EP1084098A4 - Inhibiteurs de vehicule d'anandamide comme agents analgesiques - Google Patents

Inhibiteurs de vehicule d'anandamide comme agents analgesiques

Info

Publication number
EP1084098A4
EP1084098A4 EP99930176A EP99930176A EP1084098A4 EP 1084098 A4 EP1084098 A4 EP 1084098A4 EP 99930176 A EP99930176 A EP 99930176A EP 99930176 A EP99930176 A EP 99930176A EP 1084098 A4 EP1084098 A4 EP 1084098A4
Authority
EP
European Patent Office
Prior art keywords
inhibitors
analgesic agents
anandamide transporter
anandamide
transporter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99930176A
Other languages
German (de)
English (en)
Other versions
EP1084098A1 (fr
Inventor
Alexandros Makriyannis
Andreas Goutopoulos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Connecticut
Original Assignee
University of Connecticut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Connecticut filed Critical University of Connecticut
Publication of EP1084098A1 publication Critical patent/EP1084098A1/fr
Publication of EP1084098A4 publication Critical patent/EP1084098A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/27—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
EP99930176A 1998-06-09 1999-06-09 Inhibiteurs de vehicule d'anandamide comme agents analgesiques Withdrawn EP1084098A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8856898P 1998-06-09 1998-06-09
US88568P 1998-06-09
PCT/US1999/012900 WO1999064389A1 (fr) 1998-06-09 1999-06-09 Inhibiteurs de vehicule d'anandamide comme agents analgesiques

Publications (2)

Publication Number Publication Date
EP1084098A1 EP1084098A1 (fr) 2001-03-21
EP1084098A4 true EP1084098A4 (fr) 2004-12-22

Family

ID=22212139

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99930176A Withdrawn EP1084098A4 (fr) 1998-06-09 1999-06-09 Inhibiteurs de vehicule d'anandamide comme agents analgesiques

Country Status (4)

Country Link
EP (1) EP1084098A4 (fr)
JP (1) JP2002517479A (fr)
CA (1) CA2337822A1 (fr)
WO (1) WO1999064389A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE247097T1 (de) 1998-05-04 2003-08-15 Univ Connecticut Analgetische und immunomodulierende cannabinoiden
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
FI109087B (fi) * 1998-12-23 2002-05-31 Tomi Jaervinen Menetelmä farmaseuttisen koostumuksen valmistamiseksi
US6943266B1 (en) 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
MXPA02005103A (es) 1999-10-18 2003-09-25 Alexipharma Inc Ligandos selectivos del receptor de canabinoide (cb2) perifericos.
US6900236B1 (en) 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
AU3580001A (en) * 2000-03-01 2001-09-12 University College London Modulators of the endocannabinoid uptake and of the vallinoid receptors
WO2001089589A1 (fr) 2000-05-23 2001-11-29 The Regents Of The University Of California Nouveau traitement contre la toux
WO2002012167A1 (fr) * 2000-07-28 2002-02-14 Universidad Complutense De Madrid Derives d'acide arachidonique presentant une affinite pour le transporteur d'anandamide
ES2181601B2 (es) * 2001-07-27 2004-04-01 Univ Madrid Complutense Derivados de acido araquidonico con afinidad por el transportador de anandamida
ES2174716B1 (es) * 2000-07-28 2004-08-01 Universidad Complutense De Madrid Nuevos derivados de acido araquidonico con afinidad por el transportador de anandamida.
US7173027B2 (en) 2001-01-29 2007-02-06 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
EP1414775B1 (fr) 2001-07-13 2012-12-19 The University of Connecticut Cannabinoide bicyclique
FR2835616B1 (fr) * 2002-02-01 2005-02-11 Junior Instruments Dispositif pour l'analyse automatisee d'un echantillon liquide
WO2003097573A1 (fr) * 2002-05-16 2003-11-27 Sepracor, Inc. Amines inhibant un transporteur d'anandamide de type mammalien, et procedes d'utilisation
JP2006511460A (ja) 2002-08-23 2006-04-06 ユニバーシティ オブ コネチカット 治療適応を持つケトカンナビノイド
AU2002951216A0 (en) * 2002-09-05 2002-09-19 Dbl Australia Pty Ltd Surfactants and lyotropic phases formed therefrom
GB0504362D0 (en) 2005-03-02 2005-04-06 Btg Int Ltd Cytokine modulators
PT3038622T (pt) * 2013-08-28 2018-07-13 Medivation Tech Llc Compostos heterocíclicos e métodos de utilização

