EP0993586B1 - Drying module - Google Patents
Drying module Download PDFInfo
- Publication number
- EP0993586B1 EP0993586B1 EP98940128A EP98940128A EP0993586B1 EP 0993586 B1 EP0993586 B1 EP 0993586B1 EP 98940128 A EP98940128 A EP 98940128A EP 98940128 A EP98940128 A EP 98940128A EP 0993586 B1 EP0993586 B1 EP 0993586B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- dryer module
- filter support
- module according
- filter
- heating system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B9/00—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards
- F26B9/003—Small self-contained devices, e.g. portable
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B9/00—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards
- F26B9/06—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards in stationary drums or chambers
Definitions
- the invention relates to a dryer module for drying of filter carriers, such as those used in DNA preparation be used.
- the preparation protocol described by Qiagen involves washing the one in filter elements Filter carrier adsorbed DNA with ethanol-containing buffer. Experiments have shown that traces of ethanol are the result of subsequent sequencing reactions drastically deteriorate. The enzymes involved will probably inhibited by ethanol. In this step first the larger amounts of ethanol from the filters removed in a known manner. This can happen with a Implementation of the protocol, for example in a the corresponding vacuum apparatus that the applied vacuum is applied longer, than would be necessary to remove the washing liquid. The air flow generated in the filter in this way is removed the larger amounts of ethanol from the filters.
- the invention is therefore based on the object To create device with which the remaining Residual alcohol is removed from filter media as they are for example in the Qiagen protocol.
- the invention relates to a dryer module for drying a filter carrier in the context of DNA preparation with a heater and a fan element, the heater being arranged downstream of the fan element and the filters arranged in the filter carrier being blown and dried from below, characterized, that the filters are arranged hanging in the filter carrier, and the filter carrier has spacer sleeves which can be inserted into corresponding centering shafts of a centering plate for receiving the filter carrier, heating wires running parallel to a rectangular cross section of an air shaft being arranged upstream of the centering plate as a heater and the dryer module has a tangential fan as the fan element.
- the dryer module is characterized in that the fan element is driven by an electric motor.
- the dryer module is characterized in that a nozzle for concentrating the air flow is arranged between the air shaft and the centering element for the filter carrier.
- the dryer module is characterized in that the dryer module is arranged in an opening of a table top.
- the dryer module is characterized in that the centering plate for receiving the filter carrier is arranged on support elements.
- the dryer module is characterized in that the module has a temperature sensor that the module has an electrical controller for controlling the at least one motor and the heater, the heater being controlled as a function of the temperature measured by the temperature sensor, and that the controller is provided with a delay circuit which, in the event that the dryer module is switched off, causes the at least one fan element (1) to be switched off in time after the heating (5) is switched off.
- the invention also provides the use of the dryer module in an automated environment as well as a stand-alone device.
- the step of removing the Ethanol from the area between the outlet nozzle and Plastic sheathing of the filter carrier not manually performed, but automated. Blows for this purpose the dryer module heated air (maximum 50 ° C) from below evaporated against the filter support and the ethanol. The on this way dried filter is again in a Vacuum chamber placed, then again for a certain Time to be ventilated by applying a vacuum. In This second step will leave traces of ethanol carried on. Finally, this is how it is treated Filter placed on the dryer module again to pass through to ensure that the temperature-controlled air flow traces of ethanol still present for good be evaporated. Only then will the filter holder for example put back in the pipetting robot, to the eluent for the release of the DNA from the Pipette in filters.
- two tangential fans 1 are coupled on their long sides in order to obtain an air flow that is as homogeneous as possible. This results in a uniform air flow over the entire surface of the filter carrier to be dried (not shown).
- the air flow is a maximum of 2x80 m 3 / h and can be regulated via a series transformer (not shown) via the rotational speed of the motors 3 of the pair of tangential fans 1.
- the rectangular duct 4 is constructed so that the Air flow, like a nozzle 6, towards the outlet opening is bundled. It is made of 2 mm thick iron sheet manufactured and soldered to a closed shape. On in the lower area there is a holder for one Heating 5. Below are the two tangential fans 1 attached. The upper part of the air duct 4 is in one correspondingly dimensioned recess in a table top 7 attached and thus in the work area at precisely defined Fixed position. The heating elements 5a, 5b and Fan elements 1 are located under this arrangement the work table 7.
- the opening of the air shaft 4 is preferably at ground level with the work surface of a Robot tables (not shown) in case of use of the dryer module in an automated process.
