EP1143948A3 - Liver-selective glucocorticoid antagonist for treating diabetes - Google Patents

Liver-selective glucocorticoid antagonist for treating diabetes

Info

Publication number
EP1143948A3
EP1143948A3 EP99925232A EP99925232A EP1143948A3 EP 1143948 A3 EP1143948 A3 EP 1143948A3 EP 99925232 A EP99925232 A EP 99925232A EP 99925232 A EP99925232 A EP 99925232A EP 1143948 A3 EP1143948 A3 EP 1143948A3
Authority
EP
European Patent Office
Prior art keywords
liver
treating diabetes
selective glucocorticoid
glucocorticoid antagonist
antagonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99925232A
Other languages
German (de)
French (fr)
Other versions
EP1143948A2 (en
Inventor
Theresa Apelqvist
Suad Efendic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Karo Pharma AB
Original Assignee
Karo Bio AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9812314.4A external-priority patent/GB9812314D0/en
Priority claimed from GBGB9815149.1A external-priority patent/GB9815149D0/en
Application filed by Karo Bio AB filed Critical Karo Bio AB
Publication of EP1143948A2 publication Critical patent/EP1143948A2/en
Publication of EP1143948A3 publication Critical patent/EP1143948A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP99925232A 1998-06-08 1999-06-07 Liver-selective glucocorticoid antagonist for treating diabetes Withdrawn EP1143948A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9812314.4A GB9812314D0 (en) 1998-06-08 1998-06-08 Treatment of diabetes
GB9812314 1998-06-08
GBGB9815149.1A GB9815149D0 (en) 1998-07-13 1998-07-13 Treatment of diabetes
GB9815149 1998-07-13
PCT/IB1999/001175 WO1999063976A2 (en) 1998-06-08 1999-06-07 Liver-selective glucocorticoid antagonist for treating diabetes

Publications (2)

Publication Number Publication Date
EP1143948A2 EP1143948A2 (en) 2001-10-17
EP1143948A3 true EP1143948A3 (en) 2002-09-11

Family

ID=26313822

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99925232A Withdrawn EP1143948A3 (en) 1998-06-08 1999-06-07 Liver-selective glucocorticoid antagonist for treating diabetes

Country Status (7)

Country Link
EP (1) EP1143948A3 (en)
JP (1) JP2002527355A (en)
KR (1) KR20010052431A (en)
AU (1) AU751569B2 (en)
CA (1) CA2334116A1 (en)
IL (1) IL139865A0 (en)
WO (1) WO1999063976A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9816935D0 (en) * 1998-08-05 1998-09-30 Karobio Ab Novel glucocortoid and thyroid receptor ligands for the treatment of metabolic disorders
GB9907048D0 (en) * 1999-03-27 1999-05-19 Karobio Ab Novel glucocorticoid receptor ligands for the treatment of meta bolic disorders
GB9928805D0 (en) * 1999-12-07 2000-02-02 Karobio Ab Compounds active at the Glucocorticoid and Thyroid Hormone Receptors
ES2246292T3 (en) 2000-10-30 2006-02-16 Pfizer Products Inc. GLUCOCORTICOID RECEIVER MODULATORS.
GB0029100D0 (en) * 2000-11-29 2001-01-10 Karobio Ab Compounds active at the glucocorticoid receptor
GB0029102D0 (en) 2000-11-29 2001-01-10 Karobio Ab Compounds active at the glucocorticoid receptor
WO2002049634A2 (en) * 2000-12-20 2002-06-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dissociated glucocorticoid receptor antagonists for the treatment of clucocorticoid associated side-effect
ATE437853T1 (en) * 2001-02-14 2009-08-15 Karobio Ab GLUCOCORTICOID RECEPTORS MODULATORS
US6583180B2 (en) 2001-02-14 2003-06-24 Abbott Laboratories Glucocorticoid receptor modulators
EP1285927A3 (en) 2001-08-16 2005-06-29 Schering Aktiengesellschaft Use of glucocorticoid antagonists for the prevention and treatment of diseases of the male reproductive system
JP2005539208A (en) * 2001-12-21 2005-12-22 スミスクライン ビーチャム コーポレーション Compositions and methods for altering glucose production
EA008830B1 (en) 2002-03-26 2007-08-31 Бёрингер Ингельхайм Фармасьютиклз, Инк. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7186864B2 (en) 2002-05-29 2007-03-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US8097606B2 (en) 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
US7527829B2 (en) 2003-07-31 2009-05-05 Soken Chemical & Engineering Co., Ltd. Fluid colloid crystal and process for producing three-dimensional aligned particle mass therefrom
UY28526A1 (en) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma GLUCOCORTICOID MIMETICS, METHODS OF PREPARATION PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
PE20060776A1 (en) 2004-12-27 2006-09-26 Boehringer Ingelheim Pharma MIMETICS OF GLUCOCORTICOIDES, METHODS TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS
CN101547909A (en) 2006-12-06 2009-09-30 贝林格尔.英格海姆国际有限公司 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
JP2011524867A (en) 2008-06-06 2011-09-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Glucocorticoid mimetic, method for producing the same, pharmaceutical composition, and use thereof
US8138189B2 (en) * 2009-03-26 2012-03-20 Hoffman-La Roche Inc. Substituted benzene compounds as modulators of the glucocorticoid receptor
US20120220590A1 (en) 2009-07-31 2012-08-30 Thombare Pravin S Novel compounds as modulators of glucocorticoid receptors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374148A (en) * 1980-10-21 1983-02-15 Pfizer Inc. Carboxylic acid therapeutic agents
US5929058A (en) * 1996-12-24 1999-07-27 Zymogenetics, Inc. Treatment agents and methods for treating type II diabetes and symptoms of type II diabetes

Also Published As

Publication number Publication date
EP1143948A2 (en) 2001-10-17
IL139865A0 (en) 2002-02-10
WO1999063976A3 (en) 2001-12-20
KR20010052431A (en) 2001-06-25
WO1999063976A2 (en) 1999-12-16
JP2002527355A (en) 2002-08-27
AU4160699A (en) 1999-12-30
CA2334116A1 (en) 1999-12-16
AU751569B2 (en) 2002-08-22

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