EP1024811A4 - Nouveaux derives de benzodiazepine s'utilisant comme agents anti-arythmisants - Google Patents

Nouveaux derives de benzodiazepine s'utilisant comme agents anti-arythmisants

Info

Publication number
EP1024811A4
EP1024811A4 EP98953453A EP98953453A EP1024811A4 EP 1024811 A4 EP1024811 A4 EP 1024811A4 EP 98953453 A EP98953453 A EP 98953453A EP 98953453 A EP98953453 A EP 98953453A EP 1024811 A4 EP1024811 A4 EP 1024811A4
Authority
EP
European Patent Office
Prior art keywords
antiarrhythmic agents
benzodiazepine derivatives
novel benzodiazepine
novel
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98953453A
Other languages
German (de)
English (en)
Other versions
EP1024811A1 (fr
Inventor
Nigel J Liverton
John W Butcher
David A Claremon
Harold G Selnick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806686.3A external-priority patent/GB9806686D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1024811A1 publication Critical patent/EP1024811A1/fr
Publication of EP1024811A4 publication Critical patent/EP1024811A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP98953453A 1997-10-17 1998-10-13 Nouveaux derives de benzodiazepine s'utilisant comme agents anti-arythmisants Withdrawn EP1024811A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6283397P 1997-10-17 1997-10-17
US62833P 1997-10-17
GBGB9806686.3A GB9806686D0 (en) 1998-03-27 1998-03-27 Novel benzodiazepine derivatives as antiarrhythmic agents
GB9806686 1998-03-27
PCT/US1998/021597 WO1999020281A1 (fr) 1997-10-17 1998-10-13 Nouveaux derives de benzodiazepine s'utilisant comme agents anti-arythmisants

Publications (2)

Publication Number Publication Date
EP1024811A1 EP1024811A1 (fr) 2000-08-09
EP1024811A4 true EP1024811A4 (fr) 2002-11-13

Family

ID=26313382

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98953453A Withdrawn EP1024811A4 (fr) 1997-10-17 1998-10-13 Nouveaux derives de benzodiazepine s'utilisant comme agents anti-arythmisants

Country Status (5)

Country Link
EP (1) EP1024811A4 (fr)
JP (1) JP2001520197A (fr)
AU (1) AU1082799A (fr)
CA (1) CA2306960A1 (fr)
WO (1) WO1999020281A1 (fr)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004741A (en) * 1984-06-26 1991-04-02 Merck & Co., Inc. Methods of antagonizing CCK or gastrin with benzodiazepine analogs
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines
US4994258A (en) * 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5426185A (en) * 1993-11-22 1995-06-20 Merck & Co., Inc. Antiarrhythmic benzodiazepines
CA2195973A1 (fr) * 1994-08-18 1996-02-29 David A. Claremon N-2,3-dihydro-1-(2-propyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines
WO1997048686A1 (fr) * 1996-06-21 1997-12-24 Merck & Co., Inc. Nouveaux n-1 alkyl-2-oxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3-yl)-3-amides
US5776930A (en) * 1996-06-28 1998-07-07 Merck & Company, Inc. Pharmaceutical preparation
US5817658A (en) * 1997-03-14 1998-10-06 Merck & Company, Inc. Method for treating Meniere's disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9920281A1 *

Also Published As

Publication number Publication date
AU1082799A (en) 1999-05-10
CA2306960A1 (fr) 1999-04-29
EP1024811A1 (fr) 2000-08-09
JP2001520197A (ja) 2001-10-30
WO1999020281A1 (fr) 1999-04-29

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Legal Events

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