EP1214443A4 - METHOD FOR REPAIRING TANDEM REPEATED DNA SEQUENCES AND EXTENDING THE LIFE SPAN OF A CELL USING CORE TRANSFER - Google Patents

METHOD FOR REPAIRING TANDEM REPEATED DNA SEQUENCES AND EXTENDING THE LIFE SPAN OF A CELL USING CORE TRANSFER

Info

Publication number
EP1214443A4
EP1214443A4 EP00961569A EP00961569A EP1214443A4 EP 1214443 A4 EP1214443 A4 EP 1214443A4 EP 00961569 A EP00961569 A EP 00961569A EP 00961569 A EP00961569 A EP 00961569A EP 1214443 A4 EP1214443 A4 EP 1214443A4
Authority
EP
European Patent Office
Prior art keywords
telomer
restoration
extension
somatic cells
cloned animals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP00961569A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1214443A1 (en
Inventor
Michael West
Robert L Lanza
Jose Cibelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Institute for Regenerative Medicine
Original Assignee
Advanced Cell Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Cell Technology Inc filed Critical Advanced Cell Technology Inc
Publication of EP1214443A1 publication Critical patent/EP1214443A1/en
Publication of EP1214443A4 publication Critical patent/EP1214443A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/04—Cells produced using nuclear transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
EP00961569A 1999-09-07 2000-09-06 METHOD FOR REPAIRING TANDEM REPEATED DNA SEQUENCES AND EXTENDING THE LIFE SPAN OF A CELL USING CORE TRANSFER Ceased EP1214443A4 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US15234099P 1999-09-07 1999-09-07
US152340P 1999-09-07
US17948600P 2000-02-01 2000-02-01
US179486P 2000-02-01
US52702600A 2000-03-16 2000-03-16
US527026 2000-03-16
US52087900A 2000-04-05 2000-04-05
US520879 2000-04-05
PCT/US2000/024393 WO2001018236A1 (en) 1999-09-07 2000-09-06 Telomere restoration and extension of cell life-span in animals cloned from senescent somatic cells

Publications (2)

Publication Number Publication Date
EP1214443A1 EP1214443A1 (en) 2002-06-19
EP1214443A4 true EP1214443A4 (en) 2003-08-27

Family

ID=27496015

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00961569A Ceased EP1214443A4 (en) 1999-09-07 2000-09-06 METHOD FOR REPAIRING TANDEM REPEATED DNA SEQUENCES AND EXTENDING THE LIFE SPAN OF A CELL USING CORE TRANSFER

Country Status (10)

Country Link
EP (1) EP1214443A4 (enExample)
JP (1) JP2003508079A (enExample)
CN (1) CN1377424A (enExample)
AU (1) AU7350800A (enExample)
BR (1) BR0013844A (enExample)
CA (1) CA2383790C (enExample)
IL (2) IL148457A0 (enExample)
MX (1) MXPA02002443A (enExample)
NZ (1) NZ531844A (enExample)
WO (1) WO2001018236A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL148418A0 (en) * 1999-09-07 2002-09-12 Advanced Cell Tech Inc Method for generating immune-compatible cells and tissues using nuclear transfer techniques
US7713728B2 (en) 2007-01-08 2010-05-11 The Invention Sciencefund I, Llc Systems for genome selection
US7947455B2 (en) 2007-01-08 2011-05-24 The Invention Science Fund I, Llc System for genome selection
US7985578B2 (en) 2007-01-08 2011-07-26 The Invention Science Fund I, Llc Systems for genome selection
US7718418B2 (en) 2007-01-08 2010-05-18 The Invention Science Fund I, Llc Systems for genome selection
US7709244B2 (en) 2007-01-08 2010-05-04 The Invention Science Fund I, Llc Systems for genome selection
US7648823B2 (en) 2007-01-08 2010-01-19 Searete Llc Systems for genome selection
US7888036B2 (en) 2007-01-08 2011-02-15 The Invention Science Fund I, Llc Systems for genome selection
US7947457B2 (en) 2007-01-08 2011-05-24 The Invention Science Fund I, Llc Systems for genome selection
US8521440B2 (en) 2007-01-08 2013-08-27 The Invention Science Fund I, Llc Systems for genome selection
US7709245B2 (en) 2007-01-08 2010-05-04 The Invention Science Fund I, Llc Systems for genome selection
US8012740B2 (en) 2007-01-08 2011-09-06 The Invention Science Fund I, Llc Systems for genome selection
US20110086424A1 (en) * 2008-05-06 2011-04-14 Advanced Cell Technology, Inc. Methods for producing enucleated erythroid cells derived from pluripotent stem cells
JP5888852B2 (ja) * 2010-12-08 2016-03-22 学校法人近畿大学 免疫不全動物を用いた細胞の製法
WO2012136841A1 (en) * 2011-04-08 2012-10-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for rejuvenating cells
EP2968392B1 (en) 2013-03-15 2020-08-05 Elixirgen Therapeutics, Inc. Methods of using zscan4 for rejuvenating human cells
EP3869195B1 (en) 2015-03-23 2024-03-20 Astellas Institute for Regenerative Medicine Improved assays for potency of human retinal pigment epithelium (rpe) cells and photoreceptor progenitors
AU2019333905B2 (en) * 2018-09-06 2025-12-11 The Board Of Regents Of The University Of Texas System Telomerase holoenzyme complex and methods of use thereof
EP4525895A4 (en) * 2022-05-17 2026-05-13 Nat Univ Singapore Somatic cell therapy to treat female infertility

