WO2000012118A8 - Inhibiting cardiomyocyte death - Google Patents

Inhibiting cardiomyocyte death

Info

Publication number
WO2000012118A8
WO2000012118A8 PCT/US1999/019823 US9919823W WO0012118A8 WO 2000012118 A8 WO2000012118 A8 WO 2000012118A8 US 9919823 W US9919823 W US 9919823W WO 0012118 A8 WO0012118 A8 WO 0012118A8
Authority
WO
WIPO (PCT)
Prior art keywords
cardiomyocyte death
inhibiting
methods
inhibiting cardiomyocyte
mammal
Prior art date
Application number
PCT/US1999/019823
Other languages
French (fr)
Other versions
WO2000012118A2 (en
WO2000012118A9 (en
WO2000012118A3 (en
Inventor
Mu-En Lee
Mark A Perrella
Shaw-Fang Yet
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Priority to AU60229/99A priority Critical patent/AU6022999A/en
Publication of WO2000012118A2 publication Critical patent/WO2000012118A2/en
Publication of WO2000012118A3 publication Critical patent/WO2000012118A3/en
Publication of WO2000012118A8 publication Critical patent/WO2000012118A8/en
Publication of WO2000012118A9 publication Critical patent/WO2000012118A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/99003—Heme oxygenase (1.14.99.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention features methods of inhibiting cardiomyocyte death in a mammal by administering to the myocardium of the mammal a heme oxygenase (HO). Methods of preserving an organ for transplantation and methods of inhibiting vascular stenosis are also within the invention.
PCT/US1999/019823 1998-08-28 1999-08-27 Inhibiting cardiomyocyte death WO2000012118A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU60229/99A AU6022999A (en) 1998-08-28 1999-08-27 Inhibiting cardiomyocyte death

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9837798P 1998-08-28 1998-08-28
US60/098,377 1998-08-28
US12194699P 1999-02-25 1999-02-25
US60/121,946 1999-02-25

Publications (4)

Publication Number Publication Date
WO2000012118A2 WO2000012118A2 (en) 2000-03-09
WO2000012118A3 WO2000012118A3 (en) 2000-06-29
WO2000012118A8 true WO2000012118A8 (en) 2000-08-10
WO2000012118A9 WO2000012118A9 (en) 2000-09-28

Family

ID=26794688

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/019823 WO2000012118A2 (en) 1998-08-28 1999-08-27 Inhibiting cardiomyocyte death

Country Status (2)

Country Link
AU (1) AU6022999A (en)
WO (1) WO2000012118A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2355066A1 (en) * 1998-12-17 2000-06-22 Sangstat Medical Corporation Extending graft survival by heme oxygenase-i expression induced immunomodulation
US20030022870A1 (en) * 2001-06-01 2003-01-30 Victor Dzau Methods of treating cardiac disorders
FR2842738B1 (en) * 2002-07-23 2006-02-10 Negma Lerads USE OF A RHEINE FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF CHRONIC INFLAMMATION, THE PREVENTION AND TREATMENT OF REJECTION OF ORGAN AND TISSUE TRANSPLANTATION
CN105288599A (en) * 2015-10-22 2016-02-03 徐州医学院 Application of heme oxygenase-2 in preparing preparations inhibiting organ transplantation immune rejection

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888982A (en) * 1996-04-01 1999-03-30 President And Fellows Of Harvard College Regulation of vascular smooth muscle cell heme oxygenase-1
US6057367A (en) * 1996-08-30 2000-05-02 Duke University Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses

Also Published As

Publication number Publication date
WO2000012118A2 (en) 2000-03-09
WO2000012118A9 (en) 2000-09-28
AU6022999A (en) 2000-03-21
WO2000012118A3 (en) 2000-06-29

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