EP1089979A1 - Quinoxalin-2(1h)-ones substitues utilises comme inhibiteurs de transcriptase inverse du vih - Google Patents

Quinoxalin-2(1h)-ones substitues utilises comme inhibiteurs de transcriptase inverse du vih

Info

Publication number
EP1089979A1
EP1089979A1 EP99930715A EP99930715A EP1089979A1 EP 1089979 A1 EP1089979 A1 EP 1089979A1 EP 99930715 A EP99930715 A EP 99930715A EP 99930715 A EP99930715 A EP 99930715A EP 1089979 A1 EP1089979 A1 EP 1089979A1
Authority
EP
European Patent Office
Prior art keywords
quinoxalin
dihydro
trifluoromethyl
cyclopropylethynyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99930715A
Other languages
German (de)
English (en)
Inventor
Mona Patel
Robert Joseph Mchugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of EP1089979A1 publication Critical patent/EP1089979A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne des quinoxalin-2(1H)-ones qui correspondent à la formule (I), ainsi leurs formes ou leurs mélanges stéréoisomères et leurs sels pharmaceutiquement acceptables. Ces quinoxalin-2(1H)-ones peuvent être utilisés comme inhibiteurs de transcriptase inverse du VIH. Cette invention concerne également des compositions pharmaceutiques et des trousses de diagnostic comprenant ces quinoxalin-2(1H)-ones, ainsi que des procédés d'utilisation de ces derniers dans le traitement d'infections virales ou en qualité de standard d'analyse ou de réactif.
EP99930715A 1998-06-26 1999-06-25 Quinoxalin-2(1h)-ones substitues utilises comme inhibiteurs de transcriptase inverse du vih Withdrawn EP1089979A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9089398P 1998-06-26 1998-06-26
US90893P 1998-06-26
PCT/US1999/014395 WO2000000478A1 (fr) 1998-06-26 1999-06-25 Quinoxalin-2(1h)-ones substitues utilises comme inhibiteurs de transcriptase inverse du vih

Publications (1)

Publication Number Publication Date
EP1089979A1 true EP1089979A1 (fr) 2001-04-11

Family

ID=22224840

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99930715A Withdrawn EP1089979A1 (fr) 1998-06-26 1999-06-25 Quinoxalin-2(1h)-ones substitues utilises comme inhibiteurs de transcriptase inverse du vih

Country Status (4)

Country Link
EP (1) EP1089979A1 (fr)
AU (1) AU4719699A (fr)
CA (1) CA2334332A1 (fr)
WO (1) WO2000000478A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2498111A1 (fr) 2002-09-11 2004-03-25 Merck & Co., Inc. Composes de dihydroxypyridopyrazine-1,6-diones utiles en tant qu'inhibiteurs de l'integrase du vih
CA2498566A1 (fr) * 2002-09-11 2004-06-10 Merck & Co., Inc. Composes de 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine utilises comme inhibiteurs de l'integrase du vih
US7435735B2 (en) * 2003-10-20 2008-10-14 Merck & Co., Inc. Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors
US7601716B2 (en) 2006-05-01 2009-10-13 Cephalon, Inc. Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
EP2364314B1 (fr) 2008-12-09 2014-03-12 Gilead Sciences, Inc. Modulateurs de récepteurs de type toll (tlr)
NO2477987T3 (fr) 2009-09-14 2018-06-09
EP2873669A4 (fr) * 2012-07-13 2015-11-25 Takeda Pharmaceutical Composé hétérocyclique
RU2550346C2 (ru) * 2013-09-26 2015-05-10 Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
NZ728072A (en) 2014-07-11 2018-06-29 Gilead Sciences Inc Modulators of toll-like receptors for the treatment of hiv
CN107074860B (zh) 2014-09-16 2022-07-15 吉利德科学公司 制备toll样受体调节剂的方法
JP2017526730A (ja) 2014-09-16 2017-09-14 ギリアード サイエンシーズ， インコーポレイテッド Ｔｏｌｌ様受容体モジュレーターの固体形態
WO2017070796A1 (fr) * 2015-10-30 2017-05-04 Trillium Therapeutics Inc. Dérivés hétérocycliques et leur utilisation pour le traitement de troubles du snc
CN114685384B (zh) * 2022-03-03 2023-07-14 深圳大学 一种二氟甲基反应方法及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3250774A (en) * 1962-06-22 1966-05-10 Ciba Geigy Corp Diazines and process for their manufacture
JPS62207264A (ja) * 1986-03-07 1987-09-11 Asahi Glass Co Ltd 含窒素複素環系誘導体の製造法
DE4342024A1 (de) * 1993-12-09 1995-06-14 Hoechst Ag Kombinationspräparate, enthaltend ein Chinoxalin und ein Nukleosid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0000478A1 *

Also Published As

Publication number Publication date
AU4719699A (en) 2000-01-17
WO2000000478A1 (fr) 2000-01-06
CA2334332A1 (fr) 2000-01-06

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