EP1131011A1 - Gerät zur thermischen behandlung von gewebe - Google Patents
Gerät zur thermischen behandlung von gewebeInfo
- Publication number
- EP1131011A1 EP1131011A1 EP99960383A EP99960383A EP1131011A1 EP 1131011 A1 EP1131011 A1 EP 1131011A1 EP 99960383 A EP99960383 A EP 99960383A EP 99960383 A EP99960383 A EP 99960383A EP 1131011 A1 EP1131011 A1 EP 1131011A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- electromagnetic probe
- handle
- probe assembly
- release member
- frame
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1477—Needle-like probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1485—Probes or electrodes therefor having a short rigid shaft for accessing the inner body through natural openings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00274—Prostate operation, e.g. prostatectomy, turp, bhp treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00547—Prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2218/00—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2218/001—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body having means for irrigation and/or aspiration of substances to and/or from the surgical site
- A61B2218/002—Irrigation
Definitions
- the present disclosure relates generally to a method and apparatus for thermal treatment of tissue and, more particularly, to an apparatus to be used with a conventional endoscope to provide the endoscope with thermal treatment capabilities.
- the apparatus is particularly contemplated for use with a cystoscope or a urethroscope for hyperthermia treatment of prostatic tissue.
- Benign prostate hyperplasia or hyperplasia affects over one out of every two males over the age of fifty.
- BPH is the non-cancerous enlargement of the prostate gland and is characterized generally by a constriction of the urethra by the prostate gland.
- An array of symptoms are associated with BPH including frequent urination, complications in urinary flow and associated pain.
- Drug therapy incorporates the use of one or more drugs such as ProscarTM and HydrinTM to either reduce the size of the prostate or to relax the urethral muscles thereby facilitating the normal functioning of the urinary system.
- drugs such as ProscarTM and HydrinTM
- Known drug therapies are limited in their effectiveness and present many drug side effect concerns.
- Surgical methods for treating BPH include transurethral resection of the prostate (TURP), transurethral incision of the prostate (TUIP), visual laser assisted prostatectomy (VLAP), balloon dilation and stenting.
- TURP is the most common method employed for BPH treatment today and involves the insertion of an electrosurgical cutting instrument through the urethral passage.
- the cutting elements of the instrument are positioned adjacent the prostate gland, and the instrument is energized such that the cutting elements selectively cauterize and resect tissue from the core of the prostate.
- the TURP procedure however, has many side effects including bleeding, electrograde ejaculation, impotence, incontinence, edema and a prolonged recovery period for the patient.
- An example of an electrosurgical cutting instrument utilized in conjunction with a TURP procedure is disclosed in U.S. Patent No. 5, 192,280.
- Transurethral incision of the prostate involves the use of an electrocautery device which is passed through the urethra.
- the device is employed to make multiple incisions in the prostate, thereby permitting the prostate to be displaced from the urethra wall to create an opening for urine flow.
- Success with the TUIP procedure is generally limited providing only temporary reprocedure in the future.
- VLAP Visual laser assisted prostatectomy
- a laser catheter through the urethra and directing laser energy laterally through the catheter sleeve at the urethral wall and the prostatic tissue.
- the laser energy causes the tissue to coagulate.
- the coagulated tissue eventually necrosis from lack of blood flow and is naturally removed from the body.
- Drawbacks of VLAP include increased recovery time, acute pain and irritation, and undesired burning of the urethral wall. Examples of methods and apparatuses utilized in VLAP treatment of BPH are disclosed in U.S.
- Balloon dilation and stenting procedures for BPH involve expanding and stretching the enlarged prostate with a balloon catheter to relieve pressure off the constricted urethra while stenting incorporates the insertion of tiny wire-mesh coils which expand into a scaffold to hold the urethra open. Balloon dilation and stenting, however, are only temporary procedures typically requiring follow up within a year period. In addition, stenting presents complications of stent migration and consequent irritation.
- Transurethral microwave therapy and high intensity focused ultrasound (HIFU) have been developed for the treatment of BPH.
- TUMT Transurethral microwave therapy
- HIFU high intensity focused ultrasound
- a foley-type urethral catheter having a microwave emitting antenna at a probe end is inserted into the urethral passage for a period of time sufficient to treat the tissue by microwave radiation.
- Intraurethral applicators of this type are described in
- the drawbacks of TUMT include the inability to focus the heat energy in the prostatic area and the inability to achieve high temperatures uniformly within the prostate.
- High intensity focused ultrasound includes directing high intensity ultrasound waves at the prostate tissue to create heat in a precise area to coagulate and necrose tissue.
- a transurethral probe is utilized to create the ultrasound beams for both imaging and ablation of the prostatic tissue. Disadvantages of this procedure include the inability to directly focus the ultrasound energy at the prostatic tissue.
- a more recent form of treatment for BPH involves thermally treating prostatic tissue with radio frequency electromagnetic energy.
- transurethral needle ablation involves the transurethral application of a medical instrument having a built-in RF needle electrode system. The TUNATM instrument is inserted into the urethra and advanced to a position adjacent the prostate.
- the TUNA technique is encouraging in thermal ablation procedures, particularly, in the thermal treatment of BPH, there are several disadvantages inherent to these instruments which detract from their usefulness.
- the TUNA instruments are generally complex typically incorporating built in optical systems, aspiration systems, etc...
- the TUNA instruments incorporate a complex mechanism for advancing and retracting the RF needles within the tissue and relative to the insulating sleeves.
- the instruments are relatively expensive to manufacture thereby precluding disposability of the instrument after a minimal number of uses.
- conventional TUNA instruments are generally enlarged by virtue of the various systems incorporated within the instrument, thus, increasing patient trauma and discomfort during use.
- the present disclosure is directed to an apparatus for the RF thermal treatment of prostatic tissue.
- This apparatus is intended for use in conjunction with a conventional cystoscope and incorporates an RF system and associated mechanism that is at least partially positionable within the working channel of the cystoscope.
- the apparatus by use in conjunction with a conventional cystoscope, makes use of the existing systems, e.g. , optical and illumination, of in a less complex and less expensive RF thermal treatment device.
- the apparatus may be used in cystoscopes as small as 5mm in diameter thereby providing a less invasive system for transurethral ablation as compared to the TUNA instruments and technique.
- the apparatus incorporates a novel assembly mechanism which permits the user to selectively couple a variety of RF electrode units having different energy transmitting capabilities to the apparatus to accommodate desired operative parameters.
- An apparatus for thermal treatment of tissue includes an outer member having a frame dimensioned for engagement with the hand of a surgeon and an elongated portion connected to the frame and extending distally therefrom.
- the elongated portion defines a longitudinal axis and has an axial opening.
- An electromagnetic probe assembly is releasably mounted to the outer member.
- the electromagnetic probe assembly includes a handle and an electromagnetic probe connected to the handle.
- the electromagnetic probe is at least partially positionable within the axial opening of the elongated portion and is adapted for reciprocal longitudinal movement therewithin between a non-deployed position and a deployed position.
- a manually operable release member releasably mounts the electromagnetic probe assembly to the outer member.
- the release member is dimensioned and positioned for manual manipulation to move between a first position engaging the electromagnetic probe assembly and preventing release thereof from the outer member, and a second position releasing the electromagnetic probe assembly to thereby facilitate assembly and disassembly of the electromagnetic probe assembly with respect to the outer member.
- the release member is preferably mounted to the frame of the outer member and is rotatable about the longitudinal axis to move between the first and second positions thereof.
- the handle of the electromagnetic probe assembly includes a handle extension which is received within the central opening of the release member.
- the release member is preferably normally biased to the first position thereof.
- the release member may define an inner cam surface adjacent the opening.
- the handle extension of the handle defines a corresponding outer cam surface.
- the outer cam surface cooperates with the inner cam surface upon advancement of the handle extension within the release member to move the release member to the second position thereof.
- the handle extension may define an outer rail.
- the outer rail defines the outer cam surface at its distal end and defines an abutment surface at its proximal end.
- the abutment surface is dimensioned and configured to engage the release member to prevent removal of the electromagnetic probe assembly from the outer member when the release member is in the first position thereof and the electromagnetic probe is assembled with respect to the outer member.
