EP1165059A4 - PHARMACEUTICAL COMPOSITIONS INCLUDE THE UNITS OF TROPONIN, FRAGMENTS THEREOF AND THEIR HOMOLOGOUS AND METHODS FOR THEIR USE TO INHIBIT ANGIOGENESIS - Google Patents

PHARMACEUTICAL COMPOSITIONS INCLUDE THE UNITS OF TROPONIN, FRAGMENTS THEREOF AND THEIR HOMOLOGOUS AND METHODS FOR THEIR USE TO INHIBIT ANGIOGENESIS

Info

Publication number
EP1165059A4
EP1165059A4 EP00916329A EP00916329A EP1165059A4 EP 1165059 A4 EP1165059 A4 EP 1165059A4 EP 00916329 A EP00916329 A EP 00916329A EP 00916329 A EP00916329 A EP 00916329A EP 1165059 A4 EP1165059 A4 EP 1165059A4
Authority
EP
European Patent Office
Prior art keywords
subunits
homologues
fragments
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00916329A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1165059A1 (en
Inventor
Richard M Thorn
Marc E Lanser
Marsha A Moses
Dmitri G Wiederschain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Alseres Pharmaceuticals Inc
Original Assignee
Boston Childrens Hospital
Boston Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/442,099 external-priority patent/US6465431B1/en
Application filed by Boston Childrens Hospital, Boston Life Sciences Inc filed Critical Boston Childrens Hospital
Publication of EP1165059A1 publication Critical patent/EP1165059A1/en
Publication of EP1165059A4 publication Critical patent/EP1165059A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
EP00916329A 1999-03-15 2000-03-14 PHARMACEUTICAL COMPOSITIONS INCLUDE THE UNITS OF TROPONIN, FRAGMENTS THEREOF AND THEIR HOMOLOGOUS AND METHODS FOR THEIR USE TO INHIBIT ANGIOGENESIS Withdrawn EP1165059A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26827499A 1999-03-15 1999-03-15
US268274 1999-03-15
US442099 1999-11-17
US09/442,099 US6465431B1 (en) 1999-11-17 1999-11-17 Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis
PCT/US2000/006667 WO2000054770A1 (en) 1999-03-15 2000-03-14 Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis

Publications (2)

Publication Number Publication Date
EP1165059A1 EP1165059A1 (en) 2002-01-02
EP1165059A4 true EP1165059A4 (en) 2003-03-05

Family

ID=26952984

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00916329A Withdrawn EP1165059A4 (en) 1999-03-15 2000-03-14 PHARMACEUTICAL COMPOSITIONS INCLUDE THE UNITS OF TROPONIN, FRAGMENTS THEREOF AND THEIR HOMOLOGOUS AND METHODS FOR THEIR USE TO INHIBIT ANGIOGENESIS

Country Status (5)

Country Link
EP (1) EP1165059A4 (https=)
JP (1) JP2002539161A (https=)
AU (1) AU774596B2 (https=)
CA (1) CA2367611A1 (https=)
WO (1) WO2000054770A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4545685B2 (ja) * 2003-04-16 2010-09-15 小野薬品工業株式会社 心臓疾患治療物質のスクリーニング方法および心臓疾患治療医薬組成物
JP2007526763A (ja) * 2004-01-27 2007-09-20 コンピュゲン エルティーディー． 新規のヌクレオチドおよびアミノ酸配列、ならびにそれらを心臓疾患の診断に用いるアッセイおよび方法
JP5606438B2 (ja) * 2008-07-23 2014-10-15 エフ．ホフマン−ラ ロシュ アーゲー 抗血管新生療法を受容可能な被験体の同定
JP5553547B2 (ja) * 2009-07-14 2014-07-16 俊一 梶岡 トロポニン含有医薬組成物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030085A1 (en) * 1996-02-16 1997-08-21 Children's Medical Center Corporation Troponin subunits and fragments useful as angiogenesis inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030085A1 (en) * 1996-02-16 1997-08-21 Children's Medical Center Corporation Troponin subunits and fragments useful as angiogenesis inhibitors

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
FELDMAN LAURIE ET AL: "Troponin I inhibits capillary endothelial cell proliferation by interaction with the cell's bFGF receptor.", MICROVASCULAR RESEARCH, vol. 63, no. 1, January 2002 (2002-01-01), pages 41 - 49, XP002218582, ISSN: 0026-2862 *
JHA PRAKASH K. ET AL: "Interaction of deletion mutants of troponins I and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca-2+ sensitivity of the reconstituted regulatory system", BIOCHEMISTRY, vol. 35, no. 51, 1996, pages 16573 - 16580 *
JHA PRAKASH K. ET AL: "Photo-cross-linking of rabbit skeletal troponin I deletion mutants with troponin C and its thiol mutants: The inhibitory region enhances binding of troponin I fragments to troponin C", BIOCHEMISTRY, vol. 35, no. 34, 1996, pages 11026 - 11035 *
MOSES M A ET AL: "Troponin I is present in human cartilage and inhibits angiogenesis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, 16 March 1999 (1999-03-16), pages 2645 - 2650, XP002131230, ISSN: 0027-8424 *
See also references of WO0054770A1 *
VALLINS W J ET AL: "MOLECULAR CLONING OF HUMAN CARDIAC TROPONIN I USING POLYMERASE CHAIN REACTION", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 270, no. 1/2, 17 September 1990 (1990-09-17), pages 57 - 61, XP000470204, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
CA2367611A1 (en) 2000-09-21
JP2002539161A (ja) 2002-11-19
AU774596B2 (en) 2004-07-01
WO2000054770A1 (en) 2000-09-21
WO2000054770A8 (en) 2001-01-11
AU3744900A (en) 2000-10-04
EP1165059A1 (en) 2002-01-02

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Legal Events

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: THORN, RICHARD, M.

Inventor name: MOSES, MARSHA, A.

Inventor name: LANSER, MARC, E.

Inventor name: WIEDERSCHAIN, DMITRI, G.

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 38/08 A, 7A 61K 38/10 B, 7C 07K 7/06 B, 7C 07K 7/08 B, 7A 61P 35/00 B

A4 Supplementary search report drawn up and despatched

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