EP1222212A4 - Mutants il13 - Google Patents

Mutants il13

Info

Publication number
EP1222212A4
EP1222212A4 EP00968773A EP00968773A EP1222212A4 EP 1222212 A4 EP1222212 A4 EP 1222212A4 EP 00968773 A EP00968773 A EP 00968773A EP 00968773 A EP00968773 A EP 00968773A EP 1222212 A4 EP1222212 A4 EP 1222212A4
Authority
EP
European Patent Office
Prior art keywords
mutants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00968773A
Other languages
German (de)
English (en)
Other versions
EP1222212A1 (fr
Inventor
Waldemar Debinski
Jeffrey P Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Penn State Research Foundation
Original Assignee
Penn State Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Penn State Research Foundation filed Critical Penn State Research Foundation
Publication of EP1222212A1 publication Critical patent/EP1222212A1/fr
Publication of EP1222212A4 publication Critical patent/EP1222212A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5437—IL-13
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
EP00968773A 1999-10-06 2000-10-05 Mutants il13 Withdrawn EP1222212A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15793499P 1999-10-06 1999-10-06
US157934P 1999-10-06
PCT/US2000/027567 WO2001025282A1 (fr) 1999-10-06 2000-10-05 Mutants il13

Publications (2)

Publication Number Publication Date
EP1222212A1 EP1222212A1 (fr) 2002-07-17
EP1222212A4 true EP1222212A4 (fr) 2005-05-04

Family

ID=22565965

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00968773A Withdrawn EP1222212A4 (fr) 1999-10-06 2000-10-05 Mutants il13

Country Status (5)

Country Link
EP (1) EP1222212A4 (fr)
JP (1) JP2003511019A (fr)
AU (1) AU7863900A (fr)
CA (1) CA2386248A1 (fr)
WO (1) WO2001025282A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010053371A1 (en) * 1999-01-07 2001-12-20 Waldemar Debinski Method for diagnosing, imaging, and treating tumors using restrictive receptor for interleukin 13
AU2001288405B8 (en) * 1998-04-03 2007-06-14 The Penn State Research Foundation Amino acid substitution mutants of interleukin 13
MXPA01006006A (es) 1998-12-14 2004-08-12 Genetics Inst Cadena receptora de citocina.
US7553487B2 (en) 1998-12-14 2009-06-30 Genetics Institute, Llc Method and compositions for treating asthma
WO2001034645A2 (fr) * 1999-11-11 2001-05-17 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Modulation de l'activite de il-13 au moyen de molecules il-13 qui sont des antagonistes ou des agonistes de il-13
EA200400658A1 (ru) * 2001-11-09 2004-10-28 Неофарм, Инк. Способ лечения опухолей, экспрессирующих рецептор для ил-13 (варианты)
JP4943161B2 (ja) * 2003-12-23 2012-05-30 ジェネンテック， インコーポレイテッド 新規抗ｉｌ１３モノクローナル抗体での癌の処置
AR049390A1 (es) 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
EP1877074B1 (fr) 2005-04-15 2013-03-27 The Government of the United States of America, as represented by the Secretary of Health and Human Services Traitement et prevention de la maladie intestinale inflammatoire agissant sur il-3 et sur les cellules nkt
WO2013112871A1 (fr) 2012-01-27 2013-08-01 The Board Of Trustees Of The Leland Stanford Junior University Polypeptides d'il-13 thérapeutiques
WO2015042706A1 (fr) 2013-09-24 2015-04-02 Medicenna Therapeutics Pte Ltd Protéines de fusion de liaison au récepteur de l'interleukine-4 et leurs utilisations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051643A1 (fr) * 1998-04-03 1999-10-14 The Penn State Research Foundation Molecules chimeres mutagenisees a base d'il-13
WO2001008660A2 (fr) * 1999-08-02 2001-02-08 The Regents Of The University Of Michigan Effecteurs radiatifs exempts de fibres cibles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696234A (en) * 1994-08-01 1997-12-09 Schering Corporation Muteins of mammalian cytokine interleukin-13
US5614191A (en) * 1995-03-15 1997-03-25 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051643A1 (fr) * 1998-04-03 1999-10-14 The Penn State Research Foundation Molecules chimeres mutagenisees a base d'il-13
WO2001008660A2 (fr) * 1999-08-02 2001-02-08 The Regents Of The University Of Michigan Effecteurs radiatifs exempts de fibres cibles

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DEBINSKI W THOMPSON J P: "Retargeting interleukin 13 for radioimmunodetection and radioimmunotherapy of human high-grade gliomas", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 5, October 1999 (1999-10-01), pages 3143S - 3147S, XP002955264, ISSN: 1078-0432 *
DEBINSKI W: "AN IMMUNE REGULATORY CYTOKINE RECEPTOR AND GLIOBLASTOMA MULTIFORME:AN UNEXPECTED LINK", CRITICAL REVIEWS IN ONCOGENESIS, BOCA RATON, FL, US, vol. 9, no. 3/4, 1998, pages 255 - 268, XP002946431, ISSN: 0893-9675 *
MADHANKUMAR A B ET AL: "Alanine-scanning mutagenesis of alpha-helix D segment of interleukin-13 reveals new functionally important residues of the cytokine.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 45, 8 November 2002 (2002-11-08), pages 43194 - 43205, XP002309570, ISSN: 0021-9258 *
See also references of WO0125282A1 *
THOMPSON J P ET AL: "MUTANTS OF INTERLEUKIN 13 WITH ALTERED REACTIVITY TOWARD INTERLEUKIN 13 RECEPTORS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 42, 15 October 1999 (1999-10-15), pages 29944 - 29950, XP002948379, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
EP1222212A1 (fr) 2002-07-17
CA2386248A1 (fr) 2001-04-12
JP2003511019A (ja) 2003-03-25
AU7863900A (en) 2001-05-10
WO2001025282A1 (fr) 2001-04-12

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