 6, caractérisée en ce que le bouchon monobloc est constitué d'un noyau (4) en matière thermoplastique gainé par des fils constituant une gaine (5) et comprenant une tresse centrale (6) imprégnée de poudre gélifiante (7).A straw according to claim 6, characterized in that the one-piece stopper consists of a core (4) of thermoplastic material sheathed by wires constituting a sheath (5) and comprising a central braid (6) impregnated with gelling powder (7) . Paillette selon l'une quelconque des revendications 1 à 12, caractérisée en ce que les fils de la gaine sont blancs.Paillette according to any one of Claims 1 to 12, characterized in that the threads of the sheath are white. Paillette selon l'une quelconque des revendications 1 à 12, caractérisée en ce que les fils de la gaine sont en couleur, constituant un indicateur couleur du contenu de la paillette.Glitter according to any one of Claims 1 to 12, characterized in that the threads of the sheath are in color, constituting a color indicator of the content of the glitter. Paillette selon l'une quelconque des revendications 1 à 12, caractérisée en ce que le noyau est coloré, constituant un indicateur couleur du contenu de la paillette.Glitter according to any one of claims 1 to 12, characterized in that the core is colored, constituting a color indicator of the content of the glitter. Paillette selon l'une quelconque des revendications 1 à 12, caractérisée en ce que la poudre gélifiante est colorée, constituant un indicateur couleur du contenu de la paillette Glitter according to any one of Claims 1 to 12, characterized in that the gelling powder is colored, constituting a color indicator of the content of the glitter Paillette selon l'une quelconque des revendications 1 à 16, caractérisée en ce que la poudre gélifiante est choisie parmi les alginates et l'alcool polyvinylique.A straw according to any one of claims 1 to 16, characterized in that the gelling powder is chosen from alginates and polyvinyl alcohol.
EP02291120.0A 2001-05-07 2002-05-03 Straw for the preservation of small amounts of substances, notably of biological liquids Expired - Lifetime EP1256329B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0106080 2001-05-07
FR0106080A FR2824255B1 (en) 2001-05-07 2001-05-07 STRAW FOR THE PRESERVATION OF SMALL QUANTITIES OF SUBSTANCES, ESPECIALLY BIOLOGICAL LIQUIDS

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EP1256329A1 true EP1256329A1 (en) 2002-11-13
EP1256329B1 EP1256329B1 (en) 2016-12-07

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US (1) US7056727B2 (en)
EP (1) EP1256329B1 (en)
JP (1) JP4118593B2 (en)
KR (1) KR20020085824A (en)
CN (1) CN1277527C (en)
CA (1) CA2383281C (en)
FR (1) FR2824255B1 (en)
MX (1) MXPA02004542A (en)
PL (1) PL203867B1 (en)
RU (1) RU2233783C2 (en)
TW (1) TW544309B (en)
UA (1) UA70389C2 (en)

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EP2198804A1 (en) 2008-12-18 2010-06-23 IMV Technologies Straw for the conservation of a predetermined dose of a liquid base substance, in particular a biological substance
FR3004332B1 (en) 2013-04-11 2018-03-02 Imv Technologies STRAW FOR PRESERVING A PREDETERMINED DOSE OF A LIQUID-BASED SUBSTANCE, IN PARTICULAR PURE OR DILUTED ANIMAL SEED
FR3011732B1 (en) * 2013-10-15 2016-09-09 Imv Tech (EN) STRAW FOR THE PRESERVATION OF A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCES, IN PARTICULAR PURE OR DILUTED ANIMAL SEED; AND TOGETHER THE COMPRISING
FR3011731B1 (en) 2013-10-15 2016-10-28 Imv Tech (EN) STRAW FOR THE PRESERVATION OF A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCES, IN PARTICULAR PURE OR DILUTED ANIMAL SEED; AND TOGETHER THE COMPRISING
FR3017792B1 (en) 2014-02-21 2019-08-23 Imv Technologies PAILLETTE FOR PRESERVING A PREDETERMINED DOSE OF A LIQUID-BASED SUBSTANCE, IN PARTICULAR A BIOLOGICAL SUBSTANCE
FR3017793B1 (en) 2014-02-21 2019-08-23 Imv Technologies PAILLETTE FOR PRESERVING A PREDETERMINED DOSE OF A LIQUID-BASED SUBSTANCE, IN PARTICULAR A BIOLOGICAL SUBSTANCE
FR3021522A1 (en) 2014-05-28 2015-12-04 Imv Technologies STRAW FOR THE PRESERVATION OF A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCES, IN PARTICULAR DILUTED ANIMAL SEED; DILUTION MEDIUM FOR GIVING SUCH A SUBSTANCE; AND SYSTEM COMPRISING THEM
FR3034980B1 (en) 2015-04-20 2017-05-12 Imv Tech SPRAY FOR PRESERVING A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCE
FR3036954B1 (en) 2015-06-03 2017-07-14 Imv Tech STRAW FOR PRESERVING A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCE, AND INJECTION DEVICE AND METHOD FOR CARRYING OUT THE SAME
EP3120927A1 (en) * 2015-07-24 2017-01-25 Centre National De La Recherche Scientifique Entangled fluidic device
FR3046715B1 (en) * 2016-01-19 2018-02-16 Imv Technologies DEVICE FOR PRESERVING A PREDETERMINED DOSE OF A LIQUID-BASED SUBSTANCE AND A RANGE OF SUCH DEVICES
FR3074419B1 (en) 2017-12-05 2019-12-27 Imv Technologies GLITTER FOR THE CRYOGENIC PRESERVATION OF A DOSE OF LIQUID-BASED SUBSTANCE, ASSEMBLY COMPRISING SAME AND METHOD FOR EMPTYING THE GLITTER
KR20240015455A (en) 2022-07-27 2024-02-05 성원메디칼 주식회사 Device for frozen keeping animal semen

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JP2002369742A (en) 2002-12-24
KR20020085824A (en) 2002-11-16
MXPA02004542A (en) 2002-11-20
US20020183653A1 (en) 2002-12-05
CN1277527C (en) 2006-10-04
US7056727B2 (en) 2006-06-06
PL203867B1 (en) 2009-11-30
FR2824255B1 (en) 2004-02-06
RU2233783C2 (en) 2004-08-10
CA2383281A1 (en) 2002-11-07
JP4118593B2 (en) 2008-07-16
RU2002111842A (en) 2004-01-20
TW544309B (en) 2003-08-01
CA2383281C (en) 2007-06-26
UA70389C2 (en) 2004-10-15
CN1383795A (en) 2002-12-11
PL353725A1 (en) 2002-11-18
FR2824255A1 (en) 2002-11-08
EP1256329B1 (en) 2016-12-07

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