EP1082441A1 - N-acetyltransferases mycobacteriennes - Google Patents

N-acetyltransferases mycobacteriennes

Info

Publication number
EP1082441A1
EP1082441A1 EP99925163A EP99925163A EP1082441A1 EP 1082441 A1 EP1082441 A1 EP 1082441A1 EP 99925163 A EP99925163 A EP 99925163A EP 99925163 A EP99925163 A EP 99925163A EP 1082441 A1 EP1082441 A1 EP 1082441A1
Authority
EP
European Patent Office
Prior art keywords
acetyltransferase
arylamine
protein
mycobacterial
nat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99925163A
Other languages
German (de)
English (en)
Inventor
Edith Sim
Mark Payton
John Sinclair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Publication of EP1082441A1 publication Critical patent/EP1082441A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)

Abstract

L'invention concerne des protéines de N-acétyltransférase arylamine provenant de Mycobacterium tuberculosis, ainsi qu'un gène et une protéine de N-acétyltransférase arylamine provenant de Mycobacterium smegmatis et des anticorps produits contre les produits géniques et protéines y relatifs. L'invention concerne également des méthodes permettant de détecter des mycobactéries à l'aide des anticorps et des souches mycobactériennes exprimant ces protéines ou manquant de celles-ci. Cette invention concerne par ailleurs des méthodes destinées à détecter par criblage des composés qui sont des ligands des protéines de N-acétyltransférase arylamine provenant de mycobactéries, par exemple des substrats et des inhibiteurs. Ces ligands, dont des exemples sont donnés, peuvent être utilisés dans des médicaments destinés à traiter les infections mycobactériennes, ou dans des formulations anti-mycobactériennes, et peuvent par ailleurs être conçus au moyen de structures tridimensionnelles des protéines de cette invention. L'invention concerne enfin des méthodes d'identification de séquences d'acide nucléique associées à des enzymes reconnues comme étant utiles pour synthétiser des médicaments anti-mycobactériens, ou pour servir de cibles à ceux-ci.
EP99925163A 1998-05-27 1999-05-27 N-acetyltransferases mycobacteriennes Withdrawn EP1082441A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9811407.7A GB9811407D0 (en) 1998-05-27 1998-05-27 Mycobacterial N-Acetyltransferases
GB9811407 1998-05-27
PCT/GB1999/001692 WO1999061625A1 (fr) 1998-05-27 1999-05-27 N-acetyltransferases mycobacteriennes

Publications (1)

Publication Number Publication Date
EP1082441A1 true EP1082441A1 (fr) 2001-03-14

Family

ID=10832803

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99925163A Withdrawn EP1082441A1 (fr) 1998-05-27 1999-05-27 N-acetyltransferases mycobacteriennes

Country Status (4)

Country Link
EP (1) EP1082441A1 (fr)
JP (1) JP2002516109A (fr)
GB (1) GB9811407D0 (fr)
WO (1) WO1999061625A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2133424A1 (fr) 2004-11-29 2009-12-16 Kirin Beer Kabushiki Kaisha Peptide de transport vers les chromoplastes dans les pétales et procédé de construction de plante dotée de pétales jaunâtres par son utilisation
CN110787164A (zh) * 2019-10-08 2020-02-14 天津国际生物医药联合研究院 奥替尼啶在抑制乙酰基转移酶和抗分枝杆菌感染中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05260980A (ja) * 1992-03-23 1993-10-12 Tokyo Met Gov Shinkei Kagaku Sogo Kenkyusho ヒト・アリルアミンｎ−アセチル転移酵素遺伝子
WO1994026765A1 (fr) * 1993-05-13 1994-11-24 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Utilisation des genes de m. tuberculosis, m. bovis et m. smegmatis conferant une resistance a l'isoniazide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9961625A1 *

Also Published As

Publication number Publication date
JP2002516109A (ja) 2002-06-04
GB9811407D0 (en) 1998-07-22
WO1999061625A1 (fr) 1999-12-02

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