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618955A (en) * 1992-11-30 1997-04-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Fatty acid derivatives and pharmaceutical compositions containing same
WO1997045407A1 (fr) * 1996-05-31 1997-12-04 University Of Connecticut Nouveaux inhibiteurs d'anandamide amidase utiles en tant qu'agents analgesiques

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61126069A (ja) * 1984-11-21 1986-06-13 Res Dev Corp Of Japan プロスタグランジン誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618955A (en) * 1992-11-30 1997-04-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Fatty acid derivatives and pharmaceutical compositions containing same
WO1997045407A1 (fr) * 1996-05-31 1997-12-04 University Of Connecticut Nouveaux inhibiteurs d'anandamide amidase utiles en tant qu'agents analgesiques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MECHOULAM R ET AL: "TOWARDS CANNABINOID DRUGS - REVISITED", PROGRESS IN MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 35, 3 July 1998 (1998-07-03), pages 199 - 243, XP009024019, ISSN: 0079-6468 *
See also references of WO9964389A1 *

Also Published As

Publication number Publication date
EP1084098A1 (fr) 2001-03-21
WO1999064389A1 (fr) 1999-12-16
JP2002517479A (ja) 2002-06-18
CA2337822A1 (fr) 1999-12-16

Similar Documents

Publication Publication Date Title
EP1084098A4 (fr) Inhibiteurs de vehicule d'anandamide comme agents analgesiques
HUP0104768A3 (en) 4-amino-3-oxo-azepanes as protease inhibitors and pharmaceutical compositions containing the same
GB9900416D0 (en) Inhibitors
PL349192A1 (en) Protease inhibitors
GB9912961D0 (en) Metalloprotease inhibitors
PL346781A1 (en) Factor viia inhibitors
HUP0100870A3 (en) Alpha-aminoamide derivatives useful as analgesic agents
HK1041407B (zh) 作為環氧酶-2抑制劑的二芳基苯並吡喃衍生物
EP1093367A4 (fr) Inhibiteurs de proteases
IL145085A0 (en) Dihetero-substituted metalloprotease inhibitors
EP1067894A4 (fr) Inhibiteurs de protease
HK1047289A1 (en) Factor viia inhibitors
ATE252547T1 (de) Matrixmetalloproteinaseinhibitoren
EP1079821A4 (fr) Inhibiteurs de la protease
EP1153022A4 (fr) Inhibiteurs de protease
GB0018164D0 (en) Corrosion inhibitors
EP1086083A4 (fr) Inhibiteurs de proteases
EP1140897A4 (fr) Inhibiteurs de proteases
EP1144305A4 (fr) NOUVEAUX INHIBITEURS DE sPLA 2
GB2359500B (en) Corrosion inhibitors
PL346842A1 (en) New pharmaceutical uses for nos inhibitors
GB2389113B (en) B-secretase inhibitor
EP1364653A4 (fr) Inhibiteurs de caspase 3
IL142301A0 (en) Benzamide derivatives as thrombin inhibitors
GB0202187D0 (en) "Inhibitors"

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20001222

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: GOUTOPOULOS, ANDREAS

Owner name: THE UNIVERSITY OF CONNECTICUT

RIN1 Information on inventor provided before grant (corrected)

Inventor name: GOUTOPOULOS, ANDREAS

Inventor name: THE UNIVERSITY OF CONNECTICUT

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: THE UNIVERSITY OF CONNECTICUT

RIN1 Information on inventor provided before grant (corrected)

Inventor name: GOUTOPOULOS, ANDREAS

Inventor name: MAKRIYANNIS, ALEXANDROS

A4 Supplementary search report drawn up and despatched

Effective date: 20041109

17Q First examination report despatched

Effective date: 20050609

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20071128