EP1117768A4 - Dnazymes and methods for treating restenosis - Google Patents

Dnazymes and methods for treating restenosis

Info

Publication number
EP1117768A4
EP1117768A4 EP99938479A EP99938479A EP1117768A4 EP 1117768 A4 EP1117768 A4 EP 1117768A4 EP 99938479 A EP99938479 A EP 99938479A EP 99938479 A EP99938479 A EP 99938479A EP 1117768 A4 EP1117768 A4 EP 1117768A4
Authority
EP
European Patent Office
Prior art keywords
dnazymes
methods
treating restenosis
restenosis
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99938479A
Other languages
German (de)
French (fr)
Other versions
EP1117768A1 (en
Inventor
Lun-Quan Sun
Murray J Cairns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson and Johnson Research Pty Ltd
Original Assignee
Johnson and Johnson Research Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson and Johnson Research Pty Ltd filed Critical Johnson and Johnson Research Pty Ltd
Publication of EP1117768A1 publication Critical patent/EP1117768A1/en
Publication of EP1117768A4 publication Critical patent/EP1117768A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
EP99938479A 1998-08-13 1999-08-12 Dnazymes and methods for treating restenosis Withdrawn EP1117768A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9637498P 1998-08-13 1998-08-13
US96374P 1998-08-13
PCT/IB1999/001484 WO2000009672A1 (en) 1998-08-13 1999-08-12 Dnazymes and methods for treating restenosis

Publications (2)

Publication Number Publication Date
EP1117768A1 EP1117768A1 (en) 2001-07-25
EP1117768A4 true EP1117768A4 (en) 2003-09-03

Family

ID=22257071

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99938479A Withdrawn EP1117768A4 (en) 1998-08-13 1999-08-12 Dnazymes and methods for treating restenosis

Country Status (8)

Country Link
EP (1) EP1117768A4 (en)
JP (1) JP2002525037A (en)
KR (1) KR20010072475A (en)
CN (1) CN1323344A (en)
AU (1) AU5298499A (en)
CA (1) CA2340322A1 (en)
WO (1) WO2000009672A1 (en)
ZA (1) ZA200101188B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ201499A0 (en) * 1999-08-04 1999-08-26 Unisearch Limited Treatment of inflammatory and malignant diseases
JP2002348235A (en) * 2001-03-23 2002-12-04 Clinical Supply:Kk Preventive against restenosis
DE10346487A1 (en) 2003-10-02 2005-05-12 Transmit Technologietransfer Process for the preparation of a cell and / or tissue and / or disease phase specific drug
WO2007000676A2 (en) * 2005-06-28 2007-01-04 Johnson & Johnson Research Pty. Ltd. Guanosine-rich oligonucleotides as agents for inducing cell death in eukaryotic cells
SI3093022T1 (en) 2015-05-15 2019-12-31 Sterna Biologicals Gmbh & Co. Kg Gata-3 inhibitors for use in the treatment of th2-driven asthma
WO2022146868A1 (en) * 2020-12-30 2022-07-07 The Regents Of The University Of California A biologically stable xnazyme that efficiently silences gene expression in cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015580A1 (en) * 1990-04-10 1991-10-17 Research Development Foundation Gene therapy for cell proliferative diseases
WO1994015646A1 (en) * 1993-01-07 1994-07-21 Thomas Jefferson University Antisense inhibition of c-myc to modulate the proliferation of smooth muscle cells
WO1995031541A2 (en) * 1994-05-18 1995-11-23 Ribozyme Pharmaceuticals, Inc. Methods and compositions for treatment of restenosis and cancer using ribozymes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807718A (en) * 1994-12-02 1998-09-15 The Scripps Research Institute Enzymatic DNA molecules
JP4203126B2 (en) * 1997-04-29 2008-12-24 ザ スクリップス リサーチ インスティテュート Enzymatic DNA molecule
CA2312288A1 (en) * 1998-03-27 1999-10-07 Johnson & Johnson Research Pty. Limited Catalytic nucleic acid-based diagnostic methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015580A1 (en) * 1990-04-10 1991-10-17 Research Development Foundation Gene therapy for cell proliferative diseases
WO1994015646A1 (en) * 1993-01-07 1994-07-21 Thomas Jefferson University Antisense inhibition of c-myc to modulate the proliferation of smooth muscle cells
WO1995031541A2 (en) * 1994-05-18 1995-11-23 Ribozyme Pharmaceuticals, Inc. Methods and compositions for treatment of restenosis and cancer using ribozymes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BREAKER R R: "DNA ENZYMES", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 15, May 1997 (1997-05-01), pages 427 - 431, XP002912052, ISSN: 1087-0156 *
FINKEL T AND EPSTEIN S E: "Gene therapy for vascular disease", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 9, 1 July 1995 (1995-07-01), pages 843 - 851, XP002088122, ISSN: 0892-6638 *
See also references of WO0009672A1 *

Also Published As

Publication number Publication date
EP1117768A1 (en) 2001-07-25
KR20010072475A (en) 2001-07-31
CA2340322A1 (en) 2000-02-24
ZA200101188B (en) 2002-05-13
WO2000009672A1 (en) 2000-02-24
AU5298499A (en) 2000-03-06
WO2000009672A9 (en) 2000-05-18
CN1323344A (en) 2001-11-21
JP2002525037A (en) 2002-08-13

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Inventor name: CAIRNS, MURRAY, J.

Inventor name: SUN, LUN-QUAN

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Effective date: 20030722

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