- the heater 5 is in the preferred embodiment from two heating elements 5a, 5b, as shown in FIGS. 2 and 3 will become clearer. These heating elements 5a, 5b are above the outlet opening of the tangential fan 1 attached. Two Multimicalochplatten are each considered Carrier for a heating wire used in coils of about 3 mm distance is clamped in the air flow and this heats it evenly. The coils are there so that the reverse loop outside the Airflow comes to rest, the parallel Heating wires, on the other hand, are perpendicular to the multi-micro plates are arranged.
- the filter stand consisting of a mounting element 11 and support members 10 is designed so that it centering elements (shown in Fig. 3) on its Contact points to the filter carrier (not shown) having. In particular, 30 ° phases are on the Contact areas to the spacer sleeves (see Fig. 4) to name a filter carrier.
- the filter stand includes in the preferred embodiment one as a receiving element acting upper support plate or centering plate 10, which the centering elements, namely cutouts for the Spacer sleeves and the contact surface for the edge of the Has filter carrier. On this centering plate are in attached the four corner points 4.5 cm high support elements 10, which each have a fastening bolt at their lower end 8 of 0.3 cm.
- the control of the fan elements 1 and the The heating elements 5a, 5b are activated separately via a controller interface. So after finishing of the drying process, the heater 5 is first switched off be, so that after a time delay the now cooling the heating wires acting ventilation is stopped.
- Temperature measurement is a lateral one in the nozzle 6 Recess 13 for receiving a temperature sensor intended.
- the heating elements 5a, 5b is a Temperature threshold switching controlled.
- FIG. 2 also shows the dryer module according to the invention in a cross-sectional view, but opposite the 1 of 90 ° around the vertical axis of symmetry is rotated.
- the two can be seen in parallel arranged tangential fan rollers 1 by corresponding motors 3 are driven.
- Air duct 4 are the two heating elements 5a, 5b Heater 5 arranged in parallel and almost abutting.
- the nozzle 6 is part of the shaft 4 designed to bundle the drying air.
- the dryer module in the opening of a table top 7 or the like attached.
- a top 8 preferably made of acrylic or a similar material, arranged the Filter support stand consisting of the support elements 9 and the centering plate 11 carries, the filter support stand fixed by means of fastening bolts 9 in the plate 8 and is aligned.
- FIG. 3 shows the dryer module described above in one View from above.
- the plate 8 made of acrylic exists and is therefore transparent.
- Two are shown Tangential fan 1 with drive connections 2 and motors 3, the heating elements 5a and 5b in the air shaft 4, the one Nozzle 6 forms.
- the centering plate 11 has four Centering shaft 12 for receiving appropriately shaped Spacer sleeves of the filter carrier, which in FIG. 4 are shown. Through these centering shafts 12 alignment of the filter carrier is forced.
- Fig. 4 shows a cross section through for explanation a commonly used filter carrier 14, the a plurality of filter elements 15 is formed, the are connected to each other in a known manner.
- the filter carrier usually has a top view rectangular shape.
- the outer filter elements 15 of the Filter carrier 14 have spacer sleeves 17 which for Centering of the filter carrier 14 in an automated Serve environment. Here they are used for centering in the Centering shafts 12 of the centering plate 11. Further points the filter carrier 14 has a circumferential shape formed as a collar Wall 18 on.
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Drying Of Solid Materials (AREA)
- Inorganic Insulating Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Die Erfindung betrifft ein Trocknermodul zur Trocknung von Filterträgern, wie sie bei der DNA-Präparation verwendet werden.The invention relates to a dryer module for drying of filter carriers, such as those used in DNA preparation be used.
Bei modernen DNA-Präparationen, deren Produkte zu Sequenzieraufgaben eingesetzt werden sollen, ist eine Automatisierung der arbeitsintensiven manuellen Schritte unabdingbar, was insbesondere bei den neueren Megasequenzierprojekten deutlich wird (Human Genome Project). Während früher keine sogenannten Fertig-Kits zur Verfügung standen, welche die Aufarbeitung einklonierter DNA-Sequenzen vereinfachten, existieren heute bereits. einige kommerziell verfügbare Hilfsmittel, die sich auch über Roboter zur automatischen Abarbeitung der entsprechenden Protokolle eignen (wie beispielsweise dem weitverbreiteten Qiagen-Protokoll).With modern DNA preparations, their products too Sequencing tasks to be used is one Automation of labor-intensive manual steps indispensable, especially with the newer ones Megasequencing projects (Human Genome Project). While there were no so-called ready-made kits in the past Were available, which cloned the processing Simplified DNA sequences already exist today. some commercially available aids, too via robots for automatic processing of the appropriate protocols (such as the widespread Qiagen protocol).
