EP1214404A4 - Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions - Google Patents

Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions

Info

Publication number
EP1214404A4
EP1214404A4 EP00966717A EP00966717A EP1214404A4 EP 1214404 A4 EP1214404 A4 EP 1214404A4 EP 00966717 A EP00966717 A EP 00966717A EP 00966717 A EP00966717 A EP 00966717A EP 1214404 A4 EP1214404 A4 EP 1214404A4
Authority
EP
European Patent Office
Prior art keywords
embryonic
lines
technique
tissue culture
genetic modification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00966717A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1214404A1 (en
Inventor
James Robl
Jose Cibelli
Steven L Stice
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Massachusetts Boston
University of Massachusetts Amherst
Original Assignee
University of Massachusetts Boston
University of Massachusetts Amherst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Massachusetts Boston, University of Massachusetts Amherst filed Critical University of Massachusetts Boston
Publication of EP1214404A1 publication Critical patent/EP1214404A1/en
Publication of EP1214404A4 publication Critical patent/EP1214404A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/04—Cells produced using nuclear transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
EP00966717A 1999-09-14 2000-09-14 Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions Withdrawn EP1214404A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39536899A 1999-09-14 1999-09-14
PCT/US2000/025090 WO2001019977A1 (en) 1999-09-14 2000-09-14 Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions
US395368 2002-07-12

Publications (2)

Publication Number Publication Date
EP1214404A1 EP1214404A1 (en) 2002-06-19
EP1214404A4 true EP1214404A4 (en) 2003-09-03

Family

ID=23562752

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00966717A Withdrawn EP1214404A4 (en) 1999-09-14 2000-09-14 Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions

Country Status (10)

Country Link
EP (1) EP1214404A4 (enExample)
JP (1) JP2003525031A (enExample)
CN (1) CN1379814A (enExample)
AU (1) AU7701900A (enExample)
BR (1) BR0013999A (enExample)
CA (1) CA2384413A1 (enExample)
IL (2) IL148547A0 (enExample)
MX (1) MXPA02002744A (enExample)
NZ (1) NZ517609A (enExample)
WO (1) WO2001019977A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696404B2 (en) 1996-08-19 2010-04-13 Advanced Cell Technology, Inc. Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions
JP2003509028A (ja) * 1999-09-07 2003-03-11 アドバンスド セル テクノロジー、インコーポレイテッド 核移植技術を用いた免疫適合性を有する細胞及び組織を産生する方法
CA2388497A1 (en) 1999-10-15 2001-04-26 Advanced Cell Technology, Inc. Method of producing differentiated progenitor cells by culturing morula or inner cell mass cells
JP2004500066A (ja) * 1999-12-20 2004-01-08 ユニバシティ　オブ　マサチューセッツ、ア　パブリック　インスチチユーション　オブ　ハイアー　エデュケイション　オブ　ザ　コモンウエルス　オブ　マサチューセッツ、アズ　リプリゼンテッド　バイ　イッツ　ア 異種間核移植により生成する胚あるいは幹様細胞
US7221981B2 (en) 2002-03-28 2007-05-22 Northstar Neuroscience, Inc. Electrode geometries for efficient neural stimulation
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005266A2 (en) * 1997-07-26 1999-02-04 Wisconsin Alumni Research Foundation Trans-species nuclear transfer
WO2001046401A1 (en) * 1999-12-20 2001-06-28 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Embryonic or stem-like cells produced by cross species nuclear transplantation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
EP0934403A4 (en) * 1996-08-19 2001-03-14 Univ Massachusetts ROWS OF EMBRYONIC OR STRAIN-LIKE CELLS PRODUCED BY CROSS NUCLEAR TRANSPLANTATION OF SPECIES
AU759322B2 (en) * 1998-03-02 2003-04-10 University Of Massachusetts Embryonic or stem-like cell lines produced by cross-species nuclear transplantation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005266A2 (en) * 1997-07-26 1999-02-04 Wisconsin Alumni Research Foundation Trans-species nuclear transfer
WO2001046401A1 (en) * 1999-12-20 2001-06-28 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Embryonic or stem-like cells produced by cross species nuclear transplantation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"CLAIM OF HUMAN-COW EMBRYO GREETED WITH SKEPTICISM", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 282, no. 1, 20 November 1998 (1998-11-20), pages 1390 - 1391, XP002930979, ISSN: 0036-8075 *
BLERKOM VAN J ET AL: "MITOCHONDRIAL TRANSFER BETWEEN OOCYTES: POTENTIAL APPLICATIONS OF MITOCHONDRIAL DONATION AND THE ISSUE OF HETEROPLASMY", HUMAN REPRODUCTION, IRL PRESS, OXFORD, GB, vol. 13, no. 10, 1998, pages 2857 - 2868, XP001002313, ISSN: 0268-1161 *
DOMINKO T ET AL: "BOVINE OOCYTE CYTOPLASM SUPPORTS DEVELOPMENT OF EMBRYOS PRODUCED BYNUCLEAR TRANSFER OF SOMATIC CELL NUCLEI FROM VARIOUS MAMMALIAN SPECIES", BIOLOGY OF REPRODUCTION, SOCIETY FOR THE STUDY OF REPRODUCTION, CHAMPAIGN, IL, US, vol. 60, no. 6, June 1999 (1999-06-01), pages 1496 - 1502, XP000920565, ISSN: 0006-3363 *
See also references of WO0119977A1 *

Also Published As

Publication number Publication date
MXPA02002744A (es) 2003-07-21
AU7701900A (en) 2001-04-17
IL148547A (en) 2009-09-01
IL148547A0 (en) 2002-09-12
EP1214404A1 (en) 2002-06-19
CN1379814A (zh) 2002-11-13
JP2003525031A (ja) 2003-08-26
CA2384413A1 (en) 2001-03-22
BR0013999A (pt) 2002-05-21
WO2001019977A9 (en) 2002-09-26
WO2001019977A1 (en) 2001-03-22
NZ517609A (en) 2004-02-27

Similar Documents

Publication Publication Date Title
BR9711204A (pt) Linhagens de c-lulas embriÄnicas ou similares s indiferenciadas produzidas por transplante nuclear de esp-cies hibridas
NO20022180D0 (no) Hematopoietisk differensiering av humane embryoniske stamceller
EP1017423A4 (en) CLONING OF PIGS USING DONOR CORES FROM DIFFERENTIATED CELLS
DE60037370D1 (de) Sinusförmiges Zellkulturmodul zur Kultivierung von Hepatozyten
DE69534227D1 (de) Stoffe und verfahren zur beherrschung der hyperakuten abstossung von menschlichen transplantaten
DK0843961T3 (da) Kimærisk mus og fremgangsmåde til at producere samme
WO2000051424A3 (en) Genetic modification of somatic cells and uses thereof
AU2575701A (en) Sugarbeet regeneration and transformation
TR199902728T2 (xx) Kuinolat fosforibosil transferaz ekspresyonunun d�zenlenmesi.
ATE356203T1 (de) Kerntransfer mit differenzierten fötalen und adulten spenderzellen
EP0270615A4 (en) TRANSFORMATION AND EXPRESSION OF A FOREIGN GENE IN -i (BRASSICA) SPECIES.
NZ538852A (en) Selection and isolation of living cells using mRNA-binding probes
EP1214404A4 (en) Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions
EA199700004A1 (ru) Усиленная аккумуляция трегалозы в растениях
EP1463822A4 (en) CELL LINES WITH LATENT IMMUNE WEAKAGE VIRUS AND METHOD OF USE THEREOF
EP1513927A4 (en) GENERATION OF HISTOCOMPATIBLE TISSUE USING CELL CORE TRANSPLANTATION
FR2644894B1 (fr) Trousse et methode de dosage enzymatique applicables a des cellules entieres
FR2622207B1 (fr) Vecteurs d'integration et d'expression d'un gene heterologue, cellules infectees avec ces vecteurs et procede de production d'une proteine ou de modification genetique d'animaux
DK1023453T3 (da) TGC-fremgangsmåde til induktion af en målrettet, somatisk transgenitet
MXPA02002444A (es) Metodo para generar celulas y tejidos inmunocompatibles, utilizando tecnicas de transferencia nuclear.
AU4075093A (en) Cellular aggregate stabilized culture and process for the development of embryos from a proembryogenic strain for use in vine regeneration techniques
AU6262786A (en) Growing aids virus in cell lines lacking human class ii histocompatability antigens
RU97107909A (ru) Штамм гибридных культивируемых клеток животного rattus norvegicus, используемый для получения моноклональных антител к вирусу гепатита а человека
MX9603037A (es) Materiales y metodos para manejar rechazo hiperagudo en xenotrasplante humano.
NO902039D0 (no) Fremgangsmaate ved dyrking av cellekulturer i bioreaktor.

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020408

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ROBL, JAMES

Inventor name: STICE, STEVEN, L.

Inventor name: CIBELLI, JOSE

A4 Supplementary search report drawn up and despatched

Effective date: 20030717

RIC1 Information provided on ipc code assigned before grant

Ipc: 7C 12N 5/02 B

Ipc: 7C 12N 5/00 B

Ipc: 7C 12N 5/08 B

Ipc: 7C 12N 15/00 A

Ipc: 7A 01K 67/027 B

Ipc: 7A 61K 48/00 B

17Q First examination report despatched

Effective date: 20031107

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040518