EP1237470A4 - Verfahren und system zur verbesserung von photoplethysmographischen analytmessungen durch mindergewrichtung von daten mit bewegungsartefakten - Google Patents
Verfahren und system zur verbesserung von photoplethysmographischen analytmessungen durch mindergewrichtung von daten mit bewegungsartefaktenInfo
- Publication number
- EP1237470A4 EP1237470A4 EP00992667A EP00992667A EP1237470A4 EP 1237470 A4 EP1237470 A4 EP 1237470A4 EP 00992667 A EP00992667 A EP 00992667A EP 00992667 A EP00992667 A EP 00992667A EP 1237470 A4 EP1237470 A4 EP 1237470A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- motion
- output signals
- data
- degree
- processor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
- A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
- A61B5/7214—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts using signal cancellation, e.g. based on input of two identical physiological sensors spaced apart, or based on two signals derived from the same sensor, for different optical wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
Definitions
- the present invention generally relates to photoplethysmographic measurement systems, and, in particular, to a method and system for improving photoplethysmographic analyte measurements by preprocessing measurement data to compensate for measurement artifact such as by de-weighting motion-contaminated data.
- photoplethysmographic measurement systems such as pulse oximeters
- pulse oximeters include a probe for releasably attaching to the tip of a patient's appendage (e.g., a finger, earlobe or the nasal septum).
- the probe directs light signals into the appendage where the probe is attached. Some portion of the light is absorbed by the tissue and a remaining portion of the light passes through patient tissue. The intensity of light passing through the tissue is monitored by a sensor typically contained in the probe. The intensity related signals produced by the sensor are used to compute blood analyte related values.
- measurements such as blood oxygen saturation levels computed by the pulse oximeter can be distorted by various factors including movement of the appendage where the probe is attached. For example, the movement of the patient may affect source/detector alignment, ambient light levels, blood volume fluctuation or other factors, thus resulting in potential measurement errors.
- Some instrument designs have attempted to address such artifact through the use of hardware such as filters to screen the detector signals. However, such approaches have generally had a limited ability to distinguish artifact components of the signal from desired information, resulting in loss of information and/or admission of substantial artifact into the data used for calculations.
- the present invention is directed to a system and corresponding method for use in a pulse oximeter to improve the way in which data output by a pulse oximeter sensor, such as data representing a pulse waveform, is preprocessed prior to the computation of blood oxygen saturation levels.
- the present system quantifies artifactual components (e.g., motion artifact) contained in a set of data aggregated over a certain time interval (e.g., one or more pulse cycles or portions thereof or simply a given predetermined time interval) and preprocesses the set of data such that the effect of artifactual components is reduced.
- artifactual components e.g., motion artifact
- the blood oxygen saturation levels may be computed based on multiple sets of preprocessed data so as to improve the accuracy of the pulse oximetry measurements.
- an apparatus for evaluating the reliability of output signals produced by a pulse oximeter sensor is provided. Electrical output signals produced by the sensor may be captured at a defined interval. Each captured set of signals maybe analyzed independently to estimate a degree of artifactual component reflected in the set of output signals. Unreliable sets of output signals can be addressed in a variety of ways.
- a weight metric may be generated which accurately reflects the degree of artifactual component in the output signals. The weight metric may then be used to relatively emphasize or de-emphasize each set of output signals in proportion to the degree of artifactual component estimated such that the sets of output signals used in the blood analyte computation are dominated by output signals with a relatively small artifactual component.
- sets of output signals that are deemed to be unreliable i.e., the degree of artifactual component associated therewith exceeds a certain threshold
- motion affected data is identified based on a numerical or mathematical analysis of the data.
- the electrical output signals generated by the photodetector may be separated into red and infrared data by a hardware or software based demultiplexer. The reliability of output signals maybe evaluated on the basis of data points derived from separated red and infrared pulse waveforms.
- the motion contained in output signals produced by the pulse oximetry sensor may be quantified based on spread of the data points, e.g., from a regression model such as a best-fit linear regression line.
- the red and infrared pulse waveforms are used to acquire differential absorption values dA x and dA y respectively.
- Each pulse cycle is represented by a set of data points, where each data point represents a pair of corresponding differential absorption values dA x and dA y obtained at a specific point in time within each pulse cycle.
- a principal component analysis (“PCS”) may be performed on each set of data points to estimate an amount of motion affecting the data.