- the frame of the outer member includes at least one longitudinal recess dimensioned for reception of the one outer rail to prevent rotational movement of the electromagnetic probe assembly relative to the outer member.
- the apparatus may include a ratchet and associated pawl mechanism for permitting controlled incremental movement of the electromagnetic probe assembly toward the deployed position while preventing movement of the electromagnetic probe assembly toward its non-deployed position.
- a manually engageable release trigger depends from the frame. The release trigger is movable to disengage the ratchet and associated pawl mechanism thereby permitting movement of the electromagnetic probe toward the non-deployed position.
- the electromagnetic probe includes a radio frequency electrode.
- the electromagnetic probe may define an axial channel for passage of fluids, and at least one opening extends through an outer wall of the probe in fluid communication with the axial channel to permit exit of the fluids therefrom.
- a source of fluid may be in communication with the axial channel of the electromagnetic probe.
- the source of fluid may include one of an irrigant fluid or a conductive fluid.
- FIG. 1 is a perspective view of the thermal treatment apparatus in accordance with the principles of the present disclosure, illustrating the electrosurgical instrument, power source and foot pedal for operating the instrument;
- FIG. 2 is a perspective view of the electrosurgical instrument of the apparatus of FIG. 1 illustrating the handle and the elongated portion connected to the handle;
- FIG. 3 is a disassembled view of the handle of the electrosurgical instrument illustrating the frame and the actuator mounted to the frame;
- FIG. 4 is a perspective view with parts separated of the elongated portion of the electrosurgical instrument
- FIG. 5 is an enlarged perspective view of the distal end of the elongated member with a portion cut-away illustrating the electromagnetic probe and the thermocouples associated with the electromagnetic probe;
- FIG. 6 is a cross-sectional view of the handle of the electrosurgical instrument in an initial unactuated position
- FIG. 6A is an enlarged cross-sectional view of the elongated portion in the initial unactuated position of the instrument
- FIG. 7 is a perspective view with parts separated illustrating the components of the frame of the handle;
- FIG. 8 is a perspective view with parts separated illustrating the components of the actuator of the electrosurgical instrument;
- FIGS. 9-10 are views illustrating the assembly member of the electrosurgical instrument
- FIG. 11 is a cross-sectional view taken along the lines 11-11 of FIG. 6 illustrating the assembly member in a locked position preventing disassembly of the actuator and the electromagnetic probe;
- FIG. 12 is a view similar to the view of FIG. 11 illustrating the assembly member in an unlocked position permitting disassembly of the actuator and electromagnetic probe;
- FIG. 13 is a cross-sectional view taken along the lines 13-13 of FIG. 6;
- FIG. 14 is a view illustrating a cystoscope inserted within the urethral passage of the patient and having the electrosurgical instrument mounted within a working channel thereof;
- FIG. 15 is a cross-sectional view taken along the lines 15-15 of FIG. 14 illustrating the electrosurgical instrument inserted within the working channel of the cystoscope and the components of the cystoscope;
- FIG. 16 is an enlarged view of the electrosurgical instrument inserted within the cystoscope
- FIG. 17 is a cross-sectional view of the handle of the electrosurgical instrument illustrating actuation of the actuator to deploy the electromagnetic probe
- FIG. 18 is a view illustrating penetration of the electromagnetic probe within the prostrate corresponding to the position of the actuator in FIG. 17;
- FIG. 19 is an enlarged view illustrating the electromagnetic probe positioned within the prostrate and ejecting an irrigant;
- FIG. 20 is a cross-sectional view of the handle illustrating release of the release trigger and movement of the actuator to the initial unadvanced position
- FIG. 21 is a perspective view of an alternate actuator and electromagnetic probe connectable to the electrosurgical instrument
- FIG. 22 is a view illustrating a steerable cystoscope inserted within the urethral passage and having the electrosurgical instrument mounted therein;
- FIG. 23 is an enlarged isolated view illustrating the distal end of the cystoscope deflected at a desired angular orientation with the electromagnetic probe deployed.
- the apparatus of the present disclosure is intended to deliver electromagnetic energy to tissue for thermal treatment of the tissue including tissue ablation, tissue vaporization and/or tissue coagulation.
- the apparatus has particular application in the treatment of benign prostate hyperplasia (BPH) with electromagnetic radio frequency (RF) energy, however, it is to be appreciated that the apparatus is not limited to such application.
- BPH benign prostate hyperplasia
- RF radio frequency
- the apparatus is not limited to the treatment of BPH, but, may be used in other surgical procedures such as cardiac ablation, cancer treatment, etc....
- the apparatus may be used in any minimally invasive procedure where thermal treatment of tissue is desired and access to the tissue is limited.
- the apparatus is particularly intended to be used in conjunction with an endoscope such as a cystoscope, fiber scope, laparoscope, urethroscope, etc... to provide the scope with thermal treatment capabilities. More specifically, in treatment of BPH, the apparatus may be insertable within the working channel of a cystoscope, which is positioned in the urethra to access the prostatic gland, to thermally treat the gland to relieve the symptoms of BPH.
- Apparatus 10 includes electrosurgical instrument 12, power source 14 for supplying electromagnetic energy to the instrument 12 and foot pedal 16 for activating/deactivating the instrument 12.
- Apparatus 10 may further include a source of irrigant 18 which is to be supplied to the operative area.
- irrigant 18 include water, normal saline, contrast media and the like.
- the source may include a conductive fluid such as any physiologically-compatible liquid, solution, slurry, gel, isotonic solution to facilitate the transfer of heat or energy at the operative site.
- Power source 14 may be any suitable power generator capable of supplying radiofrequency energy in the frequency range of about 300 kHz - about 800 kHz.
- One suitable power generator is disclosed in application serial no. 08/948,990, filed October 10, 1997, the contents of which are incorporated herein by reference. Referring now to FIGS. 2-3, electrosurgical instrument 12 of apparatus
- Instrument 12 includes handle 20 and elongate portion 22 connected to the handle 20 and extending distally therefrom, and defining longitudinal axis "a" .
- Handle 20 includes main frame 24 and electrode actuator 26 which is mounted for movement relative to the frame 24.
- Frame 24 consists of frame half sections 24a, 24b which are connected to each other along respective peripheral areas with suitable means including adhesives, cements, screws, etc.
- Frame 24 defines diametrically opposed finger loops 28a, 28b which are advantageously dimensioned to receive the index and middle fingers respectively of the operator.
- Electrode actuator 26 includes two sections, namely, manual engaging proximal portion 30 and distal extension 32 connected to the manual portion 30.
- Manual portion 30 defines an arcuate outer surface area "s" which is contoured to accommodate the palm area of the user's hand.
- Distal extension 32 is received within a corresponding dimensioned longitudinal bore or channel of main frame 24 and is adapted for reciprocal longitudinal movement therewithin to deploy an electromagnetic probe connected to the electrode actuator 26.
- Distal extension 32 includes first and second longitudinally extending opposed rails 34 on its outer surface. Rails 34 define distal camming rail surfaces 34a.
- Electrode actuator 26 is releasably mounted to frame 24 to permit rapid disassembly and subsequent, if desired, insertion and mounting of a
- Elongate portion 22 includes outer sleeve 36 which is preferably flexible and manufactured from a suitable flexible elastomeric or polymeric material. It is envisioned that outer sleeve 36 may be rigid and manufactured, e.g. , from stainless steel, titanium or a rigid polymer.
- An electromagnetic probe 38 is disposed within outer sleeve 36 and is reciprocally movable therewithin. Electromagnetic probe 38 is preferably configured as an RF electrode and has an insulating layer 40 coaxially mounted thereabout. As is conventional, the distal end of electromagnetic probe is uninsulated to transmit the electromagnetic (RF) energy.
- Electromagnetic probe 38 has an axial channel 42 for passage of the irrigant fluids or, if desired, conductive fluids.
- a plurality of perforations or openings 44 extend through the outer wall of electromagnetic probe 38 in communication with the axial channel 42 to permit exit of the irrigant into the treatment site.
- the distal end of electromagnetic probe 38 has a penetrating end member 46 connected thereto which defines a closed pointed end dimensioned to facilitate passage of the probe 38 through tissue. Although shown as a separate component, it is envisioned that penetrating end member 46 may be integrally formed with electromagnetic probe as a single unit.
