EP1059924A1 - Triazolo-pyridazine derivate zur behandlung von chronisch-obstruktiven atemwegserkrankungen - Google Patents

Triazolo-pyridazine derivate zur behandlung von chronisch-obstruktiven atemwegserkrankungen

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Publication number
EP1059924A1
EP1059924A1 EP99937873A EP99937873A EP1059924A1 EP 1059924 A1 EP1059924 A1 EP 1059924A1 EP 99937873 A EP99937873 A EP 99937873A EP 99937873 A EP99937873 A EP 99937873A EP 1059924 A1 EP1059924 A1 EP 1059924A1
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EP
European Patent Office
Prior art keywords
group
amino
hydroxy
alkoxy
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99937873A
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English (en)
French (fr)
Inventor
Yasuko Ashida
Yasuhiko Kawano
Kenichirou Kiyoshima
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Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
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Filing date
Publication date
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Publication of EP1059924A1 publication Critical patent/EP1059924A1/de
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines

Definitions

  • the present invention relates to an agent for acting on bronchi which comprises triazolopyridazine derivatives such as 6- ( 2 , 2-dimethyl-3 -sulfamoyl-l-propoxy) -7- isopropyl (l , 2 , 4) triazolo (l , 5-b] pyridazine , etc . .
  • triazolopyridazine derivatives such as 6- ( 2 , 2-dimethyl-3 -sulfamoyl-l-propoxy) -7- isopropyl (l , 2 , 4) triazolo (l , 5-b] pyridazine , etc . .
  • Triazolopyridazine derivatives represented by the formula:
  • R 1 is a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom
  • X is an oxygen atom or S(0) p (p is a whole number of 0 to 2)
  • Y is a group of the formula:
  • R 4 and R 5 respectively is a hydrogen atom or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring
  • R 6 and R 7 each is a hydrogen atom, an optionally substituted lower alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R 6 and R 7 may, taken together with the adjacent nitrogen atom, form an optionally substituted nitrogen- containing heterocyclic group
  • m is a whole number of 0 to 4
  • n is a whole number of 0 to 4
  • the present inventors diligently made extensive studies in order to solve the problems and, as a result, they found that it could make actions of the derivatives act at bronchi locally by preparing an inhalation, etc. comprising 6- (2 , 2-dimethyl-3-sulfamoyl-1-propoxy) -7-isopropyl [l , 2 , 4) triazolo Cl,5-b] pyridazine or a salt thereof. And, they further studied based on the finding, the present invention has been accompliched.
  • a agent for acting on bronchi which comprises a compound of the formula:
  • R 1 is a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom
  • X is an oxygen atom or S(0) p (p is a whole number of 0 to 2)
  • Y is a group of the formula:
  • R 4 and R 5 respectively is a hydrogen atom or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring
  • R 6 and R 7 each is a hydrogen atom, an optionally substituted lower alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R 6 and R 7 may, taken together with the adjacent nitrogen atom, form an optionally substituted nitrogen- containing heterocyclic group
  • m is a whole number of 0 to 4
  • n is a whole number of 0 to 4 , or a salt thereof
  • R 1 is (i) a hydrogen atom, (ii) a C 1 _ 6 alkyl group optionally having substituents selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- ordi-Cj.j alkylamino, Ci.
  • R 2 and R 3 respectively is (i) a hydrogen atom or (ii) a C 1 . 6 alkyl group optionally having substitutes selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- or i-C ⁇ alkylamino, C 1-6 alkoxy, C ⁇ alkylcarbonyloxy and a halogen atom or (iii) a C 3 .
  • X is an oxygen atom or S(0) p (p is a whole number of 0 to 2).
  • Y is (a) a group of the formula: R 4 —C—
  • R 4 and R 5 respectively is (i) a hydrogen atom or (ii) a C ⁇ alkyl group optionally having substituents selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- or di-C ⁇ alkylamino, C ⁇ alkoxy, C x _ 6 alkylcarbonyloxy and a halogen atom) , or
  • R 6 and R 7 respectively is (i) a hydrogen atom, (ii) a C 1-6 alkyl group optionally having substituents selected from the group consisting of hydroxy, amino, carboxyl, nitro. mono- or di-C 1 . 6 alkylamino, C 1 , 6 alkoxy, C ⁇ , 6 alkylcarbonyloxy and a halogen atom, (iii) a C 3 . 6 cycloalkyl group optionally having substituents selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- or di-C 1 .
  • R 6 and R 7 may, taken together with the adjacent nitrogen atom, form a group resulting from elimination of one hydrogen atom from a nitrogen atom in a 3- to 13-membered nitrogen- containing heterocyclic ring which contains one nitrogen atom in addition to carbon atoms and which may also contain 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur atoms, optionally having substituents selected from the group consisting of (i) C 1 _ 6 alkyl optionally having substituents selected from the group consisting of hydroxy, amino, mono- or di-C ⁇ alkylamino, ⁇ _ 6 alkoxy, C ⁇ alkylcarbonyloxy and a halogen atom, (ii) an amino which may be substituted by C 1 _ 6 alkyl, C ⁇ acyl or 5- to 7-membered cyclic amino, (iii) hydroxy, (iv) carboxyl, (v) nitro, (vi) Ci. s alkoxy and (vii) a halogen atom
  • R 1 is hydrogen atom or a C ⁇ alkyl group
  • R 2 is a hydrogen atom or a C 1 _ 3 alkyl group
  • R 3 is a hydrogen atom or a C 1 _ 6 alkyl group
  • X is an oxygen atom
  • Y is a group of the formula: wherein R 4' and R 5' each is (i) a hydrogen atom or (ii) a C ⁇ alkyl group optionally substituted by 1 to 4 substituents selected from hydroxy, amino, carboxyl, nitro, mono- or di-C ⁇ alkylamino, C 1 _ 6 alkoxy, C 1 _ 6 alkyl-carbonyloxy and halogen atom, R 6 and R 7 respectively is a hydrogen atom or a C 1 . 3 alkyl group, m and n is 1.