- First and second principal components derived from the PCA account for different amounts of variation among the set of data points.
- the first principal component may describe the cluster of data points disposed along a longitudinal axis and the second principal component may describe the amount of spread of the data points with respect to the longitudinal axis.
- An amount of motion associated with a set of data points may be approximated by multiplying the RMS (Root Mean Square) variation along the axis of the first principal component by the RMS variation along the axis of the second principal component.
- a method for distinguishing motion artifact from the plethysmographic signal. It has been recognized that the artifact due to motion can be distinguished from other data anomalies because motion affects tend to be relatively evenly distributed over multiple channels (a channel being the electronic or digital data received from any given emitter in a photoplethysmographic system). Accordingly, motion effects can be identified and quantified by mathematically accounting for a corresponding bias or tendency in the data.
- each data point generally includes a plethysmographic content and a motion content.
- the motion content of a data point may be represented by a shift of the data point at a 45-degree angle, the amount of shift indicating the degree of motion affecting the data point.
- the data will also be spread along some other angle which is determined by blood analyte levels.
- the random spreading of points in two directions expands the area occupied by the points.
- motion artifact present in a data point may be quantified based on the area filled by the spreading of the points.
- a set of data points may be characterized by a parallelogram, the boundary of which encompasses a majority of data points.
- the amount of motion associated with such set of data points may be estimated by approximating the area of the parallelogram which outlines the data points.
- one or more buffers or data storage units may be utilized to temporarily store data generated by a pulse oximeter so that the data may be accessed and manipulated by processing modules to improve the accuracy of analyte related computation such as an oxygen saturation level computation.
- dual buffer system architecture is utilized.
- a first buffer is used to temporarily store a set of data representing at least one pulse cycle or other time period of data from a pulse oximetry sensor.
- a first processing module accesses the raw data stored in the first buffer to preprocess the raw data and yield preprocessed data. The preprocessed data can then be used, on a set-by-set or aggregated basis, to make the desired analyte related computations.
- each set of preprocessed data may be transferred into a second buffer which is adapted to temporarily store multiple sets of preprocessed data most recently received from the first processing module.
- the dual buffer system architecture of the present invention may be used for various purposes.
- the data output by the sensor may be processed to eliminate, de- weight, or otherwise address data components that are not representative of the desired analyte related values, such as electronic noise, environmental noise, motion, or other artifact.
- the first processing module may include a combination of a motion estimator and a weight application module. The motion estimator quantifies an amount of motion associated with the raw data stored in the first buffer by performing a principal component analysis on differential absorption values derived from the output signals.
- the weight application module is configured to associate a weight with the raw data in the first buffer and transfer the weighted data to the second buffer.
- a second processing module may then assess multiple pulse cycles of improved data accumulated in the second buffer to perform its oxygen saturation level computation.
- buffered or preprocessed data may be utilized to reduce the effect of artifactual component, such as motion artifact, in raw signal output by a pulse oximeter.
- a quantity of motion artifact identified in a set of input data, representing raw signals produced by a pulse oximeter sensor during a defined time period may be utilized to selectively emphasize and/or de-emphasize the set of data based upon the quality of the data.
- the effect of data sets that are contaminated by an unacceptable amount of artifactual component may be substantially minimized or eliminated from the final computation thereof.
- a threshold value is used to distinguish between acceptable data (relatively free of motion) and unacceptable data (affected by motion). Data collected over each pulse cycle is considered in the blood analyte computation if the degree of motion associated therewith is below a threshold value. Otherwise, if the degree of motion exceeds the threshold, the data is discarded from further consideration in the final computation.
- weighting is used to either emphasize or de-emphasize data depending on the quantity of motion associated with the data. A quantity of motion content is estimated for each set of data stored in the first buffer. Then, a weight parameter is assigned to each set of data such that a motion- affected set of data may be relatively de-emphasized and/or a motion-free set of data is relatively emphasized.
- the blood analyte levels may be computed by performing a linear regression analysis on the weighted sets of data collected over multiple pulse cycles.
- the slope of the best-fit line equation derived from the linear regression analysis provides an accurate blood oxygen level since the weighted sets of data are dominated by those with relative low motion content.
- processing logic maybe utilized to compensate for motion-affected data.
- the process of estimating a quantity of motion and associating a weight parameter in proportion to the quantity of motion estimated may be embodied in the form of a software program or an executable set of instructions running on a processor.
