EP0975343A1 - Traitement du diabete a l'aide de thiazolidinedione et d'un inhibiteur des alpha-glucosidases - Google Patents

Traitement du diabete a l'aide de thiazolidinedione et d'un inhibiteur des alpha-glucosidases

Info

Publication number
EP0975343A1
EP0975343A1 EP98939513A EP98939513A EP0975343A1 EP 0975343 A1 EP0975343 A1 EP 0975343A1 EP 98939513 A EP98939513 A EP 98939513A EP 98939513 A EP98939513 A EP 98939513A EP 0975343 A1 EP0975343 A1 EP 0975343A1
Authority
EP
European Patent Office
Prior art keywords
compound
administration
glucosidase inhibitor
pharmaceutically acceptable
alpha glucosidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98939513A
Other languages
German (de)
English (en)
Inventor
Stephen Alistair SmithKline Beecham Phar SMITH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9712865.6A external-priority patent/GB9712865D0/en
Priority claimed from GBGB9806708.5A external-priority patent/GB9806708D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of EP0975343A1 publication Critical patent/EP0975343A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

L'invention concerne une méthode de traitement, chez un mammifère, du diabète sucré et des états associés à ce diabète, cette méthode consistant à administrer à un mammifère nécessitant un tel traitement, une dose efficace, non toxique et acceptable sur le plan pharmacologique, d'un agent de sensibilisation à l'insuline et d'un agent anti-hyperglycémiant inhibant les alpha-glucosidases.
EP98939513A 1997-06-18 1998-06-15 Traitement du diabete a l'aide de thiazolidinedione et d'un inhibiteur des alpha-glucosidases Withdrawn EP0975343A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9712865 1997-06-18
GBGB9712865.6A GB9712865D0 (en) 1997-06-18 1997-06-18 Novel method of treatment
GBGB9806708.5A GB9806708D0 (en) 1998-03-27 1998-03-27 Novel method
GB9806708 1998-03-27
PCT/EP1998/003691 WO1998057635A1 (fr) 1997-06-18 1998-06-15 Traitement du diabete a l'aide de thiazolidinedione et d'un inhibiteur des alpha-glucosidases

Publications (1)

Publication Number Publication Date
EP0975343A1 true EP0975343A1 (fr) 2000-02-02

Family

ID=26311746

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98939513A Withdrawn EP0975343A1 (fr) 1997-06-18 1998-06-15 Traitement du diabete a l'aide de thiazolidinedione et d'un inhibiteur des alpha-glucosidases

Country Status (24)

Country Link
EP (1) EP0975343A1 (fr)
JP (1) JP2001523271A (fr)
KR (1) KR20010013845A (fr)
CN (1) CN1274282A (fr)
AP (1) AP9901720A0 (fr)
AR (2) AR013352A1 (fr)
AU (1) AU8799998A (fr)
BG (1) BG103966A (fr)
BR (1) BR9810186A (fr)
CA (1) CA2294134A1 (fr)
CO (1) CO4940453A1 (fr)
DZ (1) DZ2519A1 (fr)
EA (1) EA200000040A1 (fr)
IL (1) IL133138A0 (fr)
MA (1) MA26510A1 (fr)
NO (1) NO996270L (fr)
NZ (1) NZ501345A (fr)
OA (1) OA11631A (fr)
PE (1) PE89199A1 (fr)
PL (1) PL337577A1 (fr)
SK (1) SK179499A3 (fr)
TR (1) TR199903072T2 (fr)
UY (1) UY25051A1 (fr)
WO (1) WO1998057635A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000064892A2 (fr) 1999-04-23 2000-11-02 Smithkline Beecham P.L.C. Nouvelle composition pharmaceutique
CA2442917C (fr) 2001-04-04 2011-02-01 Ortho-Mcneil Pharmaceutical, Inc. Polytherapie comprenant des inhibiteurs de reabsorption du glucose et des modulateurs ppar
DE60233655D1 (de) 2001-04-04 2009-10-22 Ortho Mcneil Janssen Pharm R und retinoid x rezeptorenmodulatoren
FR2832930A1 (fr) * 2001-12-03 2003-06-06 Lipha Composition pharmaceutique comprenant un inhibiteur d'alpha-glucosidase et un derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
JP2004067575A (ja) * 2002-08-06 2004-03-04 Yaizu Suisankagaku Industry Co Ltd 糖尿病治療薬効果促進剤
CN101121004B (zh) * 2006-08-08 2010-07-21 鲁南制药集团股份有限公司 含有胰岛素增敏剂和米格列醇的药物组合物
CN101584688B (zh) * 2008-05-24 2010-11-10 鲁南制药集团股份有限公司 一种治疗糖尿病及其并发症的药物组合物
CN101584705B (zh) * 2008-05-24 2010-10-27 鲁南制药集团股份有限公司 一种治疗糖尿病及其并发症的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0601001B1 (fr) * 1991-08-26 1997-04-16 PHARMACIA & UPJOHN COMPANY Composition alimentaire liquide contenant de l'acide 3-guanidinopropionique
US5917052A (en) * 1994-09-28 1999-06-29 Shaman Pharmaceuticals, Inc. Hypoglycemic agent from cryptolepis
TWI238064B (en) * 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9857635A1 *