  • the agent as defined in (1) which is an anti-asthmatic agent, an agent for preventing or treating chronic obstructive pulmonary disease (COPD) , an agent for preventing or treating hypersensitive pneumonia or an agent for preventing or treating simple pulmonary eosinophilia,
  • COPD chronic obstructive pulmonary disease
  • R 1 is a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom
  • X is an oxygen atom or S(0) p (p is a whole number of 0 to 2)
  • Y is a group of the formula: R 4
  • R 4 and R 5 respectively is a hydrogen atom or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring
  • R 6 and R 7 each is a hydrogen atom, an optionally substituted lower alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R 6 and R 7 may, taken together with the adjacent nitrogen atom, form an optionally substituted nitrogen- containing heterocyclic group
  • m is a whole number of 0 to 4
  • n is a whole number of 0 to 4 , or a salt thereof for preparing an agent for acting on bronchi, (8)
  • R 1 is (i) a hydrogen atom, (ii) a C ⁇ alkyl group optionally having substituents selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- or di-C ⁇ alkylamino, Ci. 6 alkoxy, C 1 . 6 alkylcarbonyloxy and a halogen atom or (iii) a halogen atom,
  • R 2 and R 3 respectively is (i) a hydrogen atom or (ii) a C 1-6 alkyl group optionally having substitutes selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- or di-C ⁇ alkylamino, C 1 _ 6 alkoxy, C 1-6 alkylcarbonyloxy and a halogen atom or (iii) a C 3 .
  • X is an oxygen atom or S(0) p (p is a whole number of 0 to
  • Y is (a) a group of the formula:
  • R 4 and R 5 respectively is (i) a hydrogen atom or (ii) a C ⁇ alkyl group optionally having substituents selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- or di-C x _ 6 alkylamino, C ⁇ alkoxy, C 1 _ 6 alkylcarbonyloxy and a halogen atom) , or
  • a divalent group derived from a 3- to 7-membered cyclic hydrocarbon or 3- to 7-membered heterocyclic ring which may contain 1 to 4 hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms in adidtion to carbon atoms, optionally having substituents selected from the group consisting of (i) 1 , alkyl optionally having substituents selected from the group consisting of hydroxy, amino, mono- or di-C x , 6 alkylamino, C 1 _ alkoxy, C ⁇ alkylcarbonyloxy and a halogen atom, (ii) an amino which may be substituted by C 1 . 6 alkyl, C ⁇ acyl or 5- to 7-membered cyclic amino, (iii) hydroxy, (iv) carboxyl, (v) nitro, (vi) alkoxy and (vii) a halogen atom,
  • R 6 and R 7 respectively is (i) a hydrogen atom, (ii) a C ⁇ alkyl group optionally having substituents selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- or di-C ⁇ alkylamino, C 1 . 6 alkoxy, C 1 . 6 alkylcarbonyloxy and a halogen atom, (iii) a C 3 . 6 cycloalkyl group optionally having substituents selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- or i-C ⁇ alkylamino, alkoxy, C 1 . 6 alkylcarbonyloxy and a halogen atom, or (iv) a C 6 .
  • aryl group optionally having substituents selected from the group consisting of (a) Cj.g alkyl optionally having substituents selected from the group consisting of hydroxy, amino, mono- or di-C ⁇ alkylamino, C x _ 6 alkoxy, C ⁇ alkylcarbonyloxy and a halogen atom, (b) an amino which may be substituted by C 1 . 6 alkyl, C ⁇ acyl or 5- to 7-membered cyclic amino, (c) acetamido, (d) hydroxy, (e) carboxyl, (f) nitro, (g) C 1 _ 6 alkoxy, (h) C ⁇ alkylcarbonyloxy and (i) a halogen atom, or
  • R ⁇ and R 7 may, taken together with the adjacent nitrogen atom, form a group resulting from elimination of one hydrogen atom from a nitrogen atom in a 3- to 13-membered nitrogen- containing heterocyclic ring which contains one nitrogen atom in addition to carbon atoms and which may also contain 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur atoms, optionally having substituents selected from the group consisting of (i) C 1 mentally alkyl optionally having substituents selected from the group consisting of hydroxy, amino, mono- or alkylamino, C 1-6 alkoxy, C x _ 6 alkylcarbonyloxy and a halogen atom, (ii) an amino which may be substituted by C ⁇ alkyl, Cj.
