EP1163525A1 - Cause, in vitro determination and eradication of cancer - Google Patents

Cause, in vitro determination and eradication of cancer

Info

Publication number
EP1163525A1
EP1163525A1 EP99908739A EP99908739A EP1163525A1 EP 1163525 A1 EP1163525 A1 EP 1163525A1 EP 99908739 A EP99908739 A EP 99908739A EP 99908739 A EP99908739 A EP 99908739A EP 1163525 A1 EP1163525 A1 EP 1163525A1
Authority
EP
European Patent Office
Prior art keywords
mass
stuff
stuff compound
compound
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99908739A
Other languages
German (de)
English (en)
French (fr)
Inventor
Radomir Spetik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1163525A1 publication Critical patent/EP1163525A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Definitions

  • This invention applies to origin and way of extracorporeal identification of malignant and other disorder of human organism based on blood ions and to a stuff compound as blood stimulant.
  • the up to now knowledge and identification techniques are not capable to detect the so called ..carcinogenic mood of organism" at the stage, when malignant proliferation does not exceed the level of separate cell groups affection yet and it does not appear in a macroscopic range.
  • Psychic stress as a whole organism mobilizer plays main role of initiation mechanism.
  • the area of Saley strain which is represented by limbic system with an axis hypothalamus - adrenal - thymus, when adrenaline egested to blood circulation influences the level of ions Na+, K+, Ca+ and by irritation of adrenal cortex even the level of glucocorticoids.
  • the nerve impulse - stress By activation of mineral-corticoids and of human chorio-gonadotropine (HCG) the nerve impulse - stress at the same time transmits ions Na+ to each individual cell not only by vegetative nerve system, but also by omnipresent blood, which acts as general neurotransmitter.
  • HCG human chorio-gonadotropine
  • the impulse transmission influences the blood ion concentration levels of sodium (Na+), potassium (K+) and calcium (Ca+), which are substantial for an impulse - stress transmission to each individual cell in organism, especially to cells of immune system.
  • the cells change remarkably electric potential of their cell membranes from previous state, including influence behavior of receptors - their shifting in for antigens, or possibly their shifting out depending on the membranes' electric potential level.
  • inhospitable intracellular conditions arise when intracellular organelles are influenced.
  • These cellular changes can generate an activation of mutagenous herpetic EB viruses, which have in 80% the same chain sequence as immunosuppressive interleucine 10 (IL-10).
  • IL-10 immunosuppressive interleucine 10
  • EBV is immunosuppressive as like as IL-10, so that it suppresses the immune system as regards to a malignant disease. 95% of world population is EBV positive and so only slight activation of this virus is sufficient for initiation of immunosuppression.
  • People having antibodies against this virus or who experienced mononucleosis have antibodies against EB virus as well as against interleucinelO (IL-10) immunosuppressor itself, so they cannot contract a cancer.
  • IL-10 immunosuppressive interleucine 10
  • T-lymphocytes In cooperation with HCG and thyme function suppression, when misactivation of T-lymphocytes occurs, which interrupt to produce interleucine 3 (IL-3), which does not activate macrofages and T-helpers' lymphocytes, on the contrary the Ts suppressor lymphocytes, which suppress the immune system, become active.
  • IL-3 interleucine 3
  • Ts suppressor lymphocytes which suppress the immune system.
  • multiplied cell colonies continue in immunosuppressivity through their metabolites like alpha 1 phetoprotein at simultaneous suppression of human chorio-gonadotropine (HCG) influence.
  • HCG human chorio-gonadotropine
  • the subject is as well an elucidation, that in case of extremely positive reaction to stress there appears an allergic disease and that extremely negative reaction to stress could initiate malignant proliferation.
  • the subject is as well a way of extracorporeal identification of malignant proliferation and other illnesses, which is convenient mainly for identification of cancer in human organism.
  • ion concentration levels of sodium (Na+), potassium (K+) and calcium (Ca+) the relative ratio of which determines the level of these ions in intracellular space simultaneously.
  • stress constant Cs V Na / V ⁇ , where
  • Csp 36.
  • Carcinogenic constant lower value (Ccl) 12,0 [(mmol/l) "1 ],
  • Carcinogenic constant upper value (Ccu) 13,2 [(mmol/l) "1 ].
  • Nerve-impulses are transmitted in vegetative and somatic nervous systems by sodium ions. Cells are nourished with the help of adenosine-triphosfate pump. It means, that nerve-impulse is not transmitted to cell by vegetative nerves only, but with the help of blood as well. The blood contains also ions, which thanks to their mutual concentrations transfer this impulse. In reality it means prolongation of Saley strain.
  • blood acts as general purpose and omnipresent neurotransmitter. So that nerve-impulses are transmitted by nerve system and blood as well. In such case we can distinguish short time impulses of high intensity - vegetative ones and long time impulses of lower intensity - transferred by blood. Stress acts to the immune system by oscillations created due to chaotic principle of nerve and blood systems (see figure No. 1 ). Stress is transmitted in organism by the help of sodium - potassium pump, so by ions, by nerves and blood.
  • Cc carcinogenic constant
  • a cell which is damaged by other way as well, can do nothing like to run away or to defend, and as does not exist a place to run away, a cell starts to multiply by EBV and initiates immunosuppression simultaneously.
  • the base of malignant tumor liquidation consists of neurotransmitter implementation, which adjusts cell membrane potentials to initiate reverse effect and so to activate immune cells. Parallel to this a total modification of tissue rinsing environment is necessary, not to initiate a new reverse process. It is necessary to exclude cytostatics and so to prevent a later malignant disease attack due to destruction of immune cells.
  • the proposed computer software enables from laboratory blood analysis of sodium (Na+), potassium (K+) and calcium (Ca+) ions to identify immediately the pathologic risk of organism by starting malignant proliferation or allergic disease. Further it calculates from the analysed values the masses of (Na+), (K+) and (Ca+) for the therapeutic stuff compound acting as blood stimulant.
  • the invention priority is mainly the fact, that it enables to identify malignant proliferation even before the stage of clinical detection, that means even with a mass lower than 1 gram, which is not possible to reach by contemporary mechanismes. So it is possible to trace even malignantappelmood" of organism.
  • Basic advantage is as well the extracorporeal identification of malignant disease.
  • the proposed solution is very simple and commonly accessible, economically undemanding, very easy repeatable, standardized on all working places and thus comparable, it is possible to screen in very cheap way unlimited sample of people and to examine simultaneously the whole body even in risk stages of malignant proliferation.
  • No. 1 figure shows in graphic way the course of stress oscillation changes during impulse transmission in blood and in vegetative nerve system and the influence of cell membrane electric potential by stress oscillations.
  • No. 2 figure shows the evaluation of extracorporeal identification result in graphic way, mainly of human malignant disease, including the calculation of stated element ions for 100 g of stuff compound.
  • No. 3 figure shows the table of calculation of the Na, K, Ca ion content in the stuff - RESTIMOSOL
  • the illness has not to be quite apparent, but it could proceed latently, as spring fatigue or common fatigue, which could be associated only with light febriles or subfebriles, plainly said with unpalpable easy to overlook symptoms.
  • the mentioned EBV is rigidly bound to cell so that it multiplies by geometric series as a virus.
  • the stress constant Cs V Na / V ⁇ , where V Na and V ⁇ are ion contents in blood plasma in mmol/l.
  • the multiplied cell need not necessary contain EBV, its multiplication is allowed by the presence of EBV as immunosuppressor of IL-12 and HCG and at the same time thyme suppression takes place, which does not activate T- lymphocytes. They cease the production of interleucin 3 (IL-3), so that a misactivation of macrofages and T-helpers' lymphocytes occur, but due to real danger Ts suppressor lymphocytes activate and continue in further suppression of the immune system - defence mechanismes.
  • the malignant cell initiated in this way may continue its multiplication in environment of increased content of Na+, other signal transfer is not possible.
  • compound ratios of therapeutic stuff compound were calculated under commercial name RESTIMOSOL (see figure No. 3) for the treatment of given condition.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99908739A 1999-02-19 1999-03-29 Cause, in vitro determination and eradication of cancer Withdrawn EP1163525A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ1999555A CZ9900555A3 (cs) 1999-02-19 1999-02-19 Způsob mimotělní identifikace maligního a jiného onemocnění lidí a směs látek jako stimulantu krve
CZ55599 1999-02-19
PCT/CZ1999/000009 WO2000049414A1 (en) 1999-02-19 1999-03-29 Cause, in vitro determination and eradication of cancer