- a stream of pulse waveforms provided by the photodetector may be processed by a software routine configured to determine the quantity of motion artifact present in the raw data and manipulate the raw data in such a way as to produce an improved preprocessed data which more accurately reflects the actual blood oxygen saturation levels by reducing the effect of or eliminating raw data contaminated by undesirable artifactual content, i.e., due to movement of the patient.
- FIG. 1 is a block diagram illustrating a system for improving photoplethysmographic analyte measurements in accordance with the present invention.
- FIG. 2 is a flow diagram illustrating the general steps involved in obtaining improved photoplethysmographic analyte measurements in accordance with the present invention.
- FIG. 3 is a graph illustrating an example of a pulse waveform received from the channel Y of FIG. 1.
- FIG. 4 is a graph illustrating an example of a pulse waveform received from the channel X of FIG. 1.
- FIG. 5 is a graph illustrating an example of data points of differential absorption values dA x and dA y which are relatively unaffected by motion.
- FIG. 6 is a graph illustrating a 45-degree bias contained in the data points which is caused by motion component added to the photoplethysmographic component.
- FIG. 7 is a graph illustrating first and second principal components of the data points and how they relate to a best-fit linear regression line if no motion is present in pulse waveforms.
- FIG. 8 is a graph illustrating an example of data points which are affected by relatively large amounts of motion.
- FIG. 9 is a graph illustrating weighted data points temporarily stored in the second regression buffer and a linear regression line that best fits the weighted data points.
- a system according to the present invention is generally designated at 100.
- the present invention is used in a photoplethysmographic measurement instrument to improve the accuracy of blood analyte values computed by the instrument by reducing the effect of artifact due to motion of a patient or due to motion of the measurement probe relative to the patient.
- the measurement instrument will be described in terms of a pulse oximeter which noninvasively measures an oxygen saturation level.
- Included in the illustrated pulse oximeter are one or more light emitters 104 which emit light signals at different predetermined center wavelengths.
- at least two light emitters 104 are utilized, one emitter for radiating red light and the other emitter for radiating infrared light.
- the light emitters may be light emitting diodes (LEDs) or laser diodes.
- the pulse oximeter may include a probe which is adapted to removably attach to an appendage of a patient 106, such as a finger, earlobe, nasal septum, or other tissue, during a medical examination.
- the probe directs the light signals generated by the light emitters onto one side of the appendage.
- a photodetector 108 which monitors the intensity of light that is transmitted through the tissue and produces output signals corresponding to the intensity of light received.
- the output signals produced by the photodetector are processed by a signal processor 110 and the resulting processed signals are transmitted to the system 100.
- the signal processor 110 may include, for example, amplifier circuitry, an analog to digital convertor, and other circuitry for processing the photodetector signals.
- the system 100 also separately analyzes the red and infrared signals.
- a hardware or software demultiplexer may be employed.
- the signal processor 110 may further include a demultiplexer for separating the signal into channels. In such implementations, certain other components such as A/D converters maybe duplicated for each channel.
- a composite signal including both the red and infrared components is transmitted to the system 100 and appropriate logic is used to analyze the composite signal and derive the different wavelength components therefrom.
- the composite signal may be time division multiplexed, frequency division multiplexed, or other multiplexing mechanisms may be utilized.
- one or more data storage modules e.g. buffers
- a dual buffer system architecture having a first buffer 116 and a second buffer 120 is employed.
- the first buffer 116 is used to temporarily store an aggregate set of data transmitted by the demultiplexer 100 during a defined time interval.
- the length of the defined time interval is preferably sufficient to cover at least one full plethysmographic pulse cycle, i.e., on the order of about 1.5 seconds.
- the first regression buffer 116 is in communication with the signal processor 110 to capture a set of data points representing the red and infrared digitized data transmitted thereby.
- the set of data points stored in the first regression buffer 116 may be influenced by artifact, caused by movement of the body area where the pulse oximetry probe is placed.
- the set of data points in the first buffer is accessed by an artifactual component estimator 122 configured to estimate an amount of artifactual component associated with the set of data points.
- the artifactual component estimator 122 may be configured to estimate a degree of motion artifact reflected in the data points (which will be described in more detail hereinbelow).
- the estimator 122 serves to analyze each captured set of data points independently in order to evaluate the reliability of output signals produced by the photodetector 108.
- a weight parameter generator 124 is utilized to associate a weight parameter with the set of data points in the first buffer based on the amount of artifactual component (e.g. motion) estimated.
