EP0979309A4 - Oligonukleotide mit verbesserter bioverfügbarkeit - Google Patents

Oligonukleotide mit verbesserter bioverfügbarkeit

Info

Publication number
EP0979309A4
EP0979309A4 EP98920076A EP98920076A EP0979309A4 EP 0979309 A4 EP0979309 A4 EP 0979309A4 EP 98920076 A EP98920076 A EP 98920076A EP 98920076 A EP98920076 A EP 98920076A EP 0979309 A4 EP0979309 A4 EP 0979309A4
Authority
EP
European Patent Office
Prior art keywords
oligonucleotides
enhanced bioavailability
alimentary delivery
oligonucleotide
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP98920076A
Other languages
English (en)
French (fr)
Other versions
EP0979309A1 (de
Inventor
Nicholas M Dean
C Frank Bennett
Brett P Monia
Kenneth Draper
Kevin P Anderson
Brenda F Baker
David J Ecker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of EP0979309A1 publication Critical patent/EP0979309A1/de
Publication of EP0979309A4 publication Critical patent/EP0979309A4/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
EP98920076A 1997-04-30 1998-04-30 Oligonukleotide mit verbesserter bioverfügbarkeit Ceased EP0979309A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US847151 1992-03-05
US84715197A 1997-04-30 1997-04-30
PCT/US1998/008798 WO1998049348A1 (en) 1997-04-30 1998-04-30 Oligonucleotides for enhanced bioavailability

Publications (2)

Publication Number Publication Date
EP0979309A1 EP0979309A1 (de) 2000-02-16
EP0979309A4 true EP0979309A4 (de) 2000-10-18

Family

ID=25299899

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98920076A Ceased EP0979309A4 (de) 1997-04-30 1998-04-30 Oligonukleotide mit verbesserter bioverfügbarkeit

Country Status (6)

Country Link
EP (1) EP0979309A4 (de)
JP (1) JP2000514095A (de)
KR (1) KR20010020370A (de)
AU (1) AU738352B2 (de)
CA (1) CA2286396C (de)
WO (1) WO1998049348A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6887906B1 (en) 1997-07-01 2005-05-03 Isispharmaceuticals, Inc. Compositions and methods for the delivery of oligonucleotides via the alimentary canal
EP1080225A4 (de) * 1998-05-21 2004-02-04 Isis Pharmaceuticals Inc Zusammensetzungen und methoden zur pulmonalen verabreichung von nukleinsäuren
SI1077722T1 (sl) 1998-05-22 2007-02-28 Ottawa Health Research Inst Metode in produkti za induciranje sluznicne imunosti
WO2000050050A1 (en) * 1999-02-23 2000-08-31 Isis Pharmaceuticals, Inc. Multiparticulate formulation
US6168950B1 (en) * 1999-07-23 2001-01-02 Isis Pharmaceuticals, Inc. Antisense modulation of MEKK1 expression
ES2302699T3 (es) * 1999-08-27 2008-08-01 Novartis Vaccines And Diagnostics, Inc. Oligonucleotidos quimericos antisentido y formulaciones de transfeccion celular de los mismos.
US6677445B1 (en) 1999-08-27 2004-01-13 Chiron Corporation Chimeric antisense oligonucleotides and cell transfecting formulations thereof
IL159722A0 (en) 2001-07-10 2004-06-20 Oligos Etc Inc Pharmaceutical compositions containing oligonucleotides
US20030124196A1 (en) 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
MX2011005042A (es) 2008-11-13 2011-08-17 Giuliani Int Ltd Composiciones antisentido, y metodos para obtener y usar las mismas.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0626387A1 (de) * 1993-05-12 1994-11-30 Ciba-Geigy Ag Nukleoside und Oligonukleotide mit 2'-Ethergruppen
WO1995002069A1 (en) * 1993-07-09 1995-01-19 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of protein kinase c
WO1996012497A1 (en) * 1994-10-25 1996-05-02 Hybridon, Inc. Use of 2'-substituted oligonucleotides to down-regulating gene expression
WO1997029780A1 (en) * 1996-02-14 1997-08-21 Isis Pharmaceuticals, Inc. Methoxyethoxy oligonucleotides for modulation of protein kinase c expression

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214135A (en) * 1991-08-30 1993-05-25 Chemgenes Corporation N-protected-2'-O-methyl-ribonucleosides and N-protected 2'-O-methyl-3'-cyanoethyl-N-,N-diisopropyl phosphoramidite ribonucleosides
DE69629702T2 (de) * 1995-08-01 2004-06-17 Isis Pharmaceuticals, Inc., Carlsbad Liposomale oligonukleotidzusammensetzungen

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0626387A1 (de) * 1993-05-12 1994-11-30 Ciba-Geigy Ag Nukleoside und Oligonukleotide mit 2'-Ethergruppen
WO1995002069A1 (en) * 1993-07-09 1995-01-19 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of protein kinase c
WO1996012497A1 (en) * 1994-10-25 1996-05-02 Hybridon, Inc. Use of 2'-substituted oligonucleotides to down-regulating gene expression
WO1997029780A1 (en) * 1996-02-14 1997-08-21 Isis Pharmaceuticals, Inc. Methoxyethoxy oligonucleotides for modulation of protein kinase c expression

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MARTIN P: "38. EIN NEUER ZUGANG ZU 2'-O-ALKYLRIBONUCLEOSIDEN UND EIGENSCHAFTEN DEREN OLIGONUCLEOTIDE", HELVETICA CHIMICA ACTA,CH,VERLAG HELVETICA CHIMICA ACTA. BASEL, vol. 78, 1995, pages 486 - 504, XP000857415, ISSN: 0018-019X *
See also references of WO9849348A1 *

Also Published As

Publication number Publication date
EP0979309A1 (de) 2000-02-16
WO1998049348A1 (en) 1998-11-05
CA2286396C (en) 2010-07-06
AU7272398A (en) 1998-11-24
JP2000514095A (ja) 2000-10-24
KR20010020370A (ko) 2001-03-15
AU738352B2 (en) 2001-09-13
CA2286396A1 (en) 1998-11-05

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: ECKER, DAVID, J.

Inventor name: BAKER, BRENDA, F.

Inventor name: ANDERSON, KEVIN, P.

Inventor name: DRAPER, KENNETH

Inventor name: MONIA, BRETT, P.

Inventor name: BENNETT, C., FRANK

Inventor name: DEAN, NICHOLAS, M.

RIC1 Information provided on ipc code assigned before grant

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Owner name: ISIS PHARMACEUTICALS, INC.

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