Das von Qiagen beschriebene Präparationsprotokoll beinhaltet das Waschen der in Filterelementen eines Filterträgers adsorbierten DNA mit ethanolhaltigem Puffer. Versuche zeigten, daß Spuren von Ethanol das Ergebnis der nachfolgenden Sequenzierreaktionen drastisch verschlechtern. Die beteiligten Enzyme werden wahrscheinlich von Ethanol inhibiert. In diesem Schritt werden zunächst die größeren Mengen Ethanol aus den Filtern auf bekannte Weise entfernt. Dies kann bei einer Durchführung des Protokolls beispielsweise in einer entsprechenden Vakuumapparatur dadurch bewerkstelligt werden, daß das anliegende Vakuum länger appliziert wird, als dies zur Beseitung der Waschflüssigkeit notwendig wäre. Der auf diese Weise im Filter erzeugte Luftstrom entfernt die größeren Mengen Ethanol aus den Filtern. Die besondere Konstruktion der Qiagenfilterträger verunreinigt jedoch den nachfolgenden Sequenzierprozeß, wenn nicht besondere Vorkehrungen getroffen werden, da Ethanolreste an den Wandungen zwischen den Auslaßdüsen und den Kunststoffummantelungen an der Unterseite des Filterträgers verbleiben. Es konnte weiter beobachtet werden, daß eine Verunreinigung durch Ethanol während der Elution der DNA aus dem Filtermaterial in folgender Weise stattfindet: das Eluat bildet während des Absaugens in den Eluatfängern einen Tropfen an der Auslaßdüse. Dieser Tropfen "wandert" vor seinem Abreißen an den Düsen hoch und berührt die sich dort noch befindliche ethanolhaltige Flüssigkeit. Es findet folglich eine Durchmischung statt. Der Tropfen reißt dann ab und fällt in den Eluatfänger. Somit ist eine generelle Verunreinigung des Eluats mit Ethanol gegeben, die so groß ist, daß eine "Vergiftung". des Sequenzieransatzes vorliegt. Der Stand der Technik zeigt bereits ein Trocknermodul zum Trocknen von Produkten, wobei das Trocknermodul ein Aufnahmeelement zur Aufnahme des Produktes und mindestens ein Lüfterelement aufweist, und das Lüfterelement unterhalb des Aufnahmeelementes zur Aufnahme des Produktes angeordnet ist, so daß das Produkt von unten angeblasen und getrocknet wird; vgl. bspw. US 4 812 621, DE 94 01 195, US 3 007 256 und DE 97 363. The preparation protocol described by Qiagen involves washing the one in filter elements Filter carrier adsorbed DNA with ethanol-containing buffer. Experiments have shown that traces of ethanol are the result of subsequent sequencing reactions drastically deteriorate. The enzymes involved will probably inhibited by ethanol. In this step first the larger amounts of ethanol from the filters removed in a known manner. This can happen with a Implementation of the protocol, for example in a the corresponding vacuum apparatus that the applied vacuum is applied longer, than would be necessary to remove the washing liquid. The air flow generated in the filter in this way is removed the larger amounts of ethanol from the filters. The special one However, the construction of the Qiagen filter carrier contaminates the subsequent sequencing process, if not special Precautions are taken as ethanol remains on the Walls between the outlet nozzles and the Plastic sheathing on the underside of the filter holder remain. It was also observed that a Contamination by ethanol during the elution of the DNA from the filter material takes place in the following way: the Eluate forms in the eluate catchers during aspiration a drop on the outlet nozzle. This drop "wanders" before tearing it off at the nozzles and touching them liquid containing ethanol still there. It takes place consequently, mixing takes place. The drop then tears and falls into the eluate. So is a general one Contamination of the eluate with ethanol is given that large is that "poisoning". of the sequencing approach. The prior art already shows a dryer module for drying of products, the dryer module being a receiving element for Product and has at least one fan element, and the fan element below the receiving element for receiving of the product is arranged so that the product from below is blown and dried; see. for example US 4,812,621, DE 94 01 195, US 3,007,256 and DE 97 363.
Der Erfindung liegt nun daher die Aufgabe zugrunde, eine Vorrichtung zu schaffen, mit der der verbleibende Restalkohol von Filterträgern entfernt wird, wie sie beispielsweise in dem Qiagenprotokoll verwendet werden.The invention is therefore based on the object To create device with which the remaining Residual alcohol is removed from filter media as they are for example in the Qiagen protocol.