- the weight parameter is used by a weight parameter application module 118 to discriminate between those data that are affected by an artifactual component and those that are relatively unaffected by an artifactual component.
- An unreliable set of data points can be addressed in a variety of ways.
- the weight parameter reflecting the degree of artifactual component in the data points may be used by the module 118 to relatively emphasize or de-emphasize each set of output points.
- the module 118 may be configured to eliminate sets of data points that are deemed to be unreliable, e.g. if the degree of artifactual component associated therewith exceeds a certain threshold.
- the preprocessed set of data points is then transferred into the second buffer.
- the second buffer may be sized to temporarily store multiple sets of preprocessed data most recently processed by the module 118, on a FIFO basis.
- the preprocessed data stored in the second buffer can be used by an analyte computing module 126, on a set-by-set or aggregated basis, to make the desired analyte related computations.
- the analyte computing module 126 is configured to processes multiple sets of data stored in a second buffer 120 accompanied by the corresponding weight parameters to compute the oxygen saturation level.
- the computation results made by the analyte 5 computing module 126 are then output to a display 128.
- a stream of pulse waveforms provided by the photodetector may be processed by a software routine configured to estimate a quantity of artifactual component present in the raw data and manipulate the raw data in such a way as to produce an improved preprocessed data stream which more accurately reflects the actual blood oxygen saturation levels by reducing the effect of or eliminating raw data 5 contaminated by undesirable artifactual content.
- the present invention utilizes a first buffer to capture a certain time interval of the stream of pulse waveforms produced by the photodetector and utilizes a separate process to analyze and process the data stored in the first buffer and yield preprocessed data to be temporarily stored in a second buffer.
- a first buffer to capture a certain time interval of the stream of pulse waveforms produced by the photodetector and utilizes a separate process to analyze and process the data stored in the first buffer and yield preprocessed data to be temporarily stored in a second buffer.
- the pulse waveforms are produced by a pulse oximeter sensor as a result of light signals radiated by 5 the red and infrared LEDs interacting with the tissue and blood carried therein.
- the pulse waveforms in one channel correspond to samples of red intensity and the pulse waveforms in the other channel correspond to samples of infrared intensity.
- a ratio of the red absorption to the infrared absorption may be alternatively obtained through the use of logarithms .
- FIG. 5 a graphic representation of a linear regression analysis for computing blood analyte levels is shown.
- Each data point represents a plot of a differential absorption value dA y versus a corresponding differential absorption value dA acquired at the same or adjacent point in time.
- the set of differential absorption values dA and dA y is acquired during a short time interval, i.e., one pulse cycle.
- a linear regression analysis is performed on each set of the data points individually to determine a straight line 500 that best fits the set of data points, the slope of which represents the ratio of dA y and dA x .
- This ratio of dA y and dA may be used to determine an oxygen saturation level. These data points are tightly scattered around the best-fit line 500 indicative of good data relatively unaffected by motion or other artifacts. It should be noted that the best-fit straight line may be derived from use of any standard mathematical techniques such as a least-squares regression analysis.
- An actual set of data points received from the photodetector may include an artifactual component caused by various sources, such as movement of the patient.
- FIG. 6 illustrates in graphical form an example of how motion affects a set of data points. It has been found that the same motion affects each differential absorption values dA and dA y about the same, and thus a data point 606 affected by motion may be biased at, for example, a 45-degree angle, as shown by 608. Thus, data point 606 may lie anywhere along line 608 when influenced by motion artifact.
- the straight line 600 shows where data points should lie if no motion is present.
- the lines slanted, for example, in 45- degree 604 represent how the data points 602 may be displaced when data points corresponding to the ratios of the differential absorption values dA x and dA y are affected by motion.
- FIG. 7 graphically illustrates a principal component analysis ("PCA") performed on a set of data points to estimate the amount of motion.
- PCA principal component analysis
- the set of data points distributed within a two-dimensional space is described using first 704 and second 706 principal component vectors derived from the PCA.
- Each of the principal component vectors accounts for a different amount of variation among data points.
- the first principal component vector 704 describes the cluster of data points disposed along a longitudinal axis.
- the second principal component vector 706 extends perpendicular to the first principal component, the equation of which is used to describe the spread of data points with respect to the longitudinal axis.
- any number of algorithms may be used to estimate an amount of motion associated therewith.