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055841A2 (en) * 1998-04-29 1999-11-04 University Of Edinburgh Process for obtaining stem cells
WO2001000650A1 (en) * 1999-06-30 2001-01-04 Advanced Cell Technology, Inc. Cytoplasmic transfer to de-differentiate recipient cells
WO2001018193A1 (en) * 1999-09-07 2001-03-15 Advanced Cell Technology, Inc. Method for generating immune-compatible cells and tissues using nuclear transfer techniques

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648215A (en) * 1992-05-13 1997-07-15 Board Of Regents, The University Of Texas System Telomerase diagnostic methods
US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
NZ337495A (en) * 1997-03-06 2001-06-29 Infigen Inc Bovine primordial germ cells and their use in cloning

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055841A2 (en) * 1998-04-29 1999-11-04 University Of Edinburgh Process for obtaining stem cells
WO2001000650A1 (en) * 1999-06-30 2001-01-04 Advanced Cell Technology, Inc. Cytoplasmic transfer to de-differentiate recipient cells
WO2001018193A1 (en) * 1999-09-07 2001-03-15 Advanced Cell Technology, Inc. Method for generating immune-compatible cells and tissues using nuclear transfer techniques

Non-Patent Citations (29)

* Cited by examiner, † Cited by third party
Title
ALBANELL J. ET AL: "Telomerase activity in germ cell cancers and mature teratomas", JOURNAL OF THE NATIONAL CANCER INSTITUTE (BETHESDA), vol. 91, no. 15, 4 August 1999 (1999-08-04), pages 1321 - 1326, ISSN: 0027-8874 *
ANDERSON G.B. ET AL.: "Development of bovine and porcine embryonic teratomas in athymic mice", ANIMAL REPRODUCTION SCIENCE, vol. 45, 1996, pages 231 - 240 *
BETTS D. ET AL: "Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 30 JAN 2001 LNKD- PUBMED:11158597, vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 1077 - 1082, ISSN: 0027-8424 *
BETTS D.H. ET AL: "Telomere length analysis in goat clones and their offspring", MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 72, no. 4, December 2005 (2005-12-01), pages 461 - 470, ISSN: 1040-452X *
CIBELLI ET AL: "Cloned transgenic calves produced from non quiescent fetal fibroblasts", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 5367, no. 280, 1998, pages 1256 - 1258, XP002079366, ISSN: 0036-8075 *
CIBELLI J B ET AL: "Transgenic bovine chimeric offspring produced from somatic cell-derived stem-like cells", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 16, July 1998 (1998-07-01), pages 642 - 646, XP002938434, ISSN: 1087-0156 *
JEON H.Y. ET AL: "The analysis of telomere length and telomerase activity in cloned pigs and cows.", MOLECULAR REPRODUCTION AND DEVELOPMENT JUL 2005 LNKD- PUBMED:15806556, vol. 71, no. 3, July 2005 (2005-07-01), pages 315 - 320, ISSN: 1040-452X *
JIANG L. ET AL: "Telomere lengths in cloned transgenic pigs", BIOLOGY OF REPRODUCTION, vol. 70, 2004, pages 1589 - 1593 *
JIANG L. ET AL: "Telomere lengths in cloned transgenic pigs.", BIOLOGY OF REPRODUCTION JUN 2004 LNKD- PUBMED:14749296, vol. 70, no. 6, June 2004 (2004-06-01), pages 1589 - 1593, ISSN: 0006-3363 *
KISHIGAMI S ET AL: "Somatic cell nuclear transfer: Infinite reproduction of a unique diploid genome", EXPERIMENTAL CELL RESEARCH, ACADEMIC PRESS, US, vol. 314, no. 9, 10 June 2008 (2008-06-10), pages 1945 - 1950, XP022652728, ISSN: 0014-4827, [retrieved on 20080212], DOI: 10.1016/J.YEXCR.2008.01.027 *
KUBOTA CHIKARA ET AL: "Six cloned calves produced from adult fibroblast cells after long-term culture.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 3, 1 February 2000 (2000-02-01), Feb. 1, 2000, pages 990 - 995, XP001126944, ISSN: 0027-8424 *
LANZA R P ET AL: "Prospects for the use of nuclear transfer in human transplantation", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 17, no. 12, December 1999 (1999-12-01), pages 1171 - 1174, XP000978949, ISSN: 1087-0156 *