- Elongate portion 22 may further include a pair of thermocouples 48, 50 which extend along the exterior surface of outer sleeve 36.
- the first thermocouple 48 extends to a position adjacent the distal end of outer sleeve 36 and is intended to measure the temperature of the tissue within the treatment area for monitoring purposes.
- the second thermocouple 50 extends to a position displaced from the distal end of outer sleeve 36 and is intended to measure the temperature of tissue outside and adjacent the treatment area to ensure that this tissue is not undesirably treated.
- Shrink wrapping "w" (FIG. 5) is disposed about outer sleeve 36 and thermoc thermocouples 48, 50.
- Handle 20 includes quick release or assembly member 52 mounted to the proximal end of frame 24.
- Assembly member 52 is adapted to releasably lock actuator 26 to frame 24, and is movable from a first or engaged position preventing removal of actuator 26 from frame 24 to a second or disengaged position permitting removal of the actuator 26 from the frame 24.
- assembly member 52 includes a generally circular main portion 54 and diametrical opposed tabs 56 extending from the main portion 54.
- Main portion 54 is accommodated within correspondingly dimensioned arcuate grooves 58 formed in each of frame sections 24a, 24b. Grooves
- Main portion 54 defines central aperture 60 which is configured to receive distal extension 32 of actuator 26 and permit sliding movement of the distal extension 32 therethrough.
- main portion 54 of assembly member 52 further defines a pair of grooves 62 adjacent aperture 60 and arranged in diametrical opposed relation. Grooves 62 are arranged to define slanted or oblique cam surface 62a, i.e. , the grooves 62 extend in an oblique relation with respect to a central axis "a" of assembly member 52, the significance of which will be discussed in detail hereinbelow.
- a coil spring 64 is mounted adjacent assembly member 52 and possesses spring end portions 64a, 64b.
- Spring end portion 64a is received within correspondingly dimensioned aperture 66 of assembly member 52. (See also FIGS. 9-10.)
- Spring end portion 64b engages corresponding structure 68 of frame 24 to fix the end portion 64b to the frame 24. In this manner, coil spring 64 normally biases assembly member 52 to the first or engaged position which is depicted in FIG. 11.
- electromagnetic probe 38 extends within frame 24 of handle 20 and is operatively connected to actuator 26.
- electromagnetic probe 38 is connected to ferrule 68 by suitable means including adhesives, cements, crimping or the like.
- Ferrule 68 is accommodated within ferrule connection tab 70 of actuator 26 and is fixed to the tab 70 by a snap lock fit or a bayonet coupling. Accordingly, reciprocal longitudinal movement of actuator 26 causes corresponding movement of electromagnetic probe 38 between an initial position and an advanced deployed position.
- actuator 38 is electrically connected to power source 14 through electrical connector 72 which is mounted within a corresponding recess 74 of actuator 26.
- a feed line 76 extends from electrical connector 56 to electromagnetic probe 38 to electrically connect the two components.
- actuator 26 is depicted in the initial position where electromagnetic probe 38 is contained within outer sleeve 36 as depicted in FIG. 6A.
- Actuator 26 is normally biased to the initial position by compression or coiled spring 78. More specifically, compression spring 78 engages at its distal end spring mount 80 which is positioned within recess 82 (FIG. 8) and against bearing surface 84 of actuator 26. At its proximal end, compression spring 78 engages ferrule 68 to thereby bias ferrule 68 and. thus, electromagnetic probe 38 and actuator 26, proximally to the initial position depicted in FIG. 6.
- release trigger 82 is pivotally mounted to frame 24 about pivot pin 84. Release trigger
- pawl 86 of release trigger 82 engages the teeth of ratchet portion 88 to selectively releasably lock actuator 26 at predetermined positions between the initial position and the deployed position thereof while preventing return motion of the actuator 26, to thereby enable the operator to selectively control the degree of extension of electromagnetic probe 38 beyond outer sleeve 36.
- the pawl and ratchet arrangement also provides a perceptible audio indicator to the user indicating the degree of advancement of the electromagnetic probe.
- Release trigger 82 is adapted to pivot about pivot pin 84 from the engaged position of FIG. 6 where pawl 86 is in locking engagement with ratchet portion
- a leaf spring 90 normally biases release trigger 82 to its engaged position.
- handle 20 also includes connector sleeve 92 for connecting outer sleeve 36 to frame 24.
- Connector sleeve 92 includes proximal flange 94 which is received within a corresponding dimensioned recess 96 of frame 24 to connect the two components.
- handle 20 further includes luer connector 98 which conveys through tube 100 extending through actuator 26 the irrigant or conductive fluid.
- Tube 100 is in fluid communication with an internal bore 102 of ferrule 68 (FIG. 8). Internal bore 102 is in fluid communication with axial channel 42 of electromagnetic probe 38. The assembly of instrument 12 will now be discussed.
- actuator 26 To assemble actuator 26 within frame 24, distal extension 32 of the actuator 26 is inserted in the proximal end of the frame 24 with distal cam surfaces 34a of external rails 34 on the exterior surface of actuator 26 being received within grooves 62 of quick assembly member 52 (FIG. 10). Actuator 26 is advanced within frame 24 whereby during advancement cam surfaces 34a ride along inclined cam surfaces 62a defined by grooves
- FIG. 13 is a cross-sectional view taken along the lines 13-13 of FIG. 6.
- rails 34 of actuator 26 are accommodated within longitudinal recesses 104 formed in frame half sections 24a, 24b (FIG. 7) and are guided by and confined within the recesses during advancement of the actuator 26 thereby preventing the actuator 26 from rotating within the frame 24.
- electrosurgical instrument 12 is shown positioned within a conventional cystoscope 200 for thermal treatment of prostrate "p" to alleviate the symptoms of BPH.
- One conventional cystoscope 200 with which the apparatus of the present disclosure can be utilized is the ACN Flexible CystoNephroscope manufactured by Circon ACMI of Stamford, Ct.
- Cystoscope 200 includes handle 202 and a flexible elongated portion 204 connected to the handle 202 and extending distally therefrom. Cystoscope 200 incorporates an optical apparatus to permit viewing of the tissue to be treated. As depicted in FIG. 15, the optical system preferably consists of flexible fiber optic bundles (identified by reference numeral 206) which are accommodated within a longitudinal bore extending through the elongated portion 204 of the scope 200. The fiber optic bundles 206 extend to eyepiece 208 where the surgeon can view the image transmitted by the optical system.
- Cystoscope 200 also includes an illumination system which provides illuminating light to the targeted tissue area.
- the illumination system includes a plurality of optical fibers 210 which are accommodated within a plurality of longitudinal channels (two are shown) of elongated portion 204 and extend within handle 202 where they terminate at illumination coupler 212.
- Illumination coupler 212 is connectable to a conventional light source as is known in the art.
- Cystoscope 200 further includes a working channel 214 (FIG. 16) extending through flexible elongated portion 204 and terminating at channel port 216 of handle 202.
- Working channel 214 is adapted to receive various surgical inst 216 (e.g. , electrosurgical instrument 12) to permit the performance of surgical procedures at the distal end of the cystoscope 200.
- Cystoscope 200 is preferably a 5mm scope. Cystoscope 200 is further characterized by being a steerable scope, i.e. , the distal end of the scope may be manipulated to a variety of different angles and orientation, via handle or control knob mounted on the proximal end of the scope.
- a steerable scope i.e. , the distal end of the scope may be manipulated to a variety of different angles and orientation, via handle or control knob mounted on the proximal end of the scope.
- Cystoscope 200 is inserted through urethral passage "u" of the patient and advanced within the passage until the distal end of the scope is adjacent prostate gland "p" . Thereafter, elongate portion 22 of instrument 12 is inserted into working channel 214 of cystoscope 200 and advanced into the working channel 214 until handle 20 of the instrument 12 contacts channel port 216 of scope handle 202.
- instrument 12 may be positioned within cystoscope 200 prior to insertion within the urethral passage "u” and the entire assembly may be then advanced within the urethral passage. It is envisioned that handle 20 of instrument 12 may incorporate a locking mechanism to lockingly engage channel port 216 of handle 202 of the cystoscope 200.
- electrode actuator 26 is distally advanced to move or deploy electromagnetic probe 38 from outer sleeve 36 of the instrument and the distal end face of cystoscope 200.
