EP1162886A4 - System and method for evaluating agents which prevent oxidative damage - Google Patents

System and method for evaluating agents which prevent oxidative damage

Info

Publication number
EP1162886A4
EP1162886A4 EP00910266A EP00910266A EP1162886A4 EP 1162886 A4 EP1162886 A4 EP 1162886A4 EP 00910266 A EP00910266 A EP 00910266A EP 00910266 A EP00910266 A EP 00910266A EP 1162886 A4 EP1162886 A4 EP 1162886A4
Authority
EP
European Patent Office
Prior art keywords
oxidative damage
prevent oxidative
evaluating agents
inhibiting
identifying agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00910266A
Other languages
German (de)
French (fr)
Other versions
EP1162886A1 (en
Inventor
River Laboratories Charles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Charles River Breeding Laboratories Inc
Original Assignee
Charles River Breeding Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charles River Breeding Laboratories Inc filed Critical Charles River Breeding Laboratories Inc
Publication of EP1162886A1 publication Critical patent/EP1162886A1/en
Publication of EP1162886A4 publication Critical patent/EP1162886A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

An in vitro system for identifying agents capable of inhibiting or preventing oxidative damage in a mouse fibroblast culture derived from a transgenic mouse capable of expressing human elastin promoter which generates reactive oxygen species within the mouse fibroblast culture is provided. A method for identifying agents capable of inhibiting or preventing oxidative damage via this system is also provided.
EP00910266A 1999-02-23 2000-02-22 System and method for evaluating agents which prevent oxidative damage Withdrawn EP1162886A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12141899P 1999-02-23 1999-02-23
US121418P 1999-02-23
PCT/US2000/004438 WO2000049876A1 (en) 1999-02-23 2000-02-22 System and method for evaluating agents which prevent oxidative damage

Publications (2)

Publication Number Publication Date
EP1162886A1 EP1162886A1 (en) 2001-12-19
EP1162886A4 true EP1162886A4 (en) 2003-02-12

Family

ID=22396604

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00910266A Withdrawn EP1162886A4 (en) 1999-02-23 2000-02-22 System and method for evaluating agents which prevent oxidative damage

Country Status (5)

Country Link
EP (1) EP1162886A4 (en)
JP (1) JP2002541774A (en)
AU (1) AU760969B2 (en)
CA (1) CA2362904A1 (en)
WO (1) WO2000049876A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100406569C (en) * 2001-02-05 2008-07-30 潘申权 Methods and kits for identifing scavengers of reactive oxygen species (Ros)
US20080312128A1 (en) * 2005-04-29 2008-12-18 Edward Chaum Cellular Biomarker Antioxidant Assay and Uses Thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840734A (en) * 1997-05-06 1998-11-24 Thomas Jefferson University Use of tempol in the prevention of photoaging
WO1999030682A1 (en) * 1997-12-17 1999-06-24 Color Access, Inc. Novel antioxidant mixture

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648061A (en) * 1995-05-24 1997-07-15 Thomas Jefferson University In vivo and in vitro model of cutaneous photoaging
WO1996037237A1 (en) * 1995-05-24 1996-11-28 Thomas Jefferson University An in vivo and in vitro model of cutaneous photoaging

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840734A (en) * 1997-05-06 1998-11-24 Thomas Jefferson University Use of tempol in the prevention of photoaging
WO1999030682A1 (en) * 1997-12-17 1999-06-24 Color Access, Inc. Novel antioxidant mixture

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MIYACHI YOSHIKI: "Photoaging from an oxidative standpoint.", JOURNAL OF DERMATOLOGICAL SCIENCE, vol. 9, no. 2, 1995, pages 79 - 86, XP002223927, ISSN: 0923-1811 *
See also references of WO0049876A1 *
TAKEUCHI T ET AL: "A NOVEL IN VIVO MODEL FOR EVALUATING AGENTS THAT PROTECT AGAINST ULTRAVIOLET A-INDUCED PHOTOAGING", JOURNAL OF INVESTIGATIVE DERMATOLOGY, NEW YORK, NY, US, vol. 110, April 1998 (1998-04-01), pages 343 - 347, XP000995139, ISSN: 0022-202X *

Also Published As

Publication number Publication date
WO2000049876A1 (en) 2000-08-31
JP2002541774A (en) 2002-12-10
EP1162886A1 (en) 2001-12-19
AU3238800A (en) 2000-09-14
AU760969B2 (en) 2003-05-22
CA2362904A1 (en) 2000-08-31

Similar Documents

Publication Publication Date Title
AU2002211304A1 (en) Systems and methods for assessing vascular effects of a treatment
AU1630501A (en) Compositions and methods for detecting protein modification and enzymatic activity
AU6611200A (en) System and method for delivering agents into targeted tissue of a living being
WO2000072480A3 (en) Light amplification apparatus with automatic monitoring and controls
AU6053900A (en) Compositions for treating or preventing neurodegeneration and cognitive decline
AU2209599A (en) Methods and systems for the inhibition of vascular hyperplasia
AU2002236527A1 (en) Nutrient supplements and methods for treating autism and for preventing the onset of autism
AU4302101A (en) Prognostic testing of organs intended for transplantation
EP1219636A3 (en) Modified muteins of erythropoietin (EPO) derived from in vitro or in vivo expression system of microorganisms
AU4535700A (en) Steel for heat-resistant and/or high-tensile formed parts
AU6157899A (en) Catheter flush solution and method for its use
WO1998018440A3 (en) Use of inhibitors of the activity of retinoic acid for treating sensitive skin
AU2731001A (en) System and method for determining and controlling the impact of text
AU5100798A (en) Genetic markers and methods for the detection of (listeria monocytogenes) and (listeria spp)
AU2002246655A1 (en) Compositions and methods for detecting proteolytic activity
EP1162886A4 (en) System and method for evaluating agents which prevent oxidative damage
AU4452400A (en) Construction and method for undersurface laser marking
EP1163514A4 (en) AN $i(IN VIVO) AND $i(IN VITRO) MODEL FOR CUTANEOUS PHOTOAGING AND OXIDATIVE DAMAGE
AU6500600A (en) Methods and compositions for determining enzymatic activity
AU5559300A (en) Method of making and identifying attenuated microorganisms, compositions utilizing the sequences responsible for attenuation, and preparations containing attenuated microorganisms
AU3583000A (en) Method for direct steelmaking
AU2002226980A1 (en) Sampling and storage system for genetic material from tissue
AU2000266752A1 (en) Plant promoter derived from luminal binding protein gene and methods for its use
EP1210595A4 (en) System for monitoring the expression and/or location of transgenes
WO2000012118A8 (en) Inhibiting cardiomyocyte death

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010924

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CHARLES RIVER LABORATORIES

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CHARLES RIVER LABORATORIES

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CHARLES RIVER LABORATORIES

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CHARLES RIVER LABORATORIES

A4 Supplementary search report drawn up and despatched

Effective date: 20030102

17Q First examination report despatched

Effective date: 20040225

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040706