Die Aufgabe wird durch die Merkmale des Anspruchs 1
gelöst. Vorteilhafte Ausgestaltungen der Erfindung sind
Gegenstand der Unteransprüche.The object is achieved by the features of
Die Erfindung betrifft ein
Trocknermodul zum Trocknen eines Filterträgers im Rahmen
der DNA-Präparation mit einer Heizung und einem
Lüfterelement, wobei die Heizung stromabwärts vom
Lüfterelement angeordnet ist und die in dem Filterträger
angeordneten Filter von unten angeblasen und
getrocknet werden,
dadurch gekennzeichnet,
daß die Filter in dem Filterträger hängend angeordnet
sind, und der Filterträger Abstandshülsen aufweist,
die in entsprechende Zentrierschächte einer
Zentrierplatte zur Aufnahme des Filterträgers
einführbar sind, wobei als Heizung parallel über einen
rechteckigen Querschnitt eines Luftschachtes verlaufende
Heizdrähte senkrecht zum Luftstrom stromaufwärts der
Zentrierplatte angeordnet sind und das Trocknermodul
als Lüfterelement einen Tangentiallüfter aufweist. The invention relates to a dryer module for drying a filter carrier in the context of DNA preparation with a heater and a fan element, the heater being arranged downstream of the fan element and the filters arranged in the filter carrier being blown and dried from below,
characterized,
that the filters are arranged hanging in the filter carrier, and the filter carrier has spacer sleeves which can be inserted into corresponding centering shafts of a centering plate for receiving the filter carrier, heating wires running parallel to a rectangular cross section of an air shaft being arranged upstream of the centering plate as a heater and the dryer module has a tangential fan as the fan element.
Nach einer Ausführungsform der Erfindung ist das Trocknermodul dadurch gekennzeichnet, daß das Lüfterelement durch einen elektrischen Motor angetrieben wird.According to one embodiment of the invention, the dryer module is characterized in that the fan element is driven by an electric motor.
Nach einer Ausführungsform der Erfindung ist das Trocknermodul dadurch gekennzeichnet, daß zwischen dem Luftschacht und dem Zentrierelement für den Filterträger eine Düse zur Bündelung des Luftstromes angeordnet ist.According to one embodiment of the invention, the dryer module is characterized in that a nozzle for concentrating the air flow is arranged between the air shaft and the centering element for the filter carrier.
Nach einer Ausführungsform der Erfindung ist das Trocknermodul dadurch gekennzeichnet, daß das Trocknermodul in einer Öffnung einer Tischplatte angeordnet ist.According to one embodiment of the invention, the dryer module is characterized in that the dryer module is arranged in an opening of a table top.
Nach einer Ausführungsform der Erfindung ist das Trocknermodul dadurch gekennzeichnet, daß die Zentrierplatte zur Aufnahme des Filterträgers auf Stützelementen angeordnet ist.According to one embodiment of the invention, the dryer module is characterized in that the centering plate for receiving the filter carrier is arranged on support elements.
Nach einer Ausführungsform der Erfindung ist das Trocknermodul dadurch
gekennzeichnet, daß das Modul einen Temperaturfühler
aufweist, daß
das Modul eine elektrische Steuerung zur Steuerung des mindestens
einen Motors und der Heizung aufweist, wobei
die Heizung als Funktion der vom Temperaturfühler gemessenen
Temperatur gesteuert wird, und
daß
die Steuerung mit einer Verzögerungsschaltung versehen ist,
die bewirkt, daß im Falle eines Abschaltens des Trocknermoduls
das mindestens eine Lüfterelement (1) zeitlich nach
dem Abschalten der Heizung (5) abgeschaltet wird.According to one embodiment of the invention, the dryer module is characterized in that the module has a temperature sensor that
the module has an electrical controller for controlling the at least one motor and the heater, the heater being controlled as a function of the temperature measured by the temperature sensor, and
that the controller is provided with a delay circuit which, in the event that the dryer module is switched off, causes the at least one fan element (1) to be switched off in time after the heating (5) is switched off.
Die Erfindung gibt ferner die Verwendung des Trocknermoduls in einer automatisierten Umgebung sowie als alleinstehendes Gerätan. The invention also provides the use of the dryer module in an automated environment as well as a stand-alone device.