- the area of the parallelogram 702 defining the region in which the data points are distributed is used to quantify the motion associated with the set of data points.
- the area of the parallelogram 702 may be approximated by multiplying the length of the first principal component vector by the length of the second principal component vector.
- FIG. 8 an example of data points affected by relatively large amounts of motion is shown.
- the straight line that would best fit the set of data points if the motion contents thereof are eliminated is represented by a line 800.
- a line 804 is identified as the best-fit line.
- the difference between the slope of the line 800 and the line 804 becomes greater as the magnitude of the motion content of the data points becomes greater, thereby destroying the correct relationship between the red and infrared intensity signals.
- the area of the parallelogram 802 may be used to estimate a degree of motion affecting the data. Incremental increase in the area of the parallelogram indicates an incremental reduction in the quality of data due to motion artifact contained therein.
- one way of obtaining a motion content of data is by performing a principal component analysis, in which the motion metric may be computed by multiplying the RMS variation along the axis of the first principle component by the RMS variation along the axis of the second principle component.
- the essence of the method is that motion is estimated according to the increase in the scatter of the points in several dimensions. Any method that gauges the increase in dA scatter to judge motion is within the spirit of the invention.
- the data may be excluded or de-weighted based on the degree of motion estimated.
- the data is processed using a weighting function which tends to emphasize data which is relatively unaffected by motion and de-weight data which is more affected.
- a weighting factor is computed from the motion metric. The weighting factor is used to de-emphasize data when high motion levels are detected.
- the data points are multiplied by the inverse of the square of the motion metric.
- the motion metric is compared against a threshold value. The threshold value is used to distinguish between motion-free and motion-affected pulse waveforms. Pulse waveforms are valid if the corresponding motion content is below a certain threshold value. In which case, the corresponding ratio of dA y to dA x is used in the blood analyte computation. The pulse waveforms that are beyond an acceptable limit are disregarded from further consideration in the blood analyte computation.
- FIG. 9 graphically illustrates the weighted data points stored in the second regression buffer.
- a linear regression analysis is performed on the weighted data points to obtain a best-fit line 900.
- the data points in the second regression buffer are dominated by data with low motion content.
- the second buffer contains data in which motion-free sets of data points 902, 904 are highly weighted (or emphasized) and motion- contaminated sets of data points 906, 908 are de-weighted or excluded. Motion-free points are shown as large dots, motion-contaminated data by smaller dots.
- the straight line fit relies most on the largest dots. Blood analyte levels can then be computed based on a linear equation yielding a best-fit line 900.
- the second regression buffer holds information taken from the first regression buffer over multiple plethysmographic cycles, on the order of 3 to 30 seconds. Because the data transferred from the first regression buffer are accompanied by their respective motion weighting factors (or, alternatively, consists only of data with acceptable low levels of motion), analyte computation performed using values in the second regression buffer are dominated by data with low motion content.
- the time interval covered by the second regression buffer is preferably long enough to encompass some motion-free data along with typical motion- contaminated data, but not so long as to provide blood analyte readings for an excessive time after such readings have ceased to be valid. In fact, the length of the second regression buffer may be dynamically variable depending on and proportional to, the quantity of motion present in the data.
- FIG. 2 Disclosed therein is a flowchart diagram which illustrates operation of the system for improving photoplethysmographic analyte measurements.
- a probe attached to a patient's appendage is used to direct the light signals generated by the light emitters at X and Y center wavelengths to an appendage of a patient under examination in step 200.
- the photodetector receives the light signals transmitted through the patient's appendage and converts the received light signals into analog output signals.
- the analog output signals produced by the photodetector include a plethysmographic component having characteristics that are a function of the level of the blood analyte of interest.
- the output signals may also include a motion component attributable to movement of the appendage where the probe is attached.
- the output signals are separated into red and infrared pulse waveforms and digitized by an analog-to-digital converter prior to preprocessing of the raw data from the photodetector.
- the red and infrared pulse waveforms aggregated over a time period at least equal to or exceeding one pulse cycle (although it is possible to use even less) are temporarily stored in the first data buffer.
- the red and infrared pulse waveforms are used to calculate differential absorption values dA x and dA y .
- a principal component analysis is performed on the differential absorption values stored in the first buffer. Based on the principal component analysis, a degree of motion content contained in the current set of data is estimated based on first and second principal component vectors derived from the PCA (step 212). Based on the degree of motion estimated, a weight parameter is assigned (step 214).
