EP1089731A4 - Zusammensetzungen und verfahren zur behandlung von erhöhtem blutcholesterolspiegel - Google Patents
Zusammensetzungen und verfahren zur behandlung von erhöhtem blutcholesterolspiegelInfo
- Publication number
- EP1089731A4 EP1089731A4 EP99930451A EP99930451A EP1089731A4 EP 1089731 A4 EP1089731 A4 EP 1089731A4 EP 99930451 A EP99930451 A EP 99930451A EP 99930451 A EP99930451 A EP 99930451A EP 1089731 A4 EP1089731 A4 EP 1089731A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compositions
- methods
- blood cholesterol
- elevated blood
- treating elevated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9052798P | 1998-06-24 | 1998-06-24 | |
US90527P | 1998-06-24 | ||
GBGB9817167.1A GB9817167D0 (en) | 1998-08-06 | 1998-08-06 | Compositions and methods for treating elevated blood cholesterol |
GB9817167 | 1998-08-06 | ||
PCT/US1999/013887 WO1999066929A1 (en) | 1998-06-24 | 1999-06-21 | Compositions and methods for treating elevated blood cholesterol |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1089731A1 EP1089731A1 (de) | 2001-04-11 |
EP1089731A4 true EP1089731A4 (de) | 2003-06-18 |
Family
ID=26314174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99930451A Withdrawn EP1089731A4 (de) | 1998-06-24 | 1999-06-21 | Zusammensetzungen und verfahren zur behandlung von erhöhtem blutcholesterolspiegel |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1089731A4 (de) |
JP (1) | JP2002518448A (de) |
AU (1) | AU754767B2 (de) |
CA (1) | CA2335366A1 (de) |
WO (1) | WO1999066929A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6350453B1 (en) | 1999-05-24 | 2002-02-26 | American River Nutrition, Inc. | Tocotrienols and geranylgeraniol from Bixa orellana byproducts |
AR040588A1 (es) | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
US20040202740A1 (en) * | 2003-04-08 | 2004-10-14 | Barrie Tan | Annatto extract compositions, including geranyl geraniols and methods of use |
EP2400840A4 (de) * | 2009-02-24 | 2012-08-01 | Madeira Therapeutics | Flüssige statinformulierungen |
WO2010126579A1 (en) * | 2009-04-27 | 2010-11-04 | Beth Israel Deaconess Medical Center | Methods and compositions for the treatment and diagnosis of statin-induced myopathy |
JP2015514686A (ja) | 2012-02-29 | 2015-05-21 | コヨーテ・ファーマシューティカルズ・インコーポレイテッドCoyote Pharmaceuticals, Inc. | Gga及びそのgga誘導体組成物並びにこれらを含む麻痺状態を含めた神経変性疾患を治療する方法 |
WO2014055440A1 (en) * | 2012-10-01 | 2014-04-10 | Coyote Pharmaceuticals, Inc. | Preparation of gga and derivatives thereof and their co-crystallization with urea or thiourea |
US9119808B1 (en) | 2012-10-08 | 2015-09-01 | Coyote Pharmaceuticals, Inc. | Treating neurodegenerative diseases with GGA or a derivative thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2055100A (en) * | 1979-07-27 | 1981-02-25 | Sankyo Co | Monacolin K derivatives |
EP0671170A1 (de) * | 1994-03-11 | 1995-09-13 | Bristol-Myers Squibb Company | Verwendung von Pravastatin zur Verlangsamung des Fortschreitens der Atherosklerose koronarer Arterien |
US5622985A (en) * | 1990-06-11 | 1997-04-22 | Bristol-Myers Squibb Company | Method for preventing a second heart attack employing an HMG CoA reductase inhibitor |
WO1997019091A1 (en) * | 1995-11-23 | 1997-05-29 | Laboratori Baldacci S.P.A. | Novel geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions |
US5691375A (en) * | 1994-01-18 | 1997-11-25 | Bristol-Myers Squibb Company | Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor |
JPH1087480A (ja) * | 1996-09-13 | 1998-04-07 | Eisai Co Ltd | 抗動脈硬化治療剤 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4933165A (en) * | 1989-01-18 | 1990-06-12 | Merck & Co., Inc. | Coenzyme Q10 with HMG-CoA reductase inhibitors |
US5316765A (en) * | 1989-09-07 | 1994-05-31 | Karl Folkers Foundation For Biomedical And Clinical Research | Use of coenzyme Q10 in combination with HMG-CoA reductase inhibitor therapies |
CA2044162A1 (fr) * | 1989-10-13 | 1991-04-14 | Jacques Borg | Derives des alcools gras a longue chaine, leurs applications, notamment en tant que molecules cytotrophes et cytoprotectrices, et compositions pharmaceutiques les contenant |
US5639653A (en) * | 1993-07-19 | 1997-06-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy | Method for proliferating Vγ2Vδ2 T cells |
US5574025A (en) * | 1994-10-26 | 1996-11-12 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferases |
US5763646A (en) * | 1997-03-13 | 1998-06-09 | Ranbaxy Laboratories, Ltd. | Process for manufacturing simvastatin from lovastatin or mevinolinic acid |
-
1999
- 1999-06-21 EP EP99930451A patent/EP1089731A4/de not_active Withdrawn
- 1999-06-21 CA CA002335366A patent/CA2335366A1/en not_active Abandoned
- 1999-06-21 WO PCT/US1999/013887 patent/WO1999066929A1/en not_active Application Discontinuation
- 1999-06-21 AU AU46989/99A patent/AU754767B2/en not_active Ceased
- 1999-06-21 JP JP2000555615A patent/JP2002518448A/ja not_active Withdrawn
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2055100A (en) * | 1979-07-27 | 1981-02-25 | Sankyo Co | Monacolin K derivatives |
US5622985A (en) * | 1990-06-11 | 1997-04-22 | Bristol-Myers Squibb Company | Method for preventing a second heart attack employing an HMG CoA reductase inhibitor |
US5691375A (en) * | 1994-01-18 | 1997-11-25 | Bristol-Myers Squibb Company | Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor |
EP0671170A1 (de) * | 1994-03-11 | 1995-09-13 | Bristol-Myers Squibb Company | Verwendung von Pravastatin zur Verlangsamung des Fortschreitens der Atherosklerose koronarer Arterien |
WO1997019091A1 (en) * | 1995-11-23 | 1997-05-29 | Laboratori Baldacci S.P.A. | Novel geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions |
JPH1087480A (ja) * | 1996-09-13 | 1998-04-07 | Eisai Co Ltd | 抗動脈硬化治療剤 |
Non-Patent Citations (3)
Title |
---|
FLINT OLIVER P ET AL: "Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induced myotoxicity in vitro.", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 145, no. 1, 1997, pages 91 - 98, XP002237082, ISSN: 0041-008X * |
PATENT ABSTRACTS OF JAPAN vol. 199, no. 809 31 July 1998 (1998-07-31) * |
See also references of WO9966929A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU4698999A (en) | 2000-01-10 |
AU754767B2 (en) | 2002-11-21 |
CA2335366A1 (en) | 1999-12-29 |
EP1089731A1 (de) | 2001-04-11 |
JP2002518448A (ja) | 2002-06-25 |
WO1999066929A1 (en) | 1999-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20010124 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
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AX | Request for extension of the european patent |
Free format text: AL PAYMENT 20010124;LT PAYMENT 20010124;LV PAYMENT 20010124;MK PAYMENT 20010124;RO PAYMENT 20010124;SI PAYMENT 20010124 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20030508 |
|
17Q | First examination report despatched |
Effective date: 20031106 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20040317 |