  • R 4' and R 5' each is (i) a hydrogen atom or (ii) a C ⁇ alkyl group optionally substituted by 1 to 4 substituents selected from hydroxy, amino, carboxyl, nitro, mono- or di-Cj.g alkylamino, Cj_. 6 alkoxy, C 1 _ 6 alkyl-carbonyloxy and halogen atom, R 6 and R 7 respectively is a hydrogen atom or a C x _ 3 alkyl group, m and n is 1,
  • the agent is an anti-asthmatic agent, an agent for preventing or treating chronic obstructive pulmonary disease (COPD) , an agent for preventing or treating hypersensitive pneumonia or an agent for preventing or treating simple pulmonary eosinophilia,
  • COPD chronic obstructive pulmonary disease
  • a method for preventing or treating asthma, chronic obstructive pulmonary disease (COPD), hypersensitive pneumonia or simple pulmonary eosinophilia which comprises administering an effective amount of a compound of the formula:
  • R 1 is a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom
  • X is an oxygen atom or S(0) p (p is a whole number of 0 to 2)
  • Y is a group of the formula:
  • R 4 and R 5 respectively is a hydrogen atom or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring
  • R 6 and R 7 each is a hydrogen atom, an optionally substituted lower alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R 6 and R 7 may, taken together with the adjacent nitrogen atom, form an optionally substituted nitrogen- containing heterocyclic group
  • m is a whole number of 0 to 4
  • n is a whole number of 0 to 4 , or a salt thereof to bronchi of mammals ,
  • R 1 is (i) a hydrogen atom, (ii) a C x _ 6 alkyl group optionally having substituents selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- or di-C 1 . 6 alkylamino, Cj_ 6 alkoxy, C ⁇ alkylcarbonyloxy and a halogen atom or (iii) a halogen atom,
  • R 2 and R 3 respectively is (i) a hydrogen atom or (ii) a C x _ 6 alkyl group optionally having substitutes selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- or alkylamino, C x _ 6 alkoxy, C x _ 6 alkylcarbonyloxy and a halogen atom or (iii) a C 3 .
  • alkyl optionally having substituents selected from the group consisting of hydroxy, amino, mono- or alkylamino, C ⁇ alkoxy, C 1-6 alkylcarbonyloxy and a halogen atom, (ii) an amino which may be substituted by C ⁇ alkyl, acyl or 5- to 7-membered cyclic amino, (iii) hydroxy,
  • X is an oxygen atom or S(0) p (p is a whole number of 0 to
  • Y is (a) a group of the formula:
  • R 4 and R 5 respectively is (i) a hydrogen atom or (ii) a C ⁇ alkyl group optionally having substituents selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- or i-C ⁇ alkylamino, C ⁇ _ 6 alkoxy, C ⁇ alkylcarbonyloxy and a halogen atom) , or
  • a divalent group derived from a 3- to 7-membered cyclic hydrocarbon or 3- to 7-membered heterocyclic ring which may contain 1 to 4 hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms in adidtion to carbon atoms, optionally having substituents selected from the group consisting of (i) alkyl optionally having substituents selected from the group consisting of hydroxy, amino, mono- or di-C x .
  • R 6 and R 7 respectively is (i) a hydrogen atom, (ii) a C ⁇ alkyl group optionally having substituents selected from the group consisting of hydroxy, amino, carboxyl, nitro, mono- or di-C j .g alkylamino, C 1 _ 6 alkoxy, C x . 6 alkylcarbonyloxy and a halogen atom, (iii) a C 3 .
  • alkylcarbonyloxy and a halogen atom (b) an amino which may be substituted by C ⁇ alkyl, C ⁇ acyl or 5- to 7-membered cyclic amino, (c) acetamido, (d) hydroxy, (e) carboxyl, (f) nitro, (g) C ⁇ alkoxy, (h) C ⁇ alkylcarbonyloxy and (i) a halogen atom, or
  • R 6 and R 7 may, taken together with the adjacent nitrogen atom, form a group resulting from elimination of one hydrogen atom from a nitrogen atom in a 3- to 13-membered nitrogen- containing heterocyclic ring which contains one nitrogen atom in addition to carbon atoms and which may also contain 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur atoms , optionally having substituents selected from the group consisting of (i) C ⁇ alkyl optionally having substituents selected from the group consisting of hydroxy, amino, mono- or alkylcarbonyloxy and a halogen atom, (ii) an amino which may be substituted by C x _ 6 alkyl, C ⁇ acyl or 5- to 7-membered cyclic amino, (iii) hydroxy, (iv) carboxyl, (v) nitro, (vi) C x . 6 alkoxy and (vii) a halogen atom, m is a whole number of 0 to 4; n is a whole
  • R 4' and R 5 each is (i) a hydrogen atom or (ii) a C 1 alkyl group optionally substituted by 1 to 4 substituents selected from hydroxy, amino, carboxyl, nitro, mono- or di-Cj.g alkylamino, C x _ 6 alkoxy, C 1 . 6 alkyl-carbonyloxy and halogen atom, R 6 and R 7 respectively is a hydrogen atom or a C x _ 3 alkyl group, m and n is 1 , and
  • An aerosol which comprises 6- ( 2 , 2-dimethyl-3- sulfamoyl-1-propoxy) -7-isopropyl [l,2,4] triazolo [l,5-b] pyridazine or a salt thereof and sprays (e.g., an aerosol for acting on bronchi),
  • R 1 is a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom
  • R 2 and R 3 respectively is a hydrogen atom or an optionally substituted lower alkyl group, or R 2 and R 3 may, taken together with the adjacent
  • X is an oxygen atom or S(0) p (p is a whole number of 0 to 2);
  • Y is a group of the formula:
  • R 4 and R 5 respectively is a hydrogen atom or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring
  • R 6 and R 7 each is a hydrogen atom, an optionally substituted lower alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R 6 and R 7 may, taken together with the adjacent nitrogen atom, form an optionally substituted nitrogen- containing heterocyclic group
  • m is a whole number of 0 to 4
  • n is a whole number of 0 to 4 , or a salt thereof and about 0.1 to 99wt% of additives for inhalation to the total composition
  • the inhalation as defined in (21) which is an anti-asthmatic agent, an agent for preventing or treating chronic obstructive pulmonary disease (COPD) , an agent for preventing or treating hypersensitive pneumonia or an agent for preventing or treating simple pulmonary eosinophilia,
  • R 1 is a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom
  • X is an oxygen atom or S(0) p (p is a whole number of 0 to 2)
  • Y is a group of the formula:
  • R 5 (R 4 and R 5 respectively is a hydrogen atom or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring;
  • R 6 and R 7 each is a hydrogen atom, an optionally substituted lower alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R 6 and R 7 may, taken together with the adjacent nitrogen atom, form an optionally substituted nitrogen- containing heterocyclic group;
  • m is a whole number of 0 to 4 ;
  • n is a whole number of 0 to 4 , or a salt thereof and sprays which comprises
  • triazolopyridazine derivatives [I] used for the agent of the present invention contains asymmetric carbon within its structure, it may occur as optically active isomers as well as racemic mixtures and that these isomers and mixtures also fall within the scope of the triazolopyridazine derivatives [I].
  • triazolopyridazine derivatives [I] used for the agent of the present invention which contain 6- (2, 2- dimethyl-3-sulfamoyl-l-propoxy) -7-isopropyl [l ,2, 4] triazolo Cl,5-b] pyridazine, are known compounds described in EP-A-0562439, EP-A-0648491 or O96/08496.
  • examples of the "lower alkyl group" represented by R 1 , R 2 , R 3 , R 4 , R 5 , R 6 or R 7 include a straight or branched C ⁇ alkyl group such as methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl, n-hexyl and so on.
  • Examples of the "cycloalkyl group" represented by R 2 , R 3 , R 6 or R 7 include a C 3 . 6 cycloalkyl group such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and so on.
  • substituents of the "lower alkyl group” and “cycloalkyl group” include 1 to 4 substituents selected from among hydroxy, amino, carboxyl, nitro, mono- or di-lower alkylamino (e.g. mono- or alkylamino groups such as methylamino, ethylamino, propylamino, dimethylamino , diethylamino , etc.), lower alkoxy (e.g. C ⁇ alkoxy groups such as methoxy, ethoxy, propoxy, hexyloxy, etc.), lower alkylcarbonyloxy (e.g. C ⁇ alkylcarbonyloxy groups such as acetoxy, ethylcarbonyloxy, etc.), halogen (e.g. fluorine, chlorine, bromine and iodine) and so on.
  • mono- or alkylamino e.g. mono- or alkylamino groups such as methylamino, eth
  • substituents of the "aryl group” include 1 to 5 substituents selected from among optionally substituted lower alkyl, optionally substituted amino, acetamido, hydroxy, carboxyl, nitro, lower alkoxy (e.g. x _ 6 alkoxy groups such as methoxy, ethoxy, propoxy, etc. ) , lower alkylcarbonyloxy (e.g. C x . 6 alkylcarbonyloxy groups such as acetoxy, ethylcarbonyloxy, etc.), halogen atoms (e.g. fluorine, chlorine, bromine and iodine) and so on.
  • substituents by which the lower alkyl e.g.
  • C x . 6 alkyl group such as methyl, ethyl, n-propyl, etc.
  • C x . 6 alkyl group such as methyl, ethyl, n-propyl, etc.
  • substituents selected from among hydroxy, amino, mono- or di-lower alkylamino (e.g. mono- or di-C ⁇ alkylamino groups such as methylamino, ethylamino, propylamino. dimethylamino , diethylamino , etc.), lower alkoxy (e.g. C 1 . 6 alkoxy groups such as methoxy, ethoxy, propoxy, hexyloxy, etc.), halogen (e.g. fluorine, chlorine, bromine and iodine) and so on.
  • hydroxy, amino, mono- or di-lower alkylamino e.g. mono- or di-C ⁇ alkylamino groups such as
  • substituents by which the amino group mentioned above may have include 1 or 2 substituents selected from among C ⁇ alkyl (e.g. methyl, ethyl, propyl, etc.), 5- to 7-membered cyclic amino (e.g. pyrrolidino, morpholino, piperidino, piperazino, etc.) and so on.
  • C ⁇ alkyl e.g. methyl, ethyl, propyl, etc.
  • 5- to 7-membered cyclic amino e.g. pyrrolidino, morpholino, piperidino, piperazino, etc.
  • halogen represented by R 1
  • examples of the "halogen” represented by R 1 include fluorine, chlorine, bromine, iodine and so on.
  • a 5- to 7-membered cyclic hydrocarbon such as C 5 . 7 cycloalkenes (e.g.
  • cyclopentene cyclohexene, cycloheptene, etc.
