EP1005552A1 - Mitglied der hämatopoietin-rezeptor superfamilie - Google Patents

Mitglied der hämatopoietin-rezeptor superfamilie

Info

Publication number
EP1005552A1
EP1005552A1 EP98901207A EP98901207A EP1005552A1 EP 1005552 A1 EP1005552 A1 EP 1005552A1 EP 98901207 A EP98901207 A EP 98901207A EP 98901207 A EP98901207 A EP 98901207A EP 1005552 A1 EP1005552 A1 EP 1005552A1
Authority
EP
European Patent Office
Prior art keywords
protein
seq
sequence
nucleotide
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98901207A
Other languages
English (en)
French (fr)
Inventor
Debra D. Donaldson
Mary Collins
Tamlyn Neben
Matthew Whitters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of EP1005552A1 publication Critical patent/EP1005552A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Definitions

  • nucleotide sequence of SEQ ID NO:4 from nucleotide 242 to nucleotide 1396
  • nucleotide sequence of SEQ ID NO:6 from nucleotide 71 to nucleotide 1225;
  • SEQ ID NO: 6 provides the nucleotide sequence of a cDNA encoding the human U4.
  • SEQ ID NO:7 provides predicted the amino acid sequence of the receptor chain, including a putative signal sequence from amino acids 1-23. The mature human U4 is believed to have the sequence of amino acids 24-380 of SEQ ID NO:
  • operably linked means enzymatically or chemically ligated to form a covalent bond between the isolated polynucleotide of the invention and the expression control sequence, in such a way that the U4 protein is expressed by a host cell which has been transformed (transfected) with the ligated polynucleotide/expression control sequence.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP98901207A 1997-01-16 1998-01-15 Mitglied der hämatopoietin-rezeptor superfamilie Withdrawn EP1005552A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US784863 1991-10-30
US78486397A 1997-01-16 1997-01-16
PCT/US1998/000334 WO1998031811A1 (en) 1997-01-16 1998-01-15 Member of the hematopoietin receptor superfamily

Publications (1)

Publication Number Publication Date
EP1005552A1 true EP1005552A1 (de) 2000-06-07

Family

ID=25133760

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98901207A Withdrawn EP1005552A1 (de) 1997-01-16 1998-01-15 Mitglied der hämatopoietin-rezeptor superfamilie

Country Status (4)

Country Link
EP (1) EP1005552A1 (de)
JP (1) JP2001508309A (de)
AU (1) AU5733898A (de)
WO (1) WO1998031811A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271343B1 (en) 1997-05-01 2001-08-07 Zymogenetics, Inc. Mammalian cytokine-like receptor 5
WO1998049307A1 (en) * 1997-05-01 1998-11-05 Zymogenetics, Inc. Mammalian cytokine-like receptor
GB9721961D0 (en) * 1997-10-16 1997-12-17 Glaxo Group Ltd Novel molecules
US6060276A (en) * 1998-01-22 2000-05-09 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding novel orphan cytokine receptors
US6207413B1 (en) 1998-01-22 2001-03-27 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding novel orphan cytokine receptors
AU2661199A (en) * 1998-02-06 1999-08-23 Schering Corporation Mammalian receptor proteins; related reagents and methods
US6057128A (en) 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
US7189400B2 (en) 1998-03-17 2007-03-13 Genetics Institute, Llc Methods of treatment with antagonists of MU-1
US7198789B2 (en) 1998-03-17 2007-04-03 Genetics Institute, Llc Methods and compositions for modulating interleukin-21 receptor activity
CA2324992A1 (en) * 1998-04-10 1999-10-21 Genetics Institute, Inc. U4, a member of the hematopoietin receptor superfamily
WO2000008152A1 (en) * 1998-08-04 2000-02-17 Regeneron Pharmaceuticals, Inc. Novel orphan cytokine receptors
US6803451B2 (en) 1998-09-23 2004-10-12 Zymogenetics, Inc. Cytokine receptor zalpha11 polypeptides
US6576744B1 (en) 1998-09-23 2003-06-10 Zymogenetics, Inc. Cytokine receptor zalpha11
ES2329741T3 (es) * 1998-09-23 2009-11-30 Zymogenetics, Inc. Receptor de citoquinas zalpha11.
US6800460B1 (en) 1999-03-11 2004-10-05 Schering Corporation Mammalian cytokine complexes
WO2000053631A1 (en) * 1999-03-11 2000-09-14 Schering Corporation Mammalian cytokines; related reagents and methods
ATE456654T1 (de) 2000-04-05 2010-02-15 Zymogenetics Inc Löslicher zytokinrezeptor zalpfa11
AU2002223182B2 (en) * 2000-10-06 2007-08-30 Immunex Corporation Hematopoietin receptors HPR1 and HPR2
AU2003215548A1 (en) * 2002-02-01 2003-09-02 Bayer Healthcare Ag Regulation of human hematopoietin receptor-like protein
CA2491320A1 (en) 2002-07-15 2004-01-22 Wyeth Methods and compositions for modulating t helper (th) cell development and function
DE602004025332D1 (de) 2003-03-14 2010-03-18 Wyeth Corp Antikörper gegen il21-rezeptor und deren verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643748A (en) * 1994-09-14 1997-07-01 Progenitor, Inc. HU-B1.219, a novel human hematopoietin receptor
AUPO224696A0 (en) * 1996-09-11 1996-10-03 Amrad Operations Pty. Limited A novel haemopoietin receptor and genetic sequences encoding same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9831811A1 *

Also Published As

Publication number Publication date
WO1998031811A1 (en) 1998-07-23
AU5733898A (en) 1998-08-07
JP2001508309A (ja) 2001-06-26

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Legal Events

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Inventor name: WHITTERS, MATTHEW

Inventor name: NEBEN, TAMLYN

Inventor name: COLLINS, MARY

Inventor name: DONALDSON, DEBRA, D.

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Owner name: GENETICS INSTITUTE, LLC

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