- the degree of deployment of electromagnetic probe 38 is monitored both audibly by virtue of the ratchet and associated pawl mechanism and visually by virtue of the gradient markings "m" on the external surface of the actuator 26 (FIG. 2).
- pawl 86 of release trigger 82 releasably locks or secures the actuator 26 and electromagnetic probe 38 at any desired predetermined intermediate position.
- Advancement of the electromagnetic probe 38 causes the distal end portion of the probe to enter the prostate. The location of the probe end portion may be visually monitored with the optical system of the cystoscope 200.
- the apparatus is then energized to thermally treat (e.g., ablate, vaporize or cauterize) the desired prosthetic tissue with RF energy.
- thermally treat e.g., ablate, vaporize or cauterize
- the prosthetic tissue BPH necroses and dies, thus, relieving pressure off the urethral wall and alleviating the symptoms of BPH.
- the depth of penetration of penetrating end portions of electromagnetic probe 38 may be selectively adjusted by movement of actuator 26 to permit specific regions of the prosthetic tissue "p" to be targeted for thermal treatment thus providing heating pattern flexibility and control.
- insulating layer 40 of electromagnetic probe 38 preferably contacts the urethral wall "u" to prevent damage to the wall.
- an irrigant agent may be dispensed through apertures 44 of electromagnetic probe 38 to flush and cool the area adjacent the probe end portion as depicted in FIG. 19.
- a conductive agent may be dispensed through the apertures 44 to facilitate heat transfer to enhance the ablation process.
- the apparatus Upon completion of the treatment, the apparatus is de-energized and the cystoscope 200 and apparatus are removed from the urethral passage "u" . Thereafter, release trigger 82 is depressed to release the ratchet and pawl thereby permitting actuator 26 to return to its initial position under the influence of compression spring 78 as depicted in FIG. 20. Actuator 26 is then removed by rotating assembly member 52 to the position depicted in FIG. 12 to align the grooves 62 of the assembly member 52 with rails 34 of actuator 26 thereby permitting removal of the electrode actuator. If desired, a second actuator 26 and associated electrode unit having different energy transmitting properties (e.g., a greater portion of electrode 38 uninsulated) such as the unit depicted in FIG. 21 (compare FIG.
- the assembly mechanism enables the operator to select a desired actuator and associated electrode unit to achieve a desired operative parameter and quickly and efficiently mount the actuator to the apparatus.
- the apparatus may be sold as a kit with several different actuator and electrode units having different energy transmitting capabilities, for example, including the units depicted in FIG. 5 and FIG. 21.
- the actuator may be quickly removed for disposal or sterilization if desired.
- this unit would require sterilization thereby minimizing maintenance costs of the apparatus and enhancing the life thereof.
- apparatus 10 may be used with a cystoscope 200 having steerable capabilities whereby the distal end of the scope 200 may be manipulated at a variety of different angles and orientations via a handle or control lever 250 mounted adjacent the proximal end of the scope.
- the distal end is manipulated to a desired angle and the electrode 38 is thereafter deployed at the desired angle to penetrate the prostate.
- a suitable steerable cystoscope is disclosed in U.S. Patent No. 5,704,898, the contents of which are incorporated herein by reference.
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plasma & Fusion (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10859698P | 1998-11-16 | 1998-11-16 | |
US108596P | 1998-11-16 | ||
PCT/US1999/027133 WO2000028909A1 (en) | 1998-11-16 | 1999-11-16 | Apparatus for thermal treatment of tissue |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1131011A1 true EP1131011A1 (de) | 2001-09-12 |
EP1131011A4 EP1131011A4 (de) | 2002-09-25 |
EP1131011B1 EP1131011B1 (de) | 2005-04-13 |
Family
ID=22323068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99960383A Expired - Lifetime EP1131011B1 (de) | 1998-11-16 | 1999-11-16 | Gerät zur thermischen behandlung von gewebe |
Country Status (6)
Country | Link |
---|---|
US (1) | US6526320B2 (de) |
EP (1) | EP1131011B1 (de) |
AU (1) | AU1727400A (de) |
DE (1) | DE69924750T2 (de) |
ES (1) | ES2238862T3 (de) |
WO (1) | WO2000028909A1 (de) |
Families Citing this family (205)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7992572B2 (en) | 1998-06-10 | 2011-08-09 | Asthmatx, Inc. | Methods of evaluating individuals having reversible obstructive pulmonary disease |
US6634363B1 (en) | 1997-04-07 | 2003-10-21 | Broncus Technologies, Inc. | Methods of treating lungs having reversible obstructive pulmonary disease |
US7425212B1 (en) * | 1998-06-10 | 2008-09-16 | Asthmatx, Inc. | Devices for modification of airways by transfer of energy |
US6488673B1 (en) * | 1997-04-07 | 2002-12-03 | Broncus Technologies, Inc. | Method of increasing gas exchange of a lung |
US7027869B2 (en) | 1998-01-07 | 2006-04-11 | Asthmatx, Inc. | Method for treating an asthma attack |
US7921855B2 (en) * | 1998-01-07 | 2011-04-12 | Asthmatx, Inc. | Method for treating an asthma attack |
EP1056501B1 (de) | 1998-02-24 | 2005-11-16 | Boston Scientific Limited | Dialysekatheter mit hohem durchfluss und verfahren dazu |
US8181656B2 (en) * | 1998-06-10 | 2012-05-22 | Asthmatx, Inc. | Methods for treating airways |
US20070123958A1 (en) * | 1998-06-10 | 2007-05-31 | Asthmatx, Inc. | Apparatus for treating airways in the lung |
US7198635B2 (en) | 2000-10-17 | 2007-04-03 | Asthmatx, Inc. | Modification of airways by application of energy |
US6245062B1 (en) * | 1998-10-23 | 2001-06-12 | Afx, Inc. | Directional reflector shield assembly for a microwave ablation instrument |
US6277113B1 (en) * | 1999-05-28 | 2001-08-21 | Afx, Inc. | Monopole tip for ablation catheter and methods for using same |
US6300108B1 (en) * | 1999-07-21 | 2001-10-09 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes |
US7033352B1 (en) * | 2000-01-18 | 2006-04-25 | Afx, Inc. | Flexible ablation instrument |
US6689131B2 (en) | 2001-03-08 | 2004-02-10 | Tissuelink Medical, Inc. | Electrosurgical device having a tissue reduction sensor |
US7811282B2 (en) * | 2000-03-06 | 2010-10-12 | Salient Surgical Technologies, Inc. | Fluid-assisted electrosurgical devices, electrosurgical unit with pump and methods of use thereof |
US8048070B2 (en) * | 2000-03-06 | 2011-11-01 | Salient Surgical Technologies, Inc. | Fluid-assisted medical devices, systems and methods |
EP1263341B1 (de) * | 2000-03-06 | 2008-06-11 | Salient Surgical Technologies, Inc. | Flüssigkeitsabgabesystem und steuerung für elektrochirurgische geräte |
US6558385B1 (en) | 2000-09-22 | 2003-05-06 | Tissuelink Medical, Inc. | Fluid-assisted medical device |
US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US8251070B2 (en) | 2000-03-27 | 2012-08-28 | Asthmatx, Inc. | Methods for treating airways |
US6673068B1 (en) * | 2000-04-12 | 2004-01-06 | Afx, Inc. | Electrode arrangement for use in a medical instrument |
US8251986B2 (en) | 2000-08-17 | 2012-08-28 | Angiodynamics, Inc. | Method of destroying tissue cells by eletroporation |
US6892099B2 (en) | 2001-02-08 | 2005-05-10 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation |
US6795728B2 (en) | 2001-08-17 | 2004-09-21 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation |
US6697670B2 (en) * | 2001-08-17 | 2004-02-24 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients |
US7104987B2 (en) | 2000-10-17 | 2006-09-12 | Asthmatx, Inc. | Control system and process for application of energy to airway walls and other mediums |
US20020087151A1 (en) * | 2000-12-29 | 2002-07-04 | Afx, Inc. | Tissue ablation apparatus with a sliding ablation instrument and method |
US6835193B2 (en) | 2001-07-10 | 2004-12-28 | Myocardial Therapeutics, Inc. | Methods for controlled depth injections into interior body cavities |
US6796963B2 (en) * | 2001-07-10 | 2004-09-28 | Myocardial Therapeutics, Inc. | Flexible tissue injection catheters with controlled depth penetration |
USRE42016E1 (en) | 2001-08-13 | 2010-12-28 | Angiodynamics, Inc. | Apparatus and method for the treatment of benign prostatic hyperplasia |
US7130697B2 (en) * | 2002-08-13 | 2006-10-31 | Minnesota Medical Physics Llc | Apparatus and method for the treatment of benign prostatic hyperplasia |
US6994706B2 (en) | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
WO2003049631A1 (en) * | 2001-12-12 | 2003-06-19 | Tissuelink Medical, Inc. | Fluid-assisted medical devices, systems and methods |
US7192427B2 (en) * | 2002-02-19 | 2007-03-20 | Afx, Inc. | Apparatus and method for assessing transmurality of a tissue ablation |
US20050075629A1 (en) * | 2002-02-19 | 2005-04-07 | Afx, Inc. | Apparatus and method for assessing tissue ablation transmurality |
US20030176883A1 (en) * | 2002-03-12 | 2003-09-18 | Sauer Jude S | Tissue manipulation apparatus and method of use |
CA2493556C (en) | 2002-07-25 | 2012-04-03 | Thomas L. Ii Buchman | Electrosurgical pencil with drag sensing capability |
EP1572020A4 (de) | 2002-10-29 | 2006-05-03 | Tissuelink Medical Inc | Flüssigkeitsunterstützte elektrochirurgischeschere und verfahren |
US7244257B2 (en) * | 2002-11-05 | 2007-07-17 | Sherwood Services Ag | Electrosurgical pencil having a single button variable control |
US7235072B2 (en) * | 2003-02-20 | 2007-06-26 | Sherwood Services Ag | Motion detector for controlling electrosurgical output |
FR2854052A1 (fr) * | 2003-04-25 | 2004-10-29 | Medtronic Inc | Distribution de fluide au cours du traitement transuretral de la prostate |
US20040215181A1 (en) * | 2003-04-25 | 2004-10-28 | Medtronic, Inc. | Delivery of fluid during transurethral prostate treatment |
EP1617776B1 (de) | 2003-05-01 | 2015-09-02 | Covidien AG | System zur programmierung und kontrolle eines elektrochirurgischen generatorsystems |
US20040226556A1 (en) | 2003-05-13 | 2004-11-18 | Deem Mark E. | Apparatus for treating asthma using neurotoxin |
US7241294B2 (en) * | 2003-11-19 | 2007-07-10 | Sherwood Services Ag | Pistol grip electrosurgical pencil with manual aspirator/irrigator and methods of using the same |
US7156842B2 (en) | 2003-11-20 | 2007-01-02 | Sherwood Services Ag | Electrosurgical pencil with improved controls |
US7503917B2 (en) * | 2003-11-20 | 2009-03-17 | Covidien Ag | Electrosurgical pencil with improved controls |
US7879033B2 (en) | 2003-11-20 | 2011-02-01 | Covidien Ag | Electrosurgical pencil with advanced ES controls |
US8298222B2 (en) | 2003-12-24 | 2012-10-30 | The Regents Of The University Of California | Electroporation to deliver chemotherapeutics and enhance tumor regression |
US8048067B2 (en) | 2003-12-24 | 2011-11-01 | The Regents Of The University Of California | Tissue ablation with irreversible electroporation |
US7727232B1 (en) | 2004-02-04 | 2010-06-01 | Salient Surgical Technologies, Inc. | Fluid-assisted medical devices and methods |
JP4443278B2 (ja) * | 2004-03-26 | 2010-03-31 | テルモ株式会社 | 拡張体付カテーテル |
US7247275B2 (en) * | 2004-06-21 | 2007-07-24 | Jeremy Scot Caldwell | Gel extraction device |
US7322974B2 (en) * | 2004-08-10 | 2008-01-29 | Medtronic, Inc. | TUNA device with integrated saline reservoir |
US8911438B2 (en) * | 2004-08-10 | 2014-12-16 | Medtronic, Inc. | Tuna device with integrated saline reservoir |
US7134543B2 (en) * | 2004-09-22 | 2006-11-14 | Frito-Lay North America, Inc. | Containment apparatus for multi-pass ovens |
US7261710B2 (en) * | 2004-10-13 | 2007-08-28 | Medtronic, Inc. | Transurethral needle ablation system |
US7949407B2 (en) | 2004-11-05 | 2011-05-24 | Asthmatx, Inc. | Energy delivery devices and methods |
WO2006052940A2 (en) | 2004-11-05 | 2006-05-18 | Asthmatx, Inc. | Medical device with procedure improvement features |
US20070093802A1 (en) * | 2005-10-21 | 2007-04-26 | Danek Christopher J | Energy delivery devices and methods |
US7918795B2 (en) | 2005-02-02 | 2011-04-05 | Gynesonics, Inc. | Method and device for uterine fibroid treatment |
US20060264752A1 (en) * | 2005-04-27 | 2006-11-23 | The Regents Of The University Of California | Electroporation controlled with real time imaging |
US20060293730A1 (en) | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating restenosis sites using electroporation |
US20060293725A1 (en) * | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating fatty tissue sites using electroporation |
US20060293731A1 (en) * | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating tumors using electroporation |
US8114070B2 (en) | 2005-06-24 | 2012-02-14 | Angiodynamics, Inc. | Methods and systems for treating BPH using electroporation |
US7500974B2 (en) | 2005-06-28 | 2009-03-10 | Covidien Ag | Electrode with rotatably deployable sheath |
EP1913578B1 (de) * | 2005-06-30 | 2012-08-01 | LG Electronics Inc. | Verfahren und vorrichtung zum decodieren eines audiosignals |
US7828794B2 (en) * | 2005-08-25 | 2010-11-09 | Covidien Ag | Handheld electrosurgical apparatus for controlling operating room equipment |
US8252017B2 (en) * | 2005-10-18 | 2012-08-28 | Cook Medical Technologies Llc | Invertible filter for embolic protection |
US20070156135A1 (en) * | 2006-01-03 | 2007-07-05 | Boris Rubinsky | System and methods for treating atrial fibrillation using electroporation |
US20070161905A1 (en) * | 2006-01-12 | 2007-07-12 | Gynesonics, Inc. | Intrauterine ultrasound and method for use |
US7874986B2 (en) | 2006-04-20 | 2011-01-25 | Gynesonics, Inc. | Methods and devices for visualization and ablation of tissue |
US10058342B2 (en) | 2006-01-12 | 2018-08-28 | Gynesonics, Inc. | Devices and methods for treatment of tissue |
US7815571B2 (en) * | 2006-04-20 | 2010-10-19 | Gynesonics, Inc. | Rigid delivery systems having inclined ultrasound and needle |
US11259825B2 (en) | 2006-01-12 | 2022-03-01 | Gynesonics, Inc. | Devices and methods for treatment of tissue |
US9357977B2 (en) | 2006-01-12 | 2016-06-07 | Gynesonics, Inc. | Interventional deployment and imaging system |
US20070179491A1 (en) * | 2006-01-31 | 2007-08-02 | Medtronic, Inc. | Sensing needle for ablation therapy |
US20100056926A1 (en) * | 2008-08-26 | 2010-03-04 | Gynesonics, Inc. | Ablation device with articulated imaging transducer |
US10595819B2 (en) | 2006-04-20 | 2020-03-24 | Gynesonics, Inc. | Ablation device with articulated imaging transducer |
US8206300B2 (en) | 2008-08-26 | 2012-06-26 | Gynesonics, Inc. | Ablation device with articulated imaging transducer |
US20070260240A1 (en) * | 2006-05-05 | 2007-11-08 | Sherwood Services Ag | Soft tissue RF transection and resection device |
US8048069B2 (en) * | 2006-09-29 | 2011-11-01 | Medtronic, Inc. | User interface for ablation therapy |
US7674249B2 (en) * | 2006-10-16 | 2010-03-09 | The Regents Of The University Of California | Gels with predetermined conductivity used in electroporation of tissue |
US7931647B2 (en) * | 2006-10-20 | 2011-04-26 | Asthmatx, Inc. | Method of delivering energy to a lung airway using markers |