Vorteilhafterweise wird der Schritt des Entfernens des Ethanols aus dem Bereich zwischen Auslaßdüse und Kunststoffummantelung der Filterträger nicht manuell durchgeführt, sondern automatisiert. Zu diesem Zwecke bläst das Trocknermodul erwärmte Luft (maximal 50 °C) von unten gegen den Filterträger und das Ethanol verdampft. Der auf diese Weise getrocknete Filter wird erneut in eine Vakuumkammer gestellt, um dann nochmals für eine gewisse Zeit durch ein angelegtes Vakuum belüftet zu werden. In diesem zweiten Schritt werden verbliebene Ethanolspuren weiter ausgetragen. Abschließend wird das so behandelte Filter nochmals auf das Trocknermodul gebracht, um durch den temperierten Luftstrom sicherzustellen, daß eventuell immer noch vorliegende Spuren von Ethanol endgültig abgedampft werden. Erst dann wird der Filterträger beispielsweise wieder in den Pipettierroboter eingestellt, um das Elutionsmittel für die Freisetzung der DNA aus den Filtern einzupipettieren.Advantageously, the step of removing the Ethanol from the area between the outlet nozzle and Plastic sheathing of the filter carrier not manually performed, but automated. Blows for this purpose the dryer module heated air (maximum 50 ° C) from below evaporated against the filter support and the ethanol. The on this way dried filter is again in a Vacuum chamber placed, then again for a certain Time to be ventilated by applying a vacuum. In This second step will leave traces of ethanol carried on. Finally, this is how it is treated Filter placed on the dryer module again to pass through to ensure that the temperature-controlled air flow traces of ethanol still present for good be evaporated. Only then will the filter holder for example put back in the pipetting robot, to the eluent for the release of the DNA from the Pipette in filters.
Eine bevorzugte Ausführungsform der Erfindung wird
nachfolgend anhand der Zeichnungen beschrieben, in denen
In der in der Fig. 1 dargestellten bevorzugten
Ausführungsform werden zwei Tangentiallüfter 1 an ihren
Längsseiten gekoppelt, um einen möglichst homogenen
Luftstrom zu erhalten. Es ergibt sich so ein gleichmäßiger
Luftstrom über die gesamte Fläche des zu trocknenden
Filterträgers (nicht dargestellt). Die Austrittsfläche des
Luftschachts 4, die in der bevorzugten Ausführungsform 8 cm
x 12,5 cm beträgt, ist etwas größer als die. zu trocknende
Grundfläche des Filterträgers. Der Luftstrom beträgt
maximal 2x80 m3/h und kann über einen
Vorschalttransformator (nicht dargestellt) über die
Umdrehungsgeschwindigkeit der Motore 3 des Paares der
Tangentiallüfter 1 geregelt werden.In the preferred embodiment shown in FIG. 1, two
Der rechteckige Luftschacht 4 ist so konstruiert, daß der
Luftstrom, einer Düse 6 gleich, zur Austrittsöffung hin
gebündelt wird. Er ist aus 2 mm starkem Eisenblech
gefertigt und zu einer geschlossenen Form verlötet. An
dessem unteren Bereich befindet sich eine Aufnahme für eine
Heizung 5. Darunter sind die beiden Tangentiallüfter 1
befestigt. Der obere Teil des Luftschachts 4 ist in einer
entsprechend dimensionierten Aussparung einer Tischplatte 7
befestigt und somit im Arbeitsbereich an genau definierter
Position fixiert. Die Heizelemente 5a, 5b und die
Lüfterelemente 1 befinden sich durch diese Anordnung unter
dem Arbeitstisch 7. Die Öffnung des Luftschachtes 4 ist
vorzugsweise ebenerdig mit der Arbeitsfläche eines
Robotertischs (nicht dargestellt) im Falle der Verwendung
des Trocknermoduls in einem automatisierten Verfahren.The
Die Heizung 5 besteht in der bevorzugten Ausführungsform
aus zwei Heizelementen 5a, 5b, wie dies in den Figuren 2
und 3 deutlicher werden wird. Diese Heizelemente 5a, 5b
sind über der Austrittsöffnung der Tangentiallüfter 1
befestigt. Jeweils zwei Multimicalochplatten werden als
Träger für einen Heizdraht verwendet, der in Wendeln von
ca. 3 mm Abstand in den Luftstrom eingespannt wird und
diesen dadurch gleichmäßig erwärmt. Die Wendel sind dabei
so beschaffen, daß die Umkehrschlaufe außerhalb des
Luftstroms zu liegen kommt, die parallel verlaufenden