  • benzene and so on and a 5- or 6- membered nitrogen-containing heterocyclic group consisting of carbon and nitrogen atoms e.g., pyrrole, pyridine, piperidine , etc.
  • nitrogen-containing heterocyclic group consisting of carbon and nitrogen atoms
  • Examples of the "3- to 7-membered homocyclic ring" of the "divalent group derived from the 3- to 7-membered homocyclic ring" represented by Y include a 3- to 7-membered homocyclic ring consisting exclusively of carbon atoms, for instance.
  • C 3 . 7 cycloalkanes such as cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, etc.
  • C 3 . 7 cycloalkenes such as cyclopropene , cyclobutene, cyclopentene, cyclohexene, cycloheptene, etc. and benzene can be mentioned as the common species.
  • Examples of the "divalent group derived from the 3- to 7-membered homocyclic ring” include a group resulting from either elimination of two hydrogen atoms from a single carbon atom in the 3- to 7-membered homocyclic ring or elimination of one hydrogen atom from each of two different carbon atoms .
  • the following groups can be included by way of example:
  • Examples of the "3- to 7-membered heterocyclic ring" of the "divalent group derived from the 3- to 7-membered heterocyclic ring" represented by Y include a 3- to 7- membered heterocyclic ring which may contain 1 to 4 hetero atoms selected from among nitrogen, oxygen, sulfur and other atoms in adidtion to carbon atoms, for instance.
  • oxetane, tetrahydrofuran , tetrahydropyran, pyrrole, azetidine, pyrrolidine, piperidine, piperazine, tetraydrothiophene , homopiperidine, morpholine, etc. can be employed.
  • divalent group derived from the "3- to 7-membered heterocyclic ring” is a group resulting from either elimination of two hydrogen atoms from a single carbon atom in the 3- to 7-membered heterocyclic ring or elimination of one hydrogen atom from each of two different atoms .
  • the following groups can be included
  • nitrogen-containing heterocyclic group formed by R 6 and R 7 with the adjacent nitrogen atom
  • examples of the "nitrogen-containing heterocyclic group" formed by R 6 and R 7 with the adjacent nitrogen atom include a group resulting from elimination of one hydrogen atom from a nitrogen atom in a ring such as a 3- to 13- membered nitrogen-containing heterocyclic ring which contains one nitrogen atom in addition to carbon atoms and which may also contain one to four hetero atoms , for example , selected from nitrogen, oxygen, sulfur and other atoms.
  • the following 3- to 9-membered nitrogen- containing heterocyclic groups can be generally used:
  • substituents by which the "3- to 7- membered homocyclic ring", “3- to 7-membered heterocyclic ring” and “nitrogen-containing heterocyclic group” may have include 1 to 5 substituents selected from among an optionally substituted lower alkyl, an optionally substituted amino, hydroxy, carboxyl, nitro, lower alkoxy (e.g. C ⁇ alkoxy groups such as methoxy, ethoxy, propoxy, etc. ) , halogen (e.g. fluorine, chlorine, bromine and iodine) and so on.
  • substituents by which the lower alkyl e.g.
  • C ⁇ alkyl group such as methyl, ethyl, n-propyl, etc.) mentioned just above may have, include 1 to 4 substituents selected from among hydroxy, amino, mono- or di-lower alkylamino (e.g. mono- or alkylamino groups such as methylamino , ethylamino , propylamino , dimethylamino , diethylamino, etc.), lower alkoxy (e.g. C ⁇ alkoxy groups such as methoxy, ethoxy, propoxy, hexyloxy, etc.), lower alkylcarbonyloxy (e.g.
  • mono- or alkylamino groups such as methylamino , ethylamino , propylamino , dimethylamino , diethylamino, etc.
  • lower alkoxy e.g. C ⁇ alkoxy groups such as methoxy, ethoxy, propoxy, hex
  • C ⁇ alkylcarbonyloxy groups such as acetoxy, ethylcarbonyloxy, etc.), halogen (e.g. fluorine, chlorine, bromine and iodine) and so on.
  • substituents by which the amino group mentioned above may have include 1 to 2 substituents selected from among C ⁇ alkyl (e.g. methyl, ethyl, propyl, etc.), acyl (e.g. Q. x . b acyl groups such as formyl, acetyl, propionyl, butyryl, etc.), 5- to 7-membered cyclic amino (e.g. pyrrolidino, morpholino, piperidino, piperazino, etc. ) and so on.
  • R 1 are a hydrogen atom or a C ⁇ alkyl group (e.g. methyl, ethyl, n-propyl, etc.) and more preferable examples are a hydrogen atom and so on.
  • R 2 are a hydrogen atom or a C ⁇ alkyl group (e.g. methyl, ethyl, n-propyl, etc.) and more preferable examples are a hydrogen atom and so on.
  • R 3 are a hydrogen atom or a C ⁇ alkyl group (e.g. methyl, ethyl, n-propyl, i-propyl, etc.) and more preferable examples are a branched C 3 . 6 alkyl group (e.g. i-propyl, etc.).
  • Particularly preferred is the case of cyclohexene, benzene or the like.
  • X is preferably an oxygen atom or S and more preferably an oxygen atom.
  • Y are a group of the formula:
  • R 4' and R 5' each is (i) a hydrogen atom or (ii) a C ⁇ alkyl group optionally substituted by 1 to 4 substituents selected from hydroxy, amino, carboxyl, nitro, mono- or alkyl-carbonyloxy and halogen atom, and so on.