Publications (1)

Publication Number Publication Date
EP1163525A1 true EP1163525A1 (en) 2001-12-19

Family

ID=5461898

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99908739A Withdrawn EP1163525A1 (en) 1999-02-19 1999-03-29 Cause, in vitro determination and eradication of cancer

Country Status (5)

Country Link
EP (1) EP1163525A1 (cs)
AU (1) AU2824899A (cs)
CZ (1) CZ9900555A3 (cs)
SK (1) SK13762001A3 (cs)
WO (1) WO2000049414A1 (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI535461B (zh) 2011-03-11 2016-06-01 諾金私人有限公司 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法
PL2895163T3 (pl) 2012-09-11 2019-10-31 Norgine Bv Kompozycje zawierające PEG i askorbinian

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9105986A (pt) * 1990-02-05 1992-11-10 Univ Texas Formulacao de liberacao por tempo de vitaminas,minerais e outros suplementos beneficos
RU2018833C1 (ru) * 1990-02-28 1994-08-30 Ивановский научно-исследовательский институт материнства и детства Способ прогнозирования течения процесса адаптации у школьников при возвращении из южного санатория
CA2089607C (en) * 1992-11-05 1997-11-04 Ranjit K. Chandra Nutritional supplement for the elderly

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0049414A1 *

Also Published As

Publication number Publication date
WO2000049414A1 (en) 2000-08-24
SK13762001A3 (sk) 2003-09-11
AU2824899A (en) 2000-09-04
CZ9900555A3 (cs) 2000-10-11

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