US20080132884A1 (en) * | 2006-12-01 | 2008-06-05 | Boris Rubinsky | Systems for treating tissue sites using electroporation |
US7655004B2 (en) | 2007-02-15 | 2010-02-02 | Ethicon Endo-Surgery, Inc. | Electroporation ablation apparatus, system, and method |
US8945114B2 (en) * | 2007-04-26 | 2015-02-03 | Medtronic, Inc. | Fluid sensor for ablation therapy |
US8814856B2 (en) * | 2007-04-30 | 2014-08-26 | Medtronic, Inc. | Extension and retraction mechanism for a hand-held device |
US20080275440A1 (en) * | 2007-05-03 | 2008-11-06 | Medtronic, Inc. | Post-ablation verification of lesion size |
US9186207B2 (en) * | 2007-06-14 | 2015-11-17 | Medtronic, Inc. | Distal viewing window of a medical catheter |
US9861424B2 (en) | 2007-07-11 | 2018-01-09 | Covidien Lp | Measurement and control systems and methods for electrosurgical procedures |
US8235983B2 (en) | 2007-07-12 | 2012-08-07 | Asthmatx, Inc. | Systems and methods for delivering energy to passageways in a patient |
US8152800B2 (en) | 2007-07-30 | 2012-04-10 | Vivant Medical, Inc. | Electrosurgical systems and printed circuit boards for use therewith |
US8506565B2 (en) * | 2007-08-23 | 2013-08-13 | Covidien Lp | Electrosurgical device with LED adapter |
US8579897B2 (en) * | 2007-11-21 | 2013-11-12 | Ethicon Endo-Surgery, Inc. | Bipolar forceps |
US7645142B2 (en) * | 2007-09-05 | 2010-01-12 | Vivant Medical, Inc. | Electrical receptacle assembly |
US8747398B2 (en) | 2007-09-13 | 2014-06-10 | Covidien Lp | Frequency tuning in a microwave electrosurgical system |
US8088072B2 (en) | 2007-10-12 | 2012-01-03 | Gynesonics, Inc. | Methods and systems for controlled deployment of needles in tissue |
US20090112059A1 (en) * | 2007-10-31 | 2009-04-30 | Nobis Rudolph H | Apparatus and methods for closing a gastrotomy |
US8235987B2 (en) * | 2007-12-05 | 2012-08-07 | Tyco Healthcare Group Lp | Thermal penetration and arc length controllable electrosurgical pencil |
US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
US9949794B2 (en) | 2008-03-27 | 2018-04-24 | Covidien Lp | Microwave ablation devices including expandable antennas and methods of use |
US20100004623A1 (en) * | 2008-03-27 | 2010-01-07 | Angiodynamics, Inc. | Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation |
WO2009121009A2 (en) * | 2008-03-27 | 2009-10-01 | The Regents Of The University Of California | Irreversible electroporation device for use in attenuating neointimal |
US8636733B2 (en) | 2008-03-31 | 2014-01-28 | Covidien Lp | Electrosurgical pencil including improved controls |
US8663219B2 (en) * | 2008-03-31 | 2014-03-04 | Covidien Lp | Electrosurgical pencil including improved controls |
ES2535200T3 (es) | 2008-03-31 | 2015-05-06 | Applied Medical Resources Corporation | Sistema electroquirúrgico con medios para medir la permisividad y conductividad de un tejido |
US8597292B2 (en) * | 2008-03-31 | 2013-12-03 | Covidien Lp | Electrosurgical pencil including improved controls |
US9198733B2 (en) | 2008-04-29 | 2015-12-01 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for electroporation-based therapies |
US8992517B2 (en) * | 2008-04-29 | 2015-03-31 | Virginia Tech Intellectual Properties Inc. | Irreversible electroporation to treat aberrant cell masses |
US9867652B2 (en) | 2008-04-29 | 2018-01-16 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds |
US10238447B2 (en) | 2008-04-29 | 2019-03-26 | Virginia Tech Intellectual Properties, Inc. | System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress |
US8926606B2 (en) * | 2009-04-09 | 2015-01-06 | Virginia Tech Intellectual Properties, Inc. | Integration of very short electric pulses for minimally to noninvasive electroporation |
US10702326B2 (en) | 2011-07-15 | 2020-07-07 | Virginia Tech Intellectual Properties, Inc. | Device and method for electroporation based treatment of stenosis of a tubular body part |
US11254926B2 (en) | 2008-04-29 | 2022-02-22 | Virginia Tech Intellectual Properties, Inc. | Devices and methods for high frequency electroporation |
US11272979B2 (en) | 2008-04-29 | 2022-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
US10245098B2 (en) | 2008-04-29 | 2019-04-02 | Virginia Tech Intellectual Properties, Inc. | Acute blood-brain barrier disruption using electrical energy based therapy |
AU2009243079A1 (en) | 2008-04-29 | 2009-11-05 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation to create tissue scaffolds |
US10272178B2 (en) | 2008-04-29 | 2019-04-30 | Virginia Tech Intellectual Properties Inc. | Methods for blood-brain barrier disruption using electrical energy |
US20090287081A1 (en) * | 2008-04-29 | 2009-11-19 | Gynesonics , Inc | Submucosal fibroid ablation for the treatment of menorrhagia |
US10117707B2 (en) | 2008-04-29 | 2018-11-06 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
US10448989B2 (en) | 2009-04-09 | 2019-10-22 | Virginia Tech Intellectual Properties, Inc. | High-frequency electroporation for cancer therapy |
US9283051B2 (en) | 2008-04-29 | 2016-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating a treatment volume for administering electrical-energy based therapies |
KR101719824B1 (ko) | 2008-05-09 | 2017-04-04 | 호라이라 인코포레이티드 | 기관지나무 치료용 시스템, 어셈블리 및 방법 |
US20090281477A1 (en) * | 2008-05-09 | 2009-11-12 | Angiodynamics, Inc. | Electroporation device and method |
US8771260B2 (en) * | 2008-05-30 | 2014-07-08 | Ethicon Endo-Surgery, Inc. | Actuating and articulating surgical device |
US8906035B2 (en) | 2008-06-04 | 2014-12-09 | Ethicon Endo-Surgery, Inc. | Endoscopic drop off bag |
WO2009155526A2 (en) * | 2008-06-20 | 2009-12-23 | Angiodynamics, Inc. | Device and method for the ablation of fibrin sheath formation on a venous catheter |
WO2010008834A2 (en) * | 2008-06-23 | 2010-01-21 | Angiodynamics, Inc. | Treatment devices and methods |
US8162937B2 (en) * | 2008-06-27 | 2012-04-24 | Tyco Healthcare Group Lp | High volume fluid seal for electrosurgical handpiece |
US20100010298A1 (en) * | 2008-07-14 | 2010-01-14 | Ethicon Endo-Surgery, Inc. | Endoscopic translumenal flexible overtube |
US8888792B2 (en) | 2008-07-14 | 2014-11-18 | Ethicon Endo-Surgery, Inc. | Tissue apposition clip application devices and methods |
US8157834B2 (en) | 2008-11-25 | 2012-04-17 | Ethicon Endo-Surgery, Inc. | Rotational coupling device for surgical instrument with flexible actuators |
US20100152725A1 (en) * | 2008-12-12 | 2010-06-17 | Angiodynamics, Inc. | Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation |
US20100160906A1 (en) * | 2008-12-23 | 2010-06-24 | Asthmatx, Inc. | Expandable energy delivery devices having flexible conductive elements and associated systems and methods |
US8361066B2 (en) | 2009-01-12 | 2013-01-29 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
US8753335B2 (en) * | 2009-01-23 | 2014-06-17 | Angiodynamics, Inc. | Therapeutic energy delivery device with rotational mechanism |
US20100198248A1 (en) * | 2009-02-02 | 2010-08-05 | Ethicon Endo-Surgery, Inc. | Surgical dissector |
WO2010093692A2 (en) * | 2009-02-10 | 2010-08-19 | Hobbs Eamonn P | Irreversible electroporation and tissue regeneration |
US8231620B2 (en) * | 2009-02-10 | 2012-07-31 | Tyco Healthcare Group Lp | Extension cutting blade |
US11382681B2 (en) | 2009-04-09 | 2022-07-12 | Virginia Tech Intellectual Properties, Inc. | Device and methods for delivery of high frequency electrical pulses for non-thermal ablation |
US11638603B2 (en) | 2009-04-09 | 2023-05-02 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