  • Examples of the "C ⁇ alkyl group" represented by R 4' and R 5' are methyl, ethyl, n-propyl, i-propyl and so on, and more preferable examples are methyl, ethyl and so on.
  • Y is a divalent group derived from a 3- to 7-membered homocyclic ring or heterocyclic ring which may be substituted.
  • Y is preferably a group of the formula:
  • Y More preferably examples of Y include the follow:
  • R 6 and R 7 are a hydrogen atom, a C j . 3 alkyl group (e.g. methyl, ethyl, n-propyl, etc.) and so on, and particularly a hydrogen atom is preferred.
  • Preferable example of m is a whole number of 1 to 4 , more preferable example is a whole number of 1 to 3 and most preferable example is 1.
  • n is a whole number of 1 to 4 and more preferable example is 1.
  • triazolopyridazine derivatives [ I ] used for the agent of the present invention are all compounds prepared in Examples of EP-A-0562439 and WO96/08496, and most preferable example is 6- (2, 2- dimethyl-3-sulfamoyl-l-propoxy) -7-isopropyl [l , 2 , 4] triazolo [l,5-b] pyridazine or a salt thereof.
  • the salt of triazolopyridazine derivatives [I] is preferably a physiologically acceptable acid addition salt.
  • Such salts include salt with inorganic acids (e.g., hydrochloric acid, phosphoric acid, hydrobromic acid, sulfuric acid) and salts with organic acids (e.g., acetic acid, formic acid, propionic acid, fumaricacid, maleicacid, succinic acid, tartaric acid, citric acid, malic acid, oxalic acid, benzoic acid, methanesulfonic acid, benzenesulfonic acid) .
  • inorganic acids e.g., hydrochloric acid, phosphoric acid, hydrobromic acid, sulfuric acid
  • organic acids e.g., acetic acid, formic acid, propionic acid, fumaricacid, maleicacid, succinic acid, tartaric acid, citric acid, malic acid, oxalic acid, benzoic acid, methanesulf
  • the triazolopyridazine derivatives [I] have an acidic group, such as -COOH, they may form a salt with an inorganic base (e.g., an alkali metal or alkaline earth metal such as sodium, potassium, calcium or magnesium; or ammonia) or an organic base (e.g., a tri-C ⁇ alkylamine such as triethylamine) .
  • an inorganic base e.g., an alkali metal or alkaline earth metal such as sodium, potassium, calcium or magnesium; or ammonia
  • an organic base e.g., a tri-C ⁇ alkylamine such as triethylamine
  • triazolopyridazine derivatives [ I ] or salts thereof can be prepared according to the descriptions of EP-A- 0562439 or O96/08496, particularly the descriptions of Examples of the references .
  • the agent for acting on bronchi of the present invention makes the triazolopyridazine derivatives [I] or salts thereof act on bronchi specifically, on the other hand do not make them act on a whole body. And, the agent of the present invention may act on tissues around bronchi such as trachea, lung, etc..
  • agent of the present invention can show the local actions of triazolopyridazine derivatives [ I ] or salts thereof, types of the agent are not limited.
  • the agent of the present invention can be preferably used as an inhalation.
  • additives for the inhalation may be any additives generally used in an inhalation, and examples are solid fillers such as pressurizing agents, white sugar, lactose, glucose, mannitol and sorbitol, liquid fillers e.g.
  • inert liquid such as propylene glycol
  • binders such as methyl cellulose, hydroxypropyl cellulose, polyvinylpyrrolidone , polyethylene glycol and white sugar
  • lubricants such as magnesium stearate, light silicate anhydride, talk and sodium lauryl sulfate
  • taste correctives such as citric acid, menthol, glythylithin ammonium salt, glycine and orange powder
  • preservatives such as sodium benzoate, sodium bisulfite, methyl parabene and propyl parabene, stabilizers such as citric acid and sodium citrate
  • suspending agents such as methyl cellulose, polyvinylpyrrolidone, lecithin and sorbitan trioleate
  • dispersing agents such as surface active agents, solvents such as water, isotonicity agents such as sodium chloride, pH a justor such as sulfuric acid and hydrochloric acid, and solubilizers such as ethanol.
  • the pressurizing agents include liquefied gas pressurizing agents, compressed gas etc.
  • the liquefied gas pressurizing agents include e.g. hydrocarbon fluoride (e.g. substitute Freon such as HCFC22, HCFC-123, HCFC-134a, and HCFC142), liquefied petroleum, and dimethyl ether.
  • the compressed gas includes e.g. soluble gas (e.g. carbon dioxide gas, nitrous oxide gas etc. ) and insoluble gas (e.g. nitrogen gas ) .
  • the pharmaceutical preparation of the invention may contain as active ingredients any pharmaceutical ingredients other than triazolopyridazine derivative [I] or salts thereof.
  • pharmaceutical active ingredients include anti-asthma agents (e.g. theophylline , procaterol, ketotifen, azelastine, seratrodast (bronica) etc.), anti-allergy agents (e.g. ketotifen, terfenadine, azelastine, epinastine etc.), anti-inflammatory agents (e.g. diclophenac sodium, ibuprofen, indomethacin etc.), antimicrobial agents (e.g.