- step 216 the weight parameter application module multiplies each set of raw data in the first buffer by the corresponding weight parameter to emphasize motion-free raw data and/or de- emphasize motion-affected raw data to reduce the influence of motion-affected raw data.
- step 218 the set of data is transferred from the first buffer to the second regression buffer.
- step 220 the blood oxygen saturation levels are determined by performing a linear regression analysis on multiple pulse cycles of the weighted sets of data points in the second buffer.
- the dual buffer architecture of the present system has other applications where it is desirable to process a set of raw data collected in a first data storage area to provide a preprocessed data set which may be used with other preprocessed data sets accumulated over a certain time period in a second data storage area to ultimately perform mathematical computations to provide an accurate analyte measurement. It is possible that the subsystem modules 118, 122, 124 (FIG.
- the analyte computing module 126 may be replaced with any other suitable combinations of processing modules capable of accessing a set of data stored in the first buffer 116 and processing it so as to provide an improved set of data which may be ultimately used by the analyte computing module 126 to provide a more accurate blood oxygen saturation level.
- the "second regression buffer” simply refers to the photoplethysmographic data after it is processed by calculating the artifactual content regardless of the exact form or duration of the storage of these data.
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US46588399A | 1999-12-17 | 1999-12-17 | |
US465883 | 1999-12-17 | ||
US09/632,153 US6408198B1 (en) | 1999-12-17 | 2000-08-03 | Method and system for improving photoplethysmographic analyte measurements by de-weighting motion-contaminated data |
US632153 | 2000-08-03 | ||
PCT/US2000/042647 WO2001043624A2 (en) | 1999-12-17 | 2000-12-07 | Method for de-weighting motion-contaminated data in photoplethysmographic analyte measurements |
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EP1237470A2 EP1237470A2 (de) | 2002-09-11 |
EP1237470A4 true EP1237470A4 (de) | 2006-04-26 |
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EP00992667A Withdrawn EP1237470A4 (de) | 1999-12-17 | 2000-12-07 | Verfahren und system zur verbesserung von photoplethysmographischen analytmessungen durch mindergewrichtung von daten mit bewegungsartefakten |
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US6668182B2 (en) * | 2002-01-10 | 2003-12-23 | Northeast Monitoring | Pulse oxymetry data processing |
US9936885B1 (en) | 2014-03-31 | 2018-04-10 | Sensogram Technologies, Inc. | Apparatus for ambient noise cancellation in PPG sensors |
US10117586B1 (en) | 2014-03-31 | 2018-11-06 | Sensogram Technologies, Inc. | Continuous non-invasive wearable blood pressure monitoring system |
US10327649B1 (en) | 2014-03-31 | 2019-06-25 | Sensogram Technologies, Inc. | Non-invasive wearable blood pressure monitoring system |
JP6537900B2 (ja) * | 2015-06-09 | 2019-07-03 | 日本光電工業株式会社 | 医療用装置、生体パラメータ解析方法および生体パラメータ解析プログラム |
US10117598B1 (en) | 2015-11-08 | 2018-11-06 | Sensogram Technologies, Inc. | Non-invasive wearable respiration rate monitoring system |
US20220015681A1 (en) | 2018-11-11 | 2022-01-20 | Biobeat Technologies Ltd. | Wearable apparatus and method for monitoring medical properties |
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US5934277A (en) * | 1991-09-03 | 1999-08-10 | Datex-Ohmeda, Inc. | System for pulse oximetry SpO2 determination |
US5503148A (en) * | 1994-11-01 | 1996-04-02 | Ohmeda Inc. | System for pulse oximetry SPO2 determination |
US5662105A (en) * | 1995-05-17 | 1997-09-02 | Spacelabs Medical, Inc. | System and method for the extractment of physiological signals |
US5853364A (en) * | 1995-08-07 | 1998-12-29 | Nellcor Puritan Bennett, Inc. | Method and apparatus for estimating physiological parameters using model-based adaptive filtering |
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- 2000-12-07 EP EP00992667A patent/EP1237470A4/de not_active Withdrawn
- 2000-12-07 AU AU45202/01A patent/AU4520201A/en not_active Abandoned
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EP1237470A2 (de) | 2002-09-11 |
AU4520201A (en) | 2001-06-25 |
WO2001043624A2 (en) | 2001-06-21 |
WO2001043624A3 (en) | 2002-03-07 |
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