LANZA ROBERT P ET AL: "Extension of cell life-span and telomere length in animals cloned from senescent somatic cells.", SCIENCE (WASHINGTON D C), vol. 288, no. 5466, 28 April 2000 (2000-04-28), pages 665 - 669, XP001126945, ISSN: 0036-8075 *
MARTIN G.R.: "Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA DEC 1981 LNKD- PUBMED:6950406, vol. 78, no. 12, December 1981 (1981-12-01), pages 7634 - 7638, ISSN: 0027-8424 *
MIYASHITA N. ET AL: "Remarkable differences in telomere lengths among cloned cattle derived from different cell types", BIOLOGY OF REPRODUCTION, vol. 66, no. 6, June 2002 (2002-06-01), pages 1649 - 1655, ISSN: 0006-3363 *
SCHAETZLEIN S. ET AL: "Telomere length is reset during early mammalian embryogenesis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 25 MAY 2004 LNKD- PUBMED:15148368, vol. 101, no. 21, 25 May 2004 (2004-05-25), pages 8034 - 8038, ISSN: 0027-8424 *
See also references of WO0118236A1 *
SHI W ET AL: "Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos", BIOLOGY OF REPRODUCTION, SOCIETY FOR THE STUDY OF REPRODUCTION, CHAMPAIGN, IL, US, vol. 69, no. 1, 1 July 2003 (2003-07-01), pages 301 - 309, XP002504953, ISSN: 0006-3363, [retrieved on 20030319], DOI: 10.1095/BIOLREPROD.102.012112 *
SHIELS P G ET AL: "Analysis of telomere lengths in cloned sheep.", NATURE. ENGLAND 27 MAY 1999, vol. 399, no. 6734, 27 May 1999 (1999-05-27), pages 316 - 317, XP002233924, ISSN: 0028-0836 *
SUHR S.T. ET AL: "Telomere Dynamics in Human Cells Reprogrammed to Pluripotency", PLOS ONE, vol. 4, no. 12, December 2009 (2009-12-01), ISSN: 1932-6203 *
THOMSON J.A. ET AL: "Embryonic stem cell lines derived from human blastocysts.", SCIENCE (NEW YORK, N.Y.) 6 NOV 1998 LNKD- PUBMED:9804556, vol. 282, no. 5391, 6 November 1998 (1998-11-06), pages 1145 - 1147, ISSN: 0036-8075 *
THOMSON J.A. ET AL: "Isolation of a primate embryonic stem cell line.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 15 AUG 1995 LNKD- PUBMED:7544005, vol. 92, no. 17, 15 August 1995 (1995-08-15), pages 7844 - 7848, ISSN: 0027-8424 *
TIAN X.C. ET AL: "Normal telomere lengths found in cloned cattle.", NATURE GENETICS NOV 2000 LNKD- PUBMED:11062462, vol. 26, no. 3, November 2000 (2000-11-01), pages 272 - 273, ISSN: 1061-4036 *
WAKAYAMA T. ET AL: "Cloning of mice to six generations", NATURE, vol. 407, 21 September 2000 (2000-09-21), pages 318 - 319 *
WRIGHT W.E. ET AL: "Telomerase activity in human germline and embryonic tissues and cells.", DEVELOPMENTAL GENETICS 1996 LNKD- PUBMED:8934879, vol. 18, no. 2, 1996, pages 173 - 179, ISSN: 0192-253X *
YANG X. ET AL: "Cloning adult animals - what is the genetic age of the clones?", CLONING 2000 LNKD- PUBMED:16218848, vol. 2, no. 3, 2000, pages 123 - 128, ISSN: 1520-4553 *
YANG X. ET AL: "Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning", NATURE GENETICS, vol. 39, no. 3, March 2007 (2007-03-01), pages 295 - 302, ISSN: 1061-4036 *
ZAKHARTCHENKO V ET AL: "Effects of serum starvation and re-cloning on the efficiency of nuclear transfer using bovine fetal fibroblasts", JOURNAL OF REPRODUCTION AND FERTILITY, JOURNALS OF REPRODUCTION AND FERTILITY LTD, GB, vol. 115, no. 2, March 1999 (1999-03-01), pages 325 - 331, XP001037005, ISSN: 0022-4251 *
ZAWADA ET AL: "Somatic cell cloned transgenic bovine neurons for transplantation in Parkinsonian rats", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 4, no. 5, 1 May 1998 (1998-05-01), pages 569 - 574, XP002092260, ISSN: 1078-8956 *

Also Published As

Publication number Publication date
CN1377424A (zh) 2002-10-30
WO2001018236A1 (en) 2001-03-15
IL148457A (en) 2013-01-31
BR0013844A (pt) 2002-05-14
JP2003508079A (ja) 2003-03-04
NZ531844A (en) 2005-08-26
AU7350800A (en) 2001-04-10
CA2383790C (en) 2016-11-22
MXPA02002443A (es) 2004-07-16
CA2383790A1 (en) 2001-03-15
IL148457A0 (en) 2002-09-12
EP1214443A1 (en) 2002-06-19

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