  • cefixme, cefdinir, ofloxacin, tosfloxacin etc. ) and anti-fungus agents e.g. fluconazole. itraconazole etc.
  • these ingredients are not particularly limited insofar and can be used in a suitable ratio.
  • the content of the triazolopyridazine derivative [I] or salts thereof in the pharmaceutical preparation of the invention vary depending on the disease treated, the age or sex of the patient and the conditions of the disease, the content is in the range of usually about 0.01 to 99.9 % by weight, preferably about 0.1 to 50 % by weight , more preferably about 0.5 to 20 % by weight , relative to the whole of the pharmaceutical preparation.
  • the content of various additives such as additives for an inhalation varies depending on the disease treated, the age or sex of the patient and the conditions of the disease, the content is in the range of usually about 0.1 to 99 % by weight, preferably about 10 to 99 % by weight, more preferably about 50 to 99 % by weight, most preferably about 70 to 99 % by weight, relative to the whole of the pharmaceutical preparation.
  • the content of other pharmaceutical ingredients than the triazolopyridazine derivative [I] or salts thereof varies depending on the disease treated, the age or sex of the patient and the conditions of the disease, the content is in the range of usually about 0.01 to 99.9 % by weight, preferably about 0.1 to 50 % by weight , more preferably about 0.5 to 20 % by weight, relative to the whole of the pharmaceutical preparation.
  • the agent of the invention can be formed into a powder for inharation, a suspension for inharation, a liquid preparation for inharation or a capsule for inharation by a method known in the art and administered by means of a suitable inhaler.
  • the agent of the invention can be used as an aerosol.
  • the aerosol is made completely contamination-free during use, and because the inside of the aerosol is maintained always under pressure, the content introduced in the can is completely prevented from being contaminated from the outside.
  • the aerosol is composed usually of 5 elements i.e. a vessel, a valve, a button, a content and a pressurizing agent, and is classified into a 2-phase system, a 3-phase system and a membrane system (double vessel).
  • the vessel used is a vessel stipulated under a high-pressure gas regulation , and its material is metal (e.g. tin, aluminum), glass or plastics.
  • metal vessel e.g. tin, aluminum
  • the glass vessel is excellent in solvent resistance and corrosion resistance and is easily processed, so it can be easily formed into a deformed vessel.
  • the valve is a part most influential over the jet characteristics and sealing properties of the aerosol.
  • the valve is constituted usually of a mountain cup, a stem, a housing, a spring, a dip tube and gasket rubber, and use is made of a valve equipped with a gas-phase hole or a quantification valve.
  • the stem is pressed whereby the stem hole closed with sealing gasket rubber is allowed to communicate with the inside of the vessel so that the content is released through the stem hole.
  • the button used includes a straight button, a brake cap button, a button for foam, and a button with a long nozzle.
  • the content is the topical working agent (inhalation) of the invention described above.
  • the pressurizing agent is the same as described above .
  • a 2-phase system aerosol using a liquefied gas pressurizing agent as the pressurizing agent forms an uniform liquid phase in which a suspension (stock solution) containing the triazolopyridazine derivative [ I ] or salts thereof are made compatible with the pressurizing agent, and the inside of the vessel is composed of 2 phases i.e. a liquid phase and a gaseous phase of a gas of the pressurizing agent in an upper space in the vessel.
  • fine droplets can be obtained due to the propellant force of the pressurizing agent when the liquefied pressurizing agent under pressure in the vessel is jetted out through a valve under normal pressure.
  • compressed gas the compressed gas present under compression in an upper space merely presses the stock solution.
  • the former consists of a 2-phase emulsification state of the liquid phase and a gaseous phase in an upper space
  • the latter consists of a powder solid phase, a liquefied gaseous phase, and a gaseous phase in an upper space.
  • the membrane system is a system in which only the stock solution itself is jetted out from a double vessel in which the pressurizing agent is filled in an outer vessel and the stock solution is filled in an inner vessel communicating with a valve.
  • the agent of the invention is used as an aerosol, it is formed preferably into a powder aerosol.
  • Production of the aerosol consists usually of the 2 steps of preparing the content and filling the content and the pressurizing agent .
  • Preparation of the content can be conducted in any method known in the art, and the following methods are used: (1) a method of mixing the triazolopyridazine derivative [I] or a salt thereof with an adjuvant and a solvent to form a uniform suspension, (2) a method of kneading the triazolopyridazine derivative [I] or a salt thereof with a surface active agent to form powder, and (3) a method of mixing the triazolopyridazine derivative [I] or a salt thereof with water-soluble additives for inhalation and then stirring, heating and cooling the mixture into an emulsion.
  • Filling of the content and the pressurizing agent consists usually of the steps of washing the vessel, filling the content, degassing the inside of the vessel, filling the pressurizing agent, and attaching the valve thereto.
  • Filling of the pressurizing agent involves filling under cooling, filling under pressure, or undercup filling.
  • crimp conditions are confirmed in order to examine whether the valve is correctly fitted. Further, in order to examine linkage from the product, a hot water test is conducted and water droplets are removed.
  • a flame-length test and tests for changes with time are conducted in order to confirm the storage and safety of the aerosol for use.
  • the devices used for administration may be commercial inhalers, and examples include Ventolin Rotacaps, Glaxo), Spin Heller * (Fujisawa Pharmaceutical Co., Ltd.), Intal Spincaps (Fisonz), Atrovent and Berotec Inhaletten (Boehringer Ingelheim) , Foradil (Chiba), Bentodisks (Glaxo), Pabrizer * (Teijin Ltd. ) , Bricanyl Turbuhaler (Astra) , Miat Insufflator) .
