EP1082122A1 - Isoflavonoide zur behandlung von migränekopfschmerzen - Google Patents
Isoflavonoide zur behandlung von migränekopfschmerzenInfo
- Publication number
- EP1082122A1 EP1082122A1 EP99925828A EP99925828A EP1082122A1 EP 1082122 A1 EP1082122 A1 EP 1082122A1 EP 99925828 A EP99925828 A EP 99925828A EP 99925828 A EP99925828 A EP 99925828A EP 1082122 A1 EP1082122 A1 EP 1082122A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- composition
- isoflavonoid
- isoflavonoids
- dietary product
- migraine headaches
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
Definitions
- the present invention relates to therapies for the prevention and treatment of migraine headaches and menstrual-related headaches and the symptoms associated with these headaches, particularly in women.
- Migraine headaches are characterized by some (but not necessarily all) of the following symptoms: unilateral onset of headache; moderate to severe throbbing or pulsating head pain; photophobia (light sensitivity); premonitory aura of visual changes (blurry vision and/or flashing lights); speech difficulties; and hemiparesis (weakness or paralysis on one side). Approximately 20% of individuals experiencing a migraine headache report symptoms for a duration of four to six hours and 80% report a duration of six hours to more than twenty-four hours. In the United States between 17 and 19% of women have experienced symptoms of migraine headaches or menstrual-related headaches.
- migraine headaches In women, about 60% of migraine headaches occur at plus or minus a two-day interval from onset of menstruation. The high frequency of migraine at menstruation is believed to result from the rapid decrease of estrogens in the blood at this time in the menstrual cycle.
- migraine headaches are less common than in Western countries.
- the incidence of migraine headaches among Japanese women is 40% lower than the incidence among American women.
- the incidence of migraine headaches among elderly Chinese women is approximately 50% lower than that among age-matched American women.
- Blood levels and urinary excretion of isoflavonoids have been studied in different population groups eating a regular diet containing either high or low amounts of isoflavonoids.
- Japanese women who consumed soy products on a regular basis excreted 12 to 64 times more daidzein and 41 to 59 times more equol than American or Finnish women.
- the invention features the use of purified isoflavonoids, which are constituents of soy beans and other plants such as clover, to effectively treat and prevent symptoms of headaches, in particular migraine headaches, that are caused by reduced or altered levels of endogenous estrogen. Migraine-like headaches in men are also treated with purified isoflavonoids according to the invention. Without being bound by any theory, it is believed that the isoflavonoids bind to estrogen receptors and activate cellular signal induction, and thus exert an estrogenic response. These compounds are safe and cause no significant side-effects.
- Purified isoflavonoids which may be administered according to the invention include genistein, daidzein, biochanin A, formononetin, O-desmethylangolensin, glycitein, equol and dihydrodaidzein and their conjugates; these may be administered alone or in combination.
- the invention provides a method for treating or preventing symptoms of migraine headache by administering (preferably orally) to the person a composition containing one or more purified isoflavonoids selected from the group consisting of genistein, daidzein, biochanin A, formononetin, O-desmethylangolensin, glycitein, equol, and dihydrodaidzein and their conjugates in an amount sufficient to produce a transient isoflavonoid concentration in the bloodstream of the person of at least 10 ng/ml.
- the composition is administered orally, providing a dosage of at least 20 mg of total isoflavonoid per serving.
- the orally-administrable composition can be a non-naturally occurring dietary product such as a confectionary bar, cereal, biscuit, or beverage.
- the composition can take the form of a medicament such as a pill, capsule, tablet, powder, or syrup, in which the total isoflavonoid is present in at least an amount of 20 mg per unit dose.
- the dietary product or medicament is orally consumed by the person once, twice, or three times per day, to provide a daily oral isoflavonoid dose of between 20 and 300 mg.
- the oral ingestion of the composition is sufficient to produce in the bloodstream of the person a transient concentration of total isoflavonoid of at least 10 ng/ml.
- purified isoflavonoid is meant an isoflavonoid in more concentrated form than occurs in plants.
- each isoflavonoid administered according to the invention is at least 3%, more preferably at least 30% pure by weight.
- the isoflavonoid-containing composition can be included in a transdermal delivery system or patch.
- Isoflavonoids are naturally occurring compounds, found primarily in soy beans. These compounds are also found in high concentrations in red clover and in lower amounts in many other types of plants.
- An isoflavonoid- containing fraction (containing purified isoflavonoids) useful in the invention can be extracted from a soy or plant product using known methods. It is preferred that the isoflavonoids be extracted and concentrated from soy beans or soy powder, but other plants such as clover can be used.
- An isoflavonoid- containing fraction can be extracted from a soy or plant product in concentrations between 3 and 30% isoflavonoids. Isoflavonoids are also available commercially in substantially pure form.
- the concentrated isoflavonoid is preferably administered either in pill, capsule, tablet, powder, or syrup form, or as an additive to a flavored drink, or as a component of a confectionary bar, biscuit, or cereal containing suitable flavoring to constitute a palatable product.
- An isoflavonoid-containing transdermal patch can be of conventional form, e.g., that used to deliver sustained doses of nicotine or estrogen.
- Isoflavonoids have similar chemical properties to estrogens, e.g., they are poorly soluble in water but are readily soluble in alcohols and other organic solvents.
- the isoflavonoid is mixed in a base with ingredients such as alcohol, mineral oil, glyceryl monostearate, an ether complex of fatty acids, acetyl alcohol, lanolin, propylene glycol, stearyl alcohol, and sodium lauryl sulfate.
- concentration of isoflavonoid is 1 to 40 mg per gram of the base, more preferably 10 to 25 mg per gram of base.
- Other embodiments are within the claims.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85480 | 1979-10-17 | ||
US8548098A | 1998-05-27 | 1998-05-27 | |
PCT/US1999/011532 WO1999061028A1 (en) | 1998-05-27 | 1999-05-25 | Isoflavonoids for treatment and prevention of migraine headaches |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1082122A1 true EP1082122A1 (de) | 2001-03-14 |
EP1082122A4 EP1082122A4 (de) | 2003-04-09 |
Family
ID=22191888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99925828A Withdrawn EP1082122A4 (de) | 1998-05-27 | 1999-05-25 | Isoflavonoide zur behandlung von migränekopfschmerzen |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1082122A4 (de) |
AU (1) | AU4204099A (de) |
CA (1) | CA2333556A1 (de) |
WO (1) | WO1999061028A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1132084A1 (de) * | 2000-03-06 | 2001-09-12 | Docteur Nature Srl | Transdermale Vorrichtung für die langsame Freisetzung von Phytooestrogenen aus Sojabohnen |
DK1401415T3 (da) | 2001-06-29 | 2006-10-16 | Ab Science | Anvendelse af N-phenyl-2-pyrimidinamin-derivater til behandling af inflammatoriske sygdomme |
JP2005500041A (ja) | 2001-06-29 | 2005-01-06 | アブ サイエンス | 強力で選択的かつ非毒性のc−kit阻害剤 |
EP1401416B1 (de) | 2001-06-29 | 2006-10-25 | AB Science | Die verwendung von c-kit hemmer zur behandlung von entzündlichen darmerkrankungen |
EP1401413B1 (de) | 2001-06-29 | 2006-11-22 | AB Science | Die verwendung von tyrosinkinasehemmer zur behandlung von allergischen erkrankungen |
US20050222091A1 (en) * | 2002-02-27 | 2005-10-06 | Alain Moussy | Use of tyrosine kinase inhibitors for treating cns disorders |
JP2006504409A (ja) | 2002-07-24 | 2006-02-09 | チルドレンズ ホスピタル メディカル センター | 鏡像異性のエクオールを含有する組成物および製品、およびその製造方法 |
US8668914B2 (en) | 2002-07-24 | 2014-03-11 | Brigham Young University | Use of equol for treating skin diseases |
US8580846B2 (en) | 2002-10-29 | 2013-11-12 | Brigham Young University | Use of equol for ameliorating or preventing neuropsychiatric and neurodegenerative diseases or disorders |
CA2504682A1 (en) | 2002-10-29 | 2004-05-13 | Colorado State University Research Foundation | Use of equol for treating androgen mediated diseases |
NZ526098A (en) * | 2003-05-23 | 2005-10-28 | Enzo Nutraceuticals Ltd | Use of a plant extract containing flavonoids rich in proanthocyanidins for the prevention or treatment of migraine |
CN1988882A (zh) * | 2004-07-23 | 2007-06-27 | 宝洁公司 | 基于基底的护肤制品 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998008503A1 (en) * | 1996-08-30 | 1998-03-05 | Novogen Research Pty. Ltd. | Therapeutic methods and compositions involving isoflavones |
EP0906761A2 (de) * | 1997-10-02 | 1999-04-07 | Archer-Daniels-Midland Company | Verfahren zur Herstellung und Verwendung von Phytochemikalien |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5204369A (en) * | 1991-07-01 | 1993-04-20 | The Endowment For Research In Human Biology | Method for the inhibition of aldh-i useful in the treatment of alcohol dependence or alcohol abuse |
US5807586A (en) * | 1996-07-30 | 1998-09-15 | Energetics, Inc. | Method of dietary supplementation |
-
1999
- 1999-05-25 WO PCT/US1999/011532 patent/WO1999061028A1/en not_active Application Discontinuation
- 1999-05-25 EP EP99925828A patent/EP1082122A4/de not_active Withdrawn
- 1999-05-25 CA CA002333556A patent/CA2333556A1/en not_active Abandoned
- 1999-05-25 AU AU42040/99A patent/AU4204099A/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998008503A1 (en) * | 1996-08-30 | 1998-03-05 | Novogen Research Pty. Ltd. | Therapeutic methods and compositions involving isoflavones |
EP0906761A2 (de) * | 1997-10-02 | 1999-04-07 | Archer-Daniels-Midland Company | Verfahren zur Herstellung und Verwendung von Phytochemikalien |
Non-Patent Citations (3)
Title |
---|
HIRAKURA K ET AL: "Phenolic glucosides from the root of Pueraria lobata" PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 46, no. 5, November 1997 (1997-11), pages 921-928, XP004293503 ISSN: 0031-9422 * |
KITAZONO TAKANARI ET AL: "Role of tyrosine kinase in serotonin-induced constriction of the basilar artery in vivo." STROKE, vol. 29, no. 2, February 1998 (1998-02), pages 494-498, XP002229783 ISSN: 0039-2499 * |
See also references of WO9961028A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP1082122A4 (de) | 2003-04-09 |
CA2333556A1 (en) | 1999-12-02 |
WO1999061028A1 (en) | 1999-12-02 |
AU4204099A (en) | 1999-12-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20001219 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20030224 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20031203 |