USD630321S1 (en) | 2009-05-08 | 2011-01-04 | Angio Dynamics, Inc. | Probe handle |
US8903488B2 (en) | 2009-05-28 | 2014-12-02 | Angiodynamics, Inc. | System and method for synchronizing energy delivery to the cardiac rhythm |
US9895189B2 (en) | 2009-06-19 | 2018-02-20 | Angiodynamics, Inc. | Methods of sterilization and treating infection using irreversible electroporation |
US20110093009A1 (en) * | 2009-10-16 | 2011-04-21 | Ethicon Endo-Surgery, Inc. | Otomy closure device |
EP2926757B1 (de) | 2009-10-27 | 2023-01-25 | Nuvaira, Inc. | Freisetzungsvorrichtungen mit kühlbaren energieemissionsanordnungen |
US20110098704A1 (en) | 2009-10-28 | 2011-04-28 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
US8608652B2 (en) * | 2009-11-05 | 2013-12-17 | Ethicon Endo-Surgery, Inc. | Vaginal entry surgical devices, kit, system, and method |
US20110112434A1 (en) * | 2009-11-06 | 2011-05-12 | Ethicon Endo-Surgery, Inc. | Kits and procedures for natural orifice translumenal endoscopic surgery |
US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
AU2010319477A1 (en) | 2009-11-11 | 2012-05-24 | Holaira, Inc. | Systems, apparatuses, and methods for treating tissue and controlling stenosis |
US20110118732A1 (en) | 2009-11-19 | 2011-05-19 | The Regents Of The University Of California | Controlled irreversible electroporation |
US20110152923A1 (en) * | 2009-12-18 | 2011-06-23 | Ethicon Endo-Surgery, Inc. | Incision closure device |
US9028483B2 (en) | 2009-12-18 | 2015-05-12 | Ethicon Endo-Surgery, Inc. | Surgical instrument comprising an electrode |
US20110160514A1 (en) * | 2009-12-31 | 2011-06-30 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
US9005198B2 (en) | 2010-01-29 | 2015-04-14 | Ethicon Endo-Surgery, Inc. | Surgical instrument comprising an electrode |
EP3991678A3 (de) | 2010-10-01 | 2022-06-22 | Applied Medical Resources Corporation | Elektrochirurgische instrumente und verbindungen dafür |
WO2012051433A2 (en) | 2010-10-13 | 2012-04-19 | Angiodynamics, Inc. | System and method for electrically ablating tissue of a patient |
US10092291B2 (en) | 2011-01-25 | 2018-10-09 | Ethicon Endo-Surgery, Inc. | Surgical instrument with selectively rigidizable features |
US9233241B2 (en) | 2011-02-28 | 2016-01-12 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
US9254169B2 (en) | 2011-02-28 | 2016-02-09 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
US9314620B2 (en) | 2011-02-28 | 2016-04-19 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
US9049987B2 (en) | 2011-03-17 | 2015-06-09 | Ethicon Endo-Surgery, Inc. | Hand held surgical device for manipulating an internal magnet assembly within a patient |
US9579150B2 (en) | 2011-04-08 | 2017-02-28 | Covidien Lp | Microwave ablation instrument with interchangeable antenna probe |
CN103501844A (zh) * | 2011-04-08 | 2014-01-08 | 库克医药技术有限责任公司 | 鞘可缩回的柔性注射针 |
US9078665B2 (en) | 2011-09-28 | 2015-07-14 | Angiodynamics, Inc. | Multiple treatment zone ablation probe |
US9119648B2 (en) | 2012-01-06 | 2015-09-01 | Covidien Lp | System and method for treating tissue using an expandable antenna |
US9113931B2 (en) | 2012-01-06 | 2015-08-25 | Covidien Lp | System and method for treating tissue using an expandable antenna |
US9414881B2 (en) | 2012-02-08 | 2016-08-16 | Angiodynamics, Inc. | System and method for increasing a target zone for electrical ablation |
US9427255B2 (en) | 2012-05-14 | 2016-08-30 | Ethicon Endo-Surgery, Inc. | Apparatus for introducing a steerable camera assembly into a patient |
WO2013184319A1 (en) | 2012-06-04 | 2013-12-12 | Boston Scientific Scimed, Inc. | Systems and methods for treating tissue of a passageway within a body |
US9078662B2 (en) | 2012-07-03 | 2015-07-14 | Ethicon Endo-Surgery, Inc. | Endoscopic cap electrode and method for using the same |
EP2877113B1 (de) | 2012-07-24 | 2018-07-25 | Boston Scientific Scimed, Inc. | Elektroden zur gewebebehandlung |
US9545290B2 (en) | 2012-07-30 | 2017-01-17 | Ethicon Endo-Surgery, Inc. | Needle probe guide |
US9572623B2 (en) | 2012-08-02 | 2017-02-21 | Ethicon Endo-Surgery, Inc. | Reusable electrode and disposable sheath |
US10314649B2 (en) | 2012-08-02 | 2019-06-11 | Ethicon Endo-Surgery, Inc. | Flexible expandable electrode and method of intraluminal delivery of pulsed power |
US9277957B2 (en) | 2012-08-15 | 2016-03-08 | Ethicon Endo-Surgery, Inc. | Electrosurgical devices and methods |
US9272132B2 (en) | 2012-11-02 | 2016-03-01 | Boston Scientific Scimed, Inc. | Medical device for treating airways and related methods of use |
WO2014071372A1 (en) | 2012-11-05 | 2014-05-08 | Boston Scientific Scimed, Inc. | Devices for delivering energy to body lumens |
US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
US10098527B2 (en) | 2013-02-27 | 2018-10-16 | Ethidcon Endo-Surgery, Inc. | System for performing a minimally invasive surgical procedure |
US9814618B2 (en) | 2013-06-06 | 2017-11-14 | Boston Scientific Scimed, Inc. | Devices for delivering energy and related methods of use |
US10478247B2 (en) | 2013-08-09 | 2019-11-19 | Boston Scientific Scimed, Inc. | Expandable catheter and related methods of manufacture and use |
US10166321B2 (en) | 2014-01-09 | 2019-01-01 | Angiodynamics, Inc. | High-flow port and infusion needle systems |
WO2015175570A1 (en) | 2014-05-12 | 2015-11-19 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
EP4197469A1 (de) | 2014-05-16 | 2023-06-21 | Applied Medical Resources Corporation | Elektrochirurgisches system |
EP4368134A3 (de) | 2014-05-30 | 2024-07-31 | Applied Medical Resources Corporation | Elektrochirurgische dichtungs- und dissektionssysteme |
US10694972B2 (en) | 2014-12-15 | 2020-06-30 | Virginia Tech Intellectual Properties, Inc. | Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment |
KR102545505B1 (ko) | 2014-12-23 | 2023-06-20 | 어플라이드 메디컬 리소시스 코포레이션 | 바이폴라 전기수술용 밀봉기 및 디바이더 |
USD748259S1 (en) | 2014-12-29 | 2016-01-26 | Applied Medical Resources Corporation | Electrosurgical instrument |
AU2017359338B2 (en) | 2016-11-11 | 2022-09-08 | Gynesonics, Inc. | Controlled treatment of tissue and dynamic interaction with, and comparison of, tissue and/or treatment data |
US10905492B2 (en) | 2016-11-17 | 2021-02-02 | Angiodynamics, Inc. | Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode |
US11607537B2 (en) | 2017-12-05 | 2023-03-21 | Virginia Tech Intellectual Properties, Inc. | Method for treating neurological disorders, including tumors, with electroporation |
US11311329B2 (en) | 2018-03-13 | 2022-04-26 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for immunotherapy based treatments using non-thermal ablation techniques |
US11925405B2 (en) | 2018-03-13 | 2024-03-12 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
TWM567873U (zh) * | 2018-07-06 | 2018-10-01 | 大陸商深圳望得源科技有限公司 | 光纖連接裝置 |
EP3846717A1 (de) | 2018-09-05 | 2021-07-14 | Applied Medical Resources Corporation | Steuerungssystem für elektrochirurgischen generator |
KR20210092263A (ko) | 2018-11-16 | 2021-07-23 | 어플라이드 메디컬 리소시스 코포레이션 | 전기수술용 시스템 |
US11950835B2 (en) | 2019-06-28 | 2024-04-09 | Virginia Tech Intellectual Properties, Inc. | Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy |
US11399888B2 (en) | 2019-08-14 | 2022-08-02 | Covidien Lp | Bipolar pencil |
US11564732B2 (en) | 2019-12-05 | 2023-01-31 | Covidien Lp | Tensioning mechanism for bipolar pencil |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998006341A1 (en) * | 1996-08-16 | 1998-02-19 | United States Surgical Corporation | Apparatus for thermal treatment of tissue |
