AU1082799A - Novel benzodiazepine derivatives as antiarrhythmic agents - Google Patents

Novel benzodiazepine derivatives as antiarrhythmic agents Download PDF

Info

Publication number
AU1082799A
AU1082799A AU10827/99A AU1082799A AU1082799A AU 1082799 A AU1082799 A AU 1082799A AU 10827/99 A AU10827/99 A AU 10827/99A AU 1082799 A AU1082799 A AU 1082799A AU 1082799 A AU1082799 A AU 1082799A
Authority
AU
Australia
Prior art keywords
pct
compounds
compound
pharmaceutically acceptable
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU10827/99A
Other languages
English (en)
Inventor
John W. Butcher
David A. Claremon
Nigel J. Liverton
Harold G. Selnick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806686.3A external-priority patent/GB9806686D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU1082799A publication Critical patent/AU1082799A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU10827/99A 1997-10-17 1998-10-13 Novel benzodiazepine derivatives as antiarrhythmic agents Abandoned AU1082799A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6283397P 1997-10-17 1997-10-17
US60062833 1997-10-17
GBGB9806686.3A GB9806686D0 (en) 1998-03-27 1998-03-27 Novel benzodiazepine derivatives as antiarrhythmic agents
GB9806686 1998-03-27
PCT/US1998/021597 WO1999020281A1 (fr) 1997-10-17 1998-10-13 Nouveaux derives de benzodiazepine s'utilisant comme agents anti-arythmisants

Publications (1)

Publication Number Publication Date
AU1082799A true AU1082799A (en) 1999-05-10

Family

ID=26313382

Family Applications (1)

Application Number Title Priority Date Filing Date
AU10827/99A Abandoned AU1082799A (en) 1997-10-17 1998-10-13 Novel benzodiazepine derivatives as antiarrhythmic agents

Country Status (5)

Country Link
EP (1) EP1024811A4 (fr)
JP (1) JP2001520197A (fr)
AU (1) AU1082799A (fr)
CA (1) CA2306960A1 (fr)
WO (1) WO1999020281A1 (fr)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004741A (en) * 1984-06-26 1991-04-02 Merck & Co., Inc. Methods of antagonizing CCK or gastrin with benzodiazepine analogs
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines
US4994258A (en) * 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5426185A (en) * 1993-11-22 1995-06-20 Merck & Co., Inc. Antiarrhythmic benzodiazepines
WO1996005827A1 (fr) * 1994-08-18 1996-02-29 Merck & Co., Inc. N-2,3-dihydro-1-(2-propyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines
WO1997048686A1 (fr) * 1996-06-21 1997-12-24 Merck & Co., Inc. Nouveaux n-1 alkyl-2-oxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3-yl)-3-amides
US5776930A (en) * 1996-06-28 1998-07-07 Merck & Company, Inc. Pharmaceutical preparation
US5817658A (en) * 1997-03-14 1998-10-06 Merck & Company, Inc. Method for treating Meniere's disease

Also Published As

Publication number Publication date
WO1999020281A1 (fr) 1999-04-29
EP1024811A1 (fr) 2000-08-09
EP1024811A4 (fr) 2002-11-13
JP2001520197A (ja) 2001-10-30
CA2306960A1 (fr) 1999-04-29

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted