EP0977988A4 - Test par fluorescence homogene pour mesurer l'effet des composes sur l'expression d'un gene - Google Patents

Test par fluorescence homogene pour mesurer l'effet des composes sur l'expression d'un gene

Info

Publication number
EP0977988A4
EP0977988A4 EP98920866A EP98920866A EP0977988A4 EP 0977988 A4 EP0977988 A4 EP 0977988A4 EP 98920866 A EP98920866 A EP 98920866A EP 98920866 A EP98920866 A EP 98920866A EP 0977988 A4 EP0977988 A4 EP 0977988A4
Authority
EP
European Patent Office
Prior art keywords
compounds
measuring
effect
gene expression
fluorescence assay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98920866A
Other languages
German (de)
English (en)
Other versions
EP0977988A1 (fr
Inventor
Damien J Dunnington
Keith J Moore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Ltd
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd, SmithKline Beecham Corp filed Critical SmithKline Beecham Ltd
Publication of EP0977988A1 publication Critical patent/EP0977988A1/fr
Publication of EP0977988A4 publication Critical patent/EP0977988A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
EP98920866A 1997-04-22 1998-04-22 Test par fluorescence homogene pour mesurer l'effet des composes sur l'expression d'un gene Withdrawn EP0977988A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4452797P 1997-04-22 1997-04-22
US44527P 1997-04-22
PCT/US1998/008101 WO1998048274A1 (fr) 1997-04-22 1998-04-22 Test par fluorescence homogene pour mesurer l'effet des composes sur l'expression d'un gene

Publications (2)

Publication Number Publication Date
EP0977988A1 EP0977988A1 (fr) 2000-02-09
EP0977988A4 true EP0977988A4 (fr) 2004-06-30

Family

ID=21932889

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98920866A Withdrawn EP0977988A4 (fr) 1997-04-22 1998-04-22 Test par fluorescence homogene pour mesurer l'effet des composes sur l'expression d'un gene

Country Status (4)

Country Link
EP (1) EP0977988A4 (fr)
JP (1) JP2002511744A (fr)
CA (1) CA2287427A1 (fr)
WO (1) WO1998048274A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2418496A1 (fr) * 2000-02-24 2001-08-30 Incyte Genomics, Inc. Molecules secretoires
WO2001062927A2 (fr) * 2000-02-24 2001-08-30 Incyte Genomics Inc Molecules utilisees a des fins diagnostiques et therapeutiques
CA2401076A1 (fr) * 2000-02-24 2001-08-30 Incyte Genomics, Inc. Molecules destinees a la detection et au traitement de maladies
CA2421265A1 (fr) * 2000-09-05 2002-03-14 Incyte Genomics, Inc. Molecules utilisees a des fins diagnostiques et therapeutiques
US20080249103A1 (en) * 2006-11-15 2008-10-09 Sirtris Pharmaceuticals, Inc. Sirtuin polymorphisms and methods of use thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0327960A1 (fr) * 1988-02-11 1989-08-16 F. Hoffmann-La Roche Ag Formes sécrétables de phosphatase alcaline
US5156951A (en) * 1989-07-13 1992-10-20 Becton Dickinson And Company Detecting immunological changes in HIV infected patient samples
WO1995009240A1 (fr) * 1993-09-27 1995-04-06 University Of Massachusetts Medical Center Systemes de ligands actives par les recepteurs
EP0648841A2 (fr) * 1993-10-13 1995-04-19 Northeastern Ohio Universities ADN génomique du cholestérol-7-alpha hydroxylase et méthodes pour son utilisation
WO1996013610A2 (fr) * 1994-10-31 1996-05-09 Geron Corporation Procedes et reactifs servant a identifier et a reguler des genes relatifs a la senescence
EP0747700A2 (fr) * 1995-06-07 1996-12-11 Carnegie-Mellon University Complexe avec un grand décalage de stokes pour marquage fluorescent formé par couplage de cyanine et autres fluorochromes capables de transfert d'énergie résonance

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7667191A (en) * 1990-04-19 1991-11-11 General Hospital Corporation, The Screening assays for compounds which inhibit the binding of c-myc to dna
GB9320562D0 (en) * 1993-10-06 1993-11-24 Zeneca Ltd Novel assay and applications
US5506102A (en) * 1993-10-28 1996-04-09 Ligand Pharmaceuticals Incorporated Methods of using the A form of the progesterone receptor to screen for antagonists of steroid intracellar receptor-mediated transcription
US5747338A (en) * 1996-08-15 1998-05-05 Chiron Corporation Method and construct for screening for inhibitors of transcriptional activation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0327960A1 (fr) * 1988-02-11 1989-08-16 F. Hoffmann-La Roche Ag Formes sécrétables de phosphatase alcaline
US5156951A (en) * 1989-07-13 1992-10-20 Becton Dickinson And Company Detecting immunological changes in HIV infected patient samples
WO1995009240A1 (fr) * 1993-09-27 1995-04-06 University Of Massachusetts Medical Center Systemes de ligands actives par les recepteurs
EP0648841A2 (fr) * 1993-10-13 1995-04-19 Northeastern Ohio Universities ADN génomique du cholestérol-7-alpha hydroxylase et méthodes pour son utilisation
WO1996013610A2 (fr) * 1994-10-31 1996-05-09 Geron Corporation Procedes et reactifs servant a identifier et a reguler des genes relatifs a la senescence
EP0747700A2 (fr) * 1995-06-07 1996-12-11 Carnegie-Mellon University Complexe avec un grand décalage de stokes pour marquage fluorescent formé par couplage de cyanine et autres fluorochromes capables de transfert d'énergie résonance

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BRONSTEIN I ET AL: "CHEMILUMINESCENT AND BIOLUMINESCENT REPORTER GENE ASSAYS", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 219, no. 2, 1 June 1994 (1994-06-01), pages 169 - 181, XP000446239, ISSN: 0003-2697 *
KAETHER AND GERDES: "Visualization of protein transport along the secretory pathway using green fluorescent protein", FEBS LETTERS, vol. 369, 1995, pages 267 - 271, XP002275948 *
MITRA R D ET AL: "Fluorescence resonance energy transfer between blue-emitting and red-shifted excitation derivatives of the green fluorescent protein", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 173, no. 1, 1996, pages 13 - 17, XP004042847, ISSN: 0378-1119 *
See also references of WO9848274A1 *

Also Published As

Publication number Publication date
CA2287427A1 (fr) 1998-10-29
JP2002511744A (ja) 2002-04-16
WO1998048274A1 (fr) 1998-10-29
EP0977988A1 (fr) 2000-02-09

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Owner name: SMITHKLINE BEECHAM PLC

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