Also Published As

Publication number Publication date
EA200000040A1 (ru) 2000-08-28
CN1274282A (zh) 2000-11-22
JP2001523271A (ja) 2001-11-20
SK179499A3 (en) 2000-11-07
AR013352A1 (es) 2000-12-27
PL337577A1 (en) 2000-08-28
CO4940453A1 (es) 2000-07-24
AR014881A1 (es) 2001-04-11
MA26510A1 (fr) 2004-12-20
NZ501345A (en) 2001-10-26
NO996270D0 (no) 1999-12-17
WO1998057635A1 (fr) 1998-12-23
TR199903072T2 (xx) 2000-07-21
KR20010013845A (ko) 2001-02-26
BR9810186A (pt) 2000-08-08
AU8799998A (en) 1999-01-04
CA2294134A1 (fr) 1998-12-23
AP9901720A0 (en) 1999-12-31
PE89199A1 (es) 1999-10-23
OA11631A (en) 2004-11-22
NO996270L (no) 1999-12-17
DZ2519A1 (fr) 2003-02-01
IL133138A0 (en) 2001-03-19
UY25051A1 (es) 2000-09-29
BG103966A (bg) 2000-07-31

Similar Documents

Publication Publication Date Title
AP1279A (en) Treatment of diabetes with thiazolidinedione and metformin.
US20030109553A1 (en) Treatment of diabetes with thiazolidinedione and metformin
EP1001783B1 (fr) Traitement du diabete avec du thiazolidinedione, un secretagogue d'insuline et du biguanide
US20010049380A1 (en) Treatment of diabetes with thiazolidinedione and sulphonylurea
EP0975343A1 (fr) Traitement du diabete a l'aide de thiazolidinedione et d'un inhibiteur des alpha-glucosidases
EP1001784A1 (fr) Traitement du diabete avec du thiazolidinedione, un secretagogue d'insuline et un inhibiteur d'alpha glucosidase
WO1998057649A1 (fr) Traitement du diabete a l'aide de thiazolidinedione et de sulfonyluree
US20020123514A1 (en) Treatment of diabetes with thiazolidinedione and alpha-glucosidase inhibitor
AU778947B2 (en) Treatment of diabetes with thiazolidinedione and metformin
NZ515554A (en) Treatment of diabetes with thiazolidinedione and metformin
CA2549864A1 (fr) Traitement du diabete a l'aide de thiazolidinedione et de metformine
AU1540002A (en) Treatment of diabetes with thiazolidinedione and sulphonylurea
MXPA99012098A (en) Treatment of diabetes with thiazolidinedione and alpha-glucosidase inhibitor
MXPA99012078A (en) Treatment of diabetes with thiazolidinedione and metformin
AU2928002A (en) Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19991124

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: RO PAYMENT 19991124;SI PAYMENT 19991124

17Q First examination report despatched

Effective date: 20011112

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: SMITHKLINE BEECHAM PLC

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040528

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1025263

Country of ref document: HK