EP0977988A4 - Homogeneous fluorescence assay for measuring the effect of compounds on gene expression - Google Patents
Homogeneous fluorescence assay for measuring the effect of compounds on gene expressionInfo
- Publication number
- EP0977988A4 EP0977988A4 EP98920866A EP98920866A EP0977988A4 EP 0977988 A4 EP0977988 A4 EP 0977988A4 EP 98920866 A EP98920866 A EP 98920866A EP 98920866 A EP98920866 A EP 98920866A EP 0977988 A4 EP0977988 A4 EP 0977988A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compounds
- measuring
- effect
- gene expression
- fluorescence assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4452797P | 1997-04-22 | 1997-04-22 | |
US44527P | 1997-04-22 | ||
PCT/US1998/008101 WO1998048274A1 (en) | 1997-04-22 | 1998-04-22 | Homogeneous fluorescence assay for measuring the effect of compounds on gene expression |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0977988A1 EP0977988A1 (en) | 2000-02-09 |
EP0977988A4 true EP0977988A4 (en) | 2004-06-30 |
Family
ID=21932889
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98920866A Withdrawn EP0977988A4 (en) | 1997-04-22 | 1998-04-22 | Homogeneous fluorescence assay for measuring the effect of compounds on gene expression |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0977988A4 (en) |
JP (1) | JP2002511744A (en) |
CA (1) | CA2287427A1 (en) |
WO (1) | WO1998048274A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001241709A1 (en) * | 2000-02-24 | 2001-09-03 | Incyte Genomics, Inc. | Molecules for disease detection and treatment |
CA2418496A1 (en) * | 2000-02-24 | 2001-08-30 | Incyte Genomics, Inc. | Secretory polypeptides and corresponding polynucleotides |
WO2001062927A2 (en) * | 2000-02-24 | 2001-08-30 | Incyte Genomics Inc | Polypeptides and corresponding polynucleotides for diagnostics and therapeutics |
EP1364015A2 (en) * | 2000-09-05 | 2003-11-26 | Incyte Genomics, Inc. | Molecules for diagnostics and therapeutics |
WO2008060400A2 (en) * | 2006-11-15 | 2008-05-22 | Sirtris Pharmaceuticals, Inc. | Sirtuin polymorphisms and methods of use thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0327960A1 (en) * | 1988-02-11 | 1989-08-16 | F. Hoffmann-La Roche Ag | Secretable forms of alkaline phosphatase |
US5156951A (en) * | 1989-07-13 | 1992-10-20 | Becton Dickinson And Company | Detecting immunological changes in HIV infected patient samples |
WO1995009240A1 (en) * | 1993-09-27 | 1995-04-06 | University Of Massachusetts Medical Center | Receptor-activated reporter systems |
EP0648841A2 (en) * | 1993-10-13 | 1995-04-19 | Northeastern Ohio Universities | Genomic DNA of human Cholesterol 7alpha-hydroxylase and methods for using it |
WO1996013610A2 (en) * | 1994-10-31 | 1996-05-09 | Geron Corporation | Methods and reagents for the identification and regulation of senescence-related genes |
EP0747700A2 (en) * | 1995-06-07 | 1996-12-11 | Carnegie-Mellon University | Fluorescent labelling complexes with large stokes shifts formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7667191A (en) * | 1990-04-19 | 1991-11-11 | General Hospital Corporation, The | Screening assays for compounds which inhibit the binding of c-myc to dna |
GB9320562D0 (en) * | 1993-10-06 | 1993-11-24 | Zeneca Ltd | Novel assay and applications |
US5506102A (en) * | 1993-10-28 | 1996-04-09 | Ligand Pharmaceuticals Incorporated | Methods of using the A form of the progesterone receptor to screen for antagonists of steroid intracellar receptor-mediated transcription |
US5747338A (en) * | 1996-08-15 | 1998-05-05 | Chiron Corporation | Method and construct for screening for inhibitors of transcriptional activation |
-
1998
- 1998-04-22 CA CA002287427A patent/CA2287427A1/en not_active Abandoned
- 1998-04-22 WO PCT/US1998/008101 patent/WO1998048274A1/en not_active Application Discontinuation
- 1998-04-22 EP EP98920866A patent/EP0977988A4/en not_active Withdrawn
- 1998-04-22 JP JP54630298A patent/JP2002511744A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0327960A1 (en) * | 1988-02-11 | 1989-08-16 | F. Hoffmann-La Roche Ag | Secretable forms of alkaline phosphatase |
US5156951A (en) * | 1989-07-13 | 1992-10-20 | Becton Dickinson And Company | Detecting immunological changes in HIV infected patient samples |
WO1995009240A1 (en) * | 1993-09-27 | 1995-04-06 | University Of Massachusetts Medical Center | Receptor-activated reporter systems |
EP0648841A2 (en) * | 1993-10-13 | 1995-04-19 | Northeastern Ohio Universities | Genomic DNA of human Cholesterol 7alpha-hydroxylase and methods for using it |
WO1996013610A2 (en) * | 1994-10-31 | 1996-05-09 | Geron Corporation | Methods and reagents for the identification and regulation of senescence-related genes |
EP0747700A2 (en) * | 1995-06-07 | 1996-12-11 | Carnegie-Mellon University | Fluorescent labelling complexes with large stokes shifts formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
Non-Patent Citations (4)
Title |
---|
BRONSTEIN I ET AL: "CHEMILUMINESCENT AND BIOLUMINESCENT REPORTER GENE ASSAYS", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 219, no. 2, 1 June 1994 (1994-06-01), pages 169 - 181, XP000446239, ISSN: 0003-2697 * |
KAETHER AND GERDES: "Visualization of protein transport along the secretory pathway using green fluorescent protein", FEBS LETTERS, vol. 369, 1995, pages 267 - 271, XP002275948 * |
MITRA R D ET AL: "Fluorescence resonance energy transfer between blue-emitting and red-shifted excitation derivatives of the green fluorescent protein", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 173, no. 1, 1996, pages 13 - 17, XP004042847, ISSN: 0378-1119 * |
See also references of WO9848274A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0977988A1 (en) | 2000-02-09 |
CA2287427A1 (en) | 1998-10-29 |
JP2002511744A (en) | 2002-04-16 |
WO1998048274A1 (en) | 1998-10-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): BE CH DE ES FR GB IT LI NL |
|
17P | Request for examination filed |
Effective date: 19991012 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: SMITHKLINE BEECHAM PLC Owner name: SMITHKLINE BEECHAM CORPORATION |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20040518 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20040805 |