US5807309A (en) * | 1992-08-12 | 1998-09-15 | Vidamed, Inc. | Transurethral needle ablation device and method for the treatment of the prostate |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4411266A (en) | 1980-09-24 | 1983-10-25 | Cosman Eric R | Thermocouple radio frequency lesion electrode |
US4565200A (en) | 1980-09-24 | 1986-01-21 | Cosman Eric R | Universal lesion and recording electrode system |
US5421819A (en) | 1992-08-12 | 1995-06-06 | Vidamed, Inc. | Medical probe device |
US5370675A (en) * | 1992-08-12 | 1994-12-06 | Vidamed, Inc. | Medical probe device and method |
US5435805A (en) | 1992-08-12 | 1995-07-25 | Vidamed, Inc. | Medical probe device with optical viewing capability |
US5385544A (en) | 1992-08-12 | 1995-01-31 | Vidamed, Inc. | BPH ablation method and apparatus |
US4907589A (en) | 1988-04-29 | 1990-03-13 | Cosman Eric R | Automatic over-temperature control apparatus for a therapeutic heating device |
US5409453A (en) | 1992-08-12 | 1995-04-25 | Vidamed, Inc. | Steerable medical probe with stylets |
US5562703A (en) * | 1994-06-14 | 1996-10-08 | Desai; Ashvin H. | Endoscopic surgical instrument |
US5484400A (en) | 1992-08-12 | 1996-01-16 | Vidamed, Inc. | Dual channel RF delivery system |
US5667488A (en) * | 1992-08-12 | 1997-09-16 | Vidamed, Inc. | Transurethral needle ablation device and method for the treatment of the prostate |
US5542916A (en) | 1992-08-12 | 1996-08-06 | Vidamed, Inc. | Dual-channel RF power delivery system |
US5556377A (en) * | 1992-08-12 | 1996-09-17 | Vidamed, Inc. | Medical probe apparatus with laser and/or microwave monolithic integrated circuit probe |
US5545161A (en) | 1992-12-01 | 1996-08-13 | Cardiac Pathways Corporation | Catheter for RF ablation having cooled electrode with electrically insulated sleeve |
US5348554A (en) | 1992-12-01 | 1994-09-20 | Cardiac Pathways Corporation | Catheter for RF ablation with cooled electrode |
US5389073A (en) | 1992-12-01 | 1995-02-14 | Cardiac Pathways Corporation | Steerable catheter with adjustable bend location |
US5433749A (en) | 1993-03-08 | 1995-07-18 | Clifford; Jerome R. | Apparatus for enhancing hearing in an ear |
ATE284650T1 (de) | 1993-06-10 | 2005-01-15 | Mir A Imran | Urethrales gerät zur ablation mittels hochfrequenz |
US5797956A (en) * | 1995-10-10 | 1998-08-25 | Snowden-Pencer, Inc. | Surgical instrument handle and actuator means for heart surgery |
US5755760A (en) | 1996-03-11 | 1998-05-26 | Medtronic, Inc. | Deflectable catheter |
US5776155A (en) * | 1996-12-23 | 1998-07-07 | Ethicon Endo-Surgery, Inc. | Methods and devices for attaching and detaching transmission components |
US6045549A (en) * | 1997-09-30 | 2000-04-04 | Somnus Medical Technologies, Inc. | Tissue ablation apparatus and device for use therein and method |
US5995875A (en) * | 1997-10-01 | 1999-11-30 | United States Surgical | Apparatus for thermal treatment of tissue |
US6302903B1 (en) | 1998-07-07 | 2001-10-16 | Medtronic, Inc. | Straight needle apparatus for creating a virtual electrode used for the ablation of tissue |
-
1999
- 1999-11-16 EP EP99960383A patent/EP1131011B1/de not_active Expired - Lifetime
- 1999-11-16 ES ES99960383T patent/ES2238862T3/es not_active Expired - Lifetime
- 1999-11-16 WO PCT/US1999/027133 patent/WO2000028909A1/en active IP Right Grant
- 1999-11-16 AU AU17274/00A patent/AU1727400A/en not_active Abandoned
- 1999-11-16 DE DE69924750T patent/DE69924750T2/de not_active Expired - Lifetime
-
2001
- 2001-05-16 US US09/859,140 patent/US6526320B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5807309A (en) * | 1992-08-12 | 1998-09-15 | Vidamed, Inc. | Transurethral needle ablation device and method for the treatment of the prostate |
WO1998006341A1 (en) * | 1996-08-16 | 1998-02-19 | United States Surgical Corporation | Apparatus for thermal treatment of tissue |
Non-Patent Citations (1)
Title |
---|
See also references of WO0028909A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU1727400A (en) | 2000-06-05 |
DE69924750D1 (de) | 2005-05-19 |
DE69924750T2 (de) | 2006-03-02 |
EP1131011A4 (de) | 2002-09-25 |
US6526320B2 (en) | 2003-02-25 |
WO2000028909A1 (en) | 2000-05-25 |
ES2238862T3 (es) | 2005-09-01 |
EP1131011B1 (de) | 2005-04-13 |
US20020002393A1 (en) | 2002-01-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1131011B1 (de) | Gerät zur thermischen behandlung von gewebe | |
US6428538B1 (en) | Apparatus and method for thermal treatment of body tissue | |
US6106521A (en) | Apparatus for thermal treatment of tissue | |
US5995875A (en) | Apparatus for thermal treatment of tissue | |
US5993447A (en) | Apparatus for thermal treatment of tissue | |
EP0834288B1 (de) | Vorrichtung zur thermischen Behandlung von Gewebe | |
US6241702B1 (en) | Radio frequency ablation device for treatment of the prostate | |
EP1006909B1 (de) | Transurethrale resektionsvorrichtung mit auswechselbarem kanülenbehälter | |
US6638275B1 (en) | Bipolar ablation apparatus and method | |
AU3613293A (en) | Apparatus and method for interstitial treatment | |
WO1994017856A9 (en) | Transurethral needle ablation device and method | |
WO1994020037A1 (en) | Apparatus and method for interstitial treatment | |
WO1998030160A1 (en) | Rf intraluminal ablation device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20010613 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Kind code of ref document: A1 Designated state(s): DE ES FR GB IE IT |
|
AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20020808 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): DE ES FR GB IE IT |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7A 61B 18/18 A, 7A 61B 18/14 B |
|
17Q | First examination report despatched |
Effective date: 20040325 |
|
RBV | Designated contracting states (corrected) |
Designated state(s): DE ES FR GB IE IT |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): DE ES FR GB IE IT |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
REF | Corresponds to: |
Ref document number: 69924750 Country of ref document: DE Date of ref document: 20050519 Kind code of ref document: P |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2238862 Country of ref document: ES Kind code of ref document: T3 |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
ET | Fr: translation filed | ||
26N | No opposition filed |
Effective date: 20060116 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20101126 Year of fee payment: 12 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: IT Payment date: 20101124 Year of fee payment: 12 Ref country code: GB Payment date: 20101124 Year of fee payment: 12 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20111128 Year of fee payment: 13 Ref country code: ES Payment date: 20111124 Year of fee payment: 13 Ref country code: IE Payment date: 20111123 Year of fee payment: 13 |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20121116 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: MM4A |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST Effective date: 20130731 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20121116 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 69924750 Country of ref document: DE Effective date: 20130601 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130601 Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20121116 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20121130 Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20121116 |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FD2A Effective date: 20140305 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20121117 |