Heizdrähte hingegen senkrecht zu den Multimicalochplatten
angeordnet sind.The
Der Filterständer, bestehend aus einem Aufnahmeelement
11 und Stützelementen 10, ist so ausgelegt, daß er
zentrierende Elemente (dargestellt in der Fig. 3) an seinen
Kontaktstellen zum Filterträger (nicht dargestellt)
aufweist. Insbesondere sind 30° Phasen an den
Berührungsbereichen zu den Abstandshülsen (siehe Fig. 4)
eines Filterträgers zu nennen. Der Filterständer umfaßt in
der bevorzugten Ausführungsform eine als Aufnahmeelement
wirkende obere Trägerplatte oder Zentrierplatte 10, welche
die Zentrierelemente, nämlich Aussparungen für die
Abstandshülsen und die Auflagefläche für den Rand des
Filterträgers aufweist. An dieser Zentrierplatte sind in
den vier Eckpunkten 4,5 cm hohe Stützelemente 10 befestigt,
die an ihrem unteren Ende jeweils einen Befestigungsbolzen
8 von 0,3 cm aufweisen. Diese Bolzen 9 fixieren den
Filterträgerständer exakt über den Luftaustrittsschacht 4
des Trocknermoduls, indem sie in entsprechende Bohrungen
einer auf dem Arbeitstisch angeordneten Platte 8 zur
Befestigung des Ständers eingreifen. In der bevorzugten
Ausführungsform ist die Platte 8 aus Acryl. Nach der
Einstellung des Filterträgers, der in Fig. 4 beschrieben
ist, befinden sich dessen Auslaßdüsen ca 3 cm über der
Oberkante des Luftschachts 4.The filter stand, consisting of a
Die Ansteuerung der Lüfterelemente 1 sowie die
Freischaltung der Heizelemente 5a, 5b erfolgen getrennt
über ein Controllerinterface. Somit kann nach Beendigung
des Trocknungsvorgangs zuerst die Heizung 5 abgeschaltet
werden, so daß nach zeitlichem Versatz die nun kühlend auf
die Heizdrähte einwirkende Lüftung beendet wird. Zur
Temperaturmessung ist in der Düse 6 eine seitliche
Aussparung 13 zur Aufnahme eines Temperaturfühlers
vorgesehen. Die Heizelelmente 5a, 5b wird über eine
Temperaturschwellwertschaltung gesteuert.The control of the
Fig. 2 zeigt ebenfalls das erfindungsgemäße Trocknermodul
in einer Querschnittsansicht, die jedoch gegenüber der
Ansicht der Fig. 1 um 90° um die vertikale Symmetrieachse
gedreht ist. Zu erkennen sind die beiden parallel
angeordneten Tangentiallüfterwalzen 1, die von
entsprechenden Motoren 3 angetrieben werden. In dem
Luftschacht 4 sind die beiden Heizelemente 5a, 5b der
Heizung 5 parallel und fast aneinanderstoßend angeordnet.
Darüberliegend ist die Düse 6 als Bestandteil des Schachts
4 zur Bündelung der trockenenden Luft ausgebildet. In der
hier dargestellten Ausführungsform ist das Trocknermodul in
der Öffnung einer Tischplatte 7 o.ä. befestigt. Auf der
Tischplatte 7 ist eine Platte 8, vorzugsweise aus Acryl
oder einem ähnlichen Werkstoff, angeordnet, die den
Filterträgerständer bestehend aus den Stützelementen 9 und
der Zentrierplatte 11 trägt, wobei der Filterträgerständer
mittels Befestigungsbolzen 9 in der Platte 8 fixiert und
ausgerichtet ist.2 also shows the dryer module according to the invention
in a cross-sectional view, but opposite the
1 of 90 ° around the vertical axis of symmetry
is rotated. The two can be seen in parallel
arranged
Fig. 3 zeigt das oben beschrieben Trocknermodul in einer
Ansicht von oben. Es ist dabei zu berücksichtigen, daß in
der bevorzugten Ausführungsform die Platte 8 aus Acryl
besteht und damit durchsichtig ist. Dargestellt sind zwei
Tangentiallüfter 1 mit Antriebsverbindungen 2 und Motoren
3, die Heizelelemente 5a und 5b im Luftschacht 4, der eine
Düse 6 bildet. Die Zentrierplatte 11 weist vier
Zentrierschächt 12 zur Aufnahme entsprechend geformter
Abstandshülsen des Filterträgers auf, die in der Fig. 4
dargestellt sind . Durch diese Zentrierschächte 12 wird
eine Ausrichtung des Filterträgers erzwungen.3 shows the dryer module described above in one
View from above. It should be noted that in
the preferred embodiment, the
Fig. 4 zeigt zur Erläuterung einen Querschnitt durch
einen üblicherweise verwendeten Filterträger 14, der aus
einer Vielzahl von Filterelementen 15 gebildet wird, die
auf bekannte Weise miteinander verbunden sind.