  • the triazolopyridazine derivatives [I] or salts thereof used for the agent of the present invention possess excellent an anti-allergic action, an anti-asthmatic action, an anti-PAF (platelet activating factor) action, an inhibitory action of eosinophil chemotaxis, an inhibitory action of local eosinophilic infiltration in allergic and asthmatic reactions , and is with a low toxic potential (acute toxicity: LD 50 >2g/kg).
  • the agent of the present invention can act specifically on the bronchus or its surrounding tissues by administering it topically into the mouth, throat etc.
  • Topical administration of the triazolopyridazine derivative [I] or its salts achieve a minimum effective amount, thus eliminating general and high-dosage administration. Accordingly, it can be administered into even children easily and safely. In particular, outstanding local acting effects can be demonstrated in the case of an inhalation or an aerosol.
  • the agent of the present invention can be used safety as an anti-asthmatic agent, an anti- PAF agent, an anti-allergic agent, an agent for inhibiting eosinophil chemotaxis , an agent for preventing or treating diseases related to eosinophilic infiltration (for example, allergic diseases such as urticaria, atopic dermatitis, allergic rhinitis, hypersensitive pneumonia, etc,; diseases of the skin such as eczema, dermatitis herpetiformis , psoriasis, etc., and respiratory diseases such as simple pulmonary eosinophilia (PIE syndrome), chronic obstructive pulmonary disease (COPD), etc.), particularly as an anti-asthmatic agent, an agent for preventing or treating chronic obstructive pulmonary disease (COPD), an agent for preventing or treating hypersensitive pneumonia or an agent for preventing or treating simple pulmonary eosinophilia, in mammals (e.g., humans, mice,
  • the dose of the agents of the present invention varies depending on age, body weight, symptoms, route and frequency of administration and other factors , they may be administered at about 0.001 to 10 mg/kg, preferably about 0.01 to 10 mg/kg, more preferably about 0.1 to 10 mg/kg, particularly preferably about 0.1 to 5 mg/kg in one to two portions daily for an adult .
  • Preferable route of administration may be direct inhalation into mouth, etc. by using tools for inhalation.
  • Detection of the fractions containing each object compound in the Reference Examples was carried out under TLC (Thin Layer Chromatography) monitoring.
  • TLC monitoring Merck's 60F 254 was used as the TLC plate and a UV detector for detection .
  • Merck' s silica gel 60 (70 to 230 mesh) was used as a silica gel for column chromatography.
  • mice Male Hartley guinea pigs (body weights about 500 g) were used. Bronchoconstriction induced by PAF, 1 ⁇ g/kg i.v. , in guinea pigs was measured using to the method of Konzett-Roessle . With the guinea pig immobilized in the dorsal position, tracheotomy was performed under urethane (1.5 g/kg i.v.) anesthesia and the trachea was connected through a cannula to a respirator. The side branch of the tracheal cannula was connected to a transducer (Model 7020, Ugobasile).
  • Solubitantriolate 20.0 mg Suspensions for inhalation can be prepared by mixing the above components.
  • Quantitative valve can be used for 50 11 1 .
  • Liquid preparations for inhalation can be prepared by mixing the above components .
  • the liquid preparation for inhalation can be used by using Nebulizer (Trade Mark) .
  • the powders for inhalation can be prepared by mixing the above components .
  • the capsules for inhalation can be used by using Spinhalor
  • the agent of the present invention can make an anti-asthmatic action, etc., of the triazoropyridazine derivatives [I] such as 6- (2 , 2-dimethyl-3-sulfamoyl-1- propoxy) -7-isopropyl [l,2,4] triazolo Cl,5-b] pyridazine, etc., or salts thereof act on bronchi or tissues around bronchi specifically, and therefore, since local administering could be performed by a minimum effective amount of by the triazolopyridazine derivatives [I], it could avoid to administer an amount of the triazolopyridazine derivatives [I] into a whole body.
  • the triazoropyridazine derivatives [I] such as 6- (2 , 2-dimethyl-3-sulfamoyl-1- propoxy) -7-isopropyl [l,2,4] triazolo Cl,5-b] pyridazine, etc., or salts thereof act on bron

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  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99937873A 1998-03-04 1999-03-03 Triazolo-pyridazine derivate zur behandlung von chronisch-obstruktiven atemwegserkrankungen Withdrawn EP1059924A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5158398 1998-03-04
JP5158398 1998-03-04
PCT/JP1999/001010 WO1999044611A1 (en) 1998-03-04 1999-03-03 Triazolo-pyridazine derivatives for the treatment of chronic obstructive pulmonary diseases

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AU (1) AU3274199A (de)
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Publication number Priority date Publication date Assignee Title
LT3200B (en) * 1992-03-18 1995-03-27 Takeda Chemical Industries Ltd Triazolopyridazine methodfor production thereof and use
TW304878B (de) * 1993-09-21 1997-05-11 Takeda Pharm Industry Co Ltd
CN1046517C (zh) * 1994-09-16 1999-11-17 武田药品工业株式会社 三唑并哒嗪,其制备和应用

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Title
See references of WO9944611A1 *

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