EP1007035A4 - Polythiophene als antitumormittel - Google Patents

Polythiophene als antitumormittel

Info

Publication number
EP1007035A4
EP1007035A4 EP96945379A EP96945379A EP1007035A4 EP 1007035 A4 EP1007035 A4 EP 1007035A4 EP 96945379 A EP96945379 A EP 96945379A EP 96945379 A EP96945379 A EP 96945379A EP 1007035 A4 EP1007035 A4 EP 1007035A4
Authority
EP
European Patent Office
Prior art keywords
polythiophene
tumor agents
tumor
agents
polythiophene anti
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96945379A
Other languages
English (en)
French (fr)
Other versions
EP1007035A1 (de
Inventor
Ching-Te Chang
Ching-Jer Chang
Chen-Tao Lee
Fen-Lan Lin
Jih-Dar Tsai
Curtis L Ashendel
Thomas C K Chan
Robert L Geahlen
David J Waters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industrial Technology Research Institute ITRI
Purdue Research Foundation
Original Assignee
Industrial Technology Research Institute ITRI
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industrial Technology Research Institute ITRI, Purdue Research Foundation filed Critical Industrial Technology Research Institute ITRI
Publication of EP1007035A1 publication Critical patent/EP1007035A1/de
Publication of EP1007035A4 publication Critical patent/EP1007035A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP96945379A 1996-11-26 1996-11-26 Polythiophene als antitumormittel Withdrawn EP1007035A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1996/019118 WO1998023269A1 (en) 1996-11-26 1996-11-26 Polythiophene anti-tumor agents

Publications (2)

Publication Number Publication Date
EP1007035A1 EP1007035A1 (de) 2000-06-14
EP1007035A4 true EP1007035A4 (de) 2000-11-22

Family

ID=22256220

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96945379A Withdrawn EP1007035A4 (de) 1996-11-26 1996-11-26 Polythiophene als antitumormittel

Country Status (5)

Country Link
EP (1) EP1007035A4 (de)
JP (1) JP2001506624A (de)
AU (1) AU1564797A (de)
CA (1) CA2272275A1 (de)
WO (1) WO1998023269A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2579407A1 (en) * 2004-09-14 2006-03-14 Northwestern University Carbonyl-functionalized thiophene compounds and related device stuctures
BRPI0920850A2 (pt) * 2008-10-17 2016-09-13 Biochromix Pharma Ab novos compostos e sua utilização
CN113603674B (zh) * 2021-07-23 2022-10-14 上海应用技术大学 一种5,5’位取代的3,3’-联噻吩衍生物、合成方法及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937256A (en) * 1988-06-01 1990-06-26 Basf Aktiengesellschaft Thiophene compounds
US5508440A (en) * 1993-06-04 1996-04-16 Industrial Technology Research Institute Hydroxymethylpolythiophene derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3050442A (en) * 1957-05-31 1962-08-21 Philips Corp Method of destroying nematodes with polythienyl compounds
US5045563A (en) * 1986-08-26 1991-09-03 Her Majesty The Queen In Right Of Canada, As Represented By Minister Of National Defence Of Her Majesty's Canadian Government Phototoxic compounds for use as insect control agents
US4861692A (en) * 1986-12-22 1989-08-29 Fuji Electric Company, Ltd. Electrophotographic photosensitive material containing thiophene compound
EP0454204B1 (de) * 1990-04-27 1995-06-28 Duphar International Research B.V Verfahren zur photochemischen Isomerisierung von organischen Verbindungen unter dem Einfluss eines Photosensibilisators
US5578636A (en) * 1994-04-08 1996-11-26 Purdue Research Foundation Polythiophene anti-tumor agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937256A (en) * 1988-06-01 1990-06-26 Basf Aktiengesellschaft Thiophene compounds
US5508440A (en) * 1993-06-04 1996-04-16 Industrial Technology Research Institute Hydroxymethylpolythiophene derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ASHENDEL C L_(A): "Structure-activity relationship of alpha-terthiophene series for inhibition of protein kinase C and cytotoxicity.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, no. 2604, March 1995 (1995-03-01), XP002147664 *
ASHENDEL C L_(A): "Terthiophenes as novel inhibitors of protein kinase C.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, no. 2661, March 1994 (1994-03-01), XP002147662 *
See also references of WO9823269A1 *
WATERS D J_(A) T_(A): "In vivo antitumor efficacy of a novel polythiophene against ras-transformed human bronchial epithelial cells.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, no. 2705, March 1996 (1996-03-01), XP002147663 *

Also Published As

Publication number Publication date
JP2001506624A (ja) 2001-05-22
EP1007035A1 (de) 2000-06-14
WO1998023269A1 (en) 1998-06-04
AU1564797A (en) 1998-06-22
CA2272275A1 (en) 1998-06-04

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EP1007035A4 (de) Polythiophene als antitumormittel

Legal Events

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