Üblicherweise hat der Filterträger in Draufsicht eine
rechteckige Gestalt. Die äußeren Filterelemente 15 des
Filterträger 14 weisen Abstandshülsen 17 auf, die zur
Zentrierung des Filterträgers 14 in einer automatisierten
Umgebung dienen. Hier dienen sie zur Zentrierung in den
Zentrierschächten 12 der Zentrierplatte 11. Ferner weist
der Filterträger 14 eine als Kragen ausgeformte umlaufende
Wandung 18 auf. Beim Einführen des Filterträgers in die
Zentrierplatte 11 des Trocknermoduls greifen zuerst die
Abstandshülsen 17 in die Zentrierschächte 12 ein und der
Filterträger 14 wird beispielsweise durch einen Roboter
solange nach unten bewegt, bis die Wandung 18 auf die
Zentrierplatte 11 aufsetzt und der Filterträger 14 so seine
Endposition einnimmt. Danach wird das Trocknermodul in
Betrieb genommen. Fig. 4 shows a cross section through for explanation
a commonly used
- 11
- TangentiallüfterwalzeTangentiallüfterwalze
- 22
- Antriebsverbindungdrive connection
- 33
- Motorengine
- 44
- Luftschachtairshaft
- 55
- Heizungheater
- 5a, 5b5a, 5b
- Heizelementheating element
- 66
- Düsejet
- 77
- Tischplattetabletop
- 88th
- Acrylplatteacrylic plate
- 99
- Befestigungsbolzenmounting bolts
- 1010
- Ständerstand
- 1111
- Zentrierplattecentering
- 1212
- ZentrierschachtZentrierschacht
- 1313
- TemperaturfühleraufnahmeTemperature sensor connection
- 1414
- Filterträgerfilter support
- 1515
- Filterelementfilter element
- 1616
- FilterelementdüseFilterelementdüse
- 1717
- Abstandshülsespacer
- 1818
- Wandungwall
Claims (10)
- Dryer module for drying a filter support (14) in the context of DNA preparation, having a heating system (5) and a blower member (11), the heating system (5) being arranged downstream of the blower member (1) and the filter (15) arranged in the filter support (14) being blown on and dried from below,
characterized in that
the filters (15) are arranged suspended in the filter support (14) and the filter support has spacer sleeves (17) that are insertable into corresponding centring shafts (12) in a centring plate (11) for receiving the filter support (14), the heating system (5) comprising heating wires, which extend in parallel over a rectangular cross-section of an air shaft (4) and which are arranged at right angles to the air flow and upstream of the centring plate (11), and the dryer module having a crossflow blower as blower member (1). - Dryer module according to claim 1, characterized in that the blower member (1) is driven by an electric motor (3).
- Dryer module according to claim 1 or 2, characterized in that a nozzle (6) for channeling the air flow is arranged between the air shaft (4) and the centring member (11) for the filter support (14).
- Dryer module according to any one of the preceding claims, characterized in that the dryer module is arranged in an opening in a bench top (7).
- Dryer module according to any one of the preceding claims 1 to 4, characterized in that the centring plate (11) for receiving the filter support is arranged on supporting members (10).
- Dryer module according to any one of the preceding claims, characterized in that the module has a temperature sensor.
- Dryer module according to claim 6, characterized in that the module has an electrical control means for controlling the motor (3), of which there is at least one, and the heating system (5), the heating system being controlled as a function of the temperature measured by the temperature sensor.
- Dryer module according to claim 7, characterized in that the control means is provided with a delay circuit which, when the dryer module is switched off, causes the blower member (1), of which there is at least one, to be switched off chronologically after the heating system (5) is switched off.
- Use of the dryer module according to any one of claims I to 8 in an automated environment.
