EP1181308A4 - Methodes de traitement de demence neuronale associee a une atrophie - Google Patents

Methodes de traitement de demence neuronale associee a une atrophie

Info

Publication number
EP1181308A4
EP1181308A4 EP00928662A EP00928662A EP1181308A4 EP 1181308 A4 EP1181308 A4 EP 1181308A4 EP 00928662 A EP00928662 A EP 00928662A EP 00928662 A EP00928662 A EP 00928662A EP 1181308 A4 EP1181308 A4 EP 1181308A4
Authority
EP
European Patent Office
Prior art keywords
treatment
methods
associated dementia
neuronal atrophy
atrophy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP00928662A
Other languages
German (de)
English (en)
Other versions
EP1181308A1 (fr
Inventor
Ralph A Nixon
Anne M Cataldo
Paul M Mathews
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH
NATHAN S KLINE INST FOR PSYCHI
Original Assignee
NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH
NATHAN S KLINE INST FOR PSYCHI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH, NATHAN S KLINE INST FOR PSYCHI filed Critical NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH
Publication of EP1181308A1 publication Critical patent/EP1181308A1/fr
Publication of EP1181308A4 publication Critical patent/EP1181308A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
EP00928662A 1999-04-30 2000-04-28 Methodes de traitement de demence neuronale associee a une atrophie Ceased EP1181308A4 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US13189099P 1999-04-30 1999-04-30
US13199199P 1999-04-30 1999-04-30
US131991P 1999-04-30
US131890P 1999-04-30
US14064499P 1999-06-23 1999-06-23
US14064399P 1999-06-23 1999-06-23
US140643P 1999-06-23
US140644P 1999-06-23
PCT/US2000/011739 WO2000066617A1 (fr) 1999-04-30 2000-04-28 Methodes de traitement de demence neuronale associee a une atrophie

Publications (2)

Publication Number Publication Date
EP1181308A1 EP1181308A1 (fr) 2002-02-27
EP1181308A4 true EP1181308A4 (fr) 2004-10-27

Family

ID=27494932

Family Applications (2)

Application Number Title Priority Date Filing Date
EP00928500A Withdrawn EP1181550A4 (fr) 1999-04-30 2000-04-28 Procedes d'identification de composes pour le traitement de la maladie d'alzheimer
EP00928662A Ceased EP1181308A4 (fr) 1999-04-30 2000-04-28 Methodes de traitement de demence neuronale associee a une atrophie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP00928500A Withdrawn EP1181550A4 (fr) 1999-04-30 2000-04-28 Procedes d'identification de composes pour le traitement de la maladie d'alzheimer

Country Status (5)

Country Link
EP (2) EP1181550A4 (fr)
JP (2) JP2003514216A (fr)
AU (2) AU784048B2 (fr)
CA (2) CA2372190A1 (fr)
WO (2) WO2000067016A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4824268B2 (ja) * 2001-05-02 2011-11-30 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート 学習および記憶を増強させるためのカルボニックアンヒドラーゼ活性化剤
US20070155771A1 (en) * 2003-04-11 2007-07-05 David Rubinsztein Methods and means for treating protein conformational disorders
TW201206425A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Treatment of depressive disorders
ES2301280A1 (es) * 2005-05-16 2008-06-16 Fina Biotech S.L.U. Metodo para diagnosticar la enfermedad de alzheimer.
US10278774B2 (en) 2011-03-18 2019-05-07 Covidien Lp Selectively expandable operative element support structure and methods of use
JP6391318B2 (ja) * 2014-06-27 2018-09-19 学校法人順天堂 アルツハイマー病予防治療薬のスクリーニング法
JP7344546B2 (ja) 2019-08-28 2023-09-14 日本メナード化粧品株式会社 Ａｐｅｈ産生促進剤
CN111686129A (zh) * 2020-04-14 2020-09-22 南开大学 一种溶酶体作为制备治疗阿尔兹海默症及延缓老年智力衰退药物领域的应用
CN114209716A (zh) * 2021-11-26 2022-03-22 南开大学 一种改性溶酶体作为制备治疗蛋白错误折叠或加工类疾病药物的应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028622A (en) * 1988-05-06 1991-07-02 Ajinomoto Company, Inc. Administration of amino acids as treatment for neurodegenerative disorders
EP0652012A1 (fr) * 1989-03-27 1995-05-10 Albert Naito Combinaison de sucres avec des acides aminés et autres composés
US5538983A (en) * 1990-05-16 1996-07-23 The Rockefeller University Method of treating amyloidosis by modulation of calcium
US5686269A (en) * 1994-07-28 1997-11-11 The Mclean Hospital Corporation Method of diagnosing Alzheimer's disease by detecting the level of cathepsin D in cerebrospinal fluid
WO1997044668A1 (fr) * 1996-05-17 1997-11-27 Women's And Children's Hospital Detection precoce des troubles de stockage des lysosomes
WO1998021589A1 (fr) * 1996-11-15 1998-05-22 The Trustees Of The University Of Pennsylvania Recherche de modulateurs de la transformation de l'amyloide
WO1998040484A1 (fr) * 1997-03-12 1998-09-17 The Trustees Of Columbia University In The City Of New York Polypeptide lie a un peptide amyloide-beta intracellulaire (erab)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994007144A1 (fr) * 1992-09-21 1994-03-31 United States Of America, As Represented By The Secretary, Department Of Health And Human Services Procede de criblage de composes et procedes pour traiter la maladie d'alzheimer

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028622A (en) * 1988-05-06 1991-07-02 Ajinomoto Company, Inc. Administration of amino acids as treatment for neurodegenerative disorders
EP0652012A1 (fr) * 1989-03-27 1995-05-10 Albert Naito Combinaison de sucres avec des acides aminés et autres composés
US5538983A (en) * 1990-05-16 1996-07-23 The Rockefeller University Method of treating amyloidosis by modulation of calcium
US5686269A (en) * 1994-07-28 1997-11-11 The Mclean Hospital Corporation Method of diagnosing Alzheimer's disease by detecting the level of cathepsin D in cerebrospinal fluid
WO1997044668A1 (fr) * 1996-05-17 1997-11-27 Women's And Children's Hospital Detection precoce des troubles de stockage des lysosomes
WO1998021589A1 (fr) * 1996-11-15 1998-05-22 The Trustees Of The University Of Pennsylvania Recherche de modulateurs de la transformation de l'amyloide
WO1998040484A1 (fr) * 1997-03-12 1998-09-17 The Trustees Of Columbia University In The City Of New York Polypeptide lie a un peptide amyloide-beta intracellulaire (erab)

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANGLADE P ET AL: "Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.", HISTOLOGY AND HISTOPATHOLOGY. JAN 1997, vol. 12, no. 1, January 1997 (1997-01-01), pages 25 - 31, XP008034349, ISSN: 0213-3911 *
BERNSTEIN H G ET AL: "Lysosomal proteinases as putative diagnostic tools in human neuropathology: Alzheimer disease (AD) and schizophrenia.", ACTA HISTOCHEMICA. SUPPLEMENTBAND. 1992, vol. 42, 1992, pages 19 - 24, XP008034353, ISSN: 0567-7556 *
GUO Q ET AL: "Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.", THE JOURNAL OF NEUROSCIENCE : THE OFFICIAL JOURNAL OF THE SOCIETY FOR NEUROSCIENCE. 1 JUN 1997, vol. 17, no. 11, 1 June 1997 (1997-06-01), pages 4212 - 4222, XP002293297, ISSN: 0270-6474 *
See also references of WO0066617A1 *
SOUSTEK Z: "Autolysosomes in Alzheimer's disease and their possible role in its pathogenesis. An ultrastructural study.", ZENTRALBLATT FUR PATHOLOGIE. JUL 1994, vol. 140, no. 2, July 1994 (1994-07-01), pages 143 - 148, XP008034352, ISSN: 0863-4106 *

Also Published As

Publication number Publication date
WO2000066617A1 (fr) 2000-11-09
AU772054B2 (en) 2004-04-08
AU4673400A (en) 2000-11-17
JP2002543425A (ja) 2002-12-17
AU784048B2 (en) 2006-01-19
EP1181308A1 (fr) 2002-02-27
JP2003514216A (ja) 2003-04-15
CA2372190A1 (fr) 2000-11-09
WO2000067016A1 (fr) 2000-11-09
WO2000067016A9 (fr) 2002-07-11
EP1181550A4 (fr) 2005-03-02
CA2370177A1 (fr) 2000-11-09
EP1181550A1 (fr) 2002-02-27
AU4686300A (en) 2000-11-17

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