- Use of the dryer module according to any one of claims 1 to 8 as a stand-alone apparatus.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19728496 | 1997-07-03 | ||
DE19728496A DE19728496A1 (en) | 1997-07-03 | 1997-07-03 | Dryer module |
PCT/EP1998/004121 WO1999001708A1 (en) | 1997-07-03 | 1998-07-03 | Drying module |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0993586A1 EP0993586A1 (en) | 2000-04-19 |
EP0993586B1 true EP0993586B1 (en) | 2002-01-23 |
Family
ID=7834575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98940128A Expired - Lifetime EP0993586B1 (en) | 1997-07-03 | 1998-07-03 | Drying module |
Country Status (11)
Country | Link |
---|---|
US (1) | US6226892B1 (en) |
EP (1) | EP0993586B1 (en) |
JP (1) | JP2002510383A (en) |
AT (1) | ATE212433T1 (en) |
AU (1) | AU8855398A (en) |
CA (1) | CA2295145A1 (en) |
DE (2) | DE19728496A1 (en) |
DK (1) | DK0993586T3 (en) |
ES (1) | ES2172183T3 (en) |
PT (1) | PT993586E (en) |
WO (1) | WO1999001708A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100487345B1 (en) * | 2002-11-26 | 2005-05-03 | 엘지전자 주식회사 | Dryer and Control Method of Cooling Time for the same |
CN106369967A (en) * | 2016-10-31 | 2017-02-01 | 王月娟 | Agricultural fodder dryer |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE97363C (en) * | ||||
FR880989A (en) * | 1941-12-08 | 1943-04-12 | Fraissec | Vegetable and fruit dehydrating device |
US3007256A (en) * | 1957-09-12 | 1961-11-07 | Auguste L M A Rouy | Heating and drying apparatus and method |
US4812621A (en) * | 1987-10-28 | 1989-03-14 | Tania Brotherton | Electrically heated dish drying rack |
US5216251A (en) * | 1991-10-18 | 1993-06-01 | Matschke Arthur L | Apparatus and method for a bio-conditioning germicidal dryer |
EP0569115A3 (en) * | 1992-05-05 | 1994-01-05 | General Atomics | High throughput DNA preparation system |
US6068874A (en) * | 1993-02-16 | 2000-05-30 | Dehydration Technologies, Inc. | Process of dehydrating biological products |
US5311671A (en) * | 1993-03-23 | 1994-05-17 | Brooks Floyd L | Apparatus for recovering dry cleaning fluid |
JPH0712458A (en) * | 1993-06-23 | 1995-01-17 | Murata Mfg Co Ltd | Dryer for parts |
US5440822A (en) * | 1993-07-16 | 1995-08-15 | Novel Experimental Technology | Method and apparatus for drying electrophoresis gels |
US5709038A (en) * | 1993-09-24 | 1998-01-20 | Optimum Air Corporation | Automated air filtration and drying system for waterborne paint and industrial coatings |
DE9401195U1 (en) * | 1994-01-25 | 1994-03-31 | Bartel, Walter, 78054 Villingen-Schwenningen | Sieve drying cabinet |
US5451524A (en) * | 1994-02-01 | 1995-09-19 | The Gillette Company | In vitro chamber for human organ tissue samples |
DE9413225U1 (en) * | 1994-08-16 | 1995-03-16 | Wiesenborn, Wilfried, 41812 Erkelenz | Drying unit |
US5704135A (en) * | 1995-07-10 | 1998-01-06 | Riahi; Sohrab | Instant photographic print drying device |
-
1997
- 1997-07-03 DE DE19728496A patent/DE19728496A1/en not_active Withdrawn
-
1998
- 1998-07-03 AU AU88553/98A patent/AU8855398A/en not_active Withdrawn
- 1998-07-03 CA CA002295145A patent/CA2295145A1/en not_active Abandoned
- 1998-07-03 US US09/446,497 patent/US6226892B1/en not_active Expired - Fee Related
- 1998-07-03 AT AT98940128T patent/ATE212433T1/en not_active IP Right Cessation
- 1998-07-03 JP JP50635999A patent/JP2002510383A/en active Pending
- 1998-07-03 PT PT98940128T patent/PT993586E/en unknown
- 1998-07-03 EP EP98940128A patent/EP0993586B1/en not_active Expired - Lifetime
- 1998-07-03 ES ES98940128T patent/ES2172183T3/en not_active Expired - Lifetime
- 1998-07-03 WO PCT/EP1998/004121 patent/WO1999001708A1/en active IP Right Grant
- 1998-07-03 DE DE59802912T patent/DE59802912D1/en not_active Expired - Lifetime
- 1998-07-03 DK DK98940128T patent/DK0993586T3/en active
Also Published As
Publication number | Publication date |
---|---|
CA2295145A1 (en) | 1999-01-14 |
US6226892B1 (en) | 2001-05-08 |
WO1999001708A1 (en) | 1999-01-14 |
ES2172183T3 (en) | 2002-09-16 |
EP0993586A1 (en) | 2000-04-19 |
PT993586E (en) | 2002-07-31 |
DE59802912D1 (en) | 2002-03-14 |
DK0993586T3 (en) | 2002-04-22 |
AU8855398A (en) | 1999-01-25 |
DE19728496A1 (en) | 1999-01-07 |
JP2002510383A (en) | 2002-04-02 |
ATE212433T1 